{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T18:27:12Z","timestamp":1787596032894,"version":"build-2736575974"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T00:00:00Z","timestamp":1365033600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMC Med"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1186\/1741-7015-11-92","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T08:54:12Z","timestamp":1365065652000},"source":"Crossref","is-referenced-by-count":15,"title":["Coagulopathy triggered autoimmunity: experimental antiphospholipid syndrome in factor V Leiden mice"],"prefix":"10.1186","volume":"11","author":[{"given":"Aviva","family":"Katzav","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos C","family":"Grigoriadis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"Ebert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Touloumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miri","family":"Blank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaim G","family":"Pick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yehuda","family":"Shoenfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joab","family":"Chapman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,4,4]]},"reference":[{"key":"711_CR1","doi-asserted-by":"crossref","first-page":"866","DOI":"10.5858\/2007-131-866-APCRAF","volume":"131","author":"A Rosendorff","year":"2007","unstructured":"Rosendorff A, Dorfman DM: Activated protein C resistance and factor V Leiden: a review. Arch Pathol Lab Med. 2007, 131: 866-871.","journal-title":"Arch Pathol Lab Med"},{"key":"711_CR2","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1160\/TH07-02-0150","volume":"98","author":"K Segers","year":"2007","unstructured":"Segers K, Dahlback B, Nicolaes GA: Coagulation factor V and thrombophilia: background and mechanisms. Thromb Haemost. 2007, 98: 530-542.","journal-title":"Thromb Haemost"},{"key":"711_CR3","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1055\/s-2007-996025","volume":"24","author":"V De Stefano","year":"1998","unstructured":"De Stefano V, Chiusolo P, Paciaroni K, Leone G: Epidemiology of factor V Leiden: clinical implications. Semin Thromb Hemost. 1998, 24: 367-379.","journal-title":"Semin Thromb Hemost"},{"key":"711_CR4","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1016\/S0140-6736(95)91803-5","volume":"346","author":"DC Rees","year":"1995","unstructured":"Rees DC, Cox M, Clegg JB: World distribution of factor V Leiden. Lancet. 1995, 346: 1133-1134.","journal-title":"Lancet"},{"key":"711_CR5","doi-asserted-by":"publisher","first-page":"A299","DOI":"10.1016\/j.autrev.2009.11.013","volume":"9","author":"M Biggioggero","year":"2010","unstructured":"Biggioggero M, Meroni PL: The geoepidemiology of the antiphospholipid antibody syndrome. Autoimmun Rev. 2010, 9: A299-A304.","journal-title":"Autoimmun Rev"},{"key":"711_CR6","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1163\/156855902760262790","volume":"32","author":"R Diz-Kucukkaya","year":"2002","unstructured":"Diz-Kucukkaya R, Demir K, Yenerel MN, Nalcaci M, Kaymakoglu S, Inanc M: Coexistence of homozygous factor V Leiden mutation and antiphospholipid antibodies in two patients presented with Budd-Chiari syndrome. Haematologia (Budap). 2002, 32: 73-77.","journal-title":"Haematologia (Budap)"},{"key":"711_CR7","first-page":"1232","volume":"25","author":"U Picillo","year":"1998","unstructured":"Picillo U, De Lucia D, Palatiello E, Scuotto A, Marcialis MR, Pezzella S, Tirri G: Association of primary antiphospholipid syndrome with inherited activated protein C resistance. J Rheumatol. 