{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T18:26:20Z","timestamp":1791138380036,"version":"4.1.0"},"reference-count":75,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Pediatr Endocrinol"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1186\/1687-9856-2014-15","type":"journal-article","created":{"date-parts":[[2014,7,15]],"date-time":"2014-07-15T21:01:43Z","timestamp":1405458103000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Growth hormone significantly increases the adult height of children with idiopathic short stature: comparison of subgroups and benefit"],"prefix":"10.1186","volume":"2014","author":[{"given":"Juan F","family":"Sotos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi J","family":"Tokar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,7,16]]},"reference":[{"issue":"7","key":"352_CR1","doi-asserted-by":"publisher","first-page":"3140","DOI":"10.1210\/jc.2003-031457","volume":"89","author":"EW Leschek","year":"2004","unstructured":"Leschek EW, Rose SR, Yanovski JA, Troendle JF, Quigley CA, Chipman JJ, Crowe BJ, Ross JL, Cassorla FG, Blum WF, Cutler GB, Baron J, National Institute of Child Health and Human Development-Eli Lilly & Co: Effect of growth hormone treatment on adult height in peripubertal children with idiopathic short stature: a randomized, double-blind, placebo-controlled trial. J Clin Endocrinol Metab. 2004, 89 (7): 3140-3148.","journal-title":"J Clin Endocrinol Metab"},{"issue":"9107","key":"352_CR2","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1016\/S0140-6736(05)60604-6","volume":"351","author":"ES McCaughey","year":"1998","unstructured":"McCaughey ES, Mulligan J, Voss LD, Betts PR: Randomised trial of growth hormone in short normal girls. Lancet. 1998, 351 (9107): 940-944.","journal-title":"Lancet"},{"issue":"11","key":"352_CR3","doi-asserted-by":"publisher","first-page":"4342","DOI":"10.1210\/jc.2008-0707","volume":"93","author":"K Albertsson-Wikland","year":"2008","unstructured":"Albertsson-Wikland K, Aronson AS, Gustafsson J, Hagen\u00e4s L, Ivarsson SA, Jonsson B, Kristr\u00f6m B, Marcus C, Nilsson KO, Ritz\u00e9n EM, Tuvemo T, Westphal O, Aman J: Dose-dependent effect of growth hormone on final height in children with short stature without growth hormone deficiency. J Clin Endocrinol Metab. 2008, 93 (11): 4342-4350.","journal-title":"J Clin Endocrinol Metab"},{"issue":"9","key":"352_CR4","doi-asserted-by":"publisher","first-page":"1595","DOI":"10.1515\/JPEM.2000.13.9.1595","volume":"13","author":"JP L\u00f3pez-Siguero","year":"2000","unstructured":"L\u00f3pez-Siguero JP, Garc\u00eda-Garcia E, Carralero I, Mart\u00ednez-Aedo MJ: Adult height in children with idiopathic short stature treated with growth hormone. J Pediatr Endocrinol Metab. 2000, 13 (9): 1595-1602.","journal-title":"J Pediatr Endocrinol Metab"},{"issue":"10","key":"352_CR5","doi-asserted-by":"publisher","first-page":"4649","DOI":"10.1210\/jcem.86.10.7962","volume":"86","author":"R Coutant","year":"2001","unstructured":"Coutant R, Rouleau S, Despert F, Magontier N, Loisel D, Limal JM: Growth and adult height in GH-treated children with nonacquired GH deficiency and idiopathic short stature: the influence of pituitary magnetic resonance imaging findings. J Clin Endocrinol Metab. 2001, 86 (10): 4649-4654.","journal-title":"J Clin Endocrinol Metab"},{"key":"352_CR6","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1111\/j.1651-2227.1996.tb14316.x","volume":"85","author":"JP Lopez-Siquero","year":"1996","unstructured":"Lopez-Siquero JP, Mart\u00ednez-Aedo MJ, Moreno-Molina JA: Final height after growth hormone therapy in children with idiopathic short stature and a subnormal growth rate. Acta Pediatr. 1996, 85: 113-147.","journal-title":"Acta Pediatr"},{"issue":"9019","key":"352_CR7","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/S0140-6736(96)01038-0","volume":"348","author":"PC Hindmarsh","year":"1996","unstructured":"Hindmarsh PC, Brook CG: Final height of short normal children treated with growth hormone. Lancet. 