{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T22:30:42Z","timestamp":1757543442873},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Colorectal cancer is often a deadly disease and cannot be cured at metastatic stage. Oncolytic adenoviruses have been considered as a new therapeutic option for treatment of refractory disseminated cancers, including colorectal cancer. The safety data has been excellent but tumor transduction and antitumor efficacy especially in systemic administration needs to be improved.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Here, the utility of \u03b1v\u03b2 integrin targeting moiety Arg-Gly-Asp (RGD) in the Lys-Lys-Thr-Lys (KKTK) domain of the fiber shaft or in the HI-loop of adenovirus serotype 5 for increased tumor targeting and antitumor efficacy was evaluated. To this end, novel spleen-to-liver metastatic colorectal cancer mouse model was used and the antitumor efficacy was evaluated with magnetic resonance imaging (MRI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both modifications (RGD in the HI-loop or in the fiber shaft) increased gene transfer efficacy in colorectal cancer cell lines and improved tumor-to-normal ratio in systemic administration of the vector.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Antitumor potency was not compromised with RGD modified viruses suggesting increased safety profile and tumor specificity.<\/jats:p><\/jats:sec>","DOI":"10.1186\/1479-5876-8-80","type":"journal-article","created":{"date-parts":[[2010,8,24]],"date-time":"2010-08-24T06:14:29Z","timestamp":1282630469000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Adenoviruses with an \u03b1v\u03b2 integrin targeting moiety in the fiber shaft or the HI-loop increase tumor specificity without compromising antitumor efficacy in magnetic resonance imaging of colorectal cancer metastases"],"prefix":"10.1186","volume":"8","author":[{"given":"Sergio","family":"Lavilla-Alonso","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerd","family":"Bauerschmitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Usama","family":"Abo-Ramadan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juha","family":"Halavaara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Escutenaire","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iulia","family":"Diaconu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Turgut","family":"Tatlisumak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Kanerva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akseli","family":"Hemminki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sari","family":"Pesonen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,8,23]]},"reference":[{"key":"502_CR1","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.1158\/1055-9965.EPI-09-0090","volume":"18","author":"MM Center","year":"2009","unstructured":"Center MM, Jemal A, Ward E: International trends in colorectal cancer incidence rates. Cancer Epidemiol Biomarkers Prev. 2009, 18: 1688-1694. 10.1158\/1055-9965.EPI-09-0090.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"502_CR2","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1016\/S1470-2045(08)70179-7","volume":"9","author":"MP Coleman","year":"2008","unstructured":"Coleman MP, Quaresma M, Berrino F, Lutz JM, De Angelis R, Capocaccia R, Baili P, Rachet B, Gatta G, Hakulinen T: Cancer survival in five continents: a worldwide population-based study (CONCORD). Lancet Oncol. 2008, 9: 730-756. 10.1016\/S1470-2045(08)70179-7.","journal-title":"Lancet Oncol"},{"key":"502_CR3","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.1038\/sj.gt.3301512","volume":"8","author":"T Reid","year":"2001","unstructured":"Reid T, Galanis E, Abbruzzese J, Sze D, Andrews J, Romel L, Hatfield M, Rubin J, Kirn D: Intra-arterial administration of a replication-selective adenovirus (dl1520) in patients with colorectal carcinoma metastatic to the liver: a phase I trial. Gene Ther. 2001, 8: 1618-1626. 