{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T22:06:27Z","timestamp":1781647587220,"version":"3.54.5"},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Pediatr Endocrinol"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>PHACE is a neurocutaneous syndrome associated with: Posterior fossa brain malformations, large \u201csegmental\u201d facial hemangiomas, arterial cerebrovascular-, cardiovascular-, and eye anomalies.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Case vignette<\/jats:title>\n            <jats:p>We are reporting a girl with PHACE syndrome. The patient had a congenital right-sided facial hemangioma with plaque-morphology. At age 11\u2009years and 2\u2009months she presented with short stature, markedly decreased growth velocity and signs and symptoms suggestive of hypothyroidism. Magnetic Resonance Imaging (MRI) of the brain revealed complex structural and cerebrovascular arterial anomalies, including an empty sella. Testing of pituitary function revealed multiple pituitary dysfunctions, including absolute growth hormone deficiency, hypogonadotropic hypogonadism, central hypothyroidism, and secondary adrenal insufficiency.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>This case suggests the necessity to screen all patients with PHACE syndrome and intracranial malformations for pituitary dysfunction at regular intervals.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1687-9856-2012-20","type":"journal-article","created":{"date-parts":[[2012,6,30]],"date-time":"2012-06-30T16:13:53Z","timestamp":1341072833000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A case of phace syndrome and acquired hypopituitarism?"],"prefix":"10.1186","volume":"2012","author":[{"given":"Friederike","family":"Denzer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Denzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belinda S","family":"Lennerz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Bode","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Wabitsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,6,30]]},"reference":[{"key":"27_CR1","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1001\/archderm.1996.03890270083012","volume":"132","author":"IJ Frieden","year":"1996","unstructured":"Frieden IJ, Reese V, Cohen D: PHACE syndrome: the association of posterior fossa brain malformations, hemangiomas, arterial anomalies, coarctation of the aorta and cardiac defects, and eye abnormalities. Arch Dermatol. 1996, 132: 307-311. 10.1001\/archderm.1996.03890270083012.","journal-title":"Arch Dermatol"},{"key":"27_CR2","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1002\/ajmg.a.31189","volume":"140A","author":"DW Metry","year":"2006","unstructured":"Metry DW, Haggstrom AN, Drolet BA, Baselga E, Chamlin S, Garzon M, Horii K, Lucky A, Mancini AJ, Newell B, Nopper A, Heyer G, Frieden IJ: A prospective study of PHACE syndrome in infantile hemangiomas: demographic features, clinical findings, and complications. Am J Med Genet. 2006, 140A: 975-986. 10.1002\/ajmg.a.31189.","journal-title":"Am J Med Genet"},{"key":"27_CR3","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1067\/mpd.2001.114880","volume":"139","author":"DW Metry","year":"2001","unstructured":"Metry DW, Dowd CF, Barkovich AJ, Frieden IJ: The many faces of PHACE syndrome. 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Am J Neuroradiol. 2010, 31 (10): 1980-1986. 10.3174\/ajnr.A2206.","journal-title":"Am J Neuroradiol"},{"issue":"6","key":"27_CR6","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1016\/j.pediatrneurol.2007.01.017","volume":"36","author":"G Poindexter","year":"2007","unstructured":"Poindexter G, Metry DW, Barkovich AJ, Frieden IJ: PHACE syndrome with intracerebral hemangiomas, heterotopia, and endocrine dysfunction. Pediatr Neurol. 2007, 36 (6): 402-406. 10.1016\/j.pediatrneurol.2007.01.017.","journal-title":"Pediatr Neurol"},{"key":"27_CR7","doi-asserted-by":"publisher","first-page":"255","DOI":"10.4158\/EP09179.CR","volume":"16","author":"M Merheb","year":"2010","unstructured":"Merheb M, Hourani R, Zantout MS, Azar ST: Endocrine dysfunction in a patient with PHACE syndrome, including port-wine stain of the right periorbital area. 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