{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T07:01:29Z","timestamp":1792047689161,"version":"4.4.0"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2012,2,24]],"date-time":"2012-02-24T00:00:00Z","timestamp":1330041600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neuroinflammation"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1186\/1742-2094-9-39","type":"journal-article","created":{"date-parts":[[2012,2,24]],"date-time":"2012-02-24T05:14:01Z","timestamp":1330060441000},"source":"Crossref","is-referenced-by-count":30,"title":["Microglial TIR-domain-containing adapter-inducing interferon-\u03b2 (TRIF) deficiency promotes retinal ganglion cell survival and axon regeneration via nuclear factor-\u03baB"],"prefix":"10.1186","volume":"9","author":[{"given":"Sen","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajie","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiqiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Bian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongli","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shurong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingyin","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,2,24]]},"reference":[{"key":"555_CR1_555","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/nrn1957","volume":"7","author":"NY Harel","year":"2006","unstructured":"Harel NY, Strittmatter SM: Can regenerating axons recapitulate developmental guidance during recovery from spinal cord injury? Nat Rev Neurosci 2006, 7:603\u2013616.","journal-title":"Nat Rev Neurosci"},{"key":"555_CR2_555","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/nrn1956","volume":"7","author":"G Yiu","year":"2006","unstructured":"Yiu G, He Z: Glial inhibition of CNS axon regeneration. Nat Rev Neurosci 2006, 7:617\u2013627.","journal-title":"Nat Rev Neurosci"},{"key":"555_CR3_555","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1146\/annurev.ne.16.030193.003025","volume":"16","author":"ME Schwab","year":"1993","unstructured":"Schwab ME, Kapfhammer JP, Bandtlow CE: Inhibitors of neurite growth. Annu Rev Neurosci 1993, 16:565\u2013595.","journal-title":"Annu Rev Neurosci"},{"key":"555_CR4_555","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1523\/JNEUROSCI.23-06-02284.2003","volume":"23","author":"Y Yin","year":"2003","unstructured":"Yin Y, Cui Q, Li Y, Irwin N, Fischer D, Harvey AR, Benowitz LI: Macrophage-derived factors stimulate optic nerve regeneration. J Neurosci Official J Soc Neurosci 2003, 23:2284\u20132293.","journal-title":"J Neurosci Official J Soc Neurosci"},{"key":"555_CR5_555","doi-asserted-by":"crossref","first-page":"4615","DOI":"10.1523\/JNEUROSCI.20-12-04615.2000","volume":"20","author":"S Leon","year":"2000","unstructured":"Leon S, Yin Y, Nguyen J, Irwin N, Benowitz LI: Lens injury stimulates axon regeneration in the mature rat optic nerve. J Neurosci 2000, 20:4615\u20134626.","journal-title":"J Neurosci"},{"key":"555_CR6_555","doi-asserted-by":"crossref","first-page":"19587","DOI":"10.1073\/pnas.0907085106","volume":"106","author":"Y Yin","year":"2009","unstructured":"Yin Y, Cui Q, Gilbert HY, Yang Y, Yang Z, Berlinicke C, Li Z, Zaverucha-do-Valle C, He H, Petkova V, et al.: Oncomodulin links inflammation to optic nerve regeneration. Proc Natl Acad Sci USA 2009, 106:19587\u201319592.","journal-title":"Proc Natl Acad Sci USA"},{"key":"555_CR7_555","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/nn1701","volume":"9","author":"Y Yin","year":"2006","unstructured":"Yin Y, Henzl MT, Lorber B, Nakazawa T, Thomas TT, Jiang F, Langer R, Benowitz LI: Oncomodulin is a macrophage-derived signal for axon regeneration in retinal ganglion cells. Nat Neurosci 2006, 