{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:43:47Z","timestamp":1791290627416,"version":"4.3.0"},"reference-count":48,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mol Pain"],"published-print":{"date-parts":[[2014,1,1]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> Fibromyalgia (FM) is conceptualized as a central sensitization (CS) condition, that presents high serum brain-derived neurotrophic factor (BDNF) and neuroglia activation. Although the S100B protein regulates neuroglia functions, it has been traditionally used as a proxy of central nervous system damage. However, neither BDNF nor S100B association with the clinical picture of FM has been elucidated. To explore their association with the pressure-pain threshold (PPT) in FM, we performed a cross-sectional study, including 56 females with confirmed FM aged 18\u201365 years. Linear regression models were used to adjust for potential confounding factors between serum BDNF, S100B and PPT. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> Serum BDNF and S100B were correlated (Spearman's Rho = 0.29). Serum BDNF ( log) and S100B ( log) were correlated with the PPT ( log) (Partial \u03b7<jats:sup>2<\/jats:sup> = 0.129, P = 0.012 for the BDNF ( log), and Partial \u03b7<jats:sup>2<\/jats:sup> = 0.105, P = 0.025 for the S100B ( log)). Serum BDNF ( log) was inversely associated with PPT ( log) (\u03b2 = \u22121.01, SE = 0.41), age (\u03b2 = \u22120.02, SE = 0.15) and obsessive compulsive disorder (\u03b2 = \u22120.36, SE = 0.15), while serum S100B ( log) was inversely associated with PPT ( log) (\u03b2 = \u22121.38, SE = 0.50), only. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p> Both neuroglia key mediators in the CS process were inversely correlated with the PPT. Serum assessment of BDNF and S100B deserve further study to determine its potential as a proxy for the CS spectrum in FM. <\/jats:p><\/jats:sec>","DOI":"10.1186\/1744-8069-10-46","type":"journal-article","created":{"date-parts":[[2014,7,8]],"date-time":"2014-07-08T15:02:52Z","timestamp":1404831772000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":58,"title":["Higher Serum S100B and BDNF Levels are Correlated with a Lower Pressure-Pain Threshold in Fibromyalgia"],"prefix":"10.1177","volume":"10","author":[{"given":"Simone Azevedo","family":"Zanette","sequence":"first","affiliation":[{"name":"Physical Medicine and Rehabilitation Service at Hospital de Cl\u00ednicas de Porto Alegre (HCPA), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil"},{"name":"Post Graduate Program in Medical Sciences, UFRGS, Porto Alegre, Brazil"},{"name":"Laboratory of Pain & Neuromodulation, HCPA\/UFRGS, Porto Alegre, 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