{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T09:12:09Z","timestamp":1778577129383,"version":"3.51.4"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,4,3]],"date-time":"2014-04-03T00:00:00Z","timestamp":1396483200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Bioinform Sys Biology"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1186\/1687-4153-2014-6","type":"journal-article","created":{"date-parts":[[2014,4,3]],"date-time":"2014-04-03T09:09:04Z","timestamp":1396516144000},"source":"Crossref","is-referenced-by-count":9,"title":["A comparison study of optimal and suboptimal intervention policies for gene regulatory networks in the presence of uncertainty"],"prefix":"10.1186","volume":"2014","author":[{"given":"Mohammadmahdi R","family":"Yousefi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward R","family":"Dougherty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,4,3]]},"reference":[{"issue":"1","key":"46_CR1","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1080\/00207720903144560","volume":"41","author":"ER Dougherty","year":"2010","unstructured":"Dougherty ER, Pal R, Qian X, Bittner ML, Datta A: Stationary and structural control in gene regulatory networks: basic concepts. Int. J. Syst. Sci 2010,41(1):5-16. 10.1080\/00207720903144560","journal-title":"Int. J. Syst. Sci"},{"key":"46_CR2","doi-asserted-by":"publisher","DOI":"10.1515\/9781400865260","volume-title":"Genomic Signal Processing","author":"I Shmulevich","year":"2007","unstructured":"Shmulevich I, Dougherty ER: Genomic Signal Processing. Princeton: Princeton University; 2007."},{"issue":"2","key":"46_CR3","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1093\/bioinformatics\/18.2.261","volume":"18","author":"I Shmulevich","year":"2002","unstructured":"Shmulevich I, Dougherty ER, Kim S, Zhang W, Probabilistic: Boolean networks: a rule-based uncertainty model for gene regulatory networks. Bioinformatics 2002,18(2):261-274. 10.1093\/bioinformatics\/18.2.261","journal-title":"Bioinformatics"},{"issue":"6","key":"46_CR4","doi-asserted-by":"publisher","first-page":"2375","DOI":"10.1109\/TSP.2006.873740","volume":"54","author":"R Pal","year":"2006","unstructured":"Pal R, Datta A, Dougherty ER: Optimal infinite-horizon control for probabilistic Boolean networks. IEEE Trans. Signal Process 2006,54(6):2375-2387.","journal-title":"IEEE Trans. Signal Process"},{"key":"46_CR5","doi-asserted-by":"publisher","first-page":"620767","DOI":"10.1155\/2008\/620767","volume":"2008","author":"B Faryabi","year":"2008","unstructured":"Faryabi B, Vahedi G, Chamberland J-F, Datta A, Dougherty ER: Optimal constrained stationary intervention in gene regulatory networks. EURASIP J. Bioinform. Syst. Biol 2008, 2008: 620767.","journal-title":"EURASIP J. Bioinform. Syst. Biol"},{"issue":"3","key":"46_CR6","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1109\/JSTSP.2008.923853","volume":"2","author":"B Faryabi","year":"2008","unstructured":"Faryabi B, Chamberland J-F, Vahedi G, Datta A, Dougherty ER: Optimal intervention in asynchronous genetic regulatory networks. IEEE J. Sel. Top. Signal. Process 2008,2(3):412-423.","journal-title":"IEEE J. Sel. Top. Signal. Process"},{"issue":"12","key":"46_CR7","doi-asserted-by":"publisher","first-page":"3542","DOI":"10.1109\/TBME.2013.2272891","volume":"60","author":"MR Yousefi","year":"2013","unstructured":"Yousefi MR, Datta A, Dougherty ER: Optimal intervention in Markovian gene regulatory networks with random-length therapeutic response to antitumor drug. IEEE Trans. Biomed. Eng 2013,60(12):3542-3552.","journal-title":"IEEE Trans. Biomed. Eng"},{"issue":"14","key":"46_CR8","doi-asserted-by":"publisher","first-page":"1758","DOI":"10.1093\/bioinformatics\/btt242","volume":"29","author":"MR Yousefi","year":"2013","unstructured":"Yousefi MR, Dougherty ER: Intervention in gene regulatory networks with maximal phenotype alteration. Bioinformatics 2013,29(14):1758-1767. 