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While Tax1 expression is usually lost or minimal in ATL cells, these cells still show high constitutive NF-\u03baB activity, indicating that genetic or epigenetic changes in ATL cells induce activation independent of Tax1. The aim of this study was to identify the molecules responsible for the constitutive activation of NF-\u03baB in ATL cells using a retroviral functional cloning strategy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Using enhanced green fluorescent protein (EGFP) expression and blasticidin-resistance as selection markers, several retroviral cDNA clones exhibiting constitutive NF-\u03baB activity in Rat-1 cells, including full-length CD30, were obtained from an ATL cell line. Exogenous stable expression of CD30 in Rat-1 cells constitutively activated NF-\u03baB. Elevated expression of CD30 was identified in all ATL lines examined, and primary ATL cells from a small number of patients (8 out of 66 cases).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Elevated CD30 expression is considered one of the causes of constitutive NF-\u03baB activation in ATL cells, and may be involved in ATL development.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1742-4690-2-29","type":"journal-article","created":{"date-parts":[[2005,5,6]],"date-time":"2005-05-06T06:13:33Z","timestamp":1115360013000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Elevated expression of CD30 in adult T-cell leukemia cell lines: possible role in constitutive NF-\u03baB activation"],"prefix":"10.1186","volume":"2","author":[{"given":"Masaya","family":"Higuchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehiro","family":"Matsuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Mori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuaki","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryouichi","family":"Horie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiki","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayasu","family":"Oie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Fujii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2005,5,6]]},"reference":[{"key":"75_CR1","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1007\/978-1-4899-1627-3_7","volume-title":"The Retrovirudae","author":"K Sugamura","year":"1993","unstructured":"Sugamura K, Hinuma Y: Human retroviruses: HTLV-I and HTLV-II. 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