9:843\u2013852.","journal-title":"Nat Neurosci"},{"key":"555_CR8_555","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1126\/science.1115462","volume":"310","author":"V Koprivica","year":"2005","unstructured":"Koprivica V, Cho KS, Park JB, Yiu G, Atwal J, Gore B, Kim JA, Lin E, Tessier-Lavigne M, Chen DF, He Z: EGFR activation mediates inhibition of axon regeneration by myelin and chondroitin sulfate proteoglycans. Science 2005, 310:106\u2013110.","journal-title":"Science"},{"key":"555_CR9_555","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1126\/science.1161566","volume":"322","author":"KK Park","year":"2008","unstructured":"Park KK, Liu K, Hu Y, Smith PD, Wang C, Cai B, Xu B, Connolly L, Kramvis I, Sahin M, He Z: Promoting axon regeneration in the adult CNS by modulation of the PTEN\/mTOR pathway. Science 2008, 322:963\u2013966.","journal-title":"Science"},{"key":"555_CR10_555","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1126\/science.1110647","volume":"308","author":"A Nimmerjahn","year":"2005","unstructured":"Nimmerjahn A, Kirchhoff F, Helmchen F: Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 2005, 308:1314\u20131318.","journal-title":"Science"},{"key":"555_CR11_555","doi-asserted-by":"crossref","first-page":"2686","DOI":"10.1167\/iovs.09-4537","volume":"51","author":"SG Wohl","year":"2010","unstructured":"Wohl SG, Schmeer CW, Witte OW, Isenmann S: Proliferative response of microglia and macrophages in the adult mouse eye after optic nerve lesion. Investig Ophthalmol Vis Sci 2010, 51:2686\u20132696.","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"555_CR12_555","doi-asserted-by":"crossref","first-page":"6448","DOI":"10.1167\/iovs.10-5284","volume":"51","author":"A Ebneter","year":"2010","unstructured":"Ebneter A, Casson RJ, Wood JP, Chidlow G: Microglial activation in the visual pathway in experimental glaucoma: spatiotemporal characterization and correlation with axonal injury. Investig Ophthalmol Vis Sci 2010, 51:6448\u20136460.","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"555_CR13_555","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/0006-8993(89)90078-4","volume":"491","author":"M Sawada","year":"1989","unstructured":"Sawada M, Kondo N, Suzumura A, Marunouchi T: Production of tumor necrosis factor-alpha by microglia and astrocytes in culture. Brain Res 1989, 491:394\u2013397.","journal-title":"Brain Res"},{"key":"555_CR14_555","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/0014-5793(87)80305-8","volume":"223","author":"CA Colton","year":"1987","unstructured":"Colton CA, Gilbert DL: Production of superoxide anions by a CNS macrophage, the microglia. FEBS Lett 1987, 223:284\u2013288.","journal-title":"FEBS Lett"},{"key":"555_CR15_555","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.4049\/jimmunol.150.7.2659","volume":"150","author":"SC Lee","year":"1993","unstructured":"Lee SC, Liu W, Dickson DW, Brosnan CF, Berman JW: Cytokine production by human fetal microglia and astrocytes. Differential induction by lipopolysaccharide and IL-1 beta. J Immunol 1993, 150:2659\u20132667.","journal-title":"J Immunol"},{"key":"555_CR16_555","doi-asserted-by":"crossref","first-page":"8726","DOI":"10.1523\/JNEUROSCI.2774-04.2004","volume":"24","author":"D Fischer","year":"2004","unstructured":"Fischer D, Petkova V, Thanos S, Benowitz LI: Switching mature retinal ganglion cells to a robust growth state in vivo: gene expression and synergy with RhoA inactivation. J Neurosci Official J Soc Neurosci 2004, 24:8726\u20138740.","journal-title":"J Neurosci Official J Soc Neurosci"},{"key":"555_CR17_555","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1096\/fj.00-0339com","volume":"15","author":"N