{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T08:21:38Z","timestamp":1790410898819,"version":"4.1.0"},"reference-count":115,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Pain"],"published-print":{"date-parts":[[2009,1,1]]},"abstract":"<jats:p> In this review, evidence is presented to support the hypothesis that mechanosensory transduction occurs in tubes and sacs and can initiate visceral pain. Experimental evidence for this mechanism in urinary bladder, ureter, gut, lung, uterus, tooth-pulp and tongue is reviewed. Potential therapeutic strategies are considered for the treatment of visceral pain in such conditions as renal colic, interstitial cystitis and inflammatory bowel disease by agents that interfere with mechanosensory transduction in the organs considered, including P2X<jats:sub>3<\/jats:sub> and P2X<jats:sub>2\/3<\/jats:sub> receptor antagonists that are orally bioavailable and stable in vivo and agents that inhibit or enhance ATP release and breakdown. <\/jats:p>","DOI":"10.1186\/1744-8069-5-69","type":"journal-article","created":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T07:15:32Z","timestamp":1259651732000},"source":"Crossref","is-referenced-by-count":100,"title":["Purinergic Mechanosensory Transduction and Visceral Pain"],"prefix":"10.1177","volume":"5","author":[{"given":"Geoffrey","family":"Burnstock","sequence":"first","affiliation":[{"name":"Autonomic Neuroscience Centre, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2009,1,1]]},"reference":[{"key":"bibr1-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2005.06.006"},{"key":"bibr2-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2008.02.095"},{"key":"bibr3-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1038\/377428a0"},{"key":"bibr4-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1038\/377432a0"},{"key":"bibr5-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-7580.1999.19430335.x"},{"key":"bibr6-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1997.503bb.x"},{"key":"bibr7-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.1999.00310.x"},{"key":"bibr8-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1038\/35039519"},{"key":"bibr9-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.088435"},{"key":"bibr10-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-15-05670.2001"},{"key":"bibr11-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(03)00243-4"},{"key":"bibr12-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01049.2007"},{"key":"bibr13-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2001.013469"},{"key":"bibr14-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1159\/000092049"},{"key":"bibr15-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2006.06200.x"},{"key":"bibr16-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706604"},{"key":"bibr17-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00056.2003"},{"key":"bibr18-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2007.01.039"},{"key":"bibr19-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2009.05.253"},{"key":"bibr20-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)64631-9"},{"key":"bibr21-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2003.12.017"},{"key":"bibr22-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2003.10.037"},{"key":"bibr23-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705790"},{"key":"bibr24-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1038\/nn902"},{"key":"bibr25-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.139147"},{"key":"bibr26-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.140244"},{"key":"bibr27-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.172577"},{"key":"bibr28-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2007.07251.x"},{"key":"bibr29-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00211.2007"},{"key":"bibr30-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2005.04.021"},{"key":"bibr31-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(82)90056-2"},{"key":"bibr32-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)67618-5"},{"key":"bibr33-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2004.08.003"},{"key":"bibr34-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00293.2000"},{"key":"bibr35-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1007\/s11302-008-9123-1"},{"key":"bibr36-1744-8069-5-69","first-page":"5","volume":"184","author":"Risholm L","year":"1954","journal-title":"Acta Chir Scand"},{"key":"bibr37-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1159\/000100830"},{"key":"bibr38-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-56921-0_6"},{"key":"bibr39-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(00)01643-6"},{"key":"bibr40-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastro.2003.07.008"},{"key":"bibr41-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.2170\/jjphysiol.50.235"},{"key":"bibr42-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M307603200"},{"key":"bibr43-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(99)00253-8"},{"key":"bibr44-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1007\/s11302-005-5305-2"},{"key":"bibr45-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-005-4936-8"},{"key":"bibr46-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2008.12.004"},{"key":"bibr47-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00440.2006"},{"key":"bibr48-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2008.159731"},{"key":"bibr49-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3791-08.2009"},{"key":"bibr50-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.03.143"},{"key":"bibr51-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.020206"},{"key":"bibr52-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.089714"},{"key":"bibr53-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00785.2001"},{"key":"bibr54-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2000.00403.x"},{"key":"bibr55-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.079574"},{"key":"bibr56-1744-8069-5-69","first-page":"A252","volume":"130","author":"Ru