{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T17:46:39Z","timestamp":1759599999916},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2010,9,28]],"date-time":"2010-09-28T00:00:00Z","timestamp":1285632000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Virol J"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1186\/1743-422x-7-256","type":"journal-article","created":{"date-parts":[[2010,9,28]],"date-time":"2010-09-28T18:15:19Z","timestamp":1285697719000},"source":"Crossref","is-referenced-by-count":12,"title":["Progressive multifocal leukoencephalopathy in a patient without apparent immunosuppression"],"prefix":"10.1186","volume":"7","author":[{"given":"Christos","family":"Vaklavas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elsa P","family":"Sotelo-Rafiq","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordan","family":"Lovy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel A","family":"Escobar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Apostolia M","family":"Tsimberidou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,9,28]]},"reference":[{"key":"1001_CR1","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1097\/00019052-200406000-00019","volume":"17","author":"IJ Koralnik","year":"2004","unstructured":"Koralnik IJ: New insights into progressive multifocal leukoencephalopathy. Curr Opin Neurol 2004, 17: 365-370. 10.1097\/00019052-200406000-00019","journal-title":"Curr Opin Neurol"},{"key":"1001_CR2","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1002\/ana.20933","volume":"60","author":"IJ Koralnik","year":"2006","unstructured":"Koralnik IJ: Progressive multifocal leukoencephalopathy revisited: Has the disease outgrown its name? Ann Neurol 2006, 60: 162-173. 10.1002\/ana.20933","journal-title":"Ann Neurol"},{"key":"1001_CR3","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1056\/NEJMoa051586","volume":"353","author":"G Van Assche","year":"2005","unstructured":"Van Assche G, Van Ranst M, Sciot R, Dubois B, Vermeire S, Noman M, Verbeeck J, Geboes K, Robberecht W, Rutgeerts P: Progressive multifocal leukoencephalopathy after natalizumab therapy for Crohn's disease. N Engl J Med 2005, 353: 362-368. 10.1056\/NEJMoa051586","journal-title":"N Engl J Med"},{"key":"1001_CR4","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1056\/NEJMoa051782","volume":"353","author":"BK Kleinschmidt-DeMasters","year":"2005","unstructured":"Kleinschmidt-DeMasters BK, Tyler KL: Progressive multifocal leukoencephalopathy complicating treatment with natalizumab and interferon beta-1a for multiple sclerosis. N Engl J Med 2005, 353: 369-374. 10.1056\/NEJMoa051782","journal-title":"N Engl J Med"},{"key":"1001_CR5","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.semcancer.2009.04.001","volume":"19","author":"T Dalianis","year":"2009","unstructured":"Dalianis T, Ramqvist T, Andreasson K, Kean JM, Garcea RL: KI, WU and Merkel cell polyomaviruses: a new era for human polyomavirus research. Semin Cancer Biol 2009, 19: 270-275. 10.1016\/j.semcancer.2009.04.001","journal-title":"Semin Cancer Biol"},{"key":"1001_CR6","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1093\/brain\/81.1.93","volume":"81","author":"KE Astrom","year":"1958","unstructured":"Astrom KE, Mancall EL, Richardson EP Jr: Progressive multifocal leuko-encephalopathy; a hitherto unrecognized complication of chronic lymphatic leukaemia and Hodgkin's disease. Brain 1958, 81: 93-111. 10.1093\/brain\/81.1.93","journal-title":"Brain"},{"key":"1001_CR7","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1016\/S0140-6736(71)91777-6","volume":"1","author":"BL Padgett","year":"1971","unstructured":"Padgett BL, Walker DL, ZuRhein GM, Eckroade RJ, Dessel BH: Cultivation of papova-like virus from human brain with progressive multifocal leucoencephalopathy. Lancet 1971, 1: 1257-1260. 10.1016\/S0140-6736(71)91777-6","journal-title":"Lancet"},{"key":"1001_CR8","doi-asserted-by":"publisher","first-page":"78","DOI":"10.7326\/0003-4819-107-1-78","volume":"107","author":"JR Berger","year":"1987","unstructured":"Berger JR, Kaszovitz B, Post MJ, Dickinson G: Progressive multifocal leukoencephalopathy associated with human immunodeficiency virus infection. A review of the literature with a report of sixteen cases. Ann Intern Med 1987, 107: 78-87.","journal-title":"Ann Intern Med"},{"key":"1001_CR9","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1086\/598335","volume":"48","author":"N Khanna","year":"2009","unstructured":"Khanna N, Elzi L, Mueller NJ, Garzoni C, Cavassini M, Fux CA, Vernazza P, Bernasconi E, Battegay M, Hirsch HH: Incidence and outcome of progressive multifocal leukoencephalopathy over 20 years of the Swiss HIV Cohort Study. Clin Infect Dis 2009, 48: 1459-1466. 10.1086\/598335","journal-title":"Clin Infect Dis"},{"key":"1001_CR10","doi-asserted-by":"crossref","unstructured":"Gheuens S, Pierone G, Peeters P, Koralnik IJ: Progressive multifocal leukoencephalopathy in individuals with minimal or occult immunosuppression. J Neurol Neurosurg Psychiatry 81: 247-254. 10.1136\/jnnp.2009.187666","DOI":"10.1136\/jnnp.2009.187666"},{"key":"1001_CR11","first-page":"328","volume":"347","author":"IM Rea","year":"1996","unstructured":"Rea IM, Alexander HD, Crockard AD, Morris TC: CD4 lymphopenia in very elderly people. Lancet 1996, 347: 328-329.","journal-title":"Lancet"},{"key":"1001_CR12","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1182\/blood-2007-12-127878","volume":"112","author":"DI Zonios","year":"2008","unstructured":"Zonios DI, Falloon J, Bennett JE, Shaw PA, Chaitt D, Baseler MW, Adelsberger JW, Metcalf JA, Polis MA, Kovacs SJ, et al.: Idiopathic CD4+ lymphocytopenia: natural history and prognostic factors. Blood 2008, 112: 287-294. 