1998, 25: 1232-1234.","journal-title":"J Rheumatol"},{"key":"711_CR8","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1007\/s003920070133","volume":"89","author":"M Schutt","year":"2000","unstructured":"Schutt M, Kluter H, Wiedemann GJ, Richardt G: Coexistence of factor V Leiden and primary antiphospholipid syndrome: a patient with recurrent myocardial infarctions and thrombocytopenia. Z Kardiol. 2000, 89: 1067-1071.","journal-title":"Z Kardiol"},{"key":"711_CR9","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1038\/gene.2009.32","volume":"10","author":"R Kaiser","year":"2009","unstructured":"Kaiser R, Barton JL, Chang M, Catanese JJ, Li Y, Begovich AB, Criswell LA: Factor V Leiden and thrombosis in patients with systemic lupus erythematosus: a meta-analysis. Genes Immun. 2009, 10: 495-502.","journal-title":"Genes Immun"},{"key":"711_CR10","first-page":"2162","volume":"23","author":"D Alarcon-Segovia","year":"1996","unstructured":"Alarcon-Segovia D, Ruiz-Arguelles GJ, Garces-Eisele J, Ruiz-Arguelles A: Inherited activated protein C resistance in a patient with familial primary antiphospholipid syndrome. J Rheumatol. 1996, 23: 2162-2165.","journal-title":"J Rheumatol"},{"key":"711_CR11","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/S0022-2143(97)90097-4","volume":"130","author":"J Aznar","year":"1997","unstructured":"Aznar J, Villa P, Espana F, Estelles A, Grancha S, Falco C: Activated protein C resistance phenotype in patients with antiphospholipid antibodies. J Lab Clin Med. 1997, 130: 202-208.","journal-title":"J Lab Clin Med"},{"key":"711_CR12","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1111\/j.1600-0609.1998.tb01056.x","volume":"61","author":"MI Bokarewa","year":"1998","unstructured":"Bokarewa MI, Bremme K: Production of phospholipid antibodies in selected thrombophilic women differing in genotype at the 506 site of factor V. Eur J Haematol. 1998, 61: 21-26.","journal-title":"Eur J Haematol"},{"key":"711_CR13","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1373\/clinchem.2004.043414","volume":"51","author":"J Nojima","year":"2005","unstructured":"Nojima J, Kuratsune H, Suehisa E, Iwatani Y, Kanakura Y: Acquired activated protein C resistance associated with IgG antibodies against beta2-glycoprotein I and prothrombin as a strong risk factor for venous thromboembolism. Clin Chem. 2005, 51: 545-552.","journal-title":"Clin Chem"},{"key":"711_CR14","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1097\/00001721-199604000-00009","volume":"7","author":"GJ Ruiz-Arguelles","year":"1996","unstructured":"Ruiz-Arguelles GJ, Garces-Eisele J, Alarcon-Segovia D, Ruiz-Arguelles A: Activated protein C resistance phenotype and genotype in patients with primary antiphospholipid syndrome. Blood Coagul Fibrinolysis. 1996, 7: 344-348.","journal-title":"Blood Coagul Fibrinolysis"},{"key":"711_CR15","first-page":"563","volume":"57","author":"ME Viveros","year":"2005","unstructured":"Viveros ME, Cabiedes J, Reyes E, Cabral AR: Activated protein C resistance and lupus anticoagulant activity induced by plasma and purified monospecific human IgG anti-beta2-glycoprotein-I antibodies. Rev Invest Clin. 2005, 57: 563-571.","journal-title":"Rev Invest Clin"},{"key":"711_CR16","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1191\/096120301678416060","volume":"10","author":"A Katzav","year":"2001","unstructured":"Katzav A, Pick CG, Korczyn AD, Oest E, Blank M, Shoenfeld Y, Chapman J: Hyperactivity in a mouse model of the antiphospholipid syndrome. Lupus. 2001, 10: 496-499.","journal-title":"Lupus"},{"key":"711_CR17","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1191\/0961203302lu255oa","volume":"11","author":"S Shrot","year":"2002","unstructured":"Shrot S, Katzav A, Korczyn AD, Litvinju Y, Hershenson R, Pick CG, Blank M, Zaech J, Shoenfeld Y, Sirota P, Chapman J: Behavioral and cognitive deficits occur only after prolonged exposure of mice to antiphospholipid antibodies. Lupus. 