1996, 348 (9019): 13-16.","journal-title":"Lancet"},{"issue":"4","key":"352_CR8","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1210\/jcem.83.4.4703","volume":"83","author":"JG Buchlis","year":"1998","unstructured":"Buchlis JG, Irizarry L, Crotzer BC, Shine BJ, Allen L, MacGillivray MH: Comparison of final heights of growth hormone-treated vs. untreated children with idiopathic growth failure. J Clin Endocrinol Metab. 1998, 83 (4): 1075-1079.","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"352_CR9","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1210\/jcem.87.2.8225","volume":"87","author":"JM Wit","year":"2002","unstructured":"Wit JM, Rekers-Mombarg LT, Dutch Growth Hormone Advisory Group: Final height gain by GH therapy in children with idiopathic short stature is dose dependent. J Clin Endocrinol Metab. 2002, 87 (2): 604-611.","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"352_CR10","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1001\/archpedi.156.3.230","volume":"156","author":"BS Finkelstein","year":"2002","unstructured":"Finkelstein BS, Imperiale TF, Speroff T, Marrero U, Radcliffe DJ, Cuttler L: Effect of growth hormone therapy on height in children with idiopathic short stature: a meta-analysis. Arch Pediatr Adolesc Med. 2002, 156 (3): 230-240.","journal-title":"Arch Pediatr Adolesc Med"},{"issue":"7","key":"352_CR11","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1056\/NEJM199902183400702","volume":"340","author":"RL Hintz","year":"1999","unstructured":"Hintz RL, Attie KM, Baptista J, Roche A: Effect of growth hormone treatment on adult height of children with idiopathic short stature. Genentech Collaborative Group. N Engl J Med. 1999, 340 (7): 502-507.","journal-title":"N Engl J Med"},{"issue":"Suppl 3","key":"352_CR12","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1159\/000330158","volume":"76","author":"J Dahlgren","year":"2011","unstructured":"Dahlgren J: Growth outcomes in individuals with idiopathic short stature treated with growth hormone therapy. Horm Res Paediatr. 2011, 76 (Suppl 3): 42-45.","journal-title":"Horm Res Paediatr"},{"key":"352_CR13","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/1687-9856-2011-6","volume":"2011","author":"PA Lee","year":"2011","unstructured":"Lee PA, Germak J, Gut R, Khutoryansky N, Ross J: Identification of factors associated with good response to growth hormone therapy in children with short stature: results from the ANSWER Program\u00ae. Int J Pediatr Endocrinol. 2011, 2011: 6-10.1186\/1687-9856-2011-6","journal-title":"Int J Pediatr Endocrinol"},{"issue":"9","key":"352_CR14","doi-asserted-by":"publisher","first-page":"5188","DOI":"10.1210\/jc.2004-2543","volume":"90","author":"CA Quigley","year":"2005","unstructured":"Quigley CA, Gill AM, Crowe BJ, Robling K, Chipman JJ, Rose SR, Ross JL, Cassorla FG, Wolka AM, Wit JM, Rekers-Mombarg LT, Cutler GB: Safety of growth hormone treatment in pediatric patients with idiopathic short stature. J Clin Endocrinol Metab. 2005, 90 (9): 5188-5196.","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"352_CR15","doi-asserted-by":"publisher","first-page":"E213","DOI":"10.1210\/jc.2011-2882","volume":"97","author":"L S\u00e4vendahl","year":"2012","unstructured":"S\u00e4vendahl L, Maes M, Albertsson-Wikland K, Borgstr\u00f6m B, Carel JC, Henrard S, Speybroeck N, Thomas M, Zandwijken G, Hokken-Koelega A: Long-term mortality and causes of death in isolated GHD, ISS, and SGA patients treated with recombinant growth hormone during childhood in Belgium, The Netherlands, and Sweden: preliminary report of 3 countries participating in the EU SAGhE study. J Clin Endocrinol Metab. 2012, 97 (2): E213-E217.","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"352_CR16","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1210\/jc.2011-2294","volume":"97","author":"RG Rosenfeld","year":"2012","unstructured":"Rosenfeld RG, Cohen P, Robison LL, Bercu BB, Clayton P, Hoffman AR, Radovick S, Saenger P, Savage MO, Wit JM: Long-term surveillance of growth hormone therapy. J Clin Endocrinol Metab. 