10.1182\/blood-2007-12-127878","journal-title":"Blood"},{"key":"1001_CR13","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1056\/NEJM199302113280601","volume":"328","author":"DK Smith","year":"1993","unstructured":"Smith DK, Neal JJ, Holmberg SD: Unexplained opportunistic infections and CD4+ T-lymphocytopenia without HIV infection. An investigation of cases in the United States. The Centers for Disease Control Idiopathic CD4+ T-lymphocytopenia Task Force. N Engl J Med 1993, 328: 373-379. 10.1056\/NEJM199302113280601","journal-title":"N Engl J Med"},{"key":"1001_CR14","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.1099\/vir.0.18842-0","volume":"84","author":"A Stolt","year":"2003","unstructured":"Stolt A, Sasnauskas K, Koskela P, Lehtinen M, Dillner J: Seroepidemiology of the human polyomaviruses. J Gen Virol 2003, 84: 1499-1504. 10.1099\/vir.0.18842-0","journal-title":"J Gen Virol"},{"issue":"Suppl 1","key":"1001_CR15","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1080\/13550280390195388","volume":"9","author":"A Antinori","year":"2003","unstructured":"Antinori A, Cingolani A, Lorenzini P, Giancola ML, Uccella I, Bossolasco S, Grisetti S, Moretti F, Vigo B, Bongiovanni M, et al.: Clinical epidemiology and survival of progressive multifocal leukoencephalopathy in the era of highly active antiretroviral therapy: data from the Italian Registry Investigative Neuro AIDS (IRINA). J Neurovirol 2003,9(Suppl 1):47-53.","journal-title":"J Neurovirol"},{"key":"1001_CR16","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1056\/NEJMoa0810257","volume":"361","author":"W Wenning","year":"2009","unstructured":"Wenning W, Haghikia A, Laubenberger J, Clifford DB, Behrens PF, Chan A, Gold R: Treatment of progressive multifocal leukoencephalopathy associated with natalizumab. N Engl J Med 2009, 361: 1075-1080. 10.1056\/NEJMoa0810257","journal-title":"N Engl J Med"},{"key":"1001_CR17","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1007\/s11940-008-0019-8","volume":"10","author":"AJ Aksamit","year":"2008","unstructured":"Aksamit AJ: Progressive multifocal leukoencephalopathy. Curr Treat Options Neurol 2008, 10: 178-185. 10.1007\/s11940-008-0019-8","journal-title":"Curr Treat Options Neurol"},{"key":"1001_CR18","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1056\/NEJM199805073381903","volume":"338","author":"CD Hall","year":"1998","unstructured":"Hall CD, Dafni U, Simpson D, Clifford D, Wetherill PE, Cohen B, McArthur J, Hollander H, Yainnoutsos C, Major E, et al.: Failure of cytarabine in progressive multifocal leukoencephalopathy associated with human immunodeficiency virus infection. AIDS Clinical Trials Group 243 Team. N Engl J Med 1998, 338: 1345-1351. 10.1056\/NEJM199805073381903","journal-title":"N Engl J Med"},{"key":"1001_CR19","doi-asserted-by":"publisher","first-page":"1759","DOI":"10.1097\/QAD.0b013e32830a5043","volume":"22","author":"A De Luca","year":"2008","unstructured":"De Luca A, Ammassari A, Pezzotti P, Cinque P, Gasnault J, Berenguer J, Di Giambenedetto S, Cingolani A, Taoufik Y, Miralles P, et al.: Cidofovir in addition to antiretroviral treatment is not effective for AIDS-associated progressive multifocal leukoencephalopathy: a multicohort analysis. Aids 2008, 22: 1759-1767. 10.1097\/QAD.0b013e32830a5043","journal-title":"Aids"},{"key":"1001_CR20","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1080\/713831540","volume":"9","author":"W Royal","year":"2003","unstructured":"Royal W, Dupont B, McGuire D, Chang L, Goodkin K, Ernst T, Post MJ, Fish D, Pailloux G, Poncelet H, et al.: Topotecan in the treatment of acquired immunodeficiency syndrome-related progressive multifocal leukoencephalopathy. J Neurovirol 2003, 9: 411-419. 10.1080\/713831540","journal-title":"J Neurovirol"},{"key":"1001_CR21","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1001\/archneurol.2008.557","volume":"66","author":"D Cettomai","year":"2009","unstructured":"Cettomai D, McArthur JC: Mirtazapine use in human immunodeficiency virus-infected patients with progressive multifocal leukoencephalopathy. Arch Neurol 2009, 66: 255-258. 10.1001\/archneurol.2008.557","journal-title":"Arch Neurol"},{"key":"1001_CR22","unstructured":"Study to Explore the Effect of Mefloquine in Subjects With Progressive Multifocal Leukoencephalopathy (PML)[ http:\/\/www.virologyj.com\/content\/7\/1\/256 ] --- Either ISSN or Journal title must be supplied."}],"container-title":["Virology Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1743-422X-7-256.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1743-422X-7-256\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1743-422X-7-256.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T03:49:42Z","timestamp":1559706582000},"score":1,"resource":{"primary":{"URL":"https:\/\/virologyj.biomedcentral.com\/articles\/10.1186\/1743-422X-7-256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9,28]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["1001"],"URL":"https:\/\/doi.org\/10.1186\/1743-422x-7-256","relation":{},"ISSN":["1743-422X"],"issn-type":[{"value":"1743-422X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,9,28]]},"article-number":"256"}}