{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T04:17:05Z","timestamp":1790223425392,"version":"4.1.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2012,10,4]],"date-time":"2012-10-04T00:00:00Z","timestamp":1349308800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/2.0"},{"start":{"date-parts":[[2012,10,4]],"date-time":"2012-10-04T00:00:00Z","timestamp":1349308800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neuroinflammation"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>We studied the distribution and expression of translocator protein in the human brain using <jats:sup>11<\/jats:sup>C-[R]-PK-11195 positron emission tomography (PK11195 PET) and evaluated age-related changes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>A dynamic PK11195 PET scan was performed in 15 normal healthy adults (mean age: 29\u2009\u00b18.5 years (range: 20 to 49); 7 males) and 10 children (mean age: 8.8\u2009\u00b15.2 years (range: 1.2 to 17); 5 males), who were studied for potential neuroinflammation but showed no focally increased PK11195 binding. The PET images were evaluated by calculating standard uptake values and regional binding potential, based on a simplified reference region model, as well as with a voxel-wise analysis using statistical parametric mapping.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>PK11195 uptake in the brain is relatively low, compared with the subcortical structures, and symmetrical. The overall pattern of PK11195 distribution in the brain does not change with age. PK11195 uptake was lowest in the frontal-parietal-temporal cortex and highest in the pituitary gland, midbrain, thalamus, basal ganglia, occipital cortex, hippocampus and cerebellum, in descending order. White matter showed negligible PK11195 uptake. Overall, brain PK11195 uptake increased with age, with midbrain and thalamus showing relatively higher increases with age compared with other brain regions.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>The brain shows low PK11195 uptake, which is lower in the cortex and cerebellum compared with subcortical structures, suggesting a low level of translocator protein expression. There is no hemispheric asymmetry in PK11195 uptake and the overall pattern of PK11195 distribution in the brain does not change with age. However, brain PK11195 uptake increases with age, with the thalamus and midbrain showing relatively higher increases compared with other brain regions. This increase in uptake suggests an age-related increase in translocator protein expression or the number of cells expressing these receptors or both.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1742-2094-9-232","type":"journal-article","created":{"date-parts":[[2012,10,4]],"date-time":"2012-10-04T20:14:20Z","timestamp":1349381660000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":84,"title":["Evaluation of age-related changes in translocator protein (TSPO) in human brain using 11C-[R]-PK11195 PET"],"prefix":"10.1186","volume":"9","author":[{"given":"Ajay","family":"Kumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otto","family":"Muzik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varun","family":"Shandal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Chugani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pulak","family":"Chakraborty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry T","family":"Chugani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,10,4]]},"reference":[{"key":"764_CR1_764","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/S0021-9258(17)36131-8","volume":"261","author":"RR Anholt","year":"1986","unstructured":"Anholt RR, Pedersen PL, De Souza EB, Snyder SH: The peripheral-type benzodiazepine receptor. Localization to the mitochondrial outer membrane. \n                           J Biol Chem 1986, 261:576\u2013583.","journal-title":"J Biol Chem"},{"key":"764_CR2_764","doi-asserted-by":"publisher","first-page":"3170","DOI":"10.1073\/pnas.89.8.3170","volume":"89","author":"MW McEnery","year":"1992","unstructured":"McEnery MW, Snowman AM, Trifiletti RR, Snyder SH: Isolation of the mitochondrial benzodiazepine receptor: association with the voltage-dependent anion channel and the adenine nucleotide carrier. \n                           Proc Natl Acad Sci U S A 1992, 89:3170\u20133174.