10.1093\/bioinformatics\/btt242","journal-title":"Bioinformatics"},{"issue":"3","key":"46_CR9","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.1109\/TSP.2007.908964","volume":"56","author":"R Pal","year":"2008","unstructured":"Pal R, Datta A, Dougherty ER: Robust intervention in probabilistic Boolean networks. IEEE Trans. Signal Process 2008,56(3):1280-1294.","journal-title":"IEEE Trans. Signal Process"},{"issue":"9","key":"46_CR10","doi-asserted-by":"publisher","first-page":"3667","DOI":"10.1109\/TSP.2009.2022872","volume":"57","author":"R Pal","year":"2009","unstructured":"Pal R, Datta A, Dougherty ER: Bayesian robustness in the control of gene regulatory networks. IEEE Trans. Signal Process 2009,57(9):3667-3678.","journal-title":"IEEE Trans. Signal Process"},{"issue":"12","key":"46_CR11","doi-asserted-by":"publisher","first-page":"2503","DOI":"10.1016\/S0165-1684(01)00144-X","volume":"81","author":"AM Grigoryan","year":"2001","unstructured":"Grigoryan AM, Dougherty ER: Bayesian robust optimal linear filters. Signal Process 2001,81(12):2503-2521. 10.1016\/S0165-1684(01)00144-X","journal-title":"Signal Process"},{"issue":"3","key":"46_CR12","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1137\/0323023","volume":"23","author":"PR Kumar","year":"1985","unstructured":"Kumar PR: A survey of some results in stochastic adaptive control. SIAM J. Contr. Optim 1985,23(3):329-380. 10.1137\/0323023","journal-title":"SIAM J. Contr. Optim"},{"issue":"3\/4","key":"46_CR13","first-page":"221","volume":"16","author":"R Bellman","year":"1956","unstructured":"Bellman R: A problem in the sequential design of experiments. Sankhya: Indian J. Stat 1956,16(3\/4):221-229.","journal-title":"Sankhya: Indian J. Stat"},{"issue":"1","key":"46_CR14","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1109\/TAC.1960.6429288","volume":"AC-5","author":"R Bellman","year":"1960","unstructured":"Bellman R, Kalaba R: Dynamic programming and adaptive processes: mathematical foundation. IRE Trans. Automatic Control 1960,AC-5(1):5-10.","journal-title":"IRE Trans. Automatic Control"},{"key":"46_CR15","unstructured":"Silver EA: Markovian decision processes with uncertain transition probabilities or rewards. Technical report, DTIC document, (1963)"},{"key":"46_CR16","doi-asserted-by":"crossref","DOI":"10.21236\/AD0612601","volume-title":"Markovian decision processes with uncertain transition probabilities","author":"JM Gozzolino","year":"1965","unstructured":"Gozzolino JM, Gonzalez-Zubieta R, Miller RL: Markovian decision processes with uncertain transition probabilities. Technical report, DTIC document (1965)"},{"key":"46_CR17","volume-title":"Bayesian Decision Problems and Markov Chains","author":"JJ Martin","year":"1967","unstructured":"Martin JJ: Bayesian Decision Problems and Markov Chains. New York: Wiley; 1967."},{"issue":"3","key":"46_CR18","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/0022-5193(69)90015-0","volume":"22","author":"SA SA Kauffman","year":"1969","unstructured":"SA Kauffman SA: Metabolic stability and epigenesis in randomly constructed genetic nets. J. Theor. Biol 1969,22(3):437-467. 10.1016\/0022-5193(69)90015-0","journal-title":"J. Theor. Biol"},{"key":"46_CR19","volume-title":"EURASIP J. Bioinform. Syst. Biol 2009","author":"B Faryabi","year":"2009","unstructured":"Faryabi B, Vahedi G, Chamberland J-F, Datta A, Dougherty ER: Intervention in context-sensitive probabilistic Boolean networks revisited. EURASIP J. Bioinform. Syst. Biol 2009.,2009(5):"},{"issue":"10","key":"46_CR20","doi-asserted-by":"publisher","first-page":"4966","DOI":"10.1109\/TSP.2008.928089","volume":"56","author":"X Qian","year":"2008","unstructured":"Qian X, Dougherty ER: Effect of function perturbation on the steady-state distribution of genetic regulatory networks: optimal structural intervention. IEEE Trans. Signal Process 2008,56(10):4966-4976.","journal-title":"IEEE Trans. Signal Process"},{"key":"46_CR21","volume-title":"Finite State Markovian Decision Processes","author":"C Derman","year":"1970","unstructured":"Derman C: Finite State Markovian Decision Processes. Orlando: Academic; 1970."