{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T21:34:50Z","timestamp":1793050490224,"version":"4.5.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2012,6,25]],"date-time":"2012-06-25T00:00:00Z","timestamp":1340582400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1186\/1479-5876-10-132","type":"journal-article","created":{"date-parts":[[2012,9,4]],"date-time":"2012-09-04T10:15:28Z","timestamp":1346753728000},"source":"Crossref","is-referenced-by-count":26,"title":["Claspin as a biomarker of human papillomavirus-related high grade lesions of uterine cervix"],"prefix":"10.1186","volume":"10","author":[{"given":"Maria","family":"Benevolo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Musio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amina","family":"Vocaturo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Gabriella","family":"Don\u00e0","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Rollo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Terrenato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariantonia","family":"Carosi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edoardo","family":"Pescarmona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Vocaturo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcella","family":"Mottolese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,6,25]]},"reference":[{"key":"1082_CR1","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1016\/j.dnarep.2004.03.001","volume":"3","author":"CC Chini","year":"2004","unstructured":"Chini CC, Chen J: Claspin, a regulator of Chk1 in DNA replication stress pathway. DNA Repair. 2004, 3: 1033-1037. 10.1016\/j.dnarep.2004.03.001.","journal-title":"DNA Repair"},{"key":"1082_CR2","doi-asserted-by":"publisher","first-page":"2831","DOI":"10.4161\/cc.5.24.3559","volume":"5","author":"R Freire","year":"2006","unstructured":"Freire R, van Vugt M, Mamely I, Medema RH: Claspin. Timing the cell cycle arrest when the genome is damaged. Cell Cycle. 2006, 5: 2831-2834. 10.4161\/cc.5.24.3559.","journal-title":"Cell Cycle"},{"key":"1082_CR3","doi-asserted-by":"publisher","first-page":"2367","DOI":"10.1271\/bbb.100583","volume":"74","author":"K Tanaka","year":"2010","unstructured":"Tanaka K: Multiple functions of the S-phase Checkpoint mediator. Biosci. Biotechnol. Biochem. 2010, 74: 2367-2373. 10.1271\/bbb.100583.","journal-title":"Biosci. Biotechnol. Biochem"},{"key":"1082_CR4","doi-asserted-by":"publisher","first-page":"30057","DOI":"10.1074\/jbc.M301136200","volume":"278","author":"CC Chini","year":"2003","unstructured":"Chini CC, Chen J: Human claspin is required for replication checkpoint control. J Biol Chem. 2003, 278: 30057-30062. 10.1074\/jbc.M301136200.","journal-title":"J Biol Chem"},{"key":"1082_CR5","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1002\/gcc.20710","volume":"48","author":"ML Focarelli","year":"2009","unstructured":"Focarelli ML, Soza S, Mannini L, Paulis M, Montecucco A, Musio A: Claspin inhibition leads to fragile site expression. Genes Chrom Cancer. 2009, 48: 1083-1090. 10.1002\/gcc.20710.","journal-title":"Genes Chrom Cancer"},{"key":"1082_CR6","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.canlet.2010.10.013","volume":"305","author":"N Korzeniewski","year":"2011","unstructured":"Korzeniewski N, Spardy N, Duensing A, Duensing S: Genomic instability and cancer: lessons learned from human papillomaviruses. Cancer Lett. 2011, 305: 113-122. 10.1016\/j.canlet.2010.10.013.","journal-title":"Cancer Lett"},{"key":"1082_CR7","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1002\/path.2095","volume":"211","author":"K Tsimaratou","year":"2007","unstructured":"Tsimaratou K, Kletsas D, Kastrinakis NG, Tsantoulis PK, Evangelou K, Sideridou M, Liontos M, Poulias I, Venere M, Salmas M, Kittas C, Halazonetis TD, Gorgoulis VG: Evaluation of claspin as a proliferation marker in human cancer and normal tissues. J Pathol. 2007, 211: 331-339. 