Laflamme","year":"2001","unstructured":"Laflamme N, Rivest S: Toll-like receptor 4: the missing link of the cerebral innate immune response triggered by circulating gram-negative bacterial cell wall components. FASEB J Official Publ Federation Am Societies Exp Biol 2001, 15:155\u2013163.","journal-title":"FASEB J Official Publ Federation Am Societies Exp Biol"},{"key":"555_CR18_555","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1083\/jcb.200606016","volume":"175","author":"Y Ma","year":"2006","unstructured":"Ma Y, Li J, Chiu I, Wang Y, Sloane JA, Lu J, Kosaras B, Sidman RL, Volpe JJ, Vartanian T: Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer of neuronal apoptosis. J Cell Biol 2006, 175:209\u2013215.","journal-title":"J Cell Biol"},{"key":"555_CR19_555","doi-asserted-by":"crossref","first-page":"13033","DOI":"10.1523\/JNEUROSCI.4290-06.2007","volume":"27","author":"JS Cameron","year":"2007","unstructured":"Cameron JS, Alexopoulou L, Sloane JA, DiBernardo AB, Ma Y, Kosaras B, Flavell R, Strittmatter SM, Volpe J, Sidman R, Vartanian T: Toll-like receptor 3 is a potent negative regulator of axonal growth in mammals. J Neurosci Official J Soc Neurosci 2007, 27:13033\u201313041.","journal-title":"J Neurosci Official J Soc Neurosci"},{"key":"555_CR20_555","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1038\/ncb1629","volume":"9","author":"A Rolls","year":"2007","unstructured":"Rolls A, Shechter R, London A, Ziv Y, Ronen A, Levy R, Schwartz M: Toll-like receptors modulate adult hippocampal neurogenesis. Nat Cell Biol 2007, 9:1081\u20131088.","journal-title":"Nat Cell Biol"},{"key":"555_CR21_555","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.cell.2006.02.015","volume":"124","author":"S Akira","year":"2006","unstructured":"Akira S, Uematsu S, Takeuchi O: Pathogen recognition and innate immunity. Cell 2006, 124:783\u2013801.","journal-title":"Cell"},{"key":"555_CR22_555","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/jcbfm.2010.129","volume":"31","author":"QW Yang","year":"2011","unstructured":"Yang QW, Lu FL, Zhou Y, Wang L, Zhong Q, Lin S, Xiang J, Li JC, Fang CQ, Wang JZ: HMBG1 mediates ischemia-reperfusion injury by TRIF-adaptor independent Toll-like receptor 4 signaling. J Cereb Blood Flow Metab 2011, 31:593\u2013605.","journal-title":"J Cereb Blood Flow Metab"},{"key":"555_CR23_555","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.4049\/jimmunol.181.3.1849","volume":"181","author":"H Shen","year":"2008","unstructured":"Shen H, Tesar BM, Walker WE, Goldstein DR: Dual signaling of MyD88 and TRIF is critical for maximal TLR4-induced dendritic cell maturation. J Immunol 2008, 181:1849\u20131858.","journal-title":"J Immunol"},{"key":"555_CR24_555","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1038\/cdd.2009.190","volume":"17","author":"A Weber","year":"2010","unstructured":"Weber A, Kirejczyk Z, Besch R, Potthoff S, Leverkus M, Hacker G: Proapoptotic signalling through Toll-like receptor-3 involves TRIF-dependent activation of caspase-8 and is under the control of inhibitor of apoptosis proteins in melanoma cells. Cell Death and Differentiation 2010, 17:942\u2013951.","journal-title":"Cell Death and Differentiation"},{"key":"555_CR25_555","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.4049\/jimmunol.1001499","volume":"186","author":"M Yu","year":"2011","unstructured":"Yu M, Lam J, Rada B, Leto TL, Levine SJ: Double-stranded RNA induces shedding of the 34-kDa soluble TNFR1 from human airway epithelial cells via TLR3-TRIF-RIP1-dependent signaling: roles for dual oxidase 2- and caspase-dependent pathways. J Immunol 2011, 186:1180\u20131188.","journal-title":"J