{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T09:25:34Z","timestamp":1775640334058,"version":"3.50.1"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Part Fibre Toxicol"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Particulate air pollution is associated with increased risk of cardiovascular events although the involved mechanisms are poorly understood. The objective of the present study was to investigate the effects of controlled exposure to ambient air fine and ultrafine particles on microvascular function and biomarkers related to inflammation, haemostasis and lipid and protein oxidation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Twenty-nine subjects participated in a randomized, two-factor crossover study with or without biking exercise for 180 minutes and with 24 hour exposure to particle rich (number concentrations, NC: 11600 \u00b1 5600 per cm<jats:sup>3<\/jats:sup>, mass concentrations: 13.8 \u00b1 7.4 \u03bcg\/m<jats:sup>3<\/jats:sup> and 10.5 \u00b1 4.8 \u03bcg\/m<jats:sup>3<\/jats:sup> for PM<jats:sub>10-2.5<\/jats:sub> and PM<jats:sub>2.5<\/jats:sub>, respectively) or particle filtered (NC: 555 \u00b1 1053 per cm<jats:sup>3<\/jats:sup>) air collected above a busy street. Microvascular function was assessed non-invasively by measuring digital peripheral artery tone following arm ischemia. Biomarkers included haemoglobin, red blood cells, platelet count, coagulation factors, C-reactive protein, fibrinogen, interleukin-6, tumour necrosis factor \u03b1, lag time to copper-induced oxidation of plasma lipids and protein oxidation measured as 2-aminoadipic semialdehyde in plasma.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>No statistically significant differences were observed on microvascular function or the biomarkers after exposure to particle rich or particle filtered air.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>This study indicates that exposure to air pollution particles at outdoor concentrations is not associated with detectable systemic inflammation, lipid or protein oxidation, altered haemostasis or microvascular function in young healthy participants.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1743-8977-5-13","type":"journal-article","created":{"date-parts":[[2008,11,5]],"date-time":"2008-11-05T20:28:32Z","timestamp":1225916912000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":77,"title":["Exposure to ambient concentrations of particulate air pollution does not influence vascular function or inflammatory pathways in young healthy individuals"],"prefix":"10.1186","volume":"5","author":[{"given":"Elvira V","family":"Br\u00e4uner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"M\u00f8ller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Barregard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars O","family":"Dragsted","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne","family":"Glasius","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"W\u00e5hlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Vinzents","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ole","family":"Raaschou-Nielsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffen","family":"Loft","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2008,10,6]]},"reference":[{"key":"55_CR1","doi-asserted-by":"crossref","unstructured":"Miller KA, Siscovick DS, Sheppard L, Shepherd K, Sullivan JH, Anderson GL, Kaufman JD: Long-term exposure to air pollution and incidence of cardiovascular events in women. N Engl J Med 356: 447\u2013458. 1\u20132-2007 10.1056\/NEJMoa054409","DOI":"10.1056\/NEJMoa054409"},{"key":"55_CR2","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1080\/08958370500306016","volume":"18","author":"RB Schlesinger","year":"2006","unstructured":"Schlesinger RB, Kunzli N, Hidy GM, Gotschi T, Jerrett M: The health relevance of ambient particulate matter characteristics: coherence of toxicological and epidemiological inferences. Inhal Toxicol 2006, 18: 95\u2013125. 