{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T08:45:50Z","timestamp":1783586750403,"version":"3.55.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Retrovirology"],"DOI":"10.1186\/1742-4690-1-4","type":"journal-article","created":{"date-parts":[[2004,3,30]],"date-time":"2004-03-30T06:23:45Z","timestamp":1080627825000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Increased mortality associated with HTLV-II infection in blood donors: a prospective cohort study"],"prefix":"10.1186","volume":"1","author":[{"given":"Jennie R","family":"Orland","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoguang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catharie C","family":"Nass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Garratty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James W","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Newman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna M","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward L","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"For the HOST Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2004,3,24]]},"reference":[{"key":"4_CR1","doi-asserted-by":"publisher","first-page":"1951","DOI":"10.1016\/S0140-6736(98)09460-4","volume":"353","author":"A Manns","year":"1999","unstructured":"Manns A, Hisada M, La Grenade L: Human T-lymphotropic virus type I infection. Lancet. 1999, 353: 1951-1958. 10.1016\/S0140-6736(98)09460-4.","journal-title":"Lancet"},{"key":"4_CR2","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1212\/WNL.48.2.315","volume":"48","author":"EL Murphy","year":"1997","unstructured":"Murphy EL, Fridey J, Smith JW, Engstrom J, Sacher RA, Miller K, Gibble J, Stevens J, Thomson R, Hansma D, Kaplan J, Khabbaz R, Nemo G: HTLV-associated myelopathy in a cohort of HTLV-I and HTLV-II-infected blood donors. The REDS investigators. Neurology. 1997, 48: 315-320.","journal-title":"Neurology"},{"key":"4_CR3","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1097\/00042560-199711010-00005","volume":"16","author":"LE Modahl","year":"1997","unstructured":"Modahl LE, Young KC, Varney KF, Khayam-Bashi H, Murphy EL: Are HTLV-II-seropositive injection drug users at increased risk of bacterial pneumonia, abscess, and lymphadenopathy?. J Acquir Immune Defic Syndr Hum Retrovirol. 1997, 16: 169-175.","journal-title":"J Acquir Immune Defic Syndr Hum Retrovirol"},{"key":"4_CR4","doi-asserted-by":"publisher","first-page":"1468","DOI":"10.1086\/514143","volume":"176","author":"EL Murphy","year":"1997","unstructured":"Murphy EL, Glynn SA, Fridey J, Sacher RA, Smith JW, Wright DJ, Newman B, Gibble JW, Ameti DI, Nass CC, Schreiber GB, Nemo GJ: Increased prevalence of infectious diseases and other adverse outcomes in human T lymphotropic virus types I- and II-infected blood donors. Retrovirus Epidemiology Donor Study (REDS) Study Group. J Infect Dis. 1997, 176: 1468-1475.","journal-title":"J Infect Dis"},{"key":"4_CR5","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1001\/archinte.159.13.1485","volume":"159","author":"EL Murphy","year":"1999","unstructured":"Murphy EL, Glynn SA, Fridey J, Smith JW, Sacher RA, Nass CC, Ownby HE, Wright DJ, Nemo GJ: Increased incidence of infectious diseases during prospective follow-up of human T-lymphotropic virus type II- and I-infected blood donors. Retrovirus Epidemiology Donor Study. Arch Intern Med. 1999, 159: 1485-1491. 10.1001\/archinte.159.13.1485.","journal-title":"Arch Intern Med"},{"key":"4_CR6","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1097\/00042560-199708150-00010","volume":"15","author":"MF Lechat","year":"1997","unstructured":"Lechat MF, Shrager DI, Declercq E, Bertrand F, Blattner WA, Blumberg BS: Decreased survival of HTLV-I carriers in leprosy patients from the Democratic Republic of the Congo: a historical prospective study. J Acquir Immune Defic Syndr Hum Retrovirol. 