2012, 97 (1): 68-72.","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"352_CR17","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1111\/j.1440-1754.2012.02465.x","volume":"49","author":"GR Ambler","year":"2013","unstructured":"Ambler GR, Fairchild J, Wilkinson DJ: Debate: idiopathic short stature should be treated with growth hormone. J Paediatr Child Health. 2013, 49 (3): 165-169.","journal-title":"J Paediatr Child Health"},{"key":"352_CR18","doi-asserted-by":"publisher","first-page":"470378","DOI":"10.1186\/1687-9856-2009-470378","volume":"2009","author":"AL Rosenbloom","year":"2009","unstructured":"Rosenbloom AL: Idiopathic short stature: conundrums of definition and treatment. Int J Pediatr Endocrinol. 2009, 2009: 470378-10.1155\/2009\/470378. Epub 2009 Mar 12","journal-title":"Int J Pediatr Endocrinol"},{"issue":"1","key":"352_CR19","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/S0022-3476(00)90058-1","volume":"136","author":"LD Voss","year":"2000","unstructured":"Voss LD: Growth hormone therapy for the short normal child: who needs it and who wants it? The case against growth hormone therapy. J Pediatr. 2000, 136 (1): 103-106.","journal-title":"J Pediatr"},{"issue":"1","key":"352_CR20","doi-asserted-by":"publisher","first-page":"32","DOI":"10.4997\/JRCPE.2012.108","volume":"42","author":"CJ Kelnar","year":"2012","unstructured":"Kelnar CJ: Growth hormone for short children\u2013whom should we be treating and why?. J R Coll Physicians Edinb. 2012, 42 (1): 32-33.","journal-title":"J R Coll Physicians Edinb"},{"key":"352_CR21","doi-asserted-by":"publisher","first-page":"c7157","DOI":"10.1136\/bmj.c7157","volume":"342","author":"A Deodati","year":"2011","unstructured":"Deodati A, Cianfarani S: Impact of growth hormone therapy on adult height of children with idiopathic short stature: systematic review. BMJ. 2011, 342: c7157-","journal-title":"BMJ"},{"issue":"3","key":"352_CR22","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1001\/archpedi.160.3.263","volume":"160","author":"JM Lee","year":"2006","unstructured":"Lee JM, Davis MM, Clark SJ, Hofer TP, Kemper AR: Estimated cost-effectiveness of growth hormone therapy for idiopathic short stature. Arch Pediatr Adolesc Med. 2006, 160 (3): 263-269.","journal-title":"Arch Pediatr Adolesc Med"},{"issue":"Suppl 3","key":"352_CR23","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1159\/000330153","volume":"76","author":"I Durand-Zaleski","year":"2011","unstructured":"Durand-Zaleski I: Developments in idiopathic short stature: cost versus allocation of resources. Horm Res Paediatr. 2011, 76 (Suppl 3): 33-35.","journal-title":"Horm Res Paediatr"},{"issue":"suppl 3","key":"352_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000330131","volume":"76","author":"JM Wit","year":"2011","unstructured":"Wit JM, Dunkel L: Developments in Idiopathic Short Stature. Horm Res Paediatr. 2011, 76 (suppl 3): 1-2.","journal-title":"Horm Res Paediatr"},{"issue":"5","key":"352_CR25","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1016\/j.jpeds.2004.02.028","volume":"144","author":"DB Allen","year":"2004","unstructured":"Allen DB, Fost N: hGH for short stature: ethical issues raised by expanded access. J Pediatr. 2004, 144 (5): 648-652.","journal-title":"J Pediatr"},{"issue":"5","key":"352_CR26","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1067\/mpd.2002.123766","volume":"140","author":"NC Theunissen","year":"2002","unstructured":"Theunissen NC, Kamp GA, Koopman HM, Zwinderman KA, Vogels T, Wit JM: Quality of life and self-esteem in children treated for idiopathic short stature. J Pediatr. 2002, 140 (5): 507-515.","journal-title":"J Pediatr"},{"issue":"3","key":"352_CR27","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1542\/peds.2003-1169-L","volume":"114","author":"DE Sandberg","year":"2004","unstructured":"Sandberg DE, Bukowski WM, Fung CM, Noll RB: Height and social adjustment: are extremes a cause for concern and action?. Pediatrics. 