10.1080\/08958370500306016","journal-title":"Inhal Toxicol"},{"key":"55_CR3","doi-asserted-by":"publisher","first-page":"3930","DOI":"10.1161\/CIRCULATIONAHA.105.588962","volume":"112","author":"NL Mills","year":"2005","unstructured":"Mills NL, Tornqvist H, Robinson SD, Gonzalez M, Darnley K, MacNee W, Boon NA, Donaldson K, Blomberg A, Sandstrom T, Newby DE: Diesel exhaust inhalation causes vascular dysfunction and impaired endogenous fibrinolysis. Circulation 2005, 112: 3930\u20133936. 10.1161\/CIRCULATIONAHA.105.588962","journal-title":"Circulation"},{"key":"55_CR4","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1164\/rccm.200606-872OC","volume":"176","author":"H Tornqvist","year":"2007","unstructured":"Tornqvist H, Mills NL, Gonzalez M, Miller MR, Robinson SD, Megson IL, MacNee W, Donaldson K, Soderberg S, Newby DE, Sandstrom T, Blomberg A: Persistent endothelial dysfunction in humans after diesel exhaust inhalation. Am J Respir Crit Care Med 2007, 176: 395\u2013400. 10.1164\/rccm.200606-872OC","journal-title":"Am J Respir Crit Care Med"},{"key":"55_CR5","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1089\/jam.2006.19.74","volume":"19","author":"WG Kreyling","year":"2006","unstructured":"Kreyling WG, Semmler-Behnke M, Moller W: Ultrafine particle-lung interactions: does size matter? J Aerosol Med 2006, 19: 74\u201383. 10.1089\/jam.2006.19.74","journal-title":"J Aerosol Med"},{"key":"55_CR6","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1164\/rccm.200506-865OC","volume":"173","author":"NL Mills","year":"2006","unstructured":"Mills NL, Amin N, Robinson SD, Anand A, Davies J, Patel D, de la Fuente JM, Cassee FR, Boon NA, MacNee W, Millar AM, Donaldson K, Newby DE: Do inhaled carbon nanoparticles translocate directly into the circulation in humans? Am J Respir Crit Care Med 2006, 173: 426\u2013431. 10.1164\/rccm.200506-865OC","journal-title":"Am J Respir Crit Care Med"},{"key":"55_CR7","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1289\/ehp.00108941","volume":"108","author":"F Laden","year":"2000","unstructured":"Laden F, Neas LM, Dockery DW, Schwartz J: Association of fine particulate matter from different sources with daily mortality in six U.S. cities. Environ Health Perspect 2000, 108: 941\u2013947. 10.2307\/3435052","journal-title":"Environ Health Perspect"},{"key":"55_CR8","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.1056\/NEJMoa040203","volume":"351","author":"A Peters","year":"2004","unstructured":"Peters A, von KS, Heier M, Trentinaglia I, Hormann A, Wichmann HE, Lowel H: Exposure to traffic and the onset of myocardial infarction. N Engl J Med 2004, 351: 1721\u20131730. 10.1056\/NEJMoa040203","journal-title":"N Engl J Med"},{"key":"55_CR9","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1016\/S0140-6736(02)11280-3","volume":"360","author":"G Hoek","year":"2002","unstructured":"Hoek G, Brunekreef B, Goldbohm S, Fischer P, Brandt PA: Association between mortality and indicators of traffic-related air pollution in the Netherlands: a cohort study. Lancet 2002, 360: 1203\u20131209. 10.1016\/S0140-6736(02)11280-3","journal-title":"Lancet"},{"key":"55_CR10","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1161\/01.CIR.0000153339.27064.14","volume":"111","author":"A Lerman","year":"2005","unstructured":"Lerman A, Zeiher AM: Endothelial function: cardiac events. Circulation 2005, 111: 363\u2013368. 10.1161\/01.CIR.0000153339.27064.14","journal-title":"Circulation"},{"key":"55_CR11","doi-asserted-by":"publisher","first-page":"1936","DOI":"10.1161\/01.CIR.103.15.1936","volume":"103","author":"DE Newby","year":"2001","unstructured":"Newby DE, McLeod AL, Uren NG, Flint L, Ludlam CA, Webb DJ, Fox KA, Boon NA: Impaired coronary tissue plasminogen activator release is associated with coronary atherosclerosis and cigarette smoking: direct link between endothelial dysfunction and atherothrombosis. Circulation 2001, 103: 1936\u20131941.","journal-title":"Circulation"},{"key":"55_CR12","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1056\/NEJMoa066314","volume":"357","author":"NL Mills","year":"2007","unstructured":"Mills NL, Tornqvist H, Gonzalez MC, Vink E, Robinson SD, Soderberg S, Boon NA, Donaldson K, Sandstrom T, Blomberg A, Newby DE: Ischemic and thrombotic effects of dilute diesel-exhaust inhalation in men with coronary heart disease. N Engl J Med 2007, 357: 1075\u20131082. 