{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T09:01:33Z","timestamp":1790499693950,"version":"4.1.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["All Asth Clin Immun"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1186\/1710-1492-10-2","type":"journal-article","created":{"date-parts":[[2014,1,17]],"date-time":"2014-01-17T18:02:11Z","timestamp":1389981731000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["T cell unresponsiveness in a pediatric cystic fibrosis patient: a case report"],"prefix":"10.1186","volume":"10","author":[{"given":"Rahul","family":"Kushwah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Gagnon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil B","family":"Sweezey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,1,17]]},"reference":[{"key":"406_CR1","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1126\/science.2475911","volume":"245","author":"JR Riordan","year":"1989","unstructured":"Riordan JR, Rommens JM, Kerem B, Alon N, Rozmahel R, Grzelczak Z, Zielenski J, Lok S, Plavsic N, Chou JL: Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA. Science. 1989, 245: 1066-1073. 10.1126\/science.2475911.","journal-title":"Science"},{"key":"406_CR2","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1016\/S0140-6736(03)12567-6","volume":"361","author":"F Ratjen","year":"2003","unstructured":"Ratjen F, Doring G: Cystic fibrosis. Lancet. 2003, 361: 681-689. 10.1016\/S0140-6736(03)12567-6.","journal-title":"Lancet"},{"key":"406_CR3","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1056\/NEJM199204303261804","volume":"326","author":"E Kerem","year":"1992","unstructured":"Kerem E, Reisman J, Corey M, Canny GJ, Levison H: Prediction of mortality in patients with cystic fibrosis. N Engl J Med. 1992, 326: 1187-1191. 10.1056\/NEJM199204303261804.","journal-title":"N Engl J Med"},{"key":"406_CR4","first-page":"939","volume":"151","author":"A Cantin","year":"1995","unstructured":"Cantin A: Cystic fibrosis lung inflammation: early, sustained, and severe. Am J Respir Crit Care Med. 1995, 151: 939-941.","journal-title":"Am J Respir Crit Care Med"},{"key":"406_CR5","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1172\/JCI6277","volume":"103","author":"R Bals","year":"1999","unstructured":"Bals R, Weiner DJ, Wilson JM: The innate immune system in cystic fibrosis lung disease. J Clin Invest. 1999, 103: 303-307. 10.1172\/JCI6277.","journal-title":"J Clin Invest"},{"key":"406_CR6","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1136\/thoraxjnl-2011-200585","volume":"67","author":"N Regamey","year":"2012","unstructured":"Regamey N, Tsartsali L, Hilliard TN, Fuchs O, Tan HL, Zhu J, Qiu YS, Alton EW, Jeffery PK, Bush A: Distinct patterns of inflammation in the airway lumen and bronchial mucosa of children with cystic fibrosis. Thorax. 2012, 67: 164-170. 10.1136\/thoraxjnl-2011-200585.","journal-title":"Thorax"},{"key":"406_CR7","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1046\/j.1365-2249.2001.01456.x","volume":"124","author":"C Hubeau","year":"2001","unstructured":"Hubeau C, Lorenzato M, Couetil JP, Hubert D, Dusser D, Puchelle E, Gaillard D: Quantitative analysis of inflammatory cells infiltrating the cystic fibrosis airway mucosa. Clin Exp Immunol. 2001, 124: 69-76. 10.1046\/j.1365-2249.2001.01456.x.","journal-title":"Clin Exp Immunol"},{"key":"406_CR8","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1164\/rccm.201206-1150OC","volume":"187","author":"K Tiringer","year":"2013","unstructured":"Tiringer K, Treis A, Fucik P, Gona M, Gruber S, Renner S, Dehlink E, Nachbaur E, Horak F, Jaksch P: A Th17- and Th2-skewed cytokine profile in cystic fibrosis lungs represents a potential risk factor for Pseudomonas aeruginosa infection. Am J Respir Crit Care Med. 2013, 187: 621-629. 10.1164\/rccm.201206-1150OC.","journal-title":"Am J Respir Crit Care Med"},{"key":"406_CR9","doi-asserted-by":"publisher","first-page":"404","DOI":"10.4049\/jimmunol.175.1.404","volume":"175","author":"F McAllister","year":"2005","unstructured":"McAllister F, Henry A, Kreindler JL, Dubin PJ, Ulrich L, Steele C, Finder JD, Pilewski JM, Carreno BM, Goldman SJ: Role of IL-17A, IL-17\u00a0F, and the IL-17 receptor in regulating growth-related oncogene-alpha and granulocyte colony-stimulating factor in bronchial epithelium: implications for airway inflammation in cystic fibrosis. J Immunol. 