10.1002\/path.2095.","journal-title":"J Pathol"},{"key":"1082_CR8","doi-asserted-by":"publisher","first-page":"7022","DOI":"10.1158\/0008-5472.CAN-09-0925","volume":"69","author":"N Spardy","year":"2009","unstructured":"Spardy N, Covella K, Cha E, Hoskins EE, Wells SI, Duensing A, Duensing S: Human papillomavirus 16 E7 oncoprotein attenuates DNA damage checkpoint control by increasing the proteolytic turnover of claspin. Cancer Res. 2009, 69: 7022-7029. 10.1158\/0008-5472.CAN-09-0925.","journal-title":"Cancer Res"},{"key":"1082_CR9","doi-asserted-by":"publisher","first-page":"2643","DOI":"10.1128\/JCM.02570-10","volume":"49","author":"M Benevolo","year":"2011","unstructured":"Benevolo M, Vocaturo A, Caraceni D, French D, Rosini S, Zappacosta R, Terrenato I, Ciccocioppo L, Frega A, Giorgi Rossi P: Sensitivity, Specificity, and Clinical Value of Human Papillomavirus (HPV) E6\/E7 mRNA Assay as a Triage Test for Cervical Cytology and HPV DNA Test. J Clin Microbiol. 2011, 49: 2643-2650. 10.1128\/JCM.02570-10.","journal-title":"J Clin Microbiol"},{"key":"1082_CR10","doi-asserted-by":"publisher","first-page":"4646","DOI":"10.1128\/JCM.01315-10","volume":"48","author":"J Schweizer","year":"2010","unstructured":"Schweizer J, Lu PS, Mahoney CW, Berard-Bergery M, Ho M, Ramasamy V, Silver JE, Bisht A, Labiad Y, Peck RB, Lim J, Jeronimo J, Howard R, Gravitt PE, Castle PE: Feasibility study of a human papillomavirus E6 oncoprotein test for diagnosis of cervical precancer and cancer. J Clin Microbiol. 2010, 48: 4646-4648. 10.1128\/JCM.01315-10.","journal-title":"J Clin Microbiol"},{"key":"1082_CR11","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1038\/modpathol.3800551","volume":"19","author":"M Benevolo","year":"2006","unstructured":"Benevolo M, Mottolese M, Marandino F, Vocaturo G, Sindico R, Piperno G, Mariani L, Sperduti I, Canalini P, Perrone Donnorso R, Vocaturo A: Immunohistochemical expression of p16INK4a is predictive of HR-HPV infection in cervical low-grade lesions. Mod Pathol. 2006, 19: 384-391. 10.1038\/modpathol.3800551.","journal-title":"Mod Pathol"},{"key":"1082_CR12","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1097\/00000478-200107000-00006","volume":"25","author":"JT Keating","year":"2001","unstructured":"Keating JT, Cviko A, Riethdorf S, Riethdorf L, Quade BJ, Sun D, Duensing S, Sheets EE, Munger K, Crum CP: Ki-67, Cyclin E, and p16INK4a are complimentary surrogate biomarkers for human papilloma virus-related cervical neoplasia. Am J Surg Pathol. 2001, 25: 884-891. 10.1097\/00000478-200107000-00006.","journal-title":"Am J Surg Pathol"},{"key":"1082_CR13","doi-asserted-by":"publisher","first-page":"515","DOI":"10.2217\/14796694.4.4.515","volume":"4","author":"AM Khan","year":"2008","unstructured":"Khan AM, Singer A: Biomarkers in cervical precancer management: the new frontiers. Future Oncol. 2008, 4: 515-524. 10.2217\/14796694.4.4.515.","journal-title":"Future Oncol"},{"key":"1082_CR14","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.virusres.2007.06.018","volume":"130","author":"F De Marco","year":"2007","unstructured":"De Marco F, Perluigi M, Foppoli C, Cini C, Giorgi A, Grillo C, De Marco F, Butterfield DA, Schinin\u00e0 ME, Coccia R: UVB irradiation down-regulates HPV-16 RNA expression: implications for malignant progression of transformed cells. Virus Res. 2007, 130: 249-259. 10.1016\/j.virusres.2007.06.018.","journal-title":"Virus Res"},{"key":"1082_CR15","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/S1470-2045(09)70262-1","volume":"11","author":"R Yerushalmi","year":"2010","unstructured":"Yerushalmi R, Woods R, Ravdin PM, Hayes MM, Gelmon KA: Ki67 in breast cancer: prognostic and predictive potential. Lancet Oncol. 2010, 11: 174-183. 10.1016\/S1470-2045(09)70262-1.","journal-title":"Lancet Oncol"},{"issue":"287","key":"1082_CR16","first-page":"2114","volume":"2002","author":"D Solomon","year":"2001","unstructured":"Solomon D, Davey D, Kurman R, Moriarty A, O'Connor D, Prey M, Raab S, Sherman M, Wilbur D, Wright T, Young N, for the Forum Group Members and the Bethesda 2001 Workshop: The Bethesda system: terminology for reporting results of cervical cytology. JAMA. 2001, 2002 (287): 2114-2119.","journal-title":"JAMA"},{"key":"1082_CR17","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1097\/PAS.0b013e31815bbb69","volume":"32","author":"RE Badr","year":"2008","unstructured":"Badr RE, Walts AE, Chung F, Bose S: BD ProEx C: a sensitive and specific marker of HPV-associated squamous lesions of the cervix. Am J Surg Pathol. 