{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:46:32Z","timestamp":1790664392633,"version":"4.1.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2012,8,27]],"date-time":"2012-08-27T00:00:00Z","timestamp":1346025600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Virol J"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1186\/1743-422x-9-174","type":"journal-article","created":{"date-parts":[[2012,8,28]],"date-time":"2012-08-28T00:14:15Z","timestamp":1346112855000},"source":"Crossref","is-referenced-by-count":65,"title":["The role of lipopolysaccharide as a marker of immune activation in HIV-1 infected patients: a systematic literature review"],"prefix":"10.1186","volume":"9","author":[{"given":"Matteo","family":"Vassallo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Merci\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Cottalorda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Ticchioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Dellamonica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,8,27]]},"reference":[{"key":"1882_CR1","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1097\/QAD.0b013e328339e228","volume":"24","author":"MA Wallet","year":"2010","unstructured":"Wallet MA, Rodriguez CA, Yin L, Saporta S, et al: Microbial translocation induces persistent macrophage activation unrelated to HIV-1 levels or T-cell activation following therapy. AIDS. 2010, 24: 1281-1290. 10.1097\/QAD.0b013e328339e228.","journal-title":"AIDS"},{"key":"1882_CR2","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1038\/nm1511","volume":"12","author":"JM Brenchley","year":"2006","unstructured":"Brenchley JM, Price DA, Schacker TW, Asher TE, et al: Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med. 2006, 12: 1365-1371.","journal-title":"Nat Med"},{"key":"1882_CR3","doi-asserted-by":"publisher","first-page":"6718","DOI":"10.1073\/pnas.0901983106","volume":"106","author":"A Redd","year":"2009","unstructured":"Redd A, Dabitao D, Bream J, Charvat B, et al: Microbial translocation, the innate cytokine response, and HIV-1 disease progression in Africa. Proc Natl Acad Sci USA. 2009, 106: 6718-6723. 10.1073\/pnas.0901983106.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1882_CR4","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1097\/QAD.0b013e3283471d10","volume":"25","author":"G Marchetti","year":"2011","unstructured":"Marchetti G, Cozzi-Lepri A, Merlini E, Bellistri GM, et al: Microbial translocation predicts disease progression of HIV-infected antiretroviral-naive patients with high CD4+ cell count. AIDS. 2011, 25: 1385-1394. 10.1097\/QAD.0b013e3283471d10.","journal-title":"AIDS"},{"key":"1882_CR5","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1086\/651430","volume":"201","author":"S Nowroozalizadeh","year":"2010","unstructured":"Nowroozalizadeh S, Mansson F, da Silva Z, Repits J, et al: Microbial translocation correlates with the severity of both HIV-1 and HIV-2 infections. J Infect Dis. 2010, 201: 1150-1154. 10.1086\/651430.","journal-title":"J Infect Dis"},{"key":"1882_CR6","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.jcv.2009.09.011","volume":"46","author":"S Baroncelli","year":"2009","unstructured":"Baroncelli S, Galluzzo CM, Pirillo M, Mancini MG, et al: Microbial translocation is associated with residual viral replication in HAART-treated HIV+ subjects with < 50 copies\/ml HIV-1 RNA. J Clin Virol. 2009, 46: 367-370. 10.1016\/j.jcv.2009.09.011.","journal-title":"J Clin Virol"},{"key":"1882_CR7","doi-asserted-by":"publisher","first-page":"e2516","DOI":"10.1371\/journal.pone.0002516","volume":"3","author":"P Ancuta","year":"2008","unstructured":"Ancuta P, Kamat A, Kunstman KJ, Kim E, et al: Microbial translocation is associated with increased monocyte activation and dementia in AIDS patients. Plos One. 2008, 3: e2516-10.1371\/journal.pone.0002516.","journal-title":"Plos One"},{"key":"1882_CR8","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1136\/gut.2008.150425","volume":"58","author":"HJ Epple","year":"2009","unstructured":"Epple HJ, Schneider T, Troeger H, Kunkel D, et al: Impairment of the intestinal barrier is evident in untreated but absent in suppressively treated HIV-infected patients. Gut. 2009, 58: 220-227. 10.1136\/gut.2008.150425.","journal-title":"Gut"},{"key":"1882_CR9","doi-asserted-by":"publisher","first-page":"e1001052","DOI":"10.1371\/journal.ppat.1001052","volume":"6","author":"JD Estes","year":"2010","unstructured":"Estes JD, Harris LD, Klatt NR, Tabb B, Pittaluga S, et al: Damaged intestinal epithelial integrity linked to microbial translocation in pathogenic simian immunodeficiency virus infections. Plos Pathogens. 