10.1056\/NEJMoa066314","journal-title":"N Engl J Med"},{"key":"55_CR13","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1164\/rccm.200704-632OC","volume":"177","author":"EV Br\u00e4uner","year":"2008","unstructured":"Br\u00e4uner EV, Forchhammer L, Moller P, Barregard L, Gunnarsen L, Afshari A, Wahlin P, Glasius M, Dragsted LO, Basu S, Raaschou-Nielsen O, Loft S: Indoor particles affect vascular function in the aged: an air filtration-based intervention study. Am J Respir Crit Care Med 2008, 177: 419\u2013425. 10.1164\/rccm.200704-632OC","journal-title":"Am J Respir Crit Care Med"},{"key":"55_CR14","doi-asserted-by":"publisher","first-page":"2913","DOI":"10.1161\/CIRCULATIONAHA.104.517110","volume":"111","author":"MS O'Neill","year":"2005","unstructured":"O'Neill MS, Veves A, Zanobetti A, Sarnat JA, Gold DR, Economides PA, Horton ES, Schwartz J: Diabetes enhances vulnerability to particulate air pollution-associated impairment in vascular reactivity and endothelial function. Circulation 2005, 111: 2913\u20132920. 10.1161\/CIRCULATIONAHA.104.517110","journal-title":"Circulation"},{"key":"55_CR15","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1007\/s00420-007-0199-7","volume":"81","author":"R Dales","year":"2007","unstructured":"Dales R, Liu L, Szyszkowicz M, Dalipaj M, Willey J, Kulka R, Ruddy TD: Particulate air pollution and vascular reactivity: the bus stop study. Int Arch Occup Environ Health 2007, 81: 159\u2013164. 10.1007\/s00420-007-0199-7","journal-title":"Int Arch Occup Environ Health"},{"key":"55_CR16","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1164\/rccm.200507-1123OC","volume":"173","author":"R Ruckerl","year":"2006","unstructured":"Ruckerl R, Ibald-Mulli A, Koenig W, Schneider A, Woelke G, Cyrys J, Heinrich J, Marder V, Frampton M, Wichmann HE, Peters A: Air pollution and markers of inflammation and coagulation in patients with coronary heart disease. Am J Respir Crit Care Med 2006, 173: 432\u2013441. 10.1164\/rccm.200507-1123OC","journal-title":"Am J Respir Crit Care Med"},{"key":"55_CR17","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1080\/08958370600685798","volume":"18","author":"L Barregard","year":"2006","unstructured":"Barregard L, Sallsten G, Gustafson P, Andersson L, Johansson L, Basu S, Stigendal L: Experimental exposure to wood-smoke particles in healthy humans: effects on markers of inflammation, coagulation, and lipid peroxidation. Inhal Toxicol 2006, 18: 845\u2013853. 10.1080\/08958370600685798","journal-title":"Inhal Toxicol"},{"key":"55_CR18","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1016\/S0140-6736(97)01211-7","volume":"349","author":"A Peters","year":"1997","unstructured":"Peters A, Doring A, Wichmann HE, Koenig W: Increased plasma viscosity during an air pollution episode: a link to mortality? Lancet 1997, 349: 1582\u20131587. 10.1016\/S0140-6736(97)01211-7","journal-title":"Lancet"},{"issue":"Suppl 3","key":"55_CR19","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1289\/ehp.01109s3405","volume":"109","author":"J Schwartz","year":"2001","unstructured":"Schwartz J: Air pollution and blood markers of cardiovascular risk. Environ Health Perspect 2001, 109(Suppl 3):405\u2013409. 10.2307\/3434788","journal-title":"Environ Health Perspect"},{"key":"55_CR20","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.1080\/08958370390249111","volume":"15","author":"AJ Ghio","year":"2003","unstructured":"Ghio AJ, Hall A, Bassett MA, Cascio WE, Devlin RB: Exposure to concentrated ambient air particles alters hematologic indices in humans. Inhal Toxicol 2003, 15: 1465\u20131478. 