2004, 114 (3): 744-750.","journal-title":"Pediatrics"},{"issue":"Suppl 3","key":"352_CR28","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1159\/000330155","volume":"76","author":"DE Sandberg","year":"2011","unstructured":"Sandberg DE: Psychosocial aspects of short stature and its management: good deeds require good science. Horm Res Paediatr. 2011, 76 (Suppl 3): 37-39.","journal-title":"Horm Res Paediatr"},{"issue":"2","key":"352_CR29","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.jpeds.2010.10.004","volume":"158","author":"AL Rosenbloom","year":"2011","unstructured":"Rosenbloom AL: Pediatric endo-cosmetology and the evolution of growth diagnosis and treatment. J Pediatr. 2011, 158 (2): 187-193.","journal-title":"J Pediatr"},{"issue":"8","key":"352_CR30","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1111\/j.1651-2227.1998.tb01553.x","volume":"87","author":"LT Rekers-Mombarg","year":"1998","unstructured":"Rekers-Mombarg LT, Busschbach JJ, Massa GG, Dicke J, Wit JM: Quality of life of young adults with idiopathic short stature: effect of growth hormone treatment. Dutch Growth Hormone Working Group. Acta Paediatr. 1998, 87 (8): 865-870.","journal-title":"Acta Paediatr"},{"issue":"Suppl 3","key":"352_CR31","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1159\/000330162","volume":"76","author":"JE Chaplin","year":"2011","unstructured":"Chaplin JE: Growth-related quality of life. Horm Res Paediatr. 2011, 76 (Suppl 3): 51-52.","journal-title":"Horm Res Paediatr"},{"issue":"Suppl 3","key":"352_CR32","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1159\/000330163","volume":"76","author":"M Noeker","year":"2011","unstructured":"Noeker M: Psychological functioning in idiopathic short stature. Horm Res Paediatr. 2011, 76 (Suppl 3): 52-56.","journal-title":"Horm Res Paediatr"},{"issue":"3","key":"352_CR33","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1210\/jc.2004-0092","volume":"89","author":"RG Rosenfeld","year":"2004","unstructured":"Rosenfeld RG, Hwa V: Toward a molecular basis for idiopathic short stature. J Clin Endocrinol Metab. 2004, 89 (3): 1066-1067.","journal-title":"J Clin Endocrinol Metab"},{"issue":"Suppl 3","key":"352_CR34","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1159\/000330140","volume":"76","author":"W Kiess","year":"2011","unstructured":"Kiess W, Kratzsch J, Kruis T, M\u00fcller E, Wallborn T, Odeh R, Schlicke M, Klammt J, Pf\u00e4ffle R: Genetics of human stature: Insight from single gene disorders. Horm Res Paediatr. 2011, 76 (Suppl 3): 11-13.","journal-title":"Horm Res Paediatr"},{"issue":"6","key":"352_CR35","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1111\/cen.12200","volume":"79","author":"O Hess","year":"2013","unstructured":"Hess O, Khayat M, Hwa V, Heath KE, Teitler A, Hritan Y, Allon-Shalev S, Tenenbaum-Rakover Y: A novel mutation in IGFALS, c.380T>C (p.L127P), associated with short stature, delayed puberty, osteopenia and hyperinsulinaemia in two siblings: insights into the roles of insulin growth factor-1 (IGF1). Clin Endocrinol (Oxf). 2013, 79 (6): 838-844.","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"15","key":"352_CR36","doi-asserted-by":"publisher","first-page":"3454","DOI":"10.1111\/j.1742-4658.2006.05347.x","volume":"273","author":"AP Rojas-Gil","year":"2006","unstructured":"Rojas-Gil AP, Ziros PG, Diaz L, Kletsas D, Basdra EK, Alexandrides TK, Zadik Z, Frank SJ, Papathanassopoulou V, Beratis NG, Papavassiliou AG, Spiliotis BE: Growth hormone\/JAK-STAT axis signal-transduction defect: a novel treatable cause of growth failure. FEBS J. 2006, 273 (15): 3454-3466.","journal-title":"FEBS J"},{"issue":"2","key":"352_CR37","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1530\/EJE-11-0168","volume":"165","author":"PN Pugliese-Pires","year":"2011","unstructured":"Pugliese-Pires PN, Fortin JP, Arthur T, Latronico AC, Mendonca BB, Villares SM, Arnhold IJ, Kopin AS, Jorge AA: Novel inactivating mutations in the GH secretagogue receptor gene in patients with constitutional delay of growth and puberty. Eur J Endocrinol. 