1997, 15: 387-390.","journal-title":"J Acquir Immune Defic Syndr Hum Retrovirol"},{"key":"4_CR7","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1111\/j.1349-7006.1998.tb00631.x","volume":"89","author":"K Arisawa","year":"1998","unstructured":"Arisawa K, Soda M, Akahoshi M, Matsuo T, Nakashima E, Tomonaga M, Saito H: Human T-lymphotropic virus type-I infection, antibody titers and cause-specific mortality among atomic-bomb survivors. Jpn J Cancer Res. 1998, 89: 797-805.","journal-title":"Jpn J Cancer Res"},{"key":"4_CR8","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1086\/315177","volume":"181","author":"C Boschi-Pinto","year":"2000","unstructured":"Boschi-Pinto C, Stuver S, Okayama A, Trichopoulos D, Orav EJ, Tsubouchi H, Mueller N: A follow-up study of morbidity and mortality associated with hepatitis C virus infection and its interaction with human T lymphotropic virus type I in Miyazaki, Japan. J Infect Dis. 2000, 181: 35-41. 10.1086\/315177.","journal-title":"J Infect Dis"},{"key":"4_CR9","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1007\/BF01719304","volume":"11","author":"M Giacomo","year":"1995","unstructured":"Giacomo M, Franco EG, Claudio C, Carlo C, Anna DA, Anna D, Franco F: Human T-cell leukemia virus type II infection among high risk groups and its influence on HIV-1 disease progression. Eur J Epidemiol. 1995, 11: 527-533.","journal-title":"Eur J Epidemiol"},{"key":"4_CR10","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1093\/infdis\/174.2.309","volume":"174","author":"RC Hershow","year":"1996","unstructured":"Hershow RC, Galai N, Fukuda K, Graber J, Vlahov D, Rezza G, Klein RS, Des Jarlais DC, Vitek C, Khabbaz R, Freels S, Zuckerman R, Pezzotti P, Kaplan JE: An international collaborative study of the effects of coinfection with human T-lymphotropic virus type II on human immunodeficiency virus type 1 disease progression in injection drug users. J Infect Dis. 1996, 174: 309-317.","journal-title":"J Infect Dis"},{"key":"4_CR11","first-page":"1228","volume":"6","author":"A Visconti","year":"1993","unstructured":"Visconti A, Visconti L, Bellocco R, Binkin N, Colucci G, Vernocchi L, Amendola M, Ciaci D: HTLV-II\/HIV-1 coinfection and risk for progression to AIDS among intravenous drug users. J Acquir Immune Defic Syndr. 1993, 6: 1228-1237.","journal-title":"J Acquir Immune Defic Syndr"},{"key":"4_CR12","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1097\/00002030-200107060-00012","volume":"15","author":"JJ Goedert","year":"2001","unstructured":"Goedert JJ, Fung MW, Felton S, Battjes RJ, Engels EA: Cause-specific mortality associated with HIV and HTLV-II infections among injecting drug users in the USA. Aids. 2001, 15: 1295-1302. 10.1097\/00002030-200107060-00012.","journal-title":"Aids"},{"key":"4_CR13","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1093\/oxfordjournals.aje.a008752","volume":"143","author":"HJ van Haastrecht","year":"1996","unstructured":"van Haastrecht HJ, van Ameijden EJ, van den Hoek JA, Mientjes GH, Bax JS, Coutinho RA: Predictors of mortality in the Amsterdam cohort of human immunodeficiency virus (HIV)-positive and HIV-negative drug users. Am J Epidemiol. 1996, 143: 380-391.","journal-title":"Am J Epidemiol"},{"key":"4_CR14","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1056\/NEJM199202063260604","volume":"326","author":"RF Khabbaz","year":"1992","unstructured":"Khabbaz RF, Onorato IM, Cannon RO, Hartley TM, Roberts B, Hosein B, Kaplan JE: Seroprevalence of HTLV-1 and HTLV-2 among intravenous drug users and persons in clinics for sexually transmitted diseases. N Engl J Med. 1992, 326: 375-380.","journal-title":"N Engl J Med"},{"key":"4_CR15","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1097\/00042560-199703010-00011","volume":"14","author":"GB Schreiber","year":"1997","unstructured":"Schreiber GB, Murphy EL, Horton JA, Wright DJ, Garfein R, Chien HC, Nass CC: Risk factors for human T-cell lymphotropic virus types I and II (HTLV-I and -II) in blood donors: the Retrovirus Epidemiology Donor Study. NHLBI Retrovirus Epidemiology Donor Study. J Acquir Immune Defic Syndr Hum Retrovirol. 