10.1080\/08958370390249111","journal-title":"Inhal Toxicol"},{"key":"55_CR21","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1164\/ajrccm.159.3.9709083","volume":"159","author":"S Salvi","year":"1999","unstructured":"Salvi S, Blomberg A, Rudell B, Kelly F, Sandstrom T, Holgate ST, Frew A: Acute inflammatory responses in the airways and peripheral blood after short-term exposure to diesel exhaust in healthy human volunteers. Am J Respir Crit Care Med 1999, 159: 702\u2013709.","journal-title":"Am J Respir Crit Care Med"},{"key":"55_CR22","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1164\/ajrccm.161.2.9905052","volume":"161","author":"SS Salvi","year":"2000","unstructured":"Salvi SS, Nordenhall C, Blomberg A, Rudell B, Pourazar J, Kelly FJ, Wilson S, Sandstrom T, Holgate ST, Frew AJ: Acute exposure to diesel exhaust increases IL-8 and GRO-alpha production in healthy human airways. Am J Respir Crit Care Med 2000, 161: 550\u2013557.","journal-title":"Am J Respir Crit Care Med"},{"key":"55_CR23","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1289\/ehp.7962","volume":"114","author":"MW Frampton","year":"2006","unstructured":"Frampton MW, Stewart JC, Oberdorster G, Morrow PE, Chalupa D, Pietropaoli AP, Frasier LM, Speers DM, Cox C, Huang LS, Utell MJ: Inhalation of ultrafine particles alters blood leukocyte expression of adhesion molecules in humans. Environ Health Perspect 2006, 114: 51\u201358.","journal-title":"Environ Health Perspect"},{"key":"55_CR24","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1136\/oem.2006.030023","volume":"64","author":"MS O'Neill","year":"2007","unstructured":"O'Neill MS, Veves A, Sarnat JA, Zanobetti A, Gold DR, Economides PA, Horton ES, Schwartz J: Air pollution and inflammation in type 2 diabetes: a mechanism for susceptibility. Occup Environ Med 2007, 64: 373\u2013379. 10.1136\/oem.2006.030023","journal-title":"Occup Environ Med"},{"key":"55_CR25","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.mrrev.2003.06.010","volume":"544","author":"M S\u00f8rensen","year":"2003","unstructured":"S\u00f8rensen M, Autrup H, M\u00f8ller P, Hertel O, Jensen SS, Vinzents P, Knudsen LE, Loft S: Linking exposure to environmental pollutants with biological effects. Mutat Res 2003, 544: 255\u2013271. 10.1016\/j.mrrev.2003.06.010","journal-title":"Mutat Res"},{"key":"55_CR26","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1289\/ehp.7001","volume":"112","author":"TR Nurkiewicz","year":"2004","unstructured":"Nurkiewicz TR, Porter DW, Barger M, Castranova V, Boegehold MA: Particulate matter exposure impairs systemic microvascular endothelium-dependent dilation. Environ Health Perspect 2004, 112: 1299\u20131306.","journal-title":"Environ Health Perspect"},{"key":"55_CR27","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1289\/ehp.8413","volume":"114","author":"TR Nurkiewicz","year":"2006","unstructured":"Nurkiewicz TR, Porter DW, Barger M, Millecchia L, Rao KM, Marvar PJ, Hubbs AF, Castranova V, Boegehold MA: Systemic microvascular dysfunction and inflammation after pulmonary particulate matter exposure. Environ Health Perspect 2006, 114: 412\u2013419.","journal-title":"Environ Health Perspect"},{"key":"55_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1743-8977-5-1","volume":"5","author":"TR Nurkiewicz","year":"2008","unstructured":"Nurkiewicz TR, Porter DW, Hubbs AF, Cumpston JL, Chen BT, Frazer DG, Castranova V: Nanoparticle inhalation augments particle-dependent systemic microvascular dysfunction. Part Fibre Toxicol 2008, 5: 1. 10.1186\/1743-8977-5-1","journal-title":"Part Fibre Toxicol"},{"key":"55_CR29","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1289\/ehp.9984","volume":"115","author":"EV Br\u00e4uner","year":"2007","unstructured":"Br\u00e4uner EV, Forchhammer L, Moller P, Simonsen J, Glasius M, Wahlin P, Raaschou-Nielsen O, Loft S: Exposure to ultrafine particles from ambient air and oxidative stress-induced DNA damage. Environ Health Perspect 2007, 115: 1177\u20131182.","journal-title":"Environ Health Perspect"},{"key":"55_CR30","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1080\/08958370304468","volume":"15","author":"CC Daigle","year":"2003","unstructured":"Daigle CC, Chalupa DC, Gibb FR, Morrow PE, Oberdorster G, Utell MJ, Frampton MW: Ultrafine particle deposition in humans during rest and exercise. Inhal Toxicol 2003, 15: 539\u2013552. 