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Here we use the nematode <jats:italic>C. elegans<\/jats:italic> to address the neurogenetic basis of responses to thermal stimuli over a broad range of intensities.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>\n              <jats:italic>C. elegans<\/jats:italic> responds to aversive temperature by eliciting a stereotypical behavioral sequence. Upon sensation of the noxious stimulus, it moves backwards, turns and resumes forward movement in a new direction. In order to study the response of <jats:italic>C. elegans<\/jats:italic> to a broad range of noxious thermal stimuli, we developed a novel assay that allows simultaneous characterization of multiple aspects of escape behavior elicited by thermal pulses of increasing amplitudes. We exposed the laboratory strain N2, as well as 47 strains with defects in various aspects of nervous system function, to thermal pulses ranging from \u0394T = 0.4\u00b0C to 9.1\u00b0C and recorded the resulting behavioral profiles.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Through analysis of the multidimensional behavioral profiles, we found that the combinations of molecules shaping avoidance responses to a given thermal pulse are unique. At different intensities of aversive thermal stimuli, these distinct combinations of molecules converge onto qualitatively similar stereotyped behavioral sequences.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1741-7007-10-85","type":"journal-article","created":{"date-parts":[[2012,10,31]],"date-time":"2012-10-31T17:19:28Z","timestamp":1351703968000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Multiparameter behavioral profiling reveals distinct thermal response regimes in Caenorhabditis elegans"],"prefix":"10.1186","volume":"10","author":[{"given":"Rajarshi","family":"Ghosh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aylia","family":"Mohammadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonid","family":"Kruglyak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William S","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,10,31]]},"reference":[{"key":"610_CR1","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1146\/annurev.neuro.29.051605.112958","volume":"29","author":"A Dhaka","year":"2006","unstructured":"Dhaka A, Viswanath V, Patapoutian A: Trp ion channels and temperature sensation. 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