},{"issue":"3","key":"46_CR22","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1287\/opre.21.3.728","volume":"21","author":"JK Satia","year":"1973","unstructured":"Satia JK, Lave RE: Markovian decision processes with uncertain transition probabilities. Oper. Res 1973,21(3):728-740. 10.1287\/opre.21.3.728","journal-title":"Oper. Res"},{"key":"46_CR23","volume-title":"Optimal learning: computational procedures for Bayes-adaptive Markov decision processes","author":"MO Duff","year":"2002","unstructured":"Duff MO: Optimal learning: computational procedures for Bayes-adaptive Markov decision processes. PhD thesis, University of Massachusetts, Amherst (2002)"},{"issue":"9","key":"46_CR24","doi-asserted-by":"publisher","first-page":"4930","DOI":"10.1109\/TSP.2012.2202114","volume":"60","author":"MR Yousefi","year":"2012","unstructured":"Yousefi MR, Datta A, Dougherty ER: Optimal intervention strategies for therapeutic methods with fixed-length duration of drug effectiveness. IEEE Trans. Signal Process 2012,60(9):4930-4944.","journal-title":"IEEE Trans. Signal Process"},{"issue":"14","key":"46_CR25","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1093\/bioinformatics\/btl210","volume":"22","author":"A Faure","year":"2006","unstructured":"Faure A, Naldi A, Chaouiya C, Thieffry D: Dynamical analysis of a generic Boolean model for the control of the mammalian cell cycle. Bioinformatics 2006,22(14):124-131. 10.1093\/bioinformatics\/btl210","journal-title":"Bioinformatics"},{"key":"46_CR26","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.jtbi.2011.08.042","volume":"289","author":"A Veliz-Cuba","year":"2011","unstructured":"Veliz-Cuba A: Reduction of Boolean network models. J. Theor. Biol 2011, 289: 167-172.","journal-title":"J. Theor. Biol"},{"issue":"5","key":"46_CR27","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1016\/j.patcog.2012.10.018","volume":"46","author":"LA Dalton","year":"2013","unstructured":"Dalton LA, Dougherty ER: Optimal classifiers with minimum expected error within a Bayesian framework - Part I: discrete and gaussian models. Pattern Recogn 2013,46(5):1301-1314. 10.1016\/j.patcog.2012.10.018","journal-title":"Pattern Recogn"},{"issue":"5","key":"46_CR28","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1016\/j.patcog.2012.10.019","volume":"46","author":"LA Dalton","year":"2013","unstructured":"Dalton LA, Dougherty ER: Optimal classifiers with minimum expected error within a Bayesian framework - Part II: properties and performance analysis. Pattern Recogn 2013,46(5):1288-1300. 10.1016\/j.patcog.2012.10.019","journal-title":"Pattern Recogn"},{"issue":"9","key":"46_CR29","doi-asserted-by":"publisher","first-page":"2256","DOI":"10.1109\/TSP.2013.2251336","volume":"61","author":"B-J Yoon","year":"2013","unstructured":"Yoon B-J, Qian X, Dougherty ER: Quantifying the objective cost of uncertainty in complex dynamical systems. IEEE Trans. Signal Process 2013,61(9):2256-2266.","journal-title":"IEEE Trans. Signal Process"},{"key":"46_CR30","doi-asserted-by":"publisher","DOI":"10.1002\/9781118104866","volume-title":"Epistemology of the Cell: A Systems Perspective on Biological Knowledge","author":"ER Dougherty","year":"2011","unstructured":"Dougherty ER, Bittner ML: Epistemology of the Cell: A Systems Perspective on Biological Knowledge. Hoboken: Wiley; 2011."}],"container-title":["EURASIP Journal on Bioinformatics and Systems Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1687-4153-2014-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1687-4153-2014-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1687-4153-2014-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T01:17:15Z","timestamp":1548119835000},"score":1,"resource":{"primary":{"URL":"https:\/\/bsb-eurasipjournals.springeropen.com\/articles\/10.1186\/1687-4153-2014-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,3]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["46"],"URL":"https:\/\/doi.org\/10.1186\/1687-4153-2014-6","relation":{},"ISSN":["1687-4153"],"issn-type":[{"value":"1687-4153","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,3]]},"article-number":"6"}}