{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T23:51:11Z","timestamp":1790985071592,"version":"4.1.0"},"reference-count":18,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Pain"],"published-print":{"date-parts":[[2008,1,1]]},"abstract":"<jats:p> Lysophosphatidic acid receptor subtype LPA<jats:sub>1<\/jats:sub> is crucial for the initiation of neuropathic pain and underlying changes, such as up-regulation of Ca<jats:sup>2<\/jats:sup>+ channel \u03b1<jats:sub>2<\/jats:sub>\u03b4-1 subunit in dorsal root ganglia (DRG), up-regulation of PKC\u03b3 in the spinal dorsal horn, and demyelination of dorsal root fibers. In the present study, we further examined the involvement of LPA<jats:sub>1<\/jats:sub> signaling in the reorganization of A\u03b2-fiber-mediated spinal transmission, which is presumed to underlie neuropathic allodynia. Following nerve injury, the phosphorylation of extracellular-signal regulated kinase (pERK) by A\u03b2-fiber stimulation was observed in the superficial layer of spinal dorsal horn, where nociceptive C-or A\u03b4-fibers are innervated, but not in sham-operated wild-type mice. However, the pERK signals were largely abolished in LPA<jats:sub>1<\/jats:sub> receptor knock-out ( Lpar1<jats:sup>-\/-<\/jats:sup>) mice, further supported by quantitative analyses of pERK-positive cells. These results suggest that LPA<jats:sub>1<\/jats:sub> receptor-mediated signaling mechanisms also participate in functional cross-talk between A\u03b2- and C- or A\u03b4-fibers. <\/jats:p>","DOI":"10.1186\/1744-8069-4-46","type":"journal-article","created":{"date-parts":[[2008,10,15]],"date-time":"2008-10-15T06:13:03Z","timestamp":1224051183000},"source":"Crossref","is-referenced-by-count":29,"title":["Involvement of LPA<sub>1<\/sub> Receptor Signaling in the Reorganization of Spinal Input through Abeta-Fibers in Mice with Partial Sciatic Nerve Injury"],"prefix":"10.1177","volume":"4","author":[{"given":"Weijiao","family":"Xie","sequence":"first","affiliation":[{"name":"Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852\u20138521, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misaki","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852\u20138521, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerold","family":"Chun","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Helen L. Dorris Neuropsychiatric Disease Institute, The Scripps Research Institute, 10550 North Torrey Pines Road, ICND118, La Jolla, CA 92037, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Ueda","sequence":"additional","affiliation":[{"name":"Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852\u20138521, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2008,1,1]]},"reference":[{"key":"bibr1-1744-8069-4-46","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/87.1.12"},{"key":"bibr2-1744-8069-4-46","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2005.06.003"},{"key":"bibr3-1744-8069-4-46","doi-asserted-by":"publisher","DOI":"10.1038\/355075a0"},{"key":"bibr4-1744-8069-4-46","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.0241g.x"},{"issue":"1","key":"bibr5-1744-8069-4-46","first-page":"11","volume":"4","author":"Ueda H","year":"2008","journal-title":"Molecular Pain"},{"key":"bibr6-1744-8069-4-46","doi-asserted-by":"publisher","DOI":"10.1038\/16040"},{"key":"bibr7-1744-8069-4-46","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-17-07737.2002"},{"key":"bibr8-1744-8069-4-46","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-4-25"},{"key":"bibr9-1744-8069-4-46","doi-asserted-by":"publisher","DOI":"10.1111\/j.0953-816X.2004.03203.x"},{"key":"bibr10-1744-8069-4-46","doi-asserted-by":"publisher","DOI":"10.1038\/nm1060"},{"key":"bibr11-1744-8069-4-46","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-4-6"},{"key":"bibr12-1744-8069-4-46","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2007.12.041"},{"key":"bibr13-1744-8069-4-46","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.24.13384"},{"key":"bibr14-1744-8069-4-46","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(83)90201-4"},{"key":"bibr15-1744-8069-4-46","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(94)90438-3"},{"key":"bibr16-1744-8069-4-46","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.06.001"},{"key":"bibr17-1744-8069-4-46","doi-asserted-by":"publisher","DOI":"10.1016\/B0-443-07287-6\/50009-6"},{"key":"bibr18-1744-8069-4-46","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2003.12.005"}],"container-title":["Molecular Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1186\/1744-8069-4-46","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1186\/1744-8069-4-46","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1186\/1744-8069-4-46","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T18:26:27Z","timestamp":1741631187000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1186\/1744-8069-4-46"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1,1]]},"references-count":18,"alternative-id":["10.1186\/1744-8069-4-46"],"URL":"https:\/\/doi.org\/10.1186\/1744-8069-4-46","relation":{},"ISSN":["1744-8069","1744-8069"],"issn-type":[{"value":"1744-8069","type":"print"},{"value":"1744-8069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1,1]]},"article-number":"1744-8069-4-46"}}