2011, 165 (2): 233-241.","journal-title":"Eur J Endocrinol"},{"issue":"11","key":"352_CR38","doi-asserted-by":"publisher","first-page":"E363","DOI":"10.1210\/jc.2010-0511","volume":"95","author":"HA van Duyvenvoorde","year":"2010","unstructured":"van Duyvenvoorde HA, van Setten PA, Walenkamp MJ, van Doorn J, Koenig J, Gauguin L, Oostdijk W, Ruivenkamp CA, Losekoot M, Wade JD, De Meyts P, Karperien M, Noordam C, Wit JM: Short stature associated with a novel heterozygous mutation in the insulin-like growth factor 1 gene. J Clin Endocrinol Metab. 2010, 95 (11): E363-E367.","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"352_CR39","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1016\/j.ejmg.2012.09.003","volume":"55","author":"PH Su","year":"2012","unstructured":"Su PH, Yang SF, Yu JS, Chen SJ, Chen JY: A polymorphism in the leptin receptor gene at position 223 is associated with growth hormone replacement therapy responsiveness in idiopathic short stature and growth hormone deficiency patients. Eur J Med Genet. 2012, 55 (12): 682-687.","journal-title":"Eur J Med Genet"},{"issue":"1","key":"352_CR40","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1038\/ng0597-13","volume":"16","author":"RM Ayling","year":"1997","unstructured":"Ayling RM, Ross R, Towner P, Von Laue S, Finidori J, Moutoussamy S, Buchanan CR, Clayton PE, Norman MR: A dominant-negative mutation of the growth hormone receptor causes familial short stature. Nat Genet. 1997, 16 (1): 13-14.","journal-title":"Nat Genet"},{"issue":"1","key":"352_CR41","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/s11102-012-0378-8","volume":"16","author":"L Trovato","year":"2013","unstructured":"Trovato L, Prodam F, Genoni G, De Rienzo F, Walker GE, Moia S, Riccomagno S, Bellone S, Bona G: Involvement of genes related to inflammation and cell cycle in idiopathic short stature. Pituitary. 2013, 16 (1): 83-90.","journal-title":"Pituitary"},{"issue":"10","key":"352_CR42","doi-asserted-by":"publisher","first-page":"E1636","DOI":"10.1210\/jc.2013-2142","volume":"98","author":"GA Vasques","year":"2013","unstructured":"Vasques GA, Amano N, Docko AJ, Funari MF, Quedas EP, Nishi MY, Arnhold IJ, Hasegawa T, Jorge AA: Heterozygous Mutations in Natriuretic Peptide Receptor-B (NPR2) Gene as a Cause of Short Stature in Patients Initially Classified as Idiopathic Short Stature. J Clin Endocrinol Metab. 2013, 98 (10): E1636-E1644.","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"352_CR43","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1038\/ng0597-54","volume":"16","author":"E Rao","year":"1997","unstructured":"Rao E, Weiss B, Fukami M, Rump A, Niesler B, Mertz A, Muroya K, Binder G, Kirsch S, Winkelmann M, Nordsiek G, Heinrich U, Breuning MH, Ranke MB, Rosenthal A, Ogata T, Rappold GA: Pseudoautosomal deletions encompassing a novel homeobox gene cause growth failure in idiopathic short stature and Turner syndrome. Nat Genet. 1997, 16 (1): 54-63.","journal-title":"Nat Genet"},{"issue":"Suppl 3","key":"352_CR44","first-page":"1","volume":"76","author":"L Dunkel","year":"2011","unstructured":"Dunkel L, Wit JM: Developments in idiopathic short stature. Horm Res Paediatr. 2011, 76 (Suppl 3): 1-60.","journal-title":"Horm Res Paediatr"},{"issue":"11","key":"352_CR45","doi-asserted-by":"publisher","first-page":"4210","DOI":"10.1210\/jc.2008-0509","volume":"93","author":"P Cohen","year":"2008","unstructured":"Cohen P, Rogol AD, Deal CL, Saenger P, Reiter EO, Ross JL, Chernausek SD, Savage MO, Wit JM, 2007 ISS Consensus Workshop participants: Consensus statement on the diagnosis and treatment of children with idiopathic short stature: a summary of the Growth Hormone Research Society, the Lawson Wilkins Pediatric Endocrine Society, and the European Society for Paediatric Endocrinology Workshop. J Clin Endocrinol Metab. 2008, 93 (11): 4210-4217.","journal-title":"J Clin Endocrinol Metab"},{"issue":"Suppl 2","key":"352_CR46","doi-asserted-by":"crossref","first-page":"S178","DOI":"10.4103\/2230-8210.104034","volume":"16","author":"MO Savage","year":"2012","unstructured":"Savage MO, Bang P: The variability of responses to growth hormone therapy in children with short stature. Indian J Endocrinol Metab. 