10.1080\/08958370304468","journal-title":"Inhal Toxicol"},{"key":"55_CR31","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1111\/j.1538-7836.2007.02300.x","volume":"5","author":"A Baccarelli","year":"2007","unstructured":"Baccarelli A, Zanobetti A, Martinelli I, Grillo P, Hou L, Giacomini S, Bonzini M, Lanzani G, Mannucci PM, Bertazzi PA, Schwartz J: Effects of exposure to air pollution on blood coagulation. J Thromb Haemost 2007, 5: 252\u2013260. 10.1111\/j.1538-7836.2007.02300.x","journal-title":"J Thromb Haemost"},{"key":"55_CR32","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1164\/rccm.200310-1463OC","volume":"169","author":"M Riediker","year":"2004","unstructured":"Riediker M, Cascio WE, Griggs TR, Herbst MC, Bromberg PA, Neas L, Williams RW, Devlin RB: Particulate matter exposure in cars is associated with cardiovascular effects in healthy young men. Am J Respir Crit Care Med 2004, 169: 934\u2013940. 10.1164\/rccm.200310-1463OC","journal-title":"Am J Respir Crit Care Med"},{"key":"55_CR33","doi-asserted-by":"publisher","first-page":"2103","DOI":"10.1111\/j.1538-7836.2005.01559.x","volume":"3","author":"A Blomberg","year":"2005","unstructured":"Blomberg A, Tornqvist H, Desmyter L, Deneys V, Hermans C: Exposure to diesel exhaust nanoparticles does not induce blood hypercoagulability in an at-risk population. J Thromb Haemost 2005, 3: 2103\u20132105. 10.1111\/j.1538-7836.2005.01559.x","journal-title":"J Thromb Haemost"},{"key":"55_CR34","volume-title":"Inhal Toxicol","author":"EV Br\u00e4uner","year":"2008","unstructured":"Br\u00e4uner EV, Mortensen J, Moller P, Bernard A, Vinzents P, Wahlin P, Glasius M, Loft S: Effects of Ambient Air Particulate Exposure on Blood-Gas Barrier Permeability and Lung Function. Inhal Toxicol 2008., 1:"},{"key":"55_CR35","doi-asserted-by":"publisher","first-page":"3243","DOI":"10.1161\/01.CIR.0000075928.54461.33","volume":"107","author":"JT Kuvin","year":"2003","unstructured":"Kuvin JT, Karas RH: Clinical utility of endothelial function testing: ready for prime time? Circulation 2003, 107: 3243\u20133247. 10.1161\/01.CIR.0000075928.54461.33","journal-title":"Circulation"},{"key":"55_CR36","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/S0002-8703(03)00094-2","volume":"146","author":"JT Kuvin","year":"2003","unstructured":"Kuvin JT, Patel AR, Sliney KA, Pandian NG, Sheffy J, Schnall RP, Karas RH, Udelson JE: Assessment of peripheral vascular endothelial function with finger arterial pulse wave amplitude. Am Heart J 2003, 146: 168\u2013174. 10.1016\/S0002-8703(03)00094-2","journal-title":"Am Heart J"},{"key":"55_CR37","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1016\/S0735-1097(03)00329-2","volume":"41","author":"PO Bonetti","year":"2003","unstructured":"Bonetti PO, Barsness GW, Keelan PC, Schnell TI, Pumper GM, Kuvin JT, Schnall RP, Holmes DR, Higano ST, Lerman A: Enhanced external counterpulsation improves endothelial function in patients with symptomatic coronary artery disease. J Am Coll Cardiol 2003, 41: 1761\u20131768. 10.1016\/S0735-1097(03)00329-2","journal-title":"J Am Coll Cardiol"},{"key":"55_CR38","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1080\/135475097231841","volume":"2","author":"B Daneshvar","year":"1997","unstructured":"Daneshvar B, Dragsted LO, Frandsen H, Autrup H: \u03b3-Glutamyl semialdehyde and 2-amino adipic semialdehyde: Biomarkers of oxidative damage to proteins. Biomarkers 1997, 2: 117\u2013123. 