10.1038\/sj.gt.3301512.","journal-title":"Gene Ther"},{"key":"502_CR4","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1038\/sj.gt.3301424","volume":"8","author":"J Nemunaitis","year":"2001","unstructured":"Nemunaitis J, Cunningham C, Buchanan A, Blackburn A, Edelman G, Maples P, Netto G, Tong A, Randlev B, Olson S, Kirn D: Intravenous infusion of a replication-selective adenovirus (ONYX-015) in cancer patients: safety, feasibility and biological activity. Gene Ther. 2001, 8: 746-759. 10.1038\/sj.gt.3301424.","journal-title":"Gene Ther"},{"key":"502_CR5","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1200\/JCO.2004.04.059","volume":"22","author":"B Sangro","year":"2004","unstructured":"Sangro B, Mazzolini G, Ruiz J, Herraiz M, Quiroga J, Herrero I, Benito A, Larrache J, Pueyo J, Subtil JC: Phase I trial of intratumoral injection of an adenovirus encoding interleukin-12 for advanced digestive tumors. J Clin Oncol. 2004, 22: 1389-1397. 10.1200\/JCO.2004.04.059.","journal-title":"J Clin Oncol"},{"key":"502_CR6","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1038\/sj.cgt.7700988","volume":"14","author":"T Au","year":"2007","unstructured":"Au T, Thorne S, Korn WM, Sze D, Kirn D, Reid TR: Minimal hepatic toxicity of Onyx-015: spatial restriction of coxsackie-adenoviral receptor in normal liver. Cancer Gene Ther. 2007, 14: 139-150. 10.1038\/sj.cgt.7700988.","journal-title":"Cancer Gene Ther"},{"issue":"2","key":"502_CR7","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1038\/mt.2009.262","volume":"18","author":"J Nemunaitis","year":"2009","unstructured":"Nemunaitis J, Tong AW, Nemunaitis M, Senzer N, Phadke AP, Bedell C, Adams N, Zhang YA, Maples PB, Chen S: A Phase I Study of Telomerase-specific Replication Competent Oncolytic Adenovirus (Telomelysin) for Various Solid Tumors. Mol Ther. 2009, 18 (2): 429-34. 10.1038\/mt.2009.262.","journal-title":"Mol Ther"},{"key":"502_CR8","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1038\/gt.2008.179","volume":"16","author":"JL Li","year":"2009","unstructured":"Li JL, Liu HL, Zhang XR, Xu JP, Hu WK, Liang M, Chen SY, Hu F, Chu DT: A phase I trial of intratumoral administration of recombinant oncolytic adenovirus overexpressing HSP70 in advanced solid tumor patients. Gene Ther. 2009, 16: 376-382. 10.1038\/gt.2008.179.","journal-title":"Gene Ther"},{"key":"502_CR9","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1038\/sj.cgt.7700819","volume":"12","author":"TR Reid","year":"2005","unstructured":"Reid TR, Freeman S, Post L, McCormick F, Sze DY: Effects of Onyx-015 among metastatic colorectal cancer patients that have failed prior treatment with 5-FU\/leucovorin. Cancer Gene Ther. 2005, 12: 673-681. 10.1038\/sj.cgt.7700819.","journal-title":"Cancer Gene Ther"},{"key":"502_CR10","first-page":"6070","volume":"62","author":"T Reid","year":"2002","unstructured":"Reid T, Galanis E, Abbruzzese J, Sze D, Wein LM, Andrews J, Randlev B, Heise C, Uprichard M, Hatfield M: Hepatic arterial infusion of a replication-selective oncolytic adenovirus (dl1520): phase II viral, immunologic, and clinical endpoints. Cancer Res. 2002, 62: 6070-6079.","journal-title":"Cancer Res"},{"key":"502_CR11","doi-asserted-by":"publisher","first-page":"2052","DOI":"10.1200\/JCO.2005.03.6756","volume":"24","author":"AW Tolcher","year":"2006","unstructured":"Tolcher AW, Hao D, de Bono J, Miller A, Patnaik A, Hammond LA, Smetzer L, Van Wart Hood J, Merritt J, Rowinsky EK: Phase I, pharmacokinetic, and pharmacodynamic study of intravenously administered Ad5CMV-p53, an adenoviral vector containing the wild-type p53 gene, in patients with advanced cancer. J Clin Oncol. 