2002, 11: 736-743.","journal-title":"Lupus"},{"key":"711_CR18","doi-asserted-by":"crossref","first-page":"4222","DOI":"10.1182\/blood.V96.13.4222","volume":"96","author":"J Cui","year":"2000","unstructured":"Cui J, Eitzman DT, Westrick RJ, Christie PD, Xu ZJ, Yang AY, Purkayastha AA, Yang TL, Metz AL, Gallagher KP, Tyson JA, Rosenberg RD, Ginsburg D: Spontaneous thrombosis in mice carrying the factor V Leiden mutation. Blood. 2000, 96: 4222-4226.","journal-title":"Blood"},{"key":"711_CR19","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/0020-711X(80)90229-3","volume":"11","author":"E Polz","year":"1980","unstructured":"Polz E, Wurm H, Kostner GM: Investigations on beta 2-glycoprotein-I in the rat: isolation from serum and demonstration in lipoprotein density fractions. Int J Biochem. 1980, 11: 265-270.","journal-title":"Int J Biochem"},{"key":"711_CR20","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1196\/annals.1398.053","volume":"1109","author":"C Ball-Rosen","year":"2007","unstructured":"Ball-Rosen C, Primak-Rubinovicz H, Korczyn AD, Wang N, Farchi A, Shavit S, Shoenfeld Y, Chapman J: Identification of histidine-rich glycoprotein, a potential autoantigen, in human and rat brain preparations. Ann N Y Acad Sci. 2007, 1109: 473-483.","journal-title":"Ann N Y Acad Sci"},{"key":"711_CR21","doi-asserted-by":"publisher","first-page":"1558","DOI":"10.1172\/JCI115749","volume":"89","author":"R Bakimer","year":"1992","unstructured":"Bakimer R, Fishman P, Blank M, Sredni B, Djaldetti M, Shoenfeld Y: Induction of primary antiphospholipid syndrome in mice by immunization with a human monoclonal anticardiolipin antibody (H-3). J Clin Invest. 1992, 89: 1558-1563.","journal-title":"J Clin Invest"},{"key":"711_CR22","volume-title":"The mouse brain in stereotaxic coordinates","author":"G Paxinos","year":"2004","unstructured":"Paxinos G, Franklin KBJ: The mouse brain in stereotaxic coordinates. 2004, San Diego: Academic"},{"key":"711_CR23","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.bbr.2006.01.015","volume":"169","author":"A Katzav","year":"2006","unstructured":"Katzav A, Litvinjuk Y, Pick CG, Blank M, Shoenfeld Y, Sirota P, Chapman J: Genetic and immunological factors interact in a mouse model of CNS antiphospholipid syndrome. Behav Brain Res. 2006, 169: 289-293.","journal-title":"Behav Brain Res"},{"key":"711_CR24","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1007\/s12016-009-8154-x","volume":"38","author":"A Katzav","year":"2010","unstructured":"Katzav A, Shoenfeld Y, Chapman J: The pathogenesis of neural injury in animal models of the antiphospholipid syndrome. Clin Rev Allergy Immunol. 2010, 38: 196-200.","journal-title":"Clin Rev Allergy Immunol"},{"key":"711_CR25","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1172\/JCI119572","volume":"100","author":"L Ziporen","year":"1997","unstructured":"Ziporen L, Shoenfeld Y, Levy Y, Korczyn AD: Neurological dysfunction and hyperactive behavior associated with antiphospholipid antibodies. A mouse model. J Clin Invest. 1997, 100: 613-619.","journal-title":"J Clin Invest"},{"key":"711_CR26","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.neurobiolaging.2009.02.007","volume":"32","author":"A Katzav","year":"2011","unstructured":"Katzav A, Faust-Socher A, Kvapil F, Michaelson DM, Blank M, Pick CG, Shoenfeld Y, Korczyn AD, Chapman J: Antiphospholipid syndrome induction exacerbates a transgenic Alzheimer disease model on a female background. Neurobiol Aging. 