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"764_CR3_764","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1038\/269702a0","volume":"269","author":"C Braestrup","year":"1977","unstructured":"Braestrup C, Albrechtsen R, Squires RF: High densities of benzodiazepine receptors in human cortical areas. \n                           Nature 1977, 269:702\u2013704.","journal-title":"Nature"},{"key":"764_CR4_764","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/S0197-0186(01)00118-8","volume":"40","author":"P Casellas","year":"2002","unstructured":"Casellas P, Galiegue S, Basile AS: Peripheral benzodiazepine receptors and mitochondrial function. \n                           Neurochem Int 2002, 40:475\u2013486.","journal-title":"Neurochem Int"},{"key":"764_CR5_764","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1093\/bmb\/65.1.121","volume":"65","author":"RB Banati","year":"2003","unstructured":"Banati RB: Neuropathological imaging: in vivo detection of glial activation as a measure of disease and adaptive change in the brain. \n                           Br Med Bull 2003, 65:121\u2013131.","journal-title":"Br Med Bull"},{"key":"764_CR6_764","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.pneurobio.2006.10.002","volume":"80","author":"S Venneti","year":"2006","unstructured":"Venneti S, Lopresti BJ, Wiley CA: The peripheral benzodiazepine receptor (translocator protein 18 kDa) in microglia: from pathology to imaging. \n                           Prog Neurobiol 2006, 80:308\u2013322.","journal-title":"Prog Neurobiol"},{"key":"764_CR7_764","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/0166-2236(96)10049-7","volume":"19","author":"GW Kreutzberg","year":"1996","unstructured":"Kreutzberg GW: Microglia: a sensor for pathological events in the CNS. \n                           Trends Neurosci 1996, 19:312\u2013318.","journal-title":"Trends Neurosci"},{"key":"764_CR8_764","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1023\/A:1018567510105","volume":"26","author":"RB Banati","year":"1997","unstructured":"Banati RB, Myers R, Kreutzberg GW: PK (\u2018peripheral benzodiazepine\u2019)\u2013binding sites in the CNS indicate early and discrete brain lesions: microautoradiographic detection of [3H]PK11195 binding to activated microglia. \n                           J Neurocytol 1997, 26:77\u201382.","journal-title":"J Neurocytol"},{"key":"764_CR9_764","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.nurt.2007.04.006","volume":"4","author":"A Cagnin","year":"2007","unstructured":"Cagnin A, Kassiou M, Meikle SR, Banati RB: Positron emission tomography imaging of neuroinflammation. \n                           Neurotherapeutics 2007, 4:443\u2013452.","journal-title":"Neurotherapeutics"},{"key":"764_CR10_764","first-page":"522","volume":"47","author":"PK Chakraborty","year":"2006","unstructured":"Chakraborty PK, Maiti DK, Mangner TJ: High yield and semi-automated synthesis procedure of (R)-[11C]PK11195. \n                           J Nucl Med 2006, 47:522.","journal-title":"J Nucl Med"},{"key":"764_CR11_764","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.placenta.2007.12.010","volume":"29","author":"JC Challier","year":"2008","unstructured":"Challier JC, Basu S, Bintein T, Minium J, Hotmire K, Catalano PM, Hauguel-de Mouzon S: Obesity in pregnancy stimulates macrophage accumulation and inflammation in the placenta. \n                           Placenta 2008, 29:274\u2013281.","journal-title":"Placenta"},{"key":"764_CR12_764","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1006\/nimg.1996.0066","volume":"4","author":"AA Lammertsma","year":"1996","unstructured":"Lammertsma AA, Hume SP: Simplified reference tissue model for PET receptor studies. \n                           Neuroimage 1996, 4:153\u2013158.","journal-title":"Neuroimage"},{"key":"764_CR13_764","volume-title":"Quantification of Brain Function using PET","author":"J Ashburner","year":"1996","unstructured":"Ashburner J, Haslam J, Taylor C, Cunningham VJ, Jones TA: A cluster analysis approach for the characterization of dynamic PET data. In Quantification of Brain Function using PET. San Diego: Academic Press; 1996."