1997, 14: 263-271.","journal-title":"J Acquir Immune Defic Syndr Hum Retrovirol"},{"key":"4_CR16","doi-asserted-by":"publisher","first-page":"1906","DOI":"10.1056\/NEJM199212313272703","volume":"327","author":"LB Seeff","year":"1992","unstructured":"Seeff LB, Buskell-Bales Z, Wright EC, Durako SJ, Alter HJ, Iber FL, Hollinger FB, Gitnick G, Knodell RG, Perrillo RP, et al.: Long-term mortality after transfusion-associated non-A, non-B hepatitis. The National Heart, Lung, and Blood Institute Study Group. N Engl J Med. 1992, 327: 1906-1911.","journal-title":"N Engl J Med"},{"key":"4_CR17","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1053\/jhep.2001.21905","volume":"33","author":"LB Seeff","year":"2001","unstructured":"Seeff LB, Hollinger FB, Alter HJ, Wright EC, Cain CM, Buskell ZJ, Ishak KG, Iber FL, Toro D, Samanta A, Koretz RL, Perrillo RP, Goodman ZD, Knodell RG, Gitnick G, Morgan TR, Schiff ER, Lasky S, Stevens C, Vlahcevic RZ, Weinshel E, Tanwandee T, Lin HJ, Barbosa L: Long-term mortality and morbidity of transfusion-associated non-A, non-B, and type C hepatitis: A National Heart, Lung, and Blood Institute collaborative study. Hepatology. 2001, 33: 455-463. 10.1053\/jhep.2001.21905.","journal-title":"Hepatology"},{"key":"4_CR18","doi-asserted-by":"publisher","first-page":"1691","DOI":"10.1056\/NEJM199606273342602","volume":"334","author":"C Conry-Cantilena","year":"1996","unstructured":"Conry-Cantilena C, VanRaden M, Gibble J, Melpolder J, Shakil AO, Viladomiu L, Cheung L, DiBisceglie A, Hoofnagle J, Shih JW, et al.: Routes of infection, viremia, and liver disease in blood donors found to have hepatitis C virus infection. N Engl J Med. 1996, 334: 1691-1696. 10.1056\/NEJM199606273342602.","journal-title":"N Engl J Med"},{"key":"4_CR19","doi-asserted-by":"publisher","first-page":"2031","DOI":"10.1073\/pnas.79.6.2031","volume":"79","author":"M Yoshida","year":"1982","unstructured":"Yoshida M, Miyoshi I, Hinuma Y: Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease. Proc Natl Acad Sci U S A. 1982, 79: 2031-2035.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4_CR20","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/S0140-6736(85)92734-5","volume":"2","author":"A Gessain","year":"1985","unstructured":"Gessain A, Barin F, Vernant JC, Gout O, Maurs L, Calender A, de The G: Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis. Lancet. 1985, 2: 407-410. 10.1016\/S0140-6736(85)92734-5.","journal-title":"Lancet"},{"key":"4_CR21","first-page":"19","volume-title":"AIDS Clin Rev","author":"T Gebretsadik","year":"1993","unstructured":"Gebretsadik T, Murphy EL: Counseling and medical evaluation of HTLV-I- and HTLV-II-infected patients. AIDS Clin Rev. 1993, 19-41."},{"key":"4_CR22","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1097\/00019052-200106000-00019","volume":"14","author":"M Nagai","year":"2001","unstructured":"Nagai M, Jacobson S: Immunopathogenesis of human T cell lymphotropic virus type I-associated myelopathy. Curr Opin Neurol. 2001, 14: 381-386. 10.1097\/00019052-200106000-00019.","journal-title":"Curr Opin Neurol"},{"key":"4_CR23","doi-asserted-by":"publisher","first-page":"7568","DOI":"10.1073\/pnas.95.13.7568","volume":"95","author":"TF Greten","year":"1998","unstructured":"Greten TF, Slansky JE, Kubota R, Soldan SS, Jaffee EM, Leist TP, Pardoll DM, Jacobson S, Schneck JP: Direct visualization of antigen-specific T cells: HTLV-1 Tax11-19- specific CD8(+) T cells are activated in peripheral blood and accumulate in cerebrospinal fluid from HAM\/TSP patients. Proc Natl Acad Sci U S A. 1998, 95: 7568-7573. 