F","year":"2006","journal-title":"Gastroenterology"},{"key":"bibr57-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1023\/A:1021017524660"},{"key":"bibr58-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(80)90031-7"},{"key":"bibr59-1744-8069-5-69","first-page":"43","volume":"18","author":"Cooke HJ","year":"2003","journal-title":"News Physiol Sci"},{"key":"bibr60-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.02453"},{"key":"bibr61-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7696(07)64004-2"},{"key":"bibr62-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-12-04767.2002"},{"key":"bibr63-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-002-0404-4"},{"key":"bibr64-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1016\/S1566-0702(02)00179-0"},{"key":"bibr65-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.044172"},{"key":"bibr66-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.047944"},{"key":"bibr67-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00020.2004"},{"key":"bibr68-1744-8069-5-69","unstructured":"Shinoda M, Feng B, Gebhart GF: Peripheral and central P2X3 receptor contributions to colon mechanosensitivity and hypersensitivity in the mouse. Gastroenterology in press."},{"key":"bibr69-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.2001.280.5.G787"},{"key":"bibr70-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.8.2.107"},{"key":"bibr71-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2007.134221"},{"key":"bibr72-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1097\/01.anes.0000286982.36342.3f"},{"key":"bibr73-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2007.127886"},{"key":"bibr74-1744-8069-5-69","first-page":"A133","volume":"130","author":"Banerjee B","year":"2006","journal-title":"Gastroenterology"},{"key":"bibr75-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2006.02.006"},{"key":"bibr76-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1097\/01.TA.0000078882.11919.AF"},{"key":"bibr77-1744-8069-5-69","first-page":"80","volume":"14","author":"Brouns I","year":"2003","journal-title":"Biomedical Research"},{"key":"bibr78-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.042028"},{"key":"bibr79-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.086181"},{"key":"bibr80-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2004.01.010"},{"key":"bibr81-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.10209"},{"key":"bibr82-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-005-1114-8"},{"key":"bibr83-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1038\/387505a0"},{"key":"bibr84-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1177\/00220345010800021501"},{"key":"bibr85-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2002.128973"},{"key":"bibr86-1744-8069-5-69","first-page":"245","volume":"17","author":"Renton T","year":"2003","journal-title":"J Orofac Pain"},{"key":"bibr87-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2002.88.4.1614"},{"key":"bibr88-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199904060-00037"},{"key":"bibr89-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2000.00891.x"},{"key":"bibr90-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-004-0647-3"},{"key":"bibr91-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1126\/science.1118435"},{"key":"bibr92-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2005.08.013"},{"key":"bibr93-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-006-0070-9"},{"key":"bibr94-1744-8069-5-69","doi-asserted-by":"crossref","unstructured":"Gever JR, Rothschild S, Henningsen R, Martin R, Hackos D, Panicker S, Milla ME, Oglesby I, Dillon MP, Burnstock G, Ford APDW: RO-4, a novel, potent orally bioavailable P2X3\/P2X2\/3 antagonist. Br J Pharmacol 2009 in press.","DOI":"10.1111\/j.1476-5381.2010.00796.x"},{"key":"bibr95-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2009.02.003"},{"key":"bibr96-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2009.01.097"},{"key":"bibr97-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704591"},{"key":"bibr98-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2003.09.070"},{"key":"bibr99-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-18-08139.2002"},{"key":"bibr100-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(01)00434-1"},{"key":"bibr101-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(03)00105-4"},{"key":"bibr102-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(03)03365-1"},{"key":"bibr103-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkg322"},{"key":"bibr104-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gnh044"},{"key":"bibr105-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(96)80060-2"},{"key":"bibr106-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bja.a013473"},{"key":"bibr107-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-003-0579-3"},{"key":"bibr108-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4019-03.2004"},{"key":"bibr109-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.111025298"},{"key":"bibr110-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2004.12.009"},{"key":"bibr111-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-006-0094-1"},{"key":"bibr112-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1124\/mol.106.022665"},{"key":"bibr113-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.252537299"},{"key":"bibr114-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00043.2006"},{"key":"bibr115-1744-8069-5-69","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.1093"}],"container-title":["Molecular Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1186\/1744-8069-5-69","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1186\/1744-8069-5-69","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1186\/1744-8069-5-69","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T22:43:57Z","timestamp":1741646637000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1186\/1744-8069-5-69"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1,1]]},"references-count":115,"alternative-id":["10.1186\/1744-8069-5-69"],"URL":"https:\/\/doi.org\/10.1186\/1744-8069-5-69","relation":{},"ISSN":["1744-8069","1744-8069"],"issn-type":[{"value":"1744-8069","type":"print"},{"value":"1744-8069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1,1]]},"article-number":"1744-8069-5-69"}}