2011, 32: 272-279.","journal-title":"Neurobiol Aging"},{"key":"711_CR27","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.nbd.2007.12.004","volume":"30","author":"D Tanne","year":"2008","unstructured":"Tanne D, Katzav A, Beilin O, Grigoriadis NC, Blank M, Pick CG, Landenberg P, Shoenfeld Y, Chapman J: Interaction of inflammation, thrombosis, aspirin and enoxaparin in CNS experimental antiphospholipid syndrome. Neurobiol Dis. 2008, 30: 56-64.","journal-title":"Neurobiol Dis"},{"key":"711_CR28","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/S0022-510X(02)00271-X","volume":"203\u2013204","author":"J Chapman","year":"2002","unstructured":"Chapman J, Abu-Katash M, Inzelberg R, Yust I, Neufeld MY, Vardinon N, Treves TA, Korczyn AD: Prevalence and clinical features of dementia associated with the antiphospholipid syndrome and circulating anticoagulants. J Neurol Sci. 2002, 203\u2013204: 81-84.","journal-title":"J Neurol Sci"},{"key":"711_CR29","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1159\/000017211","volume":"11","author":"A Mosek","year":"2000","unstructured":"Mosek A, Yust I, Treves TA, Vardinon N, Korczyn AD, Chapman J: Dementia and antiphospholipid antibodies. Dement Geriatr Cogn Disord. 2000, 11: 36-38.","journal-title":"Dement Geriatr Cogn Disord"},{"key":"711_CR30","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/S1568-9972(02)00146-5","volume":"2","author":"B Lang","year":"2003","unstructured":"Lang B, Vincent A: Autoantibodies to ion channels at the neuromuscular junction. Autoimmun Rev. 2003, 2: 94-100.","journal-title":"Autoimmun Rev"},{"key":"711_CR31","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/S1474-4422(08)70060-7","volume":"7","author":"J Dalmau","year":"2008","unstructured":"Dalmau J, Rosenfeld MR: Paraneoplastic syndromes of the CNS. Lancet Neurol. 2008, 7: 327-340.","journal-title":"Lancet Neurol"},{"key":"711_CR32","first-page":"449","volume":"11","author":"SR Irani","year":"2011","unstructured":"Irani SR, Vincent A: Autoimmune encephalitis \u2013 new awareness, challenging questions. Discov Med. 2011, 11: 449-458.","journal-title":"Discov Med"},{"key":"711_CR33","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1191\/0961203303lu409oa","volume":"12","author":"Y Shoenfeld","year":"2003","unstructured":"Shoenfeld Y, Nahum A, Korczyn AD, Dano M, Rabinowitz R, Beilin O, Pick CG, Leider-Trejo L, Kalashnikova L, Blank M, Chapman J: Neuronal-binding antibodies from patients with antiphospholipid syndrome induce cognitive deficits following intrathecal passive transfer. Lupus. 2003, 12: 436-442.","journal-title":"Lupus"},{"key":"711_CR34","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1177\/0961203311429550","volume":"21","author":"A Katzav","year":"2012","unstructured":"Katzav A, Kivity S, Blank M, Shoenfeld Y, Chapman J: Adjuvant immunization induces high levels of pathogenic antiphospholipid antibodies in genetically prone mice: another facet of the ASIA syndrome. Lupus. 2012, 21: 210-216.","journal-title":"Lupus"},{"key":"711_CR35","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.neurobiolaging.2009.02.007","volume":"32","author":"A Katzav","year":"2011","unstructured":"Katzav A, Faust-Socher A, Kvapil F, Michaelson DM, Blank M, Pick CG, Shoenfeld Y, Korczyn AD, Chapman J: Antiphospholipid syndrome induction exacerbates a transgenic Alzheimer disease model on a female background. Neurobiology of Aging. 2011, 32: 272-279.","journal-title":"Neurobiology of Aging"},{"key":"711_CR36","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1212\/WNL.53.1.223","volume":"53","author":"LA Kalashnikova","year":"1999","unstructured":"Kalashnikova LA, Korczyn AD, Shavit S, Rebrova O, Reshetnyak T, Chapman J: Antibodies to prothrombin in patients with Sneddon\u2019s syndrome. Neurology. 