2006, 24: 2052-2058. 10.1200\/JCO.2005.03.6756.","journal-title":"J Clin Oncol"},{"key":"502_CR12","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.ymthe.2006.02.011","volume":"14","author":"EJ Small","year":"2006","unstructured":"Small EJ, Carducci MA, Burke JM, Rodriguez R, Fong L, van Ummersen L, Yu DC, Aimi J, Ando D, Working P: A phase I trial of intravenous CG7870, a replication-selective, prostate-specific antigen-targeted oncolytic adenovirus, for the treatment of hormone-refractory, metastatic prostate cancer. Mol Ther. 2006, 14: 107-117. 10.1016\/j.ymthe.2006.02.011.","journal-title":"Mol Ther"},{"key":"502_CR13","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1089\/hum.1997.8.1-37","volume":"8","author":"S Worgall","year":"1997","unstructured":"Worgall S, Wolff G, Falck-Pedersen E, Crystal RG: Innate immune mechanisms dominate elimination of adenoviral vectors following in vivo administration. Hum Gene Ther. 1997, 8: 37-44. 10.1089\/hum.1997.8.1-37.","journal-title":"Hum Gene Ther"},{"key":"502_CR14","doi-asserted-by":"publisher","first-page":"7478","DOI":"10.1128\/JVI.79.12.7478-7491.2005","volume":"79","author":"DM Shayakhmetov","year":"2005","unstructured":"Shayakhmetov DM, Gaggar A, Ni S, Li ZY, Lieber A: Adenovirus binding to blood factors results in liver cell infection and hepatotoxicity. J Virol. 2005, 79: 7478-7491. 10.1128\/JVI.79.12.7478-7491.2005.","journal-title":"J Virol"},{"key":"502_CR15","doi-asserted-by":"publisher","first-page":"2554","DOI":"10.1182\/blood-2006-04-008532","volume":"108","author":"AL Parker","year":"2006","unstructured":"Parker AL, Waddington SN, Nicol CG, Shayakhmetov DM, Buckley SM, Denby L, Kemball-Cook G, Ni S, Lieber A, McVey JH: Multiple vitamin K-dependent coagulation zymogens promote adenovirus-mediated gene delivery to hepatocytes. Blood. 2006, 108: 2554-2561. 10.1182\/blood-2006-04-008532.","journal-title":"Blood"},{"key":"502_CR16","doi-asserted-by":"publisher","first-page":"3627","DOI":"10.1128\/JVI.02786-06","volume":"81","author":"AL Parker","year":"2007","unstructured":"Parker AL, McVey JH, Doctor JH, Lopez-Franco O, Waddington SN, Havenga MJ, Nicklin SA, Baker AH: Influence of coagulation factor zymogens on the infectivity of adenoviruses pseudotyped with fibers from subgroup D. J Virol. 2007, 81: 3627-3631. 10.1128\/JVI.02786-06.","journal-title":"J Virol"},{"key":"502_CR17","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1038\/sj.mt.6300206","volume":"15","author":"AH Baker","year":"2007","unstructured":"Baker AH, McVey JH, Waddington SN, Di Paolo NC, Shayakhmetov DM: The influence of blood on in vivo adenovirus bio-distribution and transduction. Mol Ther. 2007, 15: 1410-1416. 10.1038\/sj.mt.6300206.","journal-title":"Mol Ther"},{"key":"502_CR18","doi-asserted-by":"publisher","first-page":"5483","DOI":"10.1073\/pnas.0711757105","volume":"105","author":"O Kalyuzhniy","year":"2008","unstructured":"Kalyuzhniy O, Di Paolo NC, Silvestry M, Hofherr SE, Barry MA, Stewart PL, Shayakhmetov DM: Adenovirus serotype 5 hexon is critical for virus infection of hepatocytes in vivo. Proc Natl Acad Sci USA. 2008, 105: 5483-5488. 10.1073\/pnas.0711757105.","journal-title":"Proc Natl Acad Sci USA"},{"key":"502_CR19","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.1038\/mt.2008.132","volume":"16","author":"F Vigant","year":"2008","unstructured":"Vigant F, Descamps D, Jullienne B, Esselin S, Connault E, Opolon P, Tordjmann T, Vigne E, Perricaudet M, Benihoud K: Substitution of hexon hypervariable region 5 of adenovirus serotype 5 abrogates blood factor binding and limits gene transfer to liver. Mol Ther. 2008, 16: 1474-1480. 