},{"key":"764_CR14_764","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1006\/nimg.2000.0651","volume":"12","author":"O Muzik","year":"2000","unstructured":"Muzik O, Chugani DC, Juhasz C, Shen C, Chugani HT: Statistical parametric mapping: assessment of application in children. \n                           Neuroimage 2000, 12:538\u2013549.","journal-title":"Neuroimage"},{"key":"764_CR15_764","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1002\/glia.10144","volume":"40","author":"RB Banati","year":"2002","unstructured":"Banati RB: Visualising microglial activation \n                           in vivo\n                           . \n                           Glia 2002, 40:206\u2013217.","journal-title":"Glia"},{"key":"764_CR16_764","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1100\/tsw.2009.111","volume":"9","author":"DR Brown","year":"2009","unstructured":"Brown DR: Role of microglia in age-related changes to the nervous system. \n                           ScientificWorldJournal 2009, 9:1061\u20131071.","journal-title":"ScientificWorldJournal"},{"key":"764_CR17_764","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1016\/j.neuroimage.2011.02.020","volume":"56","author":"B Gulyas","year":"2011","unstructured":"Gulyas B, Vas A, Toth M, Takano A, Varrone A, Cselenyi Z, Schain M, Mattsson P, Halldin C: Age and disease related changes in the translocator protein (TSPO) system in the human brain: positron emission tomography measurements with [11C]vinpocetine. \n                           Neuroimage 2011, 56:1111\u20131121.","journal-title":"Neuroimage"},{"key":"764_CR18_764","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.neuron.2009.08.039","volume":"64","author":"KM Lucin","year":"2009","unstructured":"Lucin KM, Wyss-Coray T: Immune activation in brain aging and neurodegeneration: too much or too little? \n                           Neuron 2009, 64:110\u2013122.","journal-title":"Neuron"},{"key":"764_CR19_764","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.neurobiolaging.2004.05.010","volume":"26","author":"RE Mrak","year":"2005","unstructured":"Mrak RE, Griffin WS: Glia and their cytokines in progression of neurodegeneration. \n                           Neurobiol Aging 2005, 26:349\u2013354.","journal-title":"Neurobiol Aging"},{"key":"764_CR20_764","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/S0079-6123(02)36038-2","volume":"136","author":"A Peters","year":"2002","unstructured":"Peters A: Structural changes in the normally aging cerebral cortex of primates. \n                           Prog Brain Res 2002, 136:455\u2013465.","journal-title":"Prog Brain Res"},{"key":"764_CR21_764","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1016\/j.tins.2006.07.001","volume":"29","author":"WJ Streit","year":"2006","unstructured":"Streit WJ: Microglial senescence: does the brain\u2019s immune system have an expiration date? \n                           Trends Neurosci 2006, 29:506\u2013510.","journal-title":"Trends Neurosci"},{"key":"764_CR22_764","doi-asserted-by":"publisher","first-page":"3423","DOI":"10.2741\/2937","volume":"13","author":"WJ Streit","year":"2008","unstructured":"Streit WJ, Miller KR, Lopes KO, Njie E: Microglial degeneration in the aging brain\u2013bad news for neurons? \n                           Front Biosci 2008, 13:3423\u20133438.","journal-title":"Front Biosci"},{"key":"764_CR23_764","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1111\/j.1471-4159.2009.06537.x","volume":"112","author":"R von Bernhardi","year":"2010","unstructured":"von Bernhardi R, Tichauer JE, Eugenin J: Aging-dependent changes of microglial cells and their relevance for neurodegenerative disorders. \n                           J Neurochem 2010, 112:1099\u20131114.","journal-title":"J Neurochem"},{"key":"764_CR24_764","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1189\/jlb.0208108","volume":"84","author":"RN