2005, 175: 404-412.","journal-title":"J Immunol"},{"key":"406_CR10","doi-asserted-by":"publisher","first-page":"1903","DOI":"10.1084\/jem.20080397","volume":"205","author":"L Cosmi","year":"2008","unstructured":"Cosmi L, De PR, Santarlasci V, Maggi L, Capone M, Frosali F, Rodolico G, Querci V, Abbate G, Angeli R: Human interleukin 17-producing cells originate from a CD161\u2009+\u2009CD4+ T cell precursor. J Exp Med. 2008, 205: 1903-1916. 10.1084\/jem.20080397.","journal-title":"J Exp Med"},{"key":"406_CR11","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/0022-1759(93)90158-4","volume":"159","author":"T Jung","year":"1993","unstructured":"Jung T, Schauer U, Heusser C, Neumann C, Rieger C: Detection of intracellular cytokines by flow cytometry. J Immunol Methods. 1993, 159: 197-207. 10.1016\/0022-1759(93)90158-4.","journal-title":"J Immunol Methods"},{"key":"406_CR12","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1038\/nature07021","volume":"454","author":"L Yang","year":"2008","unstructured":"Yang L, Anderson DE, Baecher-Allan C, Hastings WD, Bettelli E, Oukka M, Kuchroo VK, Hafler DA: IL-21 and TGF-beta are required for differentiation of human T(H)17 cells. Nature. 2008, 454: 350-352. 10.1038\/nature07021.","journal-title":"Nature"},{"key":"406_CR13","doi-asserted-by":"publisher","first-page":"1875","DOI":"10.1084\/jem.20030152","volume":"198","author":"W Chen","year":"2003","unstructured":"Chen W, Jin W, Hardegen N, Lei KJ, Li L, Marinos N, McGrady G, Wahl SM: Conversion of peripheral CD4\u2009+\u2009CD25- naive T cells to CD4\u2009+\u2009CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med. 2003, 198: 1875-1886. 10.1084\/jem.20030152.","journal-title":"J Exp Med"},{"key":"406_CR14","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1146\/annurev.immunol.24.021605.090547","volume":"24","author":"SF Ziegler","year":"2006","unstructured":"Ziegler SF: FOXP3: of mice and men. Annu Rev Immunol. 2006, 24: 209-226. 10.1146\/annurev.immunol.24.021605.090547.","journal-title":"Annu Rev Immunol"},{"key":"406_CR15","doi-asserted-by":"publisher","first-page":"8623","DOI":"10.1073\/pnas.0809818106","volume":"106","author":"SN Mueller","year":"2009","unstructured":"Mueller SN, Ahmed R: High antigen levels are the cause of T cell exhaustion during chronic viral infection. Proc Natl Acad Sci USA. 2009, 106: 8623-8628. 10.1073\/pnas.0809818106.","journal-title":"Proc Natl Acad Sci USA"},{"key":"406_CR16","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1038\/ni.1679","volume":"10","author":"SD Blackburn","year":"2009","unstructured":"Blackburn SD, Shin H, Haining WN, Zou T, Workman CJ, Polley A, Betts MR, Freeman GJ, Vignali DA, Wherry EJ: Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection. Nat Immunol. 2009, 10: 29-37. 10.1038\/ni.1679.","journal-title":"Nat Immunol"},{"key":"406_CR17","doi-asserted-by":"publisher","first-page":"e59302","DOI":"10.1371\/journal.pone.0059302","volume":"8","author":"T Feuth","year":"2013","unstructured":"Feuth T, Arends JE, Fransen JH, Nanlohy NM, van Erpecum KJ, Siersema PD, Hoepelman AI, van Baarle D: Complementary role of HCV and HIV in T-cell activation and exhaustion in HIV\/HCV coinfection. PLoS One. 2013, 8: e59302-10.1371\/journal.pone.0059302.","journal-title":"PLoS One"},{"key":"406_CR18","doi-asserted-by":"publisher","first-page":"e47648","DOI":"10.1371\/journal.pone.0047648","volume":"7","author":"G Nebbia","year":"2012","unstructured":"Nebbia G, Peppa D, Schurich A, Khanna P, Singh HD, Cheng Y, Rosenberg W, Dusheiko G, Gilson R, Chin-Aleong J: Upregulation of the Tim-3\/galectin-9 pathway of T cell exhaustion in chronic hepatitis B virus infection. PLoS One. 2012, 7: e47648-10.1371\/journal.pone.0047648.","journal-title":"PLoS One"},{"key":"406_CR19","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.4049\/jimmunol.1202438","volume":"190","author":"J Illingworth","year":"2013","unstructured":"Illingworth J, Butler NS, Roetynck S, Mwacharo J, Pierce SK, Bejon P, Crompton PD, Marsh K, Ndungu FM: Chronic exposure to Plasmodium falciparum is associated with phenotypic evidence of B and T cell exhaustion. J Immunol. 