Immunol"},{"key":"555_CR26_555","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1126\/science.1068428","volume":"296","author":"JL Goldberg","year":"2002","unstructured":"Goldberg JL, Klassen MP, Hua Y, Barres BA: Amacrine-signaled loss of intrinsic axon growth ability by retinal ganglion cells. Science 2002, 296:1860\u20131864.","journal-title":"Science"},{"key":"555_CR27_555","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.brainres.2005.08.055","volume":"1061","author":"T Nakazawa","year":"2005","unstructured":"Nakazawa T, Morii H, Tamai M, Mori N: Selective upregulation of RB3\/stathmin4 by ciliary neurotrophic factor following optic nerve axotomy. Brain Res 2005, 1061:97\u2013106.","journal-title":"Brain Res"},{"key":"555_CR28_555","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1083\/jcb.97.1.253","volume":"97","author":"DA Hume","year":"1983","unstructured":"Hume DA, Perry VH, Gordon S: Immunohistochemical localization of a macrophage-specific antigen in developing mouse retina: phagocytosis of dying neurons and differentiation of microglial cells to form a regular array in the plexiform layers. J Cell Biol 1983, 97:253\u2013257.","journal-title":"J Cell Biol"},{"key":"555_CR29_555","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1038\/ni.1777","volume":"10","author":"M Chang","year":"2009","unstructured":"Chang M, Jin W, Sun SC: Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production. Nat Immunol 2009, 10:1089\u20131095.","journal-title":"Nat Immunol"},{"key":"555_CR30_555","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.exer.2011.02.007","volume":"93","author":"F Lamoke","year":"2011","unstructured":"Lamoke F, Labazi M, Montemari A, Parisi G, Varano M, Bartoli M: Trans-Chalcone prevents VEGF expression and retinal neovascularization in the ischemic retina. Exp Eye Res 2011, 93:350\u20134.","journal-title":"Exp Eye Res"},{"key":"555_CR31_555","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1038\/nn.2414","volume":"12","author":"B Lorber","year":"2009","unstructured":"Lorber B, Howe ML, Benowitz LI, Irwin N: Mst3b, an Ste20-like kinase, regulates axon regeneration in mature CNS and PNS pathways. Nat Neurosci 2009, 12:1407\u20131414.","journal-title":"Nat Neurosci"},{"key":"555_CR32_555","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1126\/science.1175737","volume":"326","author":"DL Moore","year":"2009","unstructured":"Moore DL, Blackmore MG, Hu Y, Kaestner KH, Bixby JL, Lemmon VP, Goldberg JL: KLF family members regulate intrinsic axon regeneration ability. Science 2009, 326:298\u2013301.","journal-title":"Science"},{"key":"555_CR33_555","doi-asserted-by":"crossref","first-page":"12565","DOI":"10.1523\/JNEUROSCI.3027-07.2007","volume":"27","author":"A Boivin","year":"2007","unstructured":"Boivin A, Pineau I, Barrette B, Filali M, Vallieres N, Rivest S, Lacroix S: Toll-like receptor signaling is critical for Wallerian degeneration and functional recovery after peripheral nerve injury. J Neurosci 2007, 27:12565\u201312576.","journal-title":"J Neurosci"},{"key":"555_CR34_555","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1167\/iovs.09-4203","volume":"51","author":"TG Hauk","year":"2010","unstructured":"Hauk TG, Leibinger M, Muller A, Andreadaki A, Knippschild U, Fischer D: Stimulation of axon regeneration in the mature optic nerve by intravitreal application of the toll-like receptor 2 agonist Pam3Cys. Invest Ophthalmol Vis Sci 2010, 51:459\u2013464.