Dilger","year":"2008","unstructured":"Dilger RN, Johnson RW: Aging, microglial cell priming, and the discordant central inflammatory response to signals from the peripheral immune system. \n                           J Leukoc Biol 2008, 84:932\u2013939.","journal-title":"J Leukoc Biol"},{"key":"764_CR25_764","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/0304-3940(88)90746-X","volume":"92","author":"JL Daval","year":"1988","unstructured":"Daval JL, Deckert J, Nakajima T, Morgan PF, Marangos PJ: Regional ontogenetic profile of central and peripheral benzodiazepine receptors in the guinea pig brain. \n                           Neurosci Lett 1988, 92:82\u201385.","journal-title":"Neurosci Lett"},{"key":"764_CR26_764","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/0165-3806(94)00163-T","volume":"84","author":"Y Itzhak","year":"1995","unstructured":"Itzhak Y, Roig-Cantisano A, Norenberg MD: Ontogeny of peripheral-type benzodiazepine receptors in cultured astrocytes and brain from rat. \n                           Brain Res Dev Brain Res 1995, 84:62\u201366.","journal-title":"Brain Res Dev Brain Res"},{"key":"764_CR27_764","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/S0165-3806(96)00150-2","volume":"97","author":"A Kurumaji","year":"1996","unstructured":"Kurumaji A, Toru M: Postnatal development of peripheral-type benzodiazepine receptors in rat brain and peripheral tissues. \n                           Brain Res Dev Brain Res 1996, 97:148\u2013151.","journal-title":"Brain Res Dev Brain Res"},{"key":"764_CR28_764","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/S0006-8993(02)03475-3","volume":"956","author":"PR Mouton","year":"2002","unstructured":"Mouton PR, Long JM, Lei DL, Howard V, Jucker M, Calhoun ME, Ingram DK: Age and gender effects on microglia and astrocyte numbers in brains of mice. \n                           Brain Res 2002, 956:30\u201335.","journal-title":"Brain Res"},{"key":"764_CR29_764","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/S0197-4580(97)00168-1","volume":"19","author":"LG Sheffield","year":"1998","unstructured":"Sheffield LG, Berman NE: Microglial expression of MHC class II increases in normal aging of nonhuman primates. \n                           Neurobiol Aging 1998, 19:47\u201355.","journal-title":"Neurobiol Aging"},{"key":"764_CR30_764","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1002\/glia.440070111","volume":"7","author":"VH Perry","year":"1993","unstructured":"Perry VH, Matyszak MK, Fearn S: Altered antigen expression of microglia in the aged rodent CNS. \n                           Glia 1993, 7:60\u201367.","journal-title":"Glia"},{"key":"764_CR31_764","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1007\/s004010050792","volume":"95","author":"JG Sheng","year":"1998","unstructured":"Sheng JG, Mrak RE, Griffin WS: Enlarged and phagocytic, but not primed, interleukin-1 alpha-immunoreactive microglia increase with age in normal human brain. \n                           Acta Neuropathol 1998, 95:229\u2013234.","journal-title":"Acta Neuropathol"},{"key":"764_CR32_764","first-page":"507","volume":"40","author":"BS Mandavilli","year":"1996","unstructured":"Mandavilli BS, Rao KS: Neurons in the cerebral cortex are most susceptible to DNA-damage in aging rat brain. \n                           Biochem Mol Biol Int 1996, 40:507\u2013514.","journal-title":"Biochem Mol Biol Int"},{"key":"764_CR33_764","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1002\/ana.410340416","volume":"34","author":"P Mecocci","year":"1993","unstructured":"Mecocci P, MacGarvey U, Kaufman AE, Koontz D, Shoffner JM, Wallace DC, Beal MF: Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain. \n                           Ann Neurol 1993, 34:609\u2013616.","journal-title":"Ann Neurol"},{"key":"764_CR34_764","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/S0165-0173(96)00016-1","volume":"23","author":"G Munch","year":"1997","unstructured":"Munch G, Thome J, Foley P, Schinzel R, Riederer P: Advanced glycation endproducts in ageing and Alzheimer\u2019s disease. \n                           Brain Res Brain Res Rev 1997, 