2010, 6: e1001052-10.1371\/journal.ppat.1001052.","journal-title":"Plos Pathogens"},{"key":"1882_CR10","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1086\/597476","volume":"199","author":"W Jiang","year":"2009","unstructured":"Jiang W, Lederman MM, Hunt P, Sieg SF, et al: Plasma levels of bacterial DNA correlate with immune activation and the magnitude of immune restoration in persons with antiretroviral-treated HIV infection. J Infect Dis. 2009, 199: 1177-1185. 10.1086\/597476.","journal-title":"J Infect Dis"},{"key":"1882_CR11","volume-title":"Delayed reduction in CD4 T cell turnover following viral control correlates with markers of microbial trnaslocation in treatment-naive patients receiving RAL-based ART: preliminary results from ACTG A5248","author":"N Funderburg","year":"2011","unstructured":"Funderburg N, Andrade A, Chan E, Lu D, Rosenkranz S, et al: Delayed reduction in CD4 T cell turnover following viral control correlates with markers of microbial trnaslocation in treatment-naive patients receiving RAL-based ART: preliminary results from ACTG A5248. 2011, Boston: 18th Conference on Retroviruses and Opportunistic Infections, February 2011, Boston, Session 28, poster 318"},{"key":"1882_CR12","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1086\/524143","volume":"197","author":"PW Hunt","year":"2008","unstructured":"Hunt PW, Brenchley J, Sinclair E, McCune JM, et al: Relationship between T cell activation and CD4+ T cell count in HIV-seropositive individuals with undetectable plasma HIV RNA levels in the absence of therapy. J Infect Dis. 2008, 197: 126-133. 10.1086\/524143.","journal-title":"J Infect Dis"},{"key":"1882_CR13","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1089\/aid.2010.0107","volume":"27","author":"M L\u00f3pez","year":"2011","unstructured":"L\u00f3pez M, Soriano V, Peris-Pertusa A, Rall\u00f3n N, et al: Elite controllers display higher activation on central memory CD8 T cells than HIV patients successfully on HAART. AIDS Res Hum Retroviruses. 2011, 27: 157-165. 10.1089\/aid.2010.0107.","journal-title":"AIDS Res Hum Retroviruses"},{"key":"1882_CR14","doi-asserted-by":"publisher","first-page":"148","DOI":"10.2174\/157016211795945296","volume":"9","author":"G D\u2019Ettorre","year":"2011","unstructured":"D\u2019Ettorre G, Paiardini M, Zaffiri L, Andreotti M, et al: HIV persistence in the gut mucosa of HIV-infected subjects undergoing antiretroviral therapy correlates with immune activation and increased levels of LPS. Curr HIV Res. 2011, 9: 148-153. 10.2174\/157016211795945296.","journal-title":"Curr HIV Res"},{"key":"1882_CR15","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1093\/infdis\/jiq109","volume":"203","author":"E Cassol","year":"2011","unstructured":"Cassol E, Rossow T, Seebregts C, Cassol S: Microbial translocation: a marker of advanced HIV-1 infection and a predictor of treatment failure?. J Infect Dis. 2011, 203: 747-748. 10.1093\/infdis\/jiq109.","journal-title":"J Infect Dis"},{"key":"1882_CR16","first-page":"728","volume":"142","author":"S Pilakka-Kanthikeel","year":"2011","unstructured":"Pilakka-Kanthikeel S, Huang S, Fenton T, Borkowsky W, et al: Microbial translocation is increased in HIV-infected children on ART and is independent of viral replication and immune activation. 18th Conference on Retroviruses and Opportunistic Infections. 2011, 142: 728-Boston, Session","journal-title":"18th Conference on Retroviruses and Opportunistic Infections"},{"key":"1882_CR17","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1097\/QAD.0b013e32831e9c76","volume":"23","author":"E Papasavvas","year":"2009","unstructured":"Papasavvas E, Pistilli M, Reynolds G, Bucki R, et al: Delayed loss of control of plasma lipopolysaccharide levels after therapy interruption in chronically HIV-1 infected patients. AIDS. 2009, 23: 369-375. 10.1097\/QAD.0b013e32831e9c76.","journal-title":"AIDS"},{"key":"1882_CR18","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1182\/blood.V96.1.218","volume":"96","author":"K Wolk","year":"2000","unstructured":"Wolk K, Docke WD, von Baehr V, Volk HD, Sabat R: Impaired antigen presentation by human monocytes during endotoxin tolerance. Blood. 2000, 96: 218-223.","journal-title":"Blood"},{"key":"1882_CR19","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1111\/j.1365-2249.2005.02934.x","volume":"142","author":"F Porcheray","year":"2005","unstructured":"Porcheray F, Viaud S, Rimaniol AC, Leone C, Samah B, et al: Macrophage activation switching: an asset for the resolution of inflammation. Clin Exp Immunol. 2005, 142: 481-489.","journal-title":"Clin Exp Immunol"},{"key":"1882_CR20","doi-asserted-by":"publisher","first-page":"5760","DOI":"10.4049\/jimmunol.176.10.5760","volume":"176","author":"P Ancuta","year":"2006","unstructured":"Ancuta P, Autissier P, Wurcel A, Zaman T, Stone D, Gabuzda D: CD16+ monocyte-derived macrophages activate resting T cells for HIV infection by producing CCR3 and CCR4 ligands. J Immunol. 