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HTLV-1 encodes a viral oncoprotein, Tax, that functions in transforming virus-infected T-cells into leukemic cells. All ATLL cases are believed to have reduced p53 activity although only a minority of ATLLs have genetic mutations in their p53 gene. It has been suggested that p53 function is inactivated by the Tax protein.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Using genetically altered mice, we report here that Tax expression does not achieve a functional equivalence of p53 inactivation as that seen with genetic mutation of p53 (i.e. a <jats:italic>p53<\/jats:italic>\n              <jats:sup>\n                <jats:italic>\u2212\/\u2212<\/jats:italic>\n              <\/jats:sup> genotype). Thus, we find statistically significant differences in tumorigenesis between <jats:italic>Tax<\/jats:italic>\n              <jats:sup>\n                <jats:italic>+<\/jats:italic>\n              <\/jats:sup>\n              <jats:italic>p53<\/jats:italic>\n              <jats:sup>\n                <jats:italic>+\/+<\/jats:italic>\n              <\/jats:sup>\n              <jats:italic>versus Tax<\/jats:italic>\n              <jats:sup>\n                <jats:italic>+<\/jats:italic>\n              <\/jats:sup>\n              <jats:italic>p53<\/jats:italic>\n              <jats:sup>\n                <jats:italic>\u2212\/\u2212<\/jats:italic>\n              <\/jats:sup> mice. We also find a role contributed by the cellular Wip1 phosphatase protein in tumor formation in Tax transgenic mice. Notably, <jats:italic>Tax<\/jats:italic>\n              <jats:sup>\n                <jats:italic>+<\/jats:italic>\n              <\/jats:sup>\n              <jats:italic>Wip<\/jats:italic>1<jats:sup>\n                <jats:italic>\u2212\/\u2212<\/jats:italic>\n              <\/jats:sup> mice show statistically significant reduced prevalence of tumorigenesis compared to <jats:italic>Tax<\/jats:italic>\n              <jats:sup>\n                <jats:italic>+<\/jats:italic>\n              <\/jats:sup>\n              <jats:italic>Wip<\/jats:italic>1<jats:sup>\n                <jats:italic>+\/+<\/jats:italic>\n              <\/jats:sup> counterparts.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Our findings provide new insights into contributions by p53 and Wip1 in the <jats:italic>in vivo<\/jats:italic> oncogenesis of Tax-induced tumors in mice.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1742-4690-9-114","type":"journal-article","created":{"date-parts":[[2012,12,21]],"date-time":"2012-12-21T09:28:43Z","timestamp":1356082123000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Wip1 and p53 contribute to HTLV-1 Tax-induced tumorigenesis"],"prefix":"10.1186","volume":"9","author":[{"given":"Linda","family":"Zane","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichiro","family":"Yasunaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Mitagami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkat","family":"Yedavalli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai-Wen","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Yen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee","family":"Ratner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiongbin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuan-Teh","family":"Jeang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,12,21]]},"reference":[{"issue":"39","key":"3379_CR1","doi-asserted-by":"publisher","first-page":"6058","DOI":"10.1038\/sj.onc.1208968","volume":"24","author":"FA Proietti","year":"2005","unstructured":"Proietti FA, Carneiro-Proietti AB, Catalan-Soares BC, Murphy EL: Global epidemiology of HTLV-I infection and associated diseases. 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