10.1080\/135475097231841","journal-title":"Biomarkers"},{"key":"55_CR39","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1079\/BJN2002523","volume":"87","author":"JF Young","year":"2002","unstructured":"Young JF, Dragsted LO, Haraldsdottir J, Daneshvar B, Kall MA, Loft S, Nilsson L, Nielsen SE, Mayer B, Hyunh-Ba T, Hermetter A, Sandstrom B: Green tea extract only affects markers of oxidative status postprandially: lasting antioxidant effect of flavonoid-free diet. Br J Nutr 2002, 87: 343\u2013355. 10.1079\/BJN2002523","journal-title":"Br J Nutr"},{"key":"55_CR40","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1161\/01.CIR.0000025404.78001.D8","volume":"106","author":"JP Halcox","year":"2002","unstructured":"Halcox JP, Schenke WH, Zalos G, Mincemoyer R, Prasad A, Waclawiw MA, Nour KR, Quyyumi AA: Prognostic value of coronary vascular endothelial dysfunction. Circulation 2002, 106: 653\u2013658. 10.1161\/01.CIR.0000025404.78001.D8","journal-title":"Circulation"},{"issue":"Suppl 9","key":"55_CR41","first-page":"IX\/70","volume":"89","author":"V Schachinger","year":"2000","unstructured":"Schachinger V, Zeiher AM: Atherosclerosis-associated endothelial dysfunction. Z Kardiol 2000, 89(Suppl 9):IX\/70-IX\/74.","journal-title":"Z Kardiol"},{"key":"55_CR42","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1016\/S0735-1097(03)00994-X","volume":"42","author":"ME Widlansky","year":"2003","unstructured":"Widlansky ME, Gokce N, Keaney JF Jr, Vita JA: The clinical implications of endothelial dysfunction. J Am Coll Cardiol 2003, 42: 1149\u20131160. 10.1016\/S0735-1097(03)00994-X","journal-title":"J Am Coll Cardiol"},{"key":"55_CR43","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.1111\/j.1538-7836.2005.01370.x","volume":"3","author":"R Stocker","year":"2005","unstructured":"Stocker R, Keaney JF Jr: New insights on oxidative stress in the artery wall. J Thromb Haemost 2005, 3: 1825\u20131834. 10.1111\/j.1538-7836.2005.01370.x","journal-title":"J Thromb Haemost"},{"key":"55_CR44","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.taap.2006.10.032","volume":"219","author":"CS Hansen","year":"2007","unstructured":"Hansen CS, Sheykhzade M, Moller P, Folkmann JK, Amtorp O, Jonassen T, Loft S: Diesel exhaust particles induce endothelial dysfunction in apoE-\/- mice. Toxicol Appl Pharmacol 2007, 219: 24\u201332. 10.1016\/j.taap.2006.10.032","journal-title":"Toxicol Appl Pharmacol"},{"key":"55_CR45","doi-asserted-by":"publisher","first-page":"2137","DOI":"10.1016\/j.jacc.2004.08.062","volume":"44","author":"PO Bonetti","year":"2004","unstructured":"Bonetti PO, Pumper GM, Higano ST, Holmes DR Jr, Kuvin JT, Lerman A: Noninvasive identification of patients with early coronary atherosclerosis by assessment of digital reactive hyperemia. J Am Coll Cardiol 2004, 44: 2137\u20132141. 10.1016\/j.jacc.2004.08.062","journal-title":"J Am Coll Cardiol"},{"key":"55_CR46","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1177\/1358863X06076227","volume":"12","author":"JT Kuvin","year":"2007","unstructured":"Kuvin JT, Mammen A, Mooney P, sheikh-Ali AA, Karas RH: Assessment of peripheral vascular endothelial function in the ambulatory setting. Vasc Med 2007, 12: 13\u201316. 10.1177\/1358863X06076227","journal-title":"Vasc Med"},{"key":"55_CR47","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1152\/japplphysiol.01285.2005","volume":"101","author":"A Nohria","year":"2006","unstructured":"Nohria A, Gerhard-Herman M, Creager MA, Hurley S, Mitra D, Ganz P: Role of nitric oxide in the regulation of digital pulse volume amplitude in humans. J Appl Physiol 2006, 101: 545\u2013548. 10.1152\/japplphysiol.01285.2005","journal-title":"J Appl Physiol"},{"key":"55_CR48","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1183\/09031936.06.00010905","volume":"27","author":"D Yinon","year":"2006","unstructured":"Yinon D, Lowenstein L, Suraya S, Beloosesky R, Zmora O, Malhotra A, Pillar G: Pre-eclampsia is associated with sleep-disordered breathing and endothelial dysfunction. Eur Respir J 2006, 27: 328\u2013333. 