{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T17:51:23Z","timestamp":1759341083438},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nanoscale Res Lett"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>We used a simple electrospinning technique to fabricate a highly potent silver-organoalkoxysilane antimicrobial composite from AgNO<jats:sub>3<\/jats:sub>-polyvinylpyrrolidone (PVP)\/3-aminopropyltrimethoxysilane (APTMS)\/tetraethoxysilane (TEOS) solution. Spectroscopic and microscopic analyses of the composite showed that the fibers contain an organoalkoxysilane \u2018skeleton,\u2019 0.18 molecules\/nm<jats:sup>2<\/jats:sup> surface amino groups, and highly dispersed and uniformly distributed silver nanoparticles (5 nm in size). Incorporation of organoalkoxysilanes is highly beneficial to the antimicrobial mat as (1) amino groups of APTMS are adhesive and biocidal to microorganisms, (2) polycondensation of APTMS and TEOS increases the membrane\u2019s surface area by forming silicon bonds that stabilize fibers and form a composite mat with membranous structure and high porosity, and (3) the organoalkoxysilanes are also instrumental to the synthesis of the very small-sized and highly dispersed silver metal particles in the fiber mat. Antimicrobial property of the composite was evaluated by disk diffusion, minimum inhibition concentration (MIC), kinetic, and extended use assays on bacteria (<jats:italic>Escherichia coli<\/jats:italic>, <jats:italic>Bacillus anthracis<\/jats:italic>, <jats:italic>Staphylococcus aureus<\/jats:italic>, and <jats:italic>Brucella suis<\/jats:italic>), a fungus (<jats:italic>Aspergillus niger<\/jats:italic>), and the Newcastle disease virus. The membrane shows quick and sustained broad-spectrum antimicrobial activity. Only 0.3 mg of fibers is required to achieve MIC against all the test organisms. Bacteria are inhibited within 30 min of contact, and the fibers can be used repeatedly. The composite is silver efficient and environment friendly, and its membranous structure is suitable for many practical applications as in air filters, antimicrobial linen, coatings, bioadhesives, and biofilms.<\/jats:p>","DOI":"10.1186\/1556-276x-8-164","type":"journal-article","created":{"date-parts":[[2013,4,10]],"date-time":"2013-04-10T14:42:12Z","timestamp":1365604932000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Highly potent silver-organoalkoxysilane antimicrobial porous nanomembrane"],"prefix":"10.1186","volume":"8","author":[{"given":"Sirajo","family":"Umar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanfeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiguang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangtao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiabo","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Runsong","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinchun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,4,10]]},"reference":[{"key":"3255_CR1","doi-asserted-by":"publisher","first-page":"9798","DOI":"10.1021\/ja061442z","volume":"128","author":"V Sambhy","year":"2006","unstructured":"Sambhy V, MacBride MM, Peterson BR, Sen A: Silver bromide nanoparticle\/polymer composites: dual action tunable antimicrobial materials. J Am Chem Soc 2006, 128: 9798\u20139808. 10.1021\/ja061442z","journal-title":"J Am Chem Soc"},{"key":"3255_CR2","doi-asserted-by":"publisher","first-page":"4066","DOI":"10.1021\/jp0564400","volume":"110","author":"C Hu","year":"2006","unstructured":"Hu C, Lan YQ, Qu JH, Hu XX, Wang AM: Ag\/AgBr\/TiO2 visible light photocatalyst for destruction of azodyes and bacteria. J Phys Chem B 2006, 110: 4066\u20134072. 10.1021\/jp0564400","journal-title":"J Phys Chem B"},{"key":"3255_CR3","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1021\/jp065590n","volume":"111","author":"M Jin","year":"2007","unstructured":"Jin M, Zhang XT, Nishimoto S, Liu ZY, Tryk DA, Emeline AV, Murakami T, Fujishima A: Light-stimulated composition conversion in TiO2-based nanofibers. J Phys Chem C 2007, 111: 658\u2013665. 