2012, 16 (Suppl 2): S178-S184.","journal-title":"Indian J Endocrinol Metab"},{"issue":"2","key":"352_CR47","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.ghir.2007.11.004","volume":"18","author":"JM Wit","year":"2008","unstructured":"Wit JM, Clayton PE, Rogol AD, Savage MO, Saenger PH, Cohen P: Idiopathic short stature: definition, epidemiology, and diagnostic evaluation. Growth Horm IGF Res. 2008, 18 (2): 89-110.","journal-title":"Growth Horm IGF Res"},{"issue":"3","key":"352_CR48","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1136\/adc.75.3.175","volume":"75","author":"LT Rekers-Mombarg","year":"1996","unstructured":"Rekers-Mombarg LT, Wit JM, Massa GG, Ranke MB, Buckler JM, Butenandt O, Chaussain JL, Frisch H, Leiberman E: Spontaneous growth in idiopathic short stature. European Study Group. Arch Dis Child. 1996, 75 (3): 175-180.","journal-title":"Arch Dis Child"},{"issue":"4","key":"352_CR49","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1159\/000184616","volume":"44","author":"MB Ranke","year":"1995","unstructured":"Ranke MB, Grauer ML, Kistner K, Blum WF, Wollmann HA: Spontaneous adult height in idiopathic short stature. Horm Res. 1995, 44 (4): 152-157.","journal-title":"Horm Res"},{"issue":"Suppl 2","key":"352_CR50","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1159\/000184851","volume":"45","author":"MB Ranke","year":"1996","unstructured":"Ranke MB: Towards a consensus on the definition of idiopathic short stature. Horm Res. 1996, 45 (Suppl 2): 64-66.","journal-title":"Horm Res"},{"issue":"Suppl 2","key":"352_CR51","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1159\/000184850","volume":"45","author":"DA Price","year":"1996","unstructured":"Price DA: Spontaneous adult height in patients with idiopathic short stature. Horm Res. 1996, 45 (Suppl 2): 59-63.","journal-title":"Horm Res"},{"issue":"2","key":"352_CR52","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1515\/JPEM.2005.18.2.171","volume":"18","author":"S Poyrazo\u011flu","year":"2005","unstructured":"Poyrazo\u011flu S, G\u00fcn\u00f6z H, Darendeliler F, Saka N, Bundak R, Ba\u015f F: Constitutional delay of growth and puberty: from presentation to final height. J Pediatr Endocrinol Metab. 2005, 18 (2): 171-179.","journal-title":"J Pediatr Endocrinol Metab"},{"issue":"1","key":"352_CR53","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1542\/peds.87.1.82","volume":"87","author":"S LaFranchi","year":"1991","unstructured":"LaFranchi S, Hanna CE, Mandel SH: Constitutional delay of growth: expected versus final adult height. Pediatrics. 1991, 87 (1): 82-87.","journal-title":"Pediatrics"},{"issue":"10","key":"352_CR54","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1136\/adc.65.10.1109","volume":"65","author":"EC Crowne","year":"1990","unstructured":"Crowne EC, Shalet SM, Wallace WH, Eminson DM, Price DA: Final height in boys with untreated constitutional delay in growth and puberty. Arch Dis Child. 1990, 65 (10): 1109-1112.","journal-title":"Arch Dis Child"},{"issue":"10","key":"352_CR55","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1007\/BF01958760","volume":"150","author":"EC Crowne","year":"1991","unstructured":"Crowne EC, Shalet SM, Wallace WH, Eminson DM, Price DA: Final height in girls with untreated constitutional delay in growth and puberty. Eur J Pediatr. 1991, 150 (10): 708-712.","journal-title":"Eur J Pediatr"},{"issue":"Suppl 3","key":"352_CR56","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1159\/000330134","volume":"76","author":"JM Wit","year":"2011","unstructured":"Wit JM: Definition and subcategorization of idiopathic short stature: between consensus and controversy. Horm Res Paediatr. 2011, 76 (Suppl 3): 3-6.","journal-title":"Horm Res Paediatr"},{"issue":"2","key":"352_CR57","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1136\/adc.73.2.131","volume":"73","author":"DC Brown","year":"1995","unstructured":"Brown DC, Butler GE, Kelnar CJ, Wu FC: A double blind, placebo controlled study of the effects of low dose testosterone undecanoate on the growth of small for age, prepubertal boys. Arch Dis Child. 