10.1038\/mt.2008.132.","journal-title":"Mol Ther"},{"key":"502_CR20","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.cell.2008.01.016","volume":"132","author":"SN Waddington","year":"2008","unstructured":"Waddington SN, McVey JH, Bhella D, Parker AL, Barker K, Atoda H, Pink R, Buckley SM, Greig JA, Denby L: Adenovirus serotype 5 hexon mediates liver gene transfer. Cell. 2008, 132: 397-409. 10.1016\/j.cell.2008.01.016.","journal-title":"Cell"},{"key":"502_CR21","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1038\/sj.gt.3301515","volume":"8","author":"R Alemany","year":"2001","unstructured":"Alemany R, Curiel DT: CAR-binding ablation does not change biodistribution and toxicity of adenoviral vectors. Gene Ther. 2001, 8: 1347-1353. 10.1038\/sj.gt.3301515.","journal-title":"Gene Ther"},{"key":"502_CR22","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1126\/science.275.5304.1320","volume":"275","author":"JM Bergelson","year":"1997","unstructured":"Bergelson JM, Cunningham JA, Droguett G, Kurt-Jones EA, Krithivas A, Hong JS, Horwitz MS, Crowell RL, Finberg RW: Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5. Science. 1997, 275: 1320-1323. 10.1126\/science.275.5304.1320.","journal-title":"Science"},{"key":"502_CR23","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/0092-8674(93)90231-E","volume":"73","author":"TJ Wickham","year":"1993","unstructured":"Wickham TJ, Mathias P, Cheresh DA, Nemerow GR: Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachment. Cell. 1993, 73: 309-319. 10.1016\/0092-8674(93)90231-E.","journal-title":"Cell"},{"key":"502_CR24","doi-asserted-by":"publisher","first-page":"11284","DOI":"10.1128\/JVI.75.23.11284-11291.2001","volume":"75","author":"DA Einfeld","year":"2001","unstructured":"Einfeld DA, Schroeder R, Roelvink PW, Lizonova A, King CR, Kovesdi I, Wickham TJ: Reducing the native tropism of adenovirus vectors requires removal of both CAR and integrin interactions. J Virol. 2001, 75: 11284-11291. 10.1128\/JVI.75.23.11284-11291.2001.","journal-title":"J Virol"},{"key":"502_CR25","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/S1525-0016(03)00182-5","volume":"8","author":"K Martin","year":"2003","unstructured":"Martin K, Brie A, Saulnier P, Perricaudet M, Yeh P, Vigne E: Simultaneous CAR- and alpha V integrin-binding ablation fails to reduce Ad5 liver tropism. Mol Ther. 2003, 8: 485-494. 10.1016\/S1525-0016(03)00182-5.","journal-title":"Mol Ther"},{"key":"502_CR26","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1089\/104303403765255165","volume":"14","author":"TA Smith","year":"2003","unstructured":"Smith TA, Idamakanti N, Rollence ML, Marshall-Neff J, Kim J, Mulgrew K, Nemerow GR, Kaleko M, Stevenson SC: Adenovirus serotype 5 fiber shaft influences in vivo gene transfer in mice. Hum Gene Ther. 2003, 14: 777-787. 10.1089\/104303403765255165.","journal-title":"Hum Gene Ther"},{"key":"502_CR27","doi-asserted-by":"publisher","first-page":"2487","DOI":"10.1099\/vir.0.81889-0","volume":"87","author":"N Bayo-Puxan","year":"2006","unstructured":"Bayo-Puxan N, Cascallo M, Gros A, Huch M, Fillat C, Alemany R: Role of the putative heparan sulfate glycosaminoglycan-binding site of the adenovirus type 5 fiber shaft on liver detargeting and knob-mediated retargeting. J Gen Virol. 2006, 87: 2487-2495. 10.1099\/vir.0.81889-0.","journal-title":"J Gen Virol"},{"key":"502_CR28","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1006\/mthe.2002.0613","volume":"5","author":"T Smith","year":"2002","unstructured":"Smith T, Idamakanti N, Kylefjord H, Rollence M, King L, Kaloss M, Kaleko M, Stevenson SC: In vivo hepatic adenoviral gene delivery occurs independently of the coxsackievirus-adenovirus receptor. Mol Ther. 2002, 5: 770-779. 