2006, 176: 5760-5771.","journal-title":"J Immunol"},{"key":"1882_CR21","doi-asserted-by":"crossref","first-page":"15","DOI":"10.4137\/III.S2011","volume":"1","author":"SM Munsaka","year":"2009","unstructured":"Munsaka SM, Agsalda M, Troelstrup D, Hu N, Yu Q, Shiramizu B: Characteristics of activated monocyte phenotype support R5-tropic human immunodeficiency virus. Immunol Immunogenetics Insights. 2009, 1: 15-20.","journal-title":"Immunol Immunogenetics Insights"},{"key":"1882_CR22","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1097\/QAD.0b013e3283471d10","volume":"25","author":"G Marchetti","year":"2011","unstructured":"Marchetti G, Cozzi-Lepri A, Merlini E, Bellistri GM, Castagna A, et al: Microbial translocation predicts disease progression of HIV-infected antiretroviral naive patients with high CD4+ cell count. AIDS. 2011, 25: 1385-1394. 10.1097\/QAD.0b013e3283471d10.","journal-title":"AIDS"},{"key":"1882_CR23","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1053\/j.gastro.2008.03.022","volume":"135","author":"A Balagopal","year":"2008","unstructured":"Balagopal A, Philp FH, Astemborski J, Block TM, et al: Human immunodeficiency virus-related microbial translocation and progression of hepatitis C. Gastroenterology. 2008, 135: 226-233. 10.1053\/j.gastro.2008.03.022.","journal-title":"Gastroenterology"},{"key":"1882_CR24","volume-title":"Microbial Translocation Is a Determinant of Persisting T Cell Hyperactivation in HIV-infected Patients Failing to Recover CD4 following Long-term HAART","author":"GM Bellistri","year":"2011","unstructured":"Bellistri GM, Pegorer P, Tincati C, Meroni L, et al: Microbial Translocation Is a Determinant of Persisting T Cell Hyperactivation in HIV-infected Patients Failing to Recover CD4 following Long-term HAART. 2011, San Francisco: 17th Conference on Retroviruses and Opportunistic Infections, February 2011, San Francisco, Session 11, poster 377"},{"key":"1882_CR25","volume-title":"Biomarkers of microbial translocation and macrophage activation are associated with progression of atherosclerosis in HIV infection: ACTG NWCS 332\/A5078 study","author":"A Keledis","year":"2012","unstructured":"Keledis A, Yang O, Kendall M, Hodis H, Currier J: Biomarkers of microbial translocation and macrophage activation are associated with progression of atherosclerosis in HIV infection: ACTG NWCS 332\/A5078 study. 2012, Seattle: Conference on Retroviruses and Opportunistic Infections, March 2012, Seattle, Session 36, poster 122"},{"key":"1882_CR26","volume-title":"CD14Dim CD16+ monocytes are proportionally increased in HIV+ infected persons and express increased levels of the procoagulant tissue factor","author":"N Funderburg","year":"2012","unstructured":"Funderburg N, Zidar D, Shive C, Lioi A, Mudd J, et al: CD14Dim CD16+ monocytes are proportionally increased in HIV+ infected persons and express increased levels of the procoagulant tissue factor. 2012, Seattle: 19th Conference on Retroviruses and Opportunistic Infections, March 2012, Seattle, Session 67, poster 321"},{"key":"1882_CR27","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1097\/QAD.0b013e32831e9c76","volume":"23","author":"E Papasavvas","year":"2009","unstructured":"Papasavvas E, Pistilli M, Reynolds G, Bucki R, Azzoni L, et al: Delayed loss of control of plasma lipopolysaccharide levels after therapy interruption in chronically HIV-1-infected patients. AIDS. 2009, 23: 369-375. 10.1097\/QAD.0b013e32831e9c76.","journal-title":"AIDS"},{"key":"1882_CR28","volume-title":"Up-regulation of Th17 cells in HIV+ patients with low CD4 cell count on effective cART","author":"A Bandera","year":"2012","unstructured":"Bandera A, Trabattoni D, Pinnetti C, Muscatello A, Cappelletti E, et al: Up-regulation of Th17 cells in HIV+ patients with low CD4 cell count on effective cART. 2012, Seattle: 19th Conference on Retroviruses and Opportunistic Infections, March 2012, Seattle, Session 68, poster 329"}],"container-title":["Virology Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1743-422X-9-174.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1743-422X-9-174\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1743-422X-9-174.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T17:30:04Z","timestamp":1643304604000},"score":1,"resource":{"primary":{"URL":"https:\/\/virologyj.biomedcentral.com\/articles\/10.1186\/1743-422X-9-174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,27]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["1882"],"URL":"https:\/\/doi.org\/10.1186\/1743-422x-9-174","relation":{},"ISSN":["1743-422X"],"issn-type":[{"value":"1743-422X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,27]]},"article-number":"174"}}