2008, 32: 899-906. 10.1097\/PAS.0b013e31815bbb69.","journal-title":"Am J Surg Pathol"},{"key":"1082_CR18","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1016\/S1470-2045(08)70208-0","volume":"9","author":"F Carozzi","year":"2008","unstructured":"Carozzi F, Confortini M, Dalla Palma P, Del Mistro A, Gillio-Tos A, De Marco L, Giorgi-Rossi P, Pontenani G, Rosso S, Sani C, Sintoni C, Segnan N, Zorzi M, Cuzick J, Rizzolo R, Ronco G, New Technologies for Cervical Cancer Screening (NTCC) Working Group: Use of p16-INK4A overexpression to increase the specificity of human papillomavirus testing: a nested substudy of the NTCC randomised controlled trial. Lancet Oncol. 2008, 9: 937-945. 10.1016\/S1470-2045(08)70208-0.","journal-title":"Lancet Oncol"},{"key":"1082_CR19","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.ctrv.2008.10.005","volume":"35","author":"I Tsoumpou","year":"2009","unstructured":"Tsoumpou I, Arbyn M, Kyrgiou M, Wentzensen N, Koliopoulos G, Martin-Hirsch P, Malamou-Mitsi V, Paraskevaidis E: p16INK4a immunostaining in cytological and histological specimens from the uterine cervix: a systematic review and meta-analysis. Cancer Treat Rev. 2009, 35: 210-220. 10.1016\/j.ctrv.2008.10.005.","journal-title":"Cancer Treat Rev"},{"key":"1082_CR20","doi-asserted-by":"publisher","first-page":"2489","DOI":"10.1002\/ijc.24774","volume":"125","author":"M Arbyn","year":"2009","unstructured":"Arbyn M, Ronco G, Cuzick J, Wentzensen N, Castle PE: How to evaluate emerging technologies in cervical cancer screening?. Int J Cancer. 2009, 125: 2489-2496. 10.1002\/ijc.24774.","journal-title":"Int J Cancer"},{"issue":"Suppl 10","key":"1082_CR21","doi-asserted-by":"publisher","first-page":"K1","DOI":"10.1016\/j.vaccine.2008.05.064","volume":"26","author":"FX Bosch","year":"2008","unstructured":"Bosch FX, Burchell AN, Schiffman M, Giuliano AR, de Sanjose S, Bruni L, Tortolero-Luna G, Kjaer SK, Mu\u00f1oz N: Epidemiology and natural history of human papillomavirus infections and type-specific implications in cervical neoplasia. Vaccine. 2008, 26 (Suppl 10): K1-16.","journal-title":"Vaccine"},{"key":"1082_CR22","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1002\/ijc.25396","volume":"128","author":"N Li","year":"2011","unstructured":"Li N, Franceschi S, Howell-Jones R, Snijders PJ, Clifford GM: Human Papillomavirus type distribution in 30,848 invasive cervical cancers worldwide: Variation by geographical region, histological type and year of publication. Int J Cancer. 2011, 128: 927-935. 10.1002\/ijc.25396.","journal-title":"Int J Cancer"},{"issue":"Suppl 10","key":"1082_CR23","doi-asserted-by":"publisher","first-page":"K29","DOI":"10.1016\/j.vaccine.2008.06.019","volume":"26","author":"J Cuzick","year":"2008","unstructured":"Cuzick J, Arbyn M, Sankaranarayanan R, Tsu V, Ronco G, Mayrand MH, Dillner J, Meijer CJ: Overview of human papillomavirus-based and other novel options for cervical cancer screening in developed and developing countries. Vaccine. 2008, 26 (Suppl 10): K29-41.","journal-title":"Vaccine"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1479-5876-10-132.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1479-5876-10-132\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1479-5876-10-132.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T18:40:46Z","timestamp":1548182446000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/1479-5876-10-132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,25]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["1082"],"URL":"https:\/\/doi.org\/10.1186\/1479-5876-10-132","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,25]]},"article-number":"132"}}