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Motion-based artifacts lead in dynamic contrast-enhanced breast magnetic resonance to diagnostic misinterpretation; therefore, motion compensation represents an important prerequisite to automatic lesion detection and diagnosis. In addition, the extraction of pertinent kinetic and morphologic features as lesion descriptors is an equally important task. In the present paper, we evaluate the performance of a computer-aided diagnosis system consisting of motion correction, lesion segmentation, and feature extraction and classification. We develop a new feature extractor, the radial Krawtchouk moment, which guarantees rotation invariance. Many novel feature extraction techniques are proposed and tested in conjunction with lesion detection. Our simulation results have shown that motion compensation combined with Minkowski functionals and Bayesian classifier can improve lesion detection and classification.<\/jats:p>","DOI":"10.1186\/1687-6180-2013-157","type":"journal-article","created":{"date-parts":[[2013,10,17]],"date-time":"2013-10-17T17:02:16Z","timestamp":1382029336000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Computer-aided diagnosis for diagnostically challenging breast lesions in DCE-MRI based on image registration and integration of morphologic and dynamic characteristics"],"prefix":"10.1186","volume":"2013","author":[{"given":"Felix","family":"Retter","sequence":"first","affiliation":[]},{"given":"Claudia","family":"Plant","sequence":"additional","affiliation":[]},{"given":"Bernhard","family":"Burgeth","sequence":"additional","affiliation":[]},{"given":"Guillermo","family":"Botella","sequence":"additional","affiliation":[]},{"given":"Thomas","family":"Schlossbauer","sequence":"additional","affiliation":[]},{"given":"Anke","family":"Meyer-B\u00e4se","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2013,10,17]]},"reference":[{"key":"554_CR1","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1148\/radiology.196.1.7784554","volume":"196","author":"S Orel","year":"1995","unstructured":"Orel S, Schnall MD, Powell CM, Hochman MG, Solin LJ, Fowble BL, Torosian MH, Rosato EF: Staging of suspected breast-cancer-effect of MR imaging and MR-guided imaging and biopsy. 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