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Smooth muscle and cardiac muscle-specific autoantibodies were observed in significant percentages in acutely or chronically affected Q fever patients when compared to healthy volunteers. Moreover, the incidence of cardiac muscle-specific autoantibody was significantly higher among chronically ill patients compared to acutely ill patients. Moreover, a band of 50 kD of a HeLa extract was detected in most of the sera of individuals with chronic infections and previous sequence analysis suggests that this antigen presents a high degree of homology with the human actin elongation factor 1 alpha. Further research would be necessary to confirm if antibodies to human cytoskeletal proteins could be of clinical importance in chronically infected Q fever patients.<\/jats:p>","DOI":"10.1186\/1740-2557-2-10","type":"journal-article","created":{"date-parts":[[2005,11,11]],"date-time":"2005-11-11T19:13:57Z","timestamp":1131736437000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Autoantibody profiles in the sera of patients with Q fever: characterization of antigens by immunofluorescence, immunoblot and sequence analysis"],"prefix":"10.1186","volume":"2","author":[{"given":"MT","family":"Camacho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Outschoorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Tellez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Sequ\u00ed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2005,11,10]]},"reference":[{"issue":"11","key":"6_CR1","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/S1473-3099(03)00804-1","volume":"3","author":"MG Madariaga","year":"2003","unstructured":"Madariaga MG, Rezai K, Trenholme GM, Weinstein RA: Q fever: a biological weapon in your backyard. 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