2013, 190: 1038-1047. 10.4049\/jimmunol.1202438.","journal-title":"J Immunol"},{"key":"406_CR20","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.pt.2012.07.001","volume":"28","author":"JP Gigley","year":"2012","unstructured":"Gigley JP, Bhadra R, Moretto MM, Khan IA: T cell exhaustion in protozoan disease. Trends Parasitol. 2012, 28: 377-384. 10.1016\/j.pt.2012.07.001.","journal-title":"Trends Parasitol"},{"key":"406_CR21","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1084\/jem.20100466","volume":"208","author":"T Okazaki","year":"2011","unstructured":"Okazaki T, Okazaki IM, Wang J, Sugiura D, Nakaki F, Yoshida T, Kato Y, Fagarasan S, Muramatsu M, Eto T: PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice. J Exp Med. 2011, 208: 395-407. 10.1084\/jem.20100466.","journal-title":"J Exp Med"},{"key":"406_CR22","doi-asserted-by":"publisher","first-page":"6545","DOI":"10.4049\/jimmunol.0903879","volume":"184","author":"C Camisaschi","year":"2010","unstructured":"Camisaschi C, Casati C, Rini F, Perego M, De Filippo A, Triebel F, Parmiani G, Belli F, Rivoltini L, Castelli C: LAG-3 expression defines a subset of CD4(+)CD25(high)Foxp3(+) regulatory T cells that are expanded at tumor sites. J Immunol. 2010, 184: 6545-6551. 10.4049\/jimmunol.0903879.","journal-title":"J Immunol"},{"key":"406_CR23","doi-asserted-by":"publisher","first-page":"2888","DOI":"10.1002\/1521-4141(2002010)32:10<2888::AID-IMMU2888>3.0.CO;2-F","volume":"32","author":"CN Manzotti","year":"2002","unstructured":"Manzotti CN, Tipping H, Perry LC, Mead KI, Blair PJ, Zheng Y, Sansom DM: Inhibition of human T cell proliferation by CTLA-4 utilizes CD80 and requires CD25+ regulatory T cells. Eur J Immunol. 2002, 32: 2888-2896. 10.1002\/1521-4141(2002010)32:10<2888::AID-IMMU2888>3.0.CO;2-F.","journal-title":"Eur J Immunol"},{"key":"406_CR24","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.1002\/j.1460-2075.1995.tb07270.x","volume":"14","author":"YJ Dong","year":"1995","unstructured":"Dong YJ, Chao AC, Kouyama K, Hsu YP, Bocian RC, Moss RB, Gardner P: Activation of CFTR chloride current by nitric oxide in human T lymphocytes. EMBO J. 1995, 14: 2700-2707.","journal-title":"EMBO J"},{"key":"406_CR25","doi-asserted-by":"publisher","first-page":"L519","DOI":"10.1152\/ajplung.00312.2006","volume":"292","author":"PJ Dubin","year":"2007","unstructured":"Dubin PJ, Kolls JK: IL-23 mediates inflammatory responses to mucoid Pseudomonas aeruginosa lung infection in mice. Am J Physiol Lung Cell Mol Physiol. 2007, 292: L519-L528.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"406_CR26","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1164\/rccm.201102-0236OC","volume":"184","author":"HL Tan","year":"2011","unstructured":"Tan HL, Regamey N, Brown S, Bush A, Lloyd CM, Davies JC: The Th17 pathway in cystic fibrosis lung disease. Am J Respir Crit Care Med. 2011, 184: 252-258. 10.1164\/rccm.201102-0236OC.","journal-title":"Am J Respir Crit Care Med"},{"key":"406_CR27","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1186\/1465-9921-14-138","volume":"14","author":"R Kushwah","year":"2013","unstructured":"Kushwah R, Gagnon S, Sweezey NB: Intrinsic predisposition of na\u00efve cystic fibrosis T cells to differentiate towards a Th17 phenotype. Respir Res. 2013, 14: 138-10.1186\/1465-9921-14-138.","journal-title":"Respir Res"}],"container-title":["Allergy, Asthma &amp; Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1710-1492-10-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T02:45:11Z","timestamp":1630550711000},"score":1,"resource":{"primary":{"URL":"https:\/\/aacijournal.biomedcentral.com\/articles\/10.1186\/1710-1492-10-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,17]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["406"],"URL":"https:\/\/doi.org\/10.1186\/1710-1492-10-2","relation":{},"ISSN":["1710-1492"],"issn-type":[{"value":"1710-1492","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,17]]},"assertion":[{"value":"11 September 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 January 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 January 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"2"}}