10.1006\/mthe.2002.0613.","journal-title":"Mol Ther"},{"key":"502_CR29","doi-asserted-by":"publisher","first-page":"1595","DOI":"10.1089\/104303403322542248","volume":"14","author":"TA Smith","year":"2003","unstructured":"Smith TA, Idamakanti N, Marshall-Neff J, Rollence ML, Wright P, Kaloss M, King L, Mech C, Dinges L, Iverson WO: Receptor interactions involved in adenoviral-mediated gene delivery after systemic administration in non-human primates. Hum Gene Ther. 2003, 14: 1595-1604. 10.1089\/104303403322542248.","journal-title":"Hum Gene Ther"},{"key":"502_CR30","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1089\/hum.2009.038","volume":"20","author":"N Bayo-Puxan","year":"2009","unstructured":"Bayo-Puxan N, Gimenez-Alejandre M, Lavilla-Alonso S, Gros A, Cascallo M, Hemminki A, Alemany R: Replacement of adenovirus type 5 fiber shaft heparan sulfate proteoglycan-binding domain with RGD for improved tumor infectivity and targeting. Hum Gene Ther. 2009, 20: 1214-1221. 10.1089\/hum.2009.038.","journal-title":"Hum Gene Ther"},{"key":"502_CR31","doi-asserted-by":"publisher","first-page":"7092","DOI":"10.1158\/0008-5472.CAN-04-0364","volume":"64","author":"HK Yu","year":"2004","unstructured":"Yu HK, Kim JS, Lee HJ, Ahn JH, Lee SK, Hong SW, Yoon Y: Suppression of colorectal cancer liver metastasis and extension of survival by expression of apolipoprotein(a) kringles. Cancer Res. 2004, 64: 7092-7098. 10.1158\/0008-5472.CAN-04-0364.","journal-title":"Cancer Res"},{"key":"502_CR32","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1002\/jgm.1373","volume":"11","author":"A Koski","year":"2009","unstructured":"Koski A, Rajecki M, Guse K, Kanerva A, Ristimaki A, Pesonen S, Escutenaire S, Hemminki A: Systemic adenoviral gene delivery to orthotopic murine breast tumors with ablation of coagulation factors, thrombocytes and Kupffer cells. J Gene Med. 2009, 11: 966-977. 10.1002\/jgm.1373.","journal-title":"J Gene Med"},{"key":"502_CR33","doi-asserted-by":"publisher","first-page":"6405","DOI":"10.1158\/1078-0432.CCR-08-0816","volume":"14","author":"JA Conti","year":"2008","unstructured":"Conti JA, Kendall TJ, Bateman A, Armstrong TA, Papa-Adams A, Xu Q, Packham G, Primrose JN, Benyon RC, Iredale JP: The desmoplastic reaction surrounding hepatic colorectal adenocarcinoma metastases aids tumor growth and survival via alphav integrin ligation. Clin Cancer Res. 2008, 14: 6405-6413. 10.1158\/1078-0432.CCR-08-0816.","journal-title":"Clin Cancer Res"},{"key":"502_CR34","doi-asserted-by":"publisher","first-page":"6351","DOI":"10.1158\/1078-0432.CCR-08-1847","volume":"14","author":"JH McCarty","year":"2008","unstructured":"McCarty JH: Alphav integrins lead the way for colorectal metastases. Clin Cancer Res. 2008, 14: 6351-6353. 10.1158\/1078-0432.CCR-08-1847.","journal-title":"Clin Cancer Res"},{"key":"502_CR35","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/0304-3835(95)03735-F","volume":"91","author":"S Fujita","year":"1995","unstructured":"Fujita S, Watanabe M, Kubota T, Teramoto T, Kitajima M: Alteration of expression in integrin beta 1-subunit correlates with invasion and metastasis in colorectal cancer. Cancer Lett. 1995, 91: 145-149. 10.1016\/0304-3835(95)03735-F.","journal-title":"Cancer Lett"},{"key":"502_CR36","doi-asserted-by":"publisher","first-page":"9641","DOI":"10.1128\/JVI.00534-07","volume":"81","author":"DY Logunov","year":"2007","unstructured":"Logunov DY, Zubkova OV, Karyagina-Zhulina AS, Shuvalova EA, Karpov AP, Shmarov MM, Tutykhina IL, Alyapkina YS, Grezina NM, Zinovieva NA: Identification of HI-like loop in CELO adenovirus fiber for incorporation of receptor binding motifs. J Virol. 2007, 81: 9641-9652. 