10.1021\/jp065590n","journal-title":"J Phys Chem C"},{"key":"3255_CR4","doi-asserted-by":"publisher","first-page":"245101","DOI":"10.1088\/0957-4484\/20\/24\/245101","volume":"20","author":"Y Wu","year":"2009","unstructured":"Wu Y, Jia WJ, An Q, Liu YF, Chen JC, Li GT: Multiaction antibacterial nanofibrous membranes fabricated by electrospinning: an excellent system for antibacterial applications. Nanotech 2009, 20: 245101\u2013245109. 10.1088\/0957-4484\/20\/24\/245101","journal-title":"Nanotech"},{"key":"3255_CR5","doi-asserted-by":"publisher","first-page":"2330","DOI":"10.1021\/jp075436g","volume":"112","author":"Y Zhang","year":"2008","unstructured":"Zhang Y, Peng H, Huang W, Zhou Y, Zhang X, Yan D: Hyperbranched poly(amidoamine) as the stabilizer and reductant to prepare colloid silver nanoparticles in situ and their antibacterial activity. J Phys Chem C 2008, 112: 2330\u20132336. 10.1021\/jp075436g","journal-title":"J Phys Chem C"},{"key":"3255_CR6","doi-asserted-by":"publisher","first-page":"3629","DOI":"10.1021\/jp068302w","volume":"111","author":"YH Kim","year":"2007","unstructured":"Kim YH, Lee DK, Cha HG, Kim CW, Kang YS: Synthesis and characterization of antibacterial Ag-SiO2 nanocomposite. J Phys Chem C 2007, 111: 3629\u20133635. 10.1021\/jp068302w","journal-title":"J Phys Chem C"},{"key":"3255_CR7","doi-asserted-by":"publisher","first-page":"2285","DOI":"10.1021\/ja040226s","volume":"127","author":"A Melaiye","year":"2005","unstructured":"Melaiye A, Sun Z, Hindi K, Milsted A, Ely D, Reneker DH, Tessier CA, Youngs WJ: Silver(I)-imidazole cyclophane gem- diol complexes encapsulated by electrospun tecophilic nanofibers: formation of nanosilver particles and antimicrobial activity. J Am Chem Soc 2005, 127: 2285\u20132291. 10.1021\/ja040226s","journal-title":"J Am Chem Soc"},{"key":"3255_CR8","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1016\/S1872-2040(07)60004-8","volume":"34","author":"J Zhao","year":"2006","unstructured":"Zhao J, Li Y, Guo HQ, Gao LX: Relative surface density and stability of the amines on bio-chip. Chin J Anal Chem 2006, 34: 1235\u20131238. 10.1016\/S1872-2040(07)60004-8","journal-title":"Chin J Anal Chem"},{"key":"3255_CR9","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/S0040-6090(98)00956-0","volume":"335","author":"QL Feng","year":"1998","unstructured":"Feng QL, Kim TN, Wu J, Park ES, Kim JO, Lim DY, Cui FZ: Antibacterial effects of Ag-HAp thin films on alumina substrates. Thin Solid Films 1998, 335: 214\u2013219. 10.1016\/S0040-6090(98)00956-0","journal-title":"Thin Solid Films"},{"key":"3255_CR10","doi-asserted-by":"publisher","first-page":"2051","DOI":"10.1021\/la703085e","volume":"24","author":"H Kong","year":"2008","unstructured":"Kong H, Jang J: Antibacterial properties of novel poly(methyl methacrylate) nanofiber containing silver nanoparticles. Langmuir 2008, 24: 2051\u20132056. 10.1021\/la703085e","journal-title":"Langmuir"},{"key":"3255_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1088\/0957-4484\/18\/7\/075605","volume":"18","author":"M Jin","year":"2007","unstructured":"Jin M, Zhang X, Nishimoto S, Liu Z, Tryk DK, Murakami T, Fujishima A: Large-scale fabrication of Ag nanoparticles in PVP nanofibres and net-like silver nanofibre films by electrospinning. Nanotech 2007, 18: 1\u20137.","journal-title":"Nanotech"},{"key":"3255_CR12","doi-asserted-by":"publisher","first-page":"4921","DOI":"10.1016\/S0142-9612(03)00415-0","volume":"24","author":"HJ Jeon","year":"2003","unstructured":"Jeon HJ, Yi SC, Oh SG: Preparation and antibacterial effects of Ag\u2013SiO2 thin films by sol\u2013gel method. Biomaterials 2003, 24: 4921\u20134928. 10.1016\/S0142-9612(03)00415-0","journal-title":"Biomaterials"},{"key":"3255_CR13","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1023\/A:1020710307359","volume":"26","author":"HJ Hah","year":"2003","unstructured":"Hah HJ, Koo SM, Lee SH: Preparation of silver nanoparticles through alcohol reduction with organoalkoxysilanes. J Sol\u2013Gel Sci and Tech 2003, 26: 467\u2013471. 