10.1073\/pnas.95.13.7568.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4_CR24","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1086\/315088","volume":"180","author":"A Manns","year":"1999","unstructured":"Manns A, Miley WJ, Wilks RJ, Morgan OS, Hanchard B, Wharfe G, Cranston B, Maloney E, Welles SL, Blattner WA, Waters D: Quantitative proviral DNA and antibody levels in the natural history of HTLV-I infection. J Infect Dis. 1999, 180: 1487-1493. 10.1086\/315088.","journal-title":"J Infect Dis"},{"key":"4_CR25","doi-asserted-by":"publisher","first-page":"586","DOI":"10.3109\/13550289809114225","volume":"4","author":"M Nagai","year":"1998","unstructured":"Nagai M, Usuku K, Matsumoto W, Kodama D, Takenouchi N, Moritoyo T, Hashiguchi S, Ichinose M, Bangham CR, Izumo S, Osame M: Analysis of HTLV-I proviral load in 202 HAM\/TSP patients and 243 asymptomatic HTLV-I carriers: high proviral load strongly predisposes to HAM\/TSP. J Neurovirol. 1998, 4: 586-593.","journal-title":"J Neurovirol"},{"key":"4_CR26","doi-asserted-by":"publisher","first-page":"1588","DOI":"10.1212\/01.WNL.0000096011.92542.DA","volume":"61","author":"JR Orland","year":"2003","unstructured":"Orland JR, Engstrom J, Fridey J, Sacher RA, Smith JW, Nass C, Garratty G, Newman B, Smith D, Wang B, Murphy EL, HTVL Outcomes Study: Prevalence and clinical features of HTLV neurologic disease in the HTLV Outcomes Study. Neurology. 2003, 61: 1588-1594.","journal-title":"Neurology"},{"key":"4_CR27","doi-asserted-by":"publisher","first-page":"1648","DOI":"10.1086\/379780","volume":"188","author":"K Ariyoshi","year":"2003","unstructured":"Ariyoshi K, Berry N, Cham F, Jaffar S, Schim van der Loeff M, Jobe O, N'Gom PT, Larsen O, Andersson S, Aaby P, Whittle H: Quantification of Human T-lymphotropic virus type I (HTLV-I) provirus load in a rural West African population: no enhancement of human immunodeficiency virus type 2 pathogenesis, but HTLV-I provirus load relates to mortality. J Infect Dis. 2003, 188: 1648-1651. 10.1086\/379780.","journal-title":"J Infect Dis"},{"key":"4_CR28","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1182\/blood.V83.4.1143.1143","volume":"83","author":"MP Busch","year":"1994","unstructured":"Busch MP, Laycock M, Kleinman SH, Wages J. W., Jr., Calabro M, Kaplan JE, Khabbaz RF, Hollingsworth CG: Accuracy of supplementary serologic testing for human T-lymphotropic virus types I and II in US blood donors. Retrovirus Epidemiology Donor Study. Blood. 1994, 83: 1143-1148.","journal-title":"Blood"},{"key":"4_CR29","unstructured":"Center for Disease Control and Prevention: . National Vital Statistics Reports. 2003, 51: 7-"}],"container-title":["Retrovirology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1742-4690-1-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T16:37:15Z","timestamp":1726245435000},"score":1,"resource":{"primary":{"URL":"https:\/\/retrovirology.biomedcentral.com\/articles\/10.1186\/1742-4690-1-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,3,24]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2004,12]]}},"alternative-id":["4"],"URL":"https:\/\/doi.org\/10.1186\/1742-4690-1-4","relation":{},"ISSN":["1742-4690"],"issn-type":[{"value":"1742-4690","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,3,24]]},"assertion":[{"value":"4 March 2004","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 March 2004","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 March 2004","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"4"}}