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"555_CR35_555","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1083\/jcb.200804010","volume":"183","author":"R Shechter","year":"2008","unstructured":"Shechter R, Ronen A, Rolls A, London A, Bakalash S, Young MJ, Schwartz M: Toll-like receptor 4 restricts retinal progenitor cell proliferation. J Cell Biol 2008, 183:393\u2013400.","journal-title":"J Cell Biol"},{"key":"555_CR36_555","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1002\/neu.480251209","volume":"25","author":"H Schaden","year":"1994","unstructured":"Schaden H, Stuermer CA, Bahr M: GAP-43 immunoreactivity and axon regeneration in retinal ganglion cells of the rat. J Neurobiol 1994, 25:1570\u20131578.","journal-title":"J Neurobiol"},{"key":"555_CR37_555","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/nrn752","volume":"3","author":"MD Nguyen","year":"2002","unstructured":"Nguyen MD, Julien JP, Rivest S: Innate immunity: the missing link in neuroprotection and neurodegeneration? Nat Rev Neurosci 2002, 3:216\u2013227.","journal-title":"Nat Rev Neurosci"},{"key":"555_CR38_555","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1146\/annurev.neuro.23.1.579","volume":"23","author":"JL Goldberg","year":"2000","unstructured":"Goldberg JL, Barres BA: The relationship between neuronal survival and regeneration. Annu Rev Neurosci 2000, 23:579\u2013612.","journal-title":"Annu Rev Neurosci"},{"key":"555_CR39_555","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1126\/science.1087262","volume":"301","author":"M Yamamoto","year":"2003","unstructured":"Yamamoto M, Sato S, Hemmi H, Hoshino K, Kaisho T, Sanjo H, Takeuchi O, Sugiyama M, Okabe M, Takeda K, Akira S: Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science 2003, 301:640\u2013643.","journal-title":"Science"},{"key":"555_CR40_555","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1016\/j.clinthera.2010.10.006","volume":"32","author":"S Nikfar","year":"2010","unstructured":"Nikfar S, Rahimi R, Abdollahi M: A meta-analysis of the efficacy and tolerability of interferon-beta in multiple sclerosis, overall and by drug and disease type. Clin Ther 2010, 32:1871\u20131888.","journal-title":"Clin Ther"},{"key":"555_CR41_555","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.2353\/ajpath.2006.060159","volume":"169","author":"K Maier","year":"2006","unstructured":"Maier K, Kuhnert AV, Taheri N, Sattler MB, Storch MK, Williams SK, Bahr M, Diem R: Effects of glatiramer acetate and interferon-beta on neurodegeneration in a model of multiple sclerosis: a comparative study. Am J Pathol 2006, 169:1353\u20131364.","journal-title":"Am J Pathol"},{"key":"555_CR42_555","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1212\/WNL.0b013e3181f8832e","volume":"75","author":"J Shimizu","year":"2010","unstructured":"Shimizu J, Hatanaka Y, Hasegawa M, Iwata A, Sugimoto I, Date H, Goto J, Shimizu T, Takatsu M, Sakurai Y, et al.: IFNbeta-1b may severely exacerbate Japanese optic-spinal MS in neuromyelitis optica spectrum. Neurology 2010, 75:1423\u20131427.","journal-title":"Neurology"},{"key":"555_CR43_555","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/j.bbi.2010.04.004","volume":"24","author":"R Field","year":"2010","unstructured":"Field R, Campion S, Warren C, Murray C, Cunningham C: Systemic challenge with the TLR3 agonist poly I:C induces amplified IFNalpha\/beta and IL-1beta responses in the diseased brain and exacerbates chronic neurodegeneration. Brain, Behavior, and Immunity 2010, 24:996\u20131007.","journal-title":"Brain, Behavior, and Immunity"},{"key":"555_CR44_555","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/glia.20928","volume":"58","author":"S Lehnardt","year":"2010","unstructured":"Lehnardt S: Innate immunity and neuroinflammation in the CNS: the role of microglia in Toll-like receptor-mediated neuronal injury. Glia 2010, 58:253\u2013263.","journal-title":"Glia"},{"key":"555_CR45_555","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.nurt.2010.05.014","volume":"7","author":"ME