{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T08:07:06Z","timestamp":1792829226722,"version":"4.5.0"},"reference-count":41,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Pain"],"published-print":{"date-parts":[[2007,1,1]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> Clinical and experimental studies of neuropathic pain support the hypothesis that a functional coupling between postganglionic sympathetic efferent and sensory afferent fibers contributes to the pain. We investigated whether neuropathic pain-related behavior in the spared nerve injury (SNI) rat model is dependent on the sympathetic nervous system. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> Permanent chemical sympathectomy was achieved by daily injection of guanethidine (50 mg\/kg s.c.) from age P8 to P21. SNI was performed at adulthood followed by 11 weeks of mechanical and thermal hypersensitivity testing. A significant but limited effect of the sympathectomy on SNI-induced pain sensitivity was observed. The effect was delayed and restricted to cold allodynia-like behavior: SNI-related cold scores were lower in the sympathectomized group compared to the control group at 8 and 11 weeks after the nerve injury but not before. Mechanical hypersensitivity tests (pinprick and von Frey hair threshold tests) showed no difference between groups during the study period. Concomitantly, pericellular tyrosine-hydroxylase immunoreactive basket structures were observed around dorsal root ganglia (DRG) neurons 8 weeks after SNI, but were absent at earlier time points after SNI and in sham operated controls. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> These results suggest that the early establishment of neuropathic pain-related behavior after distal nerve injury such as in the SNI model is mechanistically independent of the sympathetic system, whereas the system contributes to the maintenance, albeit after a delay of many weeks, of response to cold-related stimuli. <\/jats:p><\/jats:sec>","DOI":"10.1186\/1744-8069-3-21","type":"journal-article","created":{"date-parts":[[2007,8,2]],"date-time":"2007-08-02T18:16:58Z","timestamp":1186078618000},"source":"Crossref","is-referenced-by-count":52,"title":["Delayed Sympathetic Dependence in the Spared Nerve Injury (SNI) Model of Neuropathic Pain"],"prefix":"10.1177","volume":"3","author":[{"given":"Marie","family":"Pertin","sequence":"first","affiliation":[{"name":"Anesthesiology Pain Research Unit, Department of Anesthesiology, University Hospital Center and University of Lausanne, BH 10-CHUV, CH-1011 Lausanne, Switzerland"},{"name":"Department of Cell Biology and Morphology, Faculty of Biology and Medicine, University of Lausanne, Bugnon 9, CH-1005 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J","family":"Allchorne","sequence":"additional","affiliation":[{"name":"Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown MA 02921, USA"},{"name":"Centre for Neuroscience Research, Division of Veterinary Biomedical Sciences Royal (Dick) School of Veterinary Studies University of Edinburgh Summerhall, Edinburgh EH9 1QH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed T","family":"Beggah","sequence":"additional","affiliation":[{"name":"Anesthesiology Pain Research Unit, Department of Anesthesiology, University Hospital Center and University of Lausanne, BH 10-CHUV, CH-1011 Lausanne, Switzerland"},{"name":"Department of Cell Biology and Morphology, Faculty of Biology and Medicine, University of Lausanne, Bugnon 9, CH-1005 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clifford J","family":"Woolf","sequence":"additional","affiliation":[{"name":"Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown MA 02921, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Decosterd","sequence":"additional","affiliation":[{"name":"Anesthesiology Pain Research Unit, Department of Anesthesiology, University Hospital Center and 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