{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:03:10Z","timestamp":1791655390983,"version":"4.3.4"},"reference-count":5,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Retrovirology"],"published-print":{"date-parts":[[2005,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Adult T-cell leukemia (ATL) was first reported as a distinct clinical entity in 1977 in Japan. The predominant physical findings are skin lesions, lymphadenopathy and hepatosplenomegaly. The ATL cells are of mature T-helper phenotype and have a characteristic appearance with indented nuclei. There is striking frequent hypercalcemia with increased numbers of osteoclasts. Central to the identification of the disease is a striking geographic clustering in southwestern Japan and the isolation of human T-cell lymphotropic virus type-1 (HTLV-1) from the cell lines of patients. Worldwide epidemiological studies have been made through international collaborations. Several diseases were found to be related to HTLV-1 infection. Moreover, it was noted that an immunodeficiency state may be induced by HTLV-1 infection. In Japan, HTLV-1 carriers have been estimated to be 1.2 million, and more than 700 cases of ATL have been diagnosed each year.<\/jats:p>","DOI":"10.1186\/1742-4690-2-16","type":"journal-article","created":{"date-parts":[[2005,3,3]],"date-time":"2005-03-03T07:25:50Z","timestamp":1109834750000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":182,"title":["Discovery of adult T-cell leukemia"],"prefix":"10.1186","volume":"2","author":[{"given":"Kiyoshi","family":"Takatsuki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2005,3,2]]},"reference":[{"key":"62_CR1","first-page":"73","volume-title":"Topics in Hematology","author":"K Takatsuki","year":"1977","unstructured":"Takatsuki K, Uchiyama T, Sagawa K, Yodoi J: Adult T cell leukemia in Japan. Topics in Hematology. Edited by: Seno S, Takaku F, Irino S. 1977, Amsterdam, Excerpta Medica, 73-77."},{"key":"62_CR2","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1182\/blood.V50.3.481.481","volume":"50","author":"T Uchiyama","year":"1977","unstructured":"Uchiyama T, Yodoi J, Sagawa K, Takatsuki K, Uchino H: Adult T-cell leukemia: Clinical and hematologic features of 16 cases. Blood. 1977, 50: 481-492.","journal-title":"Blood"},{"key":"62_CR3","unstructured":"Takatsuki K, ed: Adult T-cell Leukaemia. 1994, Oxford, Oxford University Press"},{"key":"62_CR4","first-page":"705","volume-title":"Adult T-Cell Leukemia","author":"M Matsuoka","year":"2002","unstructured":"Matsuoka M, Takatsuki K: Adult T-Cell Leukemia. Edited by: Henderson ES, Lister TA, Greaves MF. 2002, Leukemia, Philadelphia, Saunders, 705-712. 7","edition":"7"},{"key":"62_CR5","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/1742-4690-2-17","volume":"2","author":"RC Gallo","year":"2005","unstructured":"Gallo RC: The discovery of the first human retrovirus: HTLV-1 and HTLV-2. Retrovirology. 2005, 2: 17-10.1186\/1742-4690-2-17.","journal-title":"Retrovirology"}],"container-title":["Retrovirology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1742-4690-2-16.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T03:05:11Z","timestamp":1630465511000},"score":1,"resource":{"primary":{"URL":"https:\/\/retrovirology.biomedcentral.com\/articles\/10.1186\/1742-4690-2-16"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3,2]]},"references-count":5,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["62"],"URL":"https:\/\/doi.org\/10.1186\/1742-4690-2-16","relation":{},"ISSN":["1742-4690"],"issn-type":[{"value":"1742-4690","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,3,2]]},"assertion":[{"value":"31 January 2005","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 March 2005","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 March 2005","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"16"}}