{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T01:28:16Z","timestamp":1782955696973,"version":"3.54.5"},"reference-count":48,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Pain"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The dynorphin-kappa opioid receptor (KOR) system regulates glial proliferation after sciatic nerve injury. Here, we investigated its role in cell proliferation following partial ligation of infraorbital nerve (pIONL), a model for trigeminal neuropathic pain. Mechanical allodynia was enhanced in KOR gene deleted mice (KOR\u2212\/\u2212) compared to wild type mice. Using bromodeoxyuridine (BrdU) as a mitotic marker, we assessed cell proliferation in three different areas of the trigeminal afferent pathway: trigeminal nucleus principalis (Vp), trigeminal root entry zone (TREZ), and trigeminal ganglion (TG).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"results\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In KOR\u2212\/\u2212 mice or norBNI-treated mice, the number of proliferating cells in the Vp was significantly less than in WT mice, whereas cell proliferation was enhanced in TREZ and TG. The majority of the proliferating cells were nestin positive stem cells or CD11b positive microglia in the Vp and macrophages in the TG. GFAP-positive astrocytes made a clear borderline between the CNS and the PNS in TREZ, and phosphorylated KOR staining (KOR-p) was detectable only in the astrocytes in CNS in WT mice but not in KOR\u2212\/\u2212 or norBNI-treated mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"conclusions\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>These results show that kappa opioid receptor system has different effects after pIONL in CNS and PNS: KOR activation promotes CNS astrocytosis and microglial or stem cell proliferation but inhibits macrophage proliferation in PNS. The trigeminal central root has a key role in the etiology and treatment of trigeminal neuralgia, and these newly identified responses may provide new targets for developing pain therapies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/1744-8069-6-8","type":"journal-article","created":{"date-parts":[[2010,1,29]],"date-time":"2010-01-29T02:14:46Z","timestamp":1264731286000},"source":"Crossref","is-referenced-by-count":39,"title":["Trigeminal Injury Causes kappa Opioid-Dependent Allodynic, Glial and Immune Cell Responses in Mice"],"prefix":"10.1177","volume":"6","author":[{"given":"Megumi","family":"Aita","sequence":"first","affiliation":[{"name":"Department of Pharmacology, University of Washington, Seattle, WA 98195-7280, USA"},{"name":"Department of Anesthesiology, University of Washington, Seattle, WA 98195-7280, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret R","family":"Byers","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, University of Washington, Seattle, WA 98195-7280, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Chavkin","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Washington, Seattle, WA 98195-7280, USA"},{"name":"Department of Anesthesiology, University of Washington, Seattle, WA 98195-7280, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Washington, Seattle, WA 98195-7280, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,1]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1586\/14737175.7.11.1565"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2008.06.006"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5552-03.2004"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2006.06.001"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1977.47.3.0321"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1999.90.1.0001"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ajp.0000120790.69705.5b"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.01.033"},{"key":"e_1_3_4_10_2","first-page":"1295","article-title":"Gamma knife radiosurgery for trigeminal neuralgia","volume":"56","author":"McNatt SA","year":"2005","unstructured":"McNatt SA, Gonzalez-Gomez I, Nelson MD, McComb JG: Gamma knife radiosurgery for trigeminal neuralgia. 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