1995, 73 (2): 131-135.","journal-title":"Arch Dis Child"},{"issue":"3","key":"352_CR58","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1046\/j.1365-2265.2003.01692.x","volume":"58","author":"BP Kelly","year":"2003","unstructured":"Kelly BP, Paterson WF, Donaldson MD: Final height outcome and value of height prediction in boys with constitutional delay in growth and adolescence treated with intramuscular testosterone 125\u00a0mg per month for 3\u00a0months. Clin Endocrinol (Oxf). 2003, 58 (3): 267-272.","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"4","key":"352_CR59","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1046\/j.1365-2265.2002.01492.x","volume":"56","author":"GA Kamp","year":"2002","unstructured":"Kamp GA, Ouwens DM, Hoogerbrugge CM, Zwinderman AH, Maassen JA, Wit JM: Skin fibroblasts of children with idiopathic short stature show an increased mitogenic response to IGF-I and secrete more IGFBP-3. Clin Endocrinol (Oxf). 2002, 56 (4): 439-447.","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"10","key":"352_CR60","doi-asserted-by":"publisher","first-page":"4600","DOI":"10.1210\/jc.2009-1831","volume":"95","author":"E Feigerlov\u00e1","year":"2010","unstructured":"Feigerlov\u00e1 E, Diene G, Oliver I, Gennero I, Salles JP, Arnaud C, Tauber M: Elevated insulin-like growth factor-I values in children with Prader-Willi syndrome compared with growth hormone (GH) deficiency children over two years of GH treatment. J Clin Endocrinol Metab. 2010, 95 (10): 4600-4608.","journal-title":"J Clin Endocrinol Metab"},{"key":"352_CR61","first-page":"CD004440","volume":"3","author":"J Bryant","year":"2007","unstructured":"Bryant J, Baxter L, Cave CB, Milne R: Recombinant growth hormone for idiopathic short stature in children and adolescents. Cochrane Database Syst Rev. 2007, 3: CD004440-","journal-title":"Cochrane Database Syst Rev"},{"issue":"2","key":"352_CR62","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1210\/jcem.82.2.3734","volume":"82","author":"SL Blethen","year":"1997","unstructured":"Blethen SL, Baptista J, Kuntze J, Foley T, LaFranchi S, Johanson A: Adult height in growth hormone (GH)-deficient children treated with biosynthetic GH. The Genentech Growth Study Group. J Clin Endocrinol Metab. 1997, 82 (2): 418-420.","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"352_CR63","doi-asserted-by":"publisher","first-page":"e519","DOI":"10.1542\/peds.2009-0293","volume":"124","author":"A Maiorana","year":"2009","unstructured":"Maiorana A, Cianfarani S: Impact of growth hormone therapy on adult height of children born small for gestational age. Pediatrics. 2009, 124 (3): e519-e531.","journal-title":"Pediatrics"},{"key":"352_CR64","first-page":"CD003887","volume":"1","author":"L Baxter","year":"2007","unstructured":"Baxter L, Bryant J, Cave CB, Milne R: Recombinant growth hormone for children and adolescents with Turner syndrome. Cochrane Database Syst Rev. 2007, 1: CD003887-","journal-title":"Cochrane Database Syst Rev"},{"issue":"2","key":"352_CR65","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.ghir.2007.11.003","volume":"18","author":"JM Wit","year":"2008","unstructured":"Wit JM, Reiter EO, Ross JL, Saenger PH, Savage MO, Rogol AD, Cohen P: Idiopathic short stature: management and growth hormone treatment. Growth Horm IGF Res. 2008, 18 (2): 111-135.","journal-title":"Growth Horm IGF Res"},{"issue":"1","key":"352_CR66","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.jpeds.2004.08.055","volume":"146","author":"JM Wit","year":"2005","unstructured":"Wit JM, Rekers-Mombarg LT, Cutler GB, Crowe B, Beck TJ, Roberts K, Gill A, Chaussain JL, Frisch H, Yturriaga R, Attanasio AF: Growth hormone (GH) treatment to final height in children with idiopathic short stature: evidence for a dose effect. J Pediatr. 