1999, 53: 223-225.","journal-title":"Neurology"},{"key":"711_CR37","doi-asserted-by":"publisher","first-page":"811","DOI":"10.2174\/092986707780090945","volume":"14","author":"M Todorova","year":"2007","unstructured":"Todorova M, Baleva M: Some recent insights into the prothrombogenic mechanisms of antiphospholipid antibodies. Curr Med Chem. 2007, 14: 811-826.","journal-title":"Curr Med Chem"},{"key":"711_CR38","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1191\/096120398678919967","volume":"7","author":"M Schutt","year":"1998","unstructured":"Schutt M, Kluter H, Hagedorn-Greiwe M, Fehm HL, Wiedemann GJ: Familial coexistence of primary antiphospholipid syndrome and factor VLeiden. Lupus. 1998, 7: 176-182.","journal-title":"Lupus"},{"key":"711_CR39","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.contraception.2003.08.016","volume":"69","author":"R Poka","year":"2004","unstructured":"Poka R, Vad S, Lakos G, Bereczki Z, Kiss E, Sipka S: Increased titer of anti-beta2-glycoprotein I IgG antibody among factor V Leiden carriers during oral contraceptive use. Contraception. 2004, 69: 27-30.","journal-title":"Contraception"},{"key":"711_CR40","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.ejogrb.2004.07.003","volume":"119","author":"N Mtiraoui","year":"2005","unstructured":"Mtiraoui N, Borgi L, Hizem S, Nsiri B, Finan RR, Gris JC, Almawi WY, Mahjoub T: Prevalence of antiphospholipid antibodies, factor V G1691A (Leiden) and prothrombin G20210A mutations in early and late recurrent pregnancy loss. Eur J Obstet Gynecol Reprod Biol. 2005, 119: 164-170.","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"711_CR41","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1191\/0961203303lu386sr","volume":"12","author":"R Besnier","year":"2003","unstructured":"Besnier R, Frances C, Ankri A, Aiach M, Piette JC: Factor V Leiden mutation in Sneddon syndrome. Lupus. 2003, 12: 406-408.","journal-title":"Lupus"},{"key":"711_CR42","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1055\/s-0038-1649874","volume":"74","author":"D Dizon-Townson","year":"1995","unstructured":"Dizon-Townson D, Hutchison C, Silver R, Branch DW, Ward K: The factor V Leiden mutation which predisposes to thrombosis is not common in patients with antiphospholipid syndrome. Thromb Haemost. 1995, 74: 1029-1031.","journal-title":"Thromb Haemost"},{"key":"711_CR43","first-page":"588","volume":"26","author":"JL Pablos","year":"1999","unstructured":"Pablos JL, Caliz RA, Carreira PE, Atsumi T, Serrano L, Amengual O, Santiago B, Khamashta MA, Hughes GR, Gomez-Reino JJ: Risk of thrombosis in patients with antiphospholipid antibodies and factor V Leiden mutation. J Rheumatol. 1999, 26: 588-590.","journal-title":"J Rheumatol"},{"key":"711_CR44","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1093\/humrep\/16.5.961","volume":"16","author":"R Rai","year":"2001","unstructured":"Rai R, Shlebak A, Cohen H, Backos M, Holmes Z, Marriott K, Regan L: Factor V Leiden and acquired activated protein C resistance among 1000 women with recurrent miscarriage. Hum Reprod. 2001, 16: 961-965.","journal-title":"Hum Reprod"}],"container-title":["BMC Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1741-7015-11-92.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1741-7015-11-92\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1741-7015-11-92","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,13]],"date-time":"2022-02-13T01:52:24Z","timestamp":1644717144000},"score":1,"resource":{"primary":{"URL":"http:\/\/bmcmedicine.biomedcentral.com\/articles\/10.1186\/1741-7015-11-92"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,4]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["711"],"URL":"https:\/\/doi.org\/10.1186\/1741-7015-11-92","relation":{},"ISSN":["1741-7015"],"issn-type":[{"value":"1741-7015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,4]]},"article-number":"92"}}