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We hypothesized that combined prenatal exposure to Aspergillus fumigatus (<jats:italic>A. fumigatus<\/jats:italic>) allergen and diesel exhaust particles will be associated with altered IgE production, airway inflammation, airway hyperreactivity (AHR), and airway remodeling of adult offspring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Following sensitization via the airway route to<jats:italic>A. fumigatus<\/jats:italic>and mating, pregnant BALB\/c mice were exposed to additional<jats:italic>A. fumigatus<\/jats:italic>and\/or diesel exhaust particles. At age 9-10 weeks, their offspring were sensitized and challenged with<jats:italic>A. fumigatus<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that adult offspring from mice that were exposed to<jats:italic>A. fumigatus<\/jats:italic>or diesel exhaust particles during pregnancy experienced decreases in IgE production. Adult offspring of mice that were exposed to both<jats:italic>A. fumigatus<\/jats:italic>and diesel exhaust particles during pregnancy experienced decreases in airway eosinophilia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results suggest that, in this model, allergen and\/or diesel administration during pregnancy may be associated with protection from developing systemic and airway allergic immune responses in the adult offspring.<\/jats:p><\/jats:sec>","DOI":"10.1186\/1710-1492-6-7","type":"journal-article","created":{"date-parts":[[2010,5,12]],"date-time":"2010-05-12T06:13:59Z","timestamp":1273644839000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Prenatal allergen and diesel exhaust exposure and their effects on allergy in adult offspring mice"],"prefix":"10.1186","volume":"6","author":[{"given":"Lin","family":"Corson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaijie","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunli","family":"Quan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Grunig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manisha","family":"Ballaney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ximei","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederica P","family":"Perera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip H","family":"Factor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lung-Chi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel L","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,5,11]]},"reference":[{"key":"92_CR1","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1378\/chest.126.4.1071","volume":"126","author":"RL Miller","year":"2004","unstructured":"Miller RL, Garfinkel R, Horton M, Camann D, Perera FP, Whyatt RM, Kinney PL: Polycyclic aromatic hydrocarbons, environmental tobacco smoke, and respiratory symptoms in an inner-city birth cohort. 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