{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:52:35Z","timestamp":1792651955500,"version":"4.5.0"},"reference-count":63,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mol Pain"],"published-print":{"date-parts":[[2011,1,1]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> Voltage-gated sodium channel Na<jats:sub>v<\/jats:sub>1.7 is preferentially expressed in dorsal root ganglion (DRG) and sympathetic neurons within the peripheral nervous system. Homozygous or compound heterozygous loss-of-function mutations in SCN9A, the gene which encodes Na<jats:sub>v<\/jats:sub>1.7, cause congenital insensitivity to pain (CIP) accompanied by anosmia. Global knock-out of Na<jats:sub>v<\/jats:sub>1.7 in mice is neonatal lethal reportedly from starvation, suggesting anosmia. These findings led us to hypothesize that Na<jats:sub>v<\/jats:sub>1.7 is the main sodium channel in the peripheral olfactory sensory neurons (OSN, also known as olfactory receptor neurons). <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> We used multiplex PCR-restriction enzyme polymorphism, in situ hybridization and immunohistochemistry to determine the identity of sodium channels in rodent OSNs. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> We show here that Na<jats:sub>v<\/jats:sub>1.7 is the predominant sodium channel transcript, with low abundance of other sodium channel transcripts, in olfactory epithelium from rat and mouse. Our in situ hybridization data show that Na<jats:sub>v<\/jats:sub>1.7 transcripts are present in rat OSNs. Immunostaining of Na<jats:sub>v<\/jats:sub>1.7 and Na<jats:sub>v<\/jats:sub>1.6 channels in rat shows a complementary accumulation pattern with Na<jats:sub>v<\/jats:sub>1.7 in peripheral presynaptic OSN axons, and Na<jats:sub>v<\/jats:sub>1.6 primarily in postsynaptic cells and their dendrites in the glomeruli of the olfactory bulb within the central nervous system. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p> Our data show that Na<jats:sub>v<\/jats:sub>1.7 is the dominant sodium channel in rat and mouse OSN, and may explain anosmia in Na<jats:sub>v<\/jats:sub>1.7 null mouse and patients with Na<jats:sub>v<\/jats:sub>1.7-related CIP. <\/jats:p><\/jats:sec>","DOI":"10.1186\/1744-8069-7-32","type":"journal-article","created":{"date-parts":[[2011,5,11]],"date-time":"2011-05-11T18:22:17Z","timestamp":1305138137000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":60,"title":["Na<sub>v<\/sub>1.7 is the Predominant Sodium Channel in Rodent Olfactory Sensory Neurons"],"prefix":"10.1177","volume":"7","author":[{"given":"Hye-Sook","family":"Ahn","sequence":"first","affiliation":[{"name":"Department of Neurology, Yale University School of Medicine, 333 Cedar Street, New Haven, 06520, USA"},{"name":"Center for Neuroscience and Regeneration Research, Yale University School of Medicine, 333 Cedar Street, New Haven, 06520, USA"},{"name":"Rehabilitation Research Center, Veterans Administration Connecticut Healthcare System, 950 Campbell Avenue, West Haven, Connecticut, 06516, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel A","family":"Black","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yale University School of Medicine, 333 Cedar Street, New Haven, 06520, USA"},{"name":"Center for Neuroscience and Regeneration Research, Yale University School of Medicine, 333 Cedar Street, New Haven, 06520, USA"},{"name":"Rehabilitation Research Center, Veterans Administration Connecticut Healthcare System, 950 Campbell Avenue, West Haven, Connecticut, 06516, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yale University School of Medicine, 333 Cedar Street, New Haven, 06520, USA"},{"name":"Center for Neuroscience and Regeneration Research, Yale University School of Medicine, 333 Cedar Street, New Haven, 06520, USA"},{"name":"Rehabilitation Research Center, Veterans Administration Connecticut Healthcare System, 950 Campbell Avenue, West Haven, Connecticut, 06516, 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