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The recent identification of non-coding microRNAs encoded within the <jats:italic>PVT1<\/jats:italic> region has suggested a regulatory role for this locus.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The mouse <jats:italic>Pvt1<\/jats:italic> locus encodes several microRNAs. In mouse T cell lymphomas induced by retroviral insertions into the locus, the <jats:italic>Pvt1<\/jats:italic> transcripts, and at least one of their microRNA products, mmu-miR-1204 are overexpressed. Whereas up to seven co-mutations can be found in a single tumor, in over 2,000 tumors none had insertions into both the <jats:italic>Myc<\/jats:italic> and <jats:italic>Pvt1<\/jats:italic> loci.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Judging from the large number of integrations into the <jats:italic>Pvt1<\/jats:italic> locus \u2013 more than in the nearby <jats:italic>Myc<\/jats:italic> locus \u2013 <jats:italic>Pvt1<\/jats:italic> and the microRNAs encoded by it are as important as <jats:italic>Myc<\/jats:italic> in T lymphomagenesis, and, presumably, in T cell activation. An analysis of the co-mutations in the lymphomas likely place <jats:italic>Pvt1<\/jats:italic> and <jats:italic>Myc<\/jats:italic> into the same pathway.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1742-4690-5-4","type":"journal-article","created":{"date-parts":[[2008,1,15]],"date-time":"2008-01-15T07:14:50Z","timestamp":1200381290000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":96,"title":["Pvt1-encoded microRNAs in oncogenesis"],"prefix":"10.1186","volume":"5","author":[{"given":"Gabriele B","family":"Beck-Engeser","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy M","family":"Lum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konrad","family":"Huppi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha J","family":"Caplen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce B","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Wabl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,1,14]]},"reference":[{"issue":"5996","key":"829_CR1","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1038\/312777a0","volume":"312","author":"E Webb","year":"1984","unstructured":"Webb E, Adams JM, Cory S: Variant (6; 15) translocation in a murine plasmacytoma occurs near an immunoglobulin kappa gene but far from the myc oncogene. 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