2005, 146 (1): 45-53.","journal-title":"J Pediatr"},{"issue":"9","key":"352_CR67","doi-asserted-by":"publisher","first-page":"5247","DOI":"10.1210\/jc.2004-2513","volume":"90","author":"SF Kemp","year":"2005","unstructured":"Kemp SF, Kuntze J, Attie KM, Maneatis T, Butler S, Frane J, Lippe B: Efficacy and safety results of long-term growth hormone treatment of idiopathic short stature. J Clin Endocrinol Metab. 2005, 90 (9): 5247-5253.","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"352_CR68","doi-asserted-by":"publisher","first-page":"4307","DOI":"10.1210\/jcem.84.12.6189","volume":"84","author":"HJ Guyda","year":"1999","unstructured":"Guyda HJ: Four decades of growth hormone therapy for short children: what have we achieved?. J Clin Endocrinol Metab. 1999, 84 (12): 4307-4316.","journal-title":"J Clin Endocrinol Metab"},{"issue":"Suppl 1","key":"352_CR69","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1159\/000097553","volume":"67","author":"JM Wit","year":"2007","unstructured":"Wit JM: Idiopathic short stature: reflections on its definition and spontaneous growth. Horm Res. 2007, 67 (Suppl 1): 50-57.","journal-title":"Horm Res"},{"key":"352_CR70","doi-asserted-by":"publisher","first-page":"b3276","DOI":"10.1136\/bmj.b3276","volume":"339","author":"CJ Kelly","year":"2009","unstructured":"Kelly CJ, Mir FA: Biological therapies: how can we afford them?. BMJ. 2009, 339: b3276-","journal-title":"BMJ"},{"issue":"4","key":"352_CR71","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1377\/hlthaff.24.4.1117","volume":"24","author":"CD Mullins","year":"2005","unstructured":"Mullins CD, DeVries AR, Hsu VD, Meng F, Palumbo FB: Variability and growth in spending for outpatient specialty pharmaceuticals. Health Aff (Millwood). 2005, 24 (4): 1117-1127.","journal-title":"Health Aff (Millwood)"},{"key":"352_CR72","doi-asserted-by":"publisher","first-page":"370329","DOI":"10.1186\/1687-9856-2009-370329","volume":"2009","author":"P Saenger","year":"2009","unstructured":"Saenger P: Current status of biosimilar growth hormone. Int J Pediatr Endocrinol. 2009, 2009: 370329-","journal-title":"Int J Pediatr Endocrinol"},{"issue":"9","key":"352_CR73","first-page":"45","volume":"16","author":"GR Bazalo","year":"2007","unstructured":"Bazalo GR, Joshi AV, Germak J: Comparison of human growth hormone products\u2019 cost in pediatric and adult patients. A budgetary impact model. Manag Care. 2007, 16 (9): 45-51.","journal-title":"Manag Care"},{"issue":"7","key":"352_CR74","doi-asserted-by":"publisher","first-page":"3149","DOI":"10.1210\/jc.2009-2688","volume":"95","author":"L Cuttler","year":"2010","unstructured":"Cuttler L, Silvers JB: Growth hormone and health policy. J Clin Endocrinol Metab. 2010, 95 (7): 3149-3153. 10.1210\/jc.2009-2688 Jul","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"352_CR75","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1365-2265.2006.02691.x","volume":"66","author":"DS Hardin","year":"2007","unstructured":"Hardin DS, Woo J, Butsch R, Huett B: Current prescribing practices and opinions about growth hormone therapy: results of a nationwide survey of paediatric endocrinologists. Clin Endocrinol (Oxf). 2007, 66 (1): 85-94.","journal-title":"Clin Endocrinol (Oxf)"}],"container-title":["International Journal of Pediatric Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1687-9856-2014-15.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T03:59:24Z","timestamp":1717041564000},"score":1,"resource":{"primary":{"URL":"https:\/\/ijpeonline.biomedcentral.com\/articles\/10.1186\/1687-9856-2014-15"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,16]]},"references-count":75,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["352"],"URL":"https:\/\/doi.org\/10.1186\/1687-9856-2014-15","relation":{},"ISSN":["1687-9856"],"issn-type":[{"value":"1687-9856","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,16]]},"assertion":[{"value":"30 January 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 June 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 July 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"15"}}