Lull","year":"2010","unstructured":"Lull ME, Block ML: Microglial activation and chronic neurodegeneration. Neurotherapeutics J Am Soc Exp Neuro Ther 2010, 7:354\u2013365.","journal-title":"Neurotherapeutics J Am Soc Exp Neuro Ther"},{"key":"555_CR46_555","doi-asserted-by":"crossref","first-page":"6668","DOI":"10.4049\/jimmunol.169.12.6668","volume":"169","author":"M Yamamoto","year":"2002","unstructured":"Yamamoto M, Sato S, Mori K, Hoshino K, Takeuchi O, Takeda K, Akira S: Cutting edge: a novel Toll\/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling. J Immunol 2002, 169:6668\u20136672.","journal-title":"J Immunol"},{"key":"555_CR47_555","doi-asserted-by":"crossref","first-page":"49751","DOI":"10.1074\/jbc.M305820200","volume":"278","author":"H Oshiumi","year":"2003","unstructured":"Oshiumi H, Sasai M, Shida K, Fujita T, Matsumoto M, Seya T: TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta. J Biol Chem 2003, 278:49751\u201349762.","journal-title":"J Biol Chem"},{"key":"555_CR48_555","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/nature01889","volume":"424","author":"B Beutler","year":"2003","unstructured":"Beutler B, Hoebe K, Du X, Georgel P, Janssen E, Tabeta K, Kim SO, Goode J, Lin P, Mann N, et al.: Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. Nature 2003, 424:743\u2013748.","journal-title":"Nature"},{"key":"555_CR49_555","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1248\/bpb.33.1814","volume":"33","author":"Y Cui","year":"2010","unstructured":"Cui Y, Wu J, Jung SC, Park DB, Maeng YH, Hong JY, Kim SJ, Lee SR, Eun SY: Anti-neuroinflammatory activity of nobiletin on suppression of microglial activation. Biol Pharm Bull 2010, 33:1814\u20131821.","journal-title":"Biol Pharm Bull"},{"key":"555_CR50_555","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/BF02740665","volume":"15","author":"DL Gruol","year":"1997","unstructured":"Gruol DL, Nelson TE: Physiological and pathological roles of interleukin-6 in the central nervous system. Mol Neurobiol 1997, 15:307\u2013339.","journal-title":"Mol Neurobiol"},{"key":"555_CR51_555","doi-asserted-by":"crossref","first-page":"3605","DOI":"10.1111\/j.1460-9568.2007.05615.x","volume":"25","author":"EJ Vereyken","year":"2007","unstructured":"Vereyken EJ, Bajova H, Chow S, de Graan PN, Gruol DL: Chronic interleukin-6 alters the level of synaptic proteins in hippocampus in culture and in vivo. Eur J Neurosci 2007, 25:3605\u20133616.","journal-title":"Eur J Neurosci"},{"key":"555_CR52_555","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1167\/iovs.08-1973","volume":"50","author":"A Tura","year":"2009","unstructured":"Tura A, Schuettauf F, Monnier PP, Bartz-Schmidt KU, Henke-Fahle S: Efficacy of Rho-kinase inhibition in promoting cell survival and reducing reactive gliosis in the rodent retina. Invest Ophthalmol Vis Sci 2009, 50:452\u2013461.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"555_CR53_555","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jneuroim.2007.11.006","volume":"194","author":"J Kawanokuchi","year":"2008","unstructured":"Kawanokuchi J, Shimizu K, Nitta A, Yamada K, Mizuno T, Takeuchi H, Suzumura A: Production and functions of IL-17 in microglia. J Neuroimmunol 2008, 194:54\u201361.","journal-title":"J Neuroimmunol"},{"key":"555_CR54_555","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/path.2858","volume":"224","author":"V Sivakumar","year":"2011","unstructured":"Sivakumar V, Foulds WS, Luu CD, Ling EA, Kaur C: Retinal ganglion cell death is induced by microglia derived pro-inflammatory cytokines in the hypoxic neonatal retina. J Pathol 2011, 224:245\u2013260.","journal-title":"J