10.1023\/A:1020710307359","journal-title":"J Sol\u2013Gel Sci and Tech"},{"key":"3255_CR14","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1007\/BF03218571","volume":"16","author":"KD Min","year":"2008","unstructured":"Min KD, Park WH, Youk JH, Kwark YJ: Controlling size and distribution of silver nanoparticles generated in inorganic silica nanofibers using poly(vinyl pyrrolidone). Macromol Res 2008, 16: 626\u2013630. 10.1007\/BF03218571","journal-title":"Macromol Res"},{"key":"3255_CR15","volume-title":"Handbook of X-ray Photoelectron Spectroscopy","author":"CD Wagner","year":"1979","unstructured":"Wagner CD, Riggs WM, Davis LE, Moulder JF: Handbook of X-ray Photoelectron Spectroscopy. Physical Electronics Division, Perkin-Elmer: Prairie; 1979."},{"key":"3255_CR16","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1021\/jp045798d","volume":"109","author":"X Wang","year":"2005","unstructured":"Wang X, Lin KSK, Chan JCC, Cheng S: Direct synthesis and catalytic applications of ordered large pore aminopropyl-functionalized SBA-15 mesoporous materials. J Phy Chem B 2005, 109: 1763\u20131769. 10.1021\/jp045798d","journal-title":"J Phy Chem B"},{"key":"3255_CR17","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.memsci.2008.03.049","volume":"319","author":"F Yao","year":"2008","unstructured":"Yao F, Fu GD, Zhao J, Kang ET, Neoh KG: Antibacterial effect of surface-functionalized polypropylene hollow fiber membrane from surface-initiated atom transfer radical polymerization. J Membrane Science 2008, 319: 149\u2013157. 10.1016\/j.memsci.2008.03.049","journal-title":"J Membrane Science"},{"key":"3255_CR18","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.jcis.2004.02.012","volume":"275","author":"I Sondi","year":"2004","unstructured":"Sondi I, Salopec-Sondi BJ: Silver nanoparticles as antimicrobial agent: a case study on E. coli as a model for Gram-negative bacteria. Colloid Interface Sci 2004, 275: 177\u2013182. 10.1016\/j.jcis.2004.02.012","journal-title":"Colloid Interface Sci"},{"key":"3255_CR19","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1002\/1097-4636(20001215)52:4<662::AID-JBM10>3.0.CO;2-3","volume":"52","author":"QL Feng","year":"2000","unstructured":"Feng QL, Wu J, Chen GQ, Cui FZ, Kim TN, Kim JO: A mechanistic study of the antibacterial effect of silver ions on Escherichia coli and Staphylococcus aureus . J Biomed Mater Res 2000, 52: 662\u2013668. 10.1002\/1097-4636(20001215)52:4<662::AID-JBM10>3.0.CO;2-3","journal-title":"J Biomed Mater Res"},{"key":"3255_CR20","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.1021\/bm0701088","volume":"8","author":"MK Calebretta","year":"2007","unstructured":"Calebretta MK, Kumar A, McDermott AM, Cai C: Antimicrobial activities of poly(amidoamine) dendrimers terminated with amino and poly(ethylene glycol) groups. Biomacromolecules 2007, 8: 1807\u20131811. 10.1021\/bm0701088","journal-title":"Biomacromolecules"},{"key":"3255_CR21","doi-asserted-by":"publisher","first-page":"2291","DOI":"10.1021\/bm050850c","volume":"7","author":"S Lenoir","year":"2006","unstructured":"Lenoir S, Pagnoulle C, Galleni M, Compere P, Jerome R, Detrembluer C: Polyolefin matrixes with permanent antibacterial activity: preparation, antibacterial activity, and action mode of the active species. Biomacromolecules 2006, 7: 2291\u20132296. 10.1021\/bm050850c","journal-title":"Biomacromolecules"}],"container-title":["Nanoscale Research Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1556-276X-8-164.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T04:35:57Z","timestamp":1679286957000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/1556-276X-8-164"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,10]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["3255"],"URL":"https:\/\/doi.org\/10.1186\/1556-276x-8-164","relation":{},"ISSN":["1556-276X"],"issn-type":[{"value":"1556-276X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,10]]},"assertion":[{"value":"2 November 2012","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 February 2013","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 April 2013","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"164"}}