10.1183\/09031936.06.00010905","journal-title":"Eur Respir J"},{"key":"55_CR49","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1093\/sleep\/28.5.594","volume":"28","author":"S Itzhaki","year":"2005","unstructured":"Itzhaki S, Lavie L, Pillar G, Tal G, Lavie P: Endothelial dysfunction in obstructive sleep apnea measured by peripheral arterial tone response in the finger to reactive hyperemia. Sleep 2005, 28: 594\u2013600.","journal-title":"Sleep"},{"key":"55_CR50","doi-asserted-by":"publisher","first-page":"2281","DOI":"10.1097\/00004872-200312000-00016","volume":"21","author":"ND Fisher","year":"2003","unstructured":"Fisher ND, Hughes M, Gerhard-Herman M, Hollenberg NK: Flavanol-rich cocoa induces nitric-oxide-dependent vasodilation in healthy humans. J Hypertens 2003, 21: 2281\u20132286. 10.1097\/00004872-200312000-00016","journal-title":"J Hypertens"},{"key":"55_CR51","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1289\/ehp.7562","volume":"113","author":"P Vinzents","year":"2005","unstructured":"Vinzents P, M\u00f8ller P, S\u00f8rensen M, Knudsen LE, Hertel O, Schibye B, Loft S: Personal exposure to ultrafine particles and oxidative DNA damage. Environ Health Perspect 2005, 113: 1485\u20131490.","journal-title":"Environ Health Perspect"},{"key":"55_CR52","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1289\/ehp.5646","volume":"111","author":"M S\u00f8rensen","year":"2003","unstructured":"S\u00f8rensen M, Dragsted LO, Hertel O, Knudsen LE, Loft S: Personal PM2.5exposure and markers of oxidative stress in blood. Environ Health Perspect 2003, 111: 161\u2013166.","journal-title":"Environ Health Perspect"},{"key":"55_CR53","first-page":"191","volume":"12","author":"M S\u00f8rensen","year":"2003","unstructured":"S\u00f8rensen M, Autrup H, Hertel O, Wallin H, Knudsen LE, Loft S: Personal exposure to PM2.5in an urban environment and biomarkers of genotoxicity. Cancer Epidemiol Biomarkers Prev 2003, 12: 191\u2013196.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"55_CR54","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1161\/01.CIR.0000053568.13058.67","volume":"107","author":"A Nemmar","year":"2003","unstructured":"Nemmar A, Hoet PH, Dinsdale D, Vermylen J, Hoylaerts MF, Nemery B: Diesel exhaust particles in lung acutely enhance experimental peripheral thrombosis. Circulation 2003, 107: 1202\u20131208. 10.1161\/01.CIR.0000053568.13058.67","journal-title":"Circulation"},{"key":"55_CR55","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.1161\/01.CIR.0000013838.94747.64","volume":"105","author":"RD Brook","year":"2002","unstructured":"Brook RD, Brook JR, Urch B, Vincent R, Rajagopalan S, Silverman F: Inhalation of fine particulate air pollution and ozone causes acute arterial vasoconstriction in healthy adults. Circulation 2002, 105: 1534\u20131536. 10.1161\/01.CIR.0000013838.94747.64","journal-title":"Circulation"},{"key":"55_CR56","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1289\/ehp.7939","volume":"113","author":"C Sioutas","year":"2005","unstructured":"Sioutas C, Delfino RJ, Singh M: Exposure assessment for atmospheric ultrafine particles (UFPs) and implications in epidemiologic research. Environ Health Perspect 2005, 113: 947\u2013955.","journal-title":"Environ Health Perspect"}],"container-title":["Particle and Fibre Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1743-8977-5-13.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T23:42:29Z","timestamp":1630453349000},"score":1,"resource":{"primary":{"URL":"https:\/\/particleandfibretoxicology.biomedcentral.com\/articles\/10.1186\/1743-8977-5-13"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10,6]]},"references-count":56,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["55"],"URL":"https:\/\/doi.org\/10.1186\/1743-8977-5-13","relation":{},"ISSN":["1743-8977"],"issn-type":[{"value":"1743-8977","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10,6]]},"assertion":[{"value":"31 May 2008","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 October 2008","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 October 2008","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"13"}}