23:134\u2013143.","journal-title":"Brain Res Brain Res Rev"},{"key":"764_CR35_764","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/S0140-6736(01)05625-2","volume":"358","author":"A Cagnin","year":"2001","unstructured":"Cagnin A, Brooks DJ, Kennedy AM, Gunn RN, Myers R, Turkheimer FE, Jones T, Banati RB: In-vivo \n                           measurement of activated microglia in dementia. \n                           Lancet 2001, 358:461\u2013467.","journal-title":"Lancet"},{"key":"764_CR36_764","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/0306-4522(90)90229-W","volume":"39","author":"LJ Lawson","year":"1990","unstructured":"Lawson LJ, Perry VH, Dri P, Gordon S: Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain. \n                           Neuroscience 1990, 39:151\u2013170.","journal-title":"Neuroscience"},{"key":"764_CR37_764","doi-asserted-by":"publisher","first-page":"3439","DOI":"10.1097\/00001756-200111160-00012","volume":"12","author":"RB Banati","year":"2001","unstructured":"Banati RB, Cagnin A, Brooks DJ, Gunn RN, Myers R, Jones T, Birch R, Anand P: Long-term trans-synaptic glial responses in the human thalamus after peripheral nerve injury. \n                           Neuroreport 2001, 12:3439\u20133442.","journal-title":"Neuroreport"},{"key":"764_CR38_764","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/0304-3940(91)90047-W","volume":"133","author":"R Myers","year":"1991","unstructured":"Myers R, Manjil LG, Frackowiak RS, Cremer JE: [3H]PK 11195 and the localisation of secondary thalamic lesions following focal ischaemia in rat motor cortex. \n                           Neurosci Lett 1991, 133:20\u201324.","journal-title":"Neurosci Lett"},{"key":"764_CR39_764","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1016\/j.nbd.2009.11.004","volume":"37","author":"MG Tansey","year":"2010","unstructured":"Tansey MG, Goldberg MS: Neuroinflammation in Parkinson\u2019s disease: its role in neuronal death and implications for therapeutic intervention. \n                           Neurobiol Dis 2010, 37:510\u2013518.","journal-title":"Neurobiol Dis"},{"key":"764_CR40_764","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/j.nbd.2005.08.002","volume":"21","author":"A Gerhard","year":"2006","unstructured":"Gerhard A, Pavese N, Hotton G, Turkheimer F, Es M, Hammers A, Eggert K, Oertel W, Banati RB, Brooks DJ: In vivo \n                           imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson\u2019s disease. \n                           Neurobiol Dis 2006, 21:404\u2013412.","journal-title":"Neurobiol Dis"},{"key":"764_CR41_764","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1212\/01.WNL.0000078192.95645.E6","volume":"61","author":"A Gerhard","year":"2003","unstructured":"Gerhard A, Banati RB, Goerres GB, Cagnin A, Myers R, Gunn RN, Turkheimer F, Good CD, Mathias CJ, Quinn N, Schwarz J, Brooks DJ: [11C](R)-PK11195 PET imaging of microglial activation in multiple system atrophy. \n                           Neurology 2003, 61:686\u2013689.","journal-title":"Neurology"}],"container-title":["Journal of Neuroinflammation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1742-2094-9-232.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/1742-2094-9-232\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1742-2094-9-232","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1742-2094-9-232.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T21:33:13Z","timestamp":1630531993000},"score":1,"resource":{"primary":{"URL":"https:\/\/jneuroinflammation.biomedcentral.com\/articles\/10.1186\/1742-2094-9-232"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,4]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["764"],"URL":"https:\/\/doi.org\/10.1186\/1742-2094-9-232","relation":{},"ISSN":["1742-2094"],"issn-type":[{"value":"1742-2094","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,4]]},"assertion":[{"value":"14 August 2012","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 September 2012","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 October 2012","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"232"}}