{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:22:02Z","timestamp":1777530122134,"version":"3.51.4"},"reference-count":24,"publisher":"Scientific Scholar","content-domain":{"domain":["cytojournal.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\nBackground:<\/jats:title>\nCells with hand mirror morphology have not, to the best of our knowledge, been described in a primary effusion sample. This paper describes a case of T-cell lymphoma with eosinophilia in a patient with suspected peritoneal carcinomatosis. Rarely, a T-cell lymphoproliferative process may mimic primary peritoneal carcinomatosis, clinically suggested by a presentation in CT imaging of omental caking with bilateral massive loculated effusions in a patient without lymphadenopathy or splenomegaly.<\/jats:p>\n<\/jats:sec>\n\nMethods:<\/jats:title>\nA 60 year old caucasian male presented with vague abdominal discomfort and increasing abdominal girth. Computed tomography showed a two centimeter thick omental cake and a small loculated effusion. The clinical presentation and imaging findings were most consistent with peritoneal carcinomatosis. Cytologic evaluation of the effusion was undertaken for diagnostic study.<\/jats:p>\n<\/jats:sec>\n\nResults:<\/jats:title>\nRapid intraprocedural interpretation of the effusion sample showed a monomorphic population of cells with hand-mirror cell morphology exhibiting cytoplasmic extensions (uropodia) with 3-5 course dark cytoplasmic granules and a rim of vacuolated cytoplasm capping the opposing mirror head side. These cells were seen within a background of mature eosinophils. Flow cytometric evaluation of the ascites fluid demonstrated an atypical T-cell population with the following immunophenotype: CD2-, CD3+, CD4-, CD5-, CD7-, CD8+, CD56+. T-cell receptor (TCR) gene rearrangement was positive for clonal TCR-gamma gene rearrangement, supporting the diagnosis of a T-lymphoprolifereative disorder.<\/jats:p>\n<\/jats:sec>\n\nConclusion:<\/jats:title>\nA T-cell lymphoproliferative process may present with hand mirror morphology in an effusion sample. These cells may show polar cytoplasmic vacuolization and 3-5 course granules within the handle of these unique cells. Cytoplasm shows peripheral constriction around the nucleus.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/1742-6413-3-13","type":"journal-article","created":{"date-parts":[[2006,5,9]],"date-time":"2006-05-09T06:23:51Z","timestamp":1147155831000},"page":"13","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["T-cell lymphoproliferative disorder of hand-mirror cell morphology presenting in an eosinophilic loculated peritoneal effusion, with omental \"caking\""],"prefix":"10.25259","volume":"3","author":[{"given":"Richard","family":"Siderits","sequence":"first","affiliation":[{"name":"Laboratory Sciences, Department of Cytology, Robert Wood Johnson University Hospital - Hamilton, Hamilton, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janusz","family":"Godyn","sequence":"additional","affiliation":[{"name":"Laboratory Sciences, Department of Cytology, Robert Wood Johnson University Hospital - Hamilton, Hamilton, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dearon","family":"Tufankjian","sequence":"additional","affiliation":[{"name":"Department of Vascular & Interventional Radiology, Robert Wood Johnson University Hospital - Hamilton, Hamilton, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osman","family":"Ouattara","sequence":"additional","affiliation":[{"name":"Laboratory Sciences, Department of Cytology, Robert Wood Johnson University Hospital - Hamilton, Hamilton, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2006,5,8]]},"reference":[{"key":"10.1186\/1742-6413-3-13\/ref-1","first-page":"993","article-title":"In Koss\u2032 Diagnostic cytology and its histopathologic basis .Edited by: Koss L, Melamed L","author":"Koss","journal-title":"Philadelphia: Lipincott Williams & Wilkins;"},{"key":"10.1186\/1742-6413-3-13\/ref-2","article-title":"Lancet 1 (8012) : 655-656.1977, Mar 19","author":"Schumacher"},{"key":"10.1186\/1742-6413-3-13\/ref-3","article-title":"Lancet 1 (8023) : 1214-1215.1977 Jun 4","author":"Schumacher"},{"key":"10.1186\/1742-6413-3-13\/ref-4","first-page":"275","article-title":"In Modern Cytopathology","author":"Geisinger","journal-title":"Philadelphia: Churchill Livingstone;"},{"key":"10.1186\/1742-6413-3-13\/ref-5","first-page":"111","article-title":"In Atlas of Diagnostic Cytopathology .Edited by: 2","author":"Atkinson B:","journal-title":"Philadelphia: Saunders;"},{"key":"10.1186\/1742-6413-3-13\/ref-6","first-page":"130","article-title":"In Cytology Diagnostic Principles and Clinical Correlates .2nd edition","author":"Cibas","journal-title":"Philadelphia: Saunders;"},{"key":"10.1186\/1742-6413-3-13\/ref-7","first-page":"230","article-title":"In Body Fluids .3rd edition","author":"Kjeldsberg","journal-title":"ASCP press;"},{"key":"10.1186\/1742-6413-3-13\/ref-8","first-page":"143","article-title":"In Diagnostic Cytopathology .2nd edition","author":"Grey","journal-title":"Philadelphia: Churchill Livingston;"},{"key":"10.1186\/1742-6413-3-13\/ref-9","article-title":"Diagn Cytopathol 1999, 20 (6) : 382-384.","author":"Vakar-Lopez"},{"key":"10.1186\/1742-6413-3-13\/ref-10","first-page":"253","article-title":"Computed tomography findings","author":"Jacobs","journal-title":"Clin Imaging"},{"key":"10.1186\/1742-6413-3-13\/ref-11","article-title":"J Obstet Gynaecol 2004, 24 (4) : 463-465.","author":"Eren"},{"key":"10.1186\/1742-6413-3-13\/ref-12","article-title":"AJR Am J Roentgenol 1993, 160 (3) : 661.","author":"Maya"},{"key":"10.1186\/1742-6413-3-13\/ref-13","article-title":"Diagn Cytopathol 2004, 30 (4) : 268-270.","author":"Wu"},{"key":"10.1186\/1742-6413-3-13\/ref-14","first-page":"1283","article-title":"A case report","author":"Papadimitriou","journal-title":"Acta Cytol"},{"key":"10.1186\/1742-6413-3-13\/ref-15","article-title":"Review 1995, 43 (11) : 1173-1177.","author":"Uemura"},{"key":"10.1186\/1742-6413-3-13\/ref-16","first-page":"1646","article-title":"In Neoplastic Hematopathology .2nd edition","author":"Knowles D: Acute lymphoblastic leukemia; 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