10.1128\/JVI.00534-07.","journal-title":"J Virol"},{"issue":"Supplement 1","key":"502_CR37","first-page":"S113","volume":"16","author":"NT Kimball KJ","year":"2008","unstructured":"Kimball KJ NT, Barnes MN, Makhija S, Wang M, Siegal GP, Harris R, Aurigemma R, Alvarez RD: A phase I study of a tropism modified conditionally replicative adenovirus (CRAd) for recurrent ovarian cancer. Mol Ther. 2008, 16 (Supplement 1): S113-","journal-title":"Mol Ther"},{"issue":"11","key":"502_CR38","doi-asserted-by":"crossref","first-page":"2671","DOI":"10.1002\/ijc.24980","volume":"126","author":"SJ Gros","year":"2009","unstructured":"Gros SJ, Dohrmann T, Peldschus K, Schurr PG, Kaifi JT, Kalinina T, Reichelt U, Mann O, Strate TG, Adam G: Complementary use of fluorescence and MR imaging of metastatic esophageal cancer in a novel orthotopic mouse model. Int J Cancer. 2009, 126 (11): 2671-81.","journal-title":"Int J Cancer"},{"key":"502_CR39","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.jss.2007.04.021","volume":"147","author":"A Rajput","year":"2008","unstructured":"Rajput A, Dominguez San Martin I, Rose R, Beko A, Levea C, Sharratt E, Mazurchuk R, Hoffman RM, Brattain MG, Wang J: Characterization of HCT116 human colon cancer cells in an orthotopic model. J Surg Res. 2008, 147: 276-281. 10.1016\/j.jss.2007.04.021.","journal-title":"J Surg Res"},{"key":"502_CR40","doi-asserted-by":"publisher","first-page":"1520","DOI":"10.1038\/sj.gt.3301030","volume":"6","author":"H Fechner","year":"1999","unstructured":"Fechner H, Haack A, Wang H, Wang X, Eizema K, Pauschinger M, Schoemaker R, Veghel R, Houtsmuller A, Schultheiss HP: Expression of coxsackie adenovirus receptor and alphav-integrin does not correlate with adenovector targeting in vivo indicating anatomical vector barriers. Gene Ther. 1999, 6: 1520-1535. 10.1038\/sj.gt.3301030.","journal-title":"Gene Ther"},{"key":"502_CR41","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1002\/ijc.11563","volume":"108","author":"DM Nettelbeck","year":"2004","unstructured":"Nettelbeck DM, Rivera AA, Kupsch J, Dieckmann D, Douglas JT, Kontermann RE, Alemany R, Curiel DT: Retargeting of adenoviral infection to melanoma: combining genetic ablation of native tropism with a recombinant bispecific single-chain diabody (scDb) adapter that binds to fiber knob and HMWMAA. Int J Cancer. 2004, 108: 136-145. 10.1002\/ijc.11563.","journal-title":"Int J Cancer"},{"key":"502_CR42","doi-asserted-by":"publisher","first-page":"1647","DOI":"10.1089\/10430340260201734","volume":"13","author":"H Wu","year":"2002","unstructured":"Wu H, Seki T, Dmitriev I, Uil T, Kashentseva E, Han T, Curiel DT: Double modification of adenovirus fiber with RGD and polylysine motifs improves coxsackievirus-adenovirus receptor-independent gene transfer efficiency. Hum Gene Ther. 2002, 13: 1647-1653. 10.1089\/10430340260201734.","journal-title":"Hum Gene Ther"},{"key":"502_CR43","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1038\/sj.mt.6300239","volume":"15","author":"M Cascallo","year":"2007","unstructured":"Cascallo M, Alonso MM, Rojas JJ, Perez-Gimenez A, Fueyo J, Alemany R: Systemic toxicity-efficacy profile of ICOVIR-5, a potent and selective oncolytic adenovirus based on the pRB pathway. Mol Ther. 2007, 15: 1607-1615. 10.1038\/sj.mt.6300239.","journal-title":"Mol Ther"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1479-5876-8-80.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,29]],"date-time":"2024-03-29T21:05:09Z","timestamp":1711746309000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/1479-5876-8-80"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8,23]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["502"],"URL":"https:\/\/doi.org\/10.1186\/1479-5876-8-80","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8,23]]},"assertion":[{"value":"20 April 2010","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 August 2010","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 August 2010","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"80"}}