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Based on the studies previously demonstrated that the similar molecules present on the mosquito cells involved in the uptake process of JEV, West Nile virus (WNV) and Dengue virus (DV), it is proposed that the same receptor molecules for mosquito-borne flaviviruses (JEV, WNV and DV) may present on the surface of C6\/36 mosquito cells. By co-immunoprecipitation assay, we investigated a 74-KDa protein on the C6\/36 cells binds JEV, and the mass spectrometry results indicated it may be heat shock cognate protein 70(HSC70) from <jats:italic>Aedes aegypti<\/jats:italic>. Based upon some other viruses use of heat shock protein 70 (HSP70) family proteins as cell receptors, its possible HSC70's involvement in the fusion of the JEV E protein with the C6\/36 cells membrane, and known form of cation channels in the interaction of HSC70 with the lipid bilayer, it will further be proposed that HSC70 as a penetration receptor mediates JEV entry into C6\/36 cells.<\/jats:p>","DOI":"10.1186\/1743-422x-4-83","type":"journal-article","created":{"date-parts":[[2007,9,6]],"date-time":"2007-09-06T06:13:17Z","timestamp":1189059197000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Does Japanese encephalitis virus share the same cellular receptor with other mosquito-borne flaviviruses on the C6\/36 mosquito cells?"],"prefix":"10.1186","volume":"4","author":[{"given":"Junping","family":"Ren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianbing","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyu","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2007,9,6]]},"reference":[{"issue":"Suppl 2","key":"296_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0264-410X(00)00037-2","volume":"18","author":"TF Tsai","year":"2000","unstructured":"Tsai TF: New initiatives for the control of Japanese encephalitis by vaccination: minutes of a WHO\/CVI meeting, Bangkok, Thailand, 13\u201315 October 1998. 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