{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T07:49:52Z","timestamp":1791100192290,"version":"4.1.0"},"reference-count":70,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Pain"],"published-print":{"date-parts":[[2010,1,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>In order to evaluate the neural mechanisms underlying the abnormal facial pain that may develop following regeneration of the injured inferior alveolar nerve (IAN), the properties of the IAN innervated in the mental region were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Fluorogold (FG) injection into the mental region 14 days after IAN transection showed massive labeling of trigeminal ganglion (TG). The escape threshold to mechanical stimulation of the mental skin was significantly lower (i.e. mechanical allodynia) at 11\u201314 days after IAN transection than before surgery. The background activity, mechanically evoked responses and afterdischarges of IAN A\u03b4-fibers were significantly higher in IAN-transected rats than naive. The small\/medium diameter TG neurons showed an increase in both tetrodotoxin (TTX)-resistant (TTX-R) and -sensitive (TTX-S) sodium currents ( I\n                      <jats:sub>Na<\/jats:sub>\n                      ) and decrease in total potassium current, transient current ( I\n                      <jats:sub>A<\/jats:sub>\n                      ) and sustained current ( I\n                      <jats:sub>K<\/jats:sub>\n                      ) in IAN-transected rats. The amplitude, overshoot amplitude and number of action potentials evoked by the depolarizing pulses after 1 \u03bcM TTX administration in TG neurons were significantly higher, whereas the threshold current to elicit spikes was smaller in IAN-transected rats than naive. Resting membrane potential was significantly smaller in IAN-transected rats than that of naive.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      These data suggest that the increase in both TTX-S I\n                      <jats:sub>Na<\/jats:sub>\n                      and TTX-R I\n                      <jats:sub>Na<\/jats:sub>\n                      and the decrease in I\n                      <jats:sub>A<\/jats:sub>\n                      and I\n                      <jats:sub>k<\/jats:sub>\n                      in small\/medium TG neurons in IAN-transected rats are involved in the activation of spike generation, resulting in hyperexcitability of A\u03b4-IAN fibers innervating the mental region after IAN transection.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/1744-8069-6-9","type":"journal-article","created":{"date-parts":[[2010,2,26]],"date-time":"2010-02-26T14:16:00Z","timestamp":1267193760000},"source":"Crossref","is-referenced-by-count":46,"title":["Alteration of Primary Afferent Activity following Inferior Alveolar Nerve Transection in Rats"],"prefix":"10.1177","volume":"6","author":[{"given":"Kazuharu","family":"Nakagawa","sequence":"first","affiliation":[{"name":"Department of Dysphagia Rehabilitation, Nihon University School of Dentistry, 1-8-13 Kanda-Surugadai, Chiyoda-ku, Tokyo, 101-8310, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamoru","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Dentistry at Tokyo, Nippon Dental University, 1-9-20 Fujimi-cho, Chiyoda-ku, Tokyo, 102-8159, 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J","family":"Sessle","sequence":"additional","affiliation":[{"name":"Department of Oral Physiology, Faculty of Dentistry, University of Toronto, 124 Edward Street, Toronto, Ontario, M5G 1G6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masamichi","family":"Shinoda","sequence":"additional","affiliation":[{"name":"Department of Physiology, Nihon University School of Dentistry, 1-8-13 Kanda-Surugadai, Chiyoda-ku, Tokyo, 101-8310, Japan"},{"name":"Division of Functional Morphology, Dental Research Center, Nihon University School of Dentistry, 1-8-13 Kanda-Surugadai, Chiyoda-ku, Tokyo, 101-8310, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Iwata","sequence":"additional","affiliation":[{"name":"Department of Physiology, Nihon University School of Dentistry, 1-8-13 Kanda-Surugadai, Chiyoda-ku, Tokyo, 101-8310, Japan"},{"name":"Division of Functional Morphology, Dental Research Center, Nihon University School of Dentistry, 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