Pathol"},{"key":"555_CR55_555","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1136\/bjo.79.9.834","volume":"79","author":"AD Dick","year":"1995","unstructured":"Dick AD, Ford AL, Forrester JV, Sedgwick JD: Flow cytometric identification of a minority population of MHC class II positive cells in the normal rat retina distinct from CD45lowCD11b\/c + CD4low parenchymal microglia. Br J Ophthalmol 1995, 79:834\u2013840.","journal-title":"Br J Ophthalmol"},{"key":"555_CR56_555","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1111\/j.1365-2567.2010.03379.x","volume":"132","author":"YS Lee","year":"2011","unstructured":"Lee YS, Amadi-Obi A, Yu CR, Egwuagu CE: Retinal cells suppress intraocular inflammation (uveitis) through production of interleukin-27 and interleukin-10. Immunology 2011, 132:492\u2013502.","journal-title":"Immunology"},{"key":"555_CR57_555","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.febslet.2007.01.061","volume":"581","author":"CM Ethen","year":"2007","unstructured":"Ethen CM, Hussong SA, Reilly C, Feng X, Olsen TW, Ferrington DA: Transformation of the proteasome with age-related macular degeneration. FEBS Lett 2007, 581:885\u2013890.","journal-title":"FEBS Lett"},{"key":"555_CR58_555","doi-asserted-by":"crossref","first-page":"11653","DOI":"10.1523\/JNEUROSCI.23-37-11653.2003","volume":"23","author":"M Diaz-Hernandez","year":"2003","unstructured":"Diaz-Hernandez M, Hernandez F, Martin-Aparicio E, Gomez-Ramos P, Moran MA, Castano JG, Ferrer I, Avila J, Lucas JJ: Neuronal induction of the immunoproteasome in Huntington's disease. J Neurosci 2003, 23:11653\u201311661.","journal-title":"J Neurosci"},{"key":"555_CR59_555","doi-asserted-by":"crossref","first-page":"10340","DOI":"10.1128\/JVI.00865-07","volume":"81","author":"L Kercher","year":"2007","unstructured":"Kercher L, Favara C, Striebel JF, LaCasse R, Chesebro B: Prion protein expression differences in microglia and astroglia influence scrapie-induced neurodegeneration in the retina and brain of transgenic mice. J Virol 2007, 81:10340\u201310351.","journal-title":"J Virol"},{"key":"555_CR60_555","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1055\/s-0028-1109728","volume":"226","author":"W Lagreze","year":"2009","unstructured":"Lagreze W: Treatment of optic neuropathies-state of the art. Klin Monbl Augenheilkd 2009, 226:875\u2013880.","journal-title":"Klin Monbl Augenheilkd"},{"key":"555_CR61_555","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1055\/s-0028-1124020","volume":"29","author":"JB Selhorst","year":"2009","unstructured":"Selhorst JB, Chen Y: The optic nerve. Semin Neurol 2009, 29:29\u201335.","journal-title":"Semin Neurol"}],"updated-by":[{"DOI":"10.1186\/1742-2094-10-48","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2013,4,19]],"date-time":"2013-04-19T00:00:00Z","timestamp":1366329600000}}],"container-title":["Journal of Neuroinflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1742-2094-9-39.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1742-2094-9-39\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1742-2094-9-39","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,20]],"date-time":"2024-04-20T09:28:07Z","timestamp":1713605287000},"score":1,"resource":{"primary":{"URL":"http:\/\/jneuroinflammation.biomedcentral.com\/articles\/10.1186\/1742-2094-9-39"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,24]]},"references-count":61,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["555"],"URL":"https:\/\/doi.org\/10.1186\/1742-2094-9-39","relation":{},"ISSN":["1742-2094"],"issn-type":[{"value":"1742-2094","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,24]]},"article-number":"555"}}