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The rats were sacrificed and brain tissues were harvested on day 21 after the procedure.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The results showed that BIA was larger in control group than in treatment group (p &lt; 0.001). The sensorimotor functional test (Corner test) identified a higher frequency of turning movement to left in control group than in treatment group (p &lt; 0.05). mRNA expressions of Bax, caspase 3, interleukin (IL)-18, toll-like receptor-4 and plasminogen activator inhibitor-1 were higher, whereas Bcl-2 and IL-8\/Gro were lower in control group than in treatment group (all p &lt; 0.05). Western blot demonstrated a lower CXCR4 and stromal-cell derived factor-1 (SDF-1) in control group than in treatment group (all p &lt; 0.01). Immunohistofluorescent staining showed lower expressions of CXCR4, SDF-1, von Willebran factor and doublecortin, whereas the number of apoptotic nuclei on TUNEL assay was higher in control group than in treatment group (all p &lt; 0.001). Immunohistochemical staining showed that cellular proliferation and number of small vessels were lower but glial fibrillary acid protein was higher in control group than in treatment group (all p &lt; 0.01).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>ADMSC therapy significantly limited BIA and improved sensorimotor dysfunction after acute IS.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1479-5876-8-63","type":"journal-article","created":{"date-parts":[[2010,6,29]],"date-time":"2010-06-29T06:16:03Z","timestamp":1277792163000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":176,"title":["Adipose-derived mesenchymal stem cells markedly attenuate brain infarct size and improve neurological function in rats"],"prefix":"10.1186","volume":"8","author":[{"given":"Steve","family":"Leu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Chun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Man","family":"Yuen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Hung","family":"Yen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Hsien","family":"Kao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheuk-Kwan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hon-Kan","family":"Yip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,6,28]]},"reference":[{"key":"485_CR1","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1001\/archneur.56.6.748","volume":"56","author":"GJ Hankey","year":"1999","unstructured":"Hankey GJ: Stroke: how large a public health problem, and how can the neurologist help?. 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