{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:50:32Z","timestamp":1753883432785,"version":"3.41.2"},"reference-count":22,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mol Pain"],"published-print":{"date-parts":[[2013,1,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p> Antagonists of N-type voltage-gated calcium channels (VGCC), Ca<jats:sub>v<\/jats:sub>2.2, can manage severe chronic pain with intrathecal use and may be effective systemically. A series of novel \u03c9-conotoxins that selectively inhibit N-type VGCCs was isolated from Conus catus. In the present study, the potency and reversibility of \u03c9-conotoxins CVID, CVIE and CVIF to inhibit N-type calcium currents were investigated in mouse isolated dorsal root ganglion (DRG) neurons. The systemic potency of each \u03c9-conotoxin to reverse signs of mouse chronic inflammatory pain was also compared. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> In DRG neurons, the rank order of potency to inhibit N-type calcium currents was CVIE &gt; CVIF &gt; CVID. After subcutaneous administration, CVID and CVIE, but not CVIF, partially reversed impaired weight bearing in mice injected with Freund's complete adjuvant (CFA) three days prior to testing. No side-effects associated with systemic administration of \u03c9-conotoxins were observed. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> The present study indicates a potential for CVID and CVIE to be developed as systemically active analgesics with no accompanying neurological side-effects. <\/jats:p><\/jats:sec>","DOI":"10.1186\/1744-8069-9-51","type":"journal-article","created":{"date-parts":[[2013,10,20]],"date-time":"2013-10-20T17:01:54Z","timestamp":1382288514000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Novel \u03c9-Conotoxins from <i>C. Catus<\/i> Reverse Signs of Mouse Inflammatory Pain after Systemic Administration"],"prefix":"10.1177","volume":"9","author":[{"given":"Mahsa","family":"Sadeghi","sequence":"first","affiliation":[{"name":"Discipline of Pharmacology, University of Sydney, Sydney, NSW 2006, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swetha S","family":"Murali","sequence":"additional","affiliation":[{"name":"Discipline of Pharmacology, University of Sydney, Sydney, NSW 2006, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J","family":"Lewis","sequence":"additional","affiliation":[{"name":"Institute for Molecular Bioscience, University of Queensland, St Lucia, QLD 4072, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul F","family":"Alewood","sequence":"additional","affiliation":[{"name":"Institute for Molecular Bioscience, University of Queensland, St Lucia, QLD 4072, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarasa","family":"Mohammadi","sequence":"additional","affiliation":[{"name":"Discipline of Pharmacology, University of Sydney, Sydney, NSW 2006, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MacDonald J","family":"Christie","sequence":"additional","affiliation":[{"name":"Discipline of Pharmacology, University of Sydney, Sydney, NSW 2006, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,1,1]]},"reference":[{"key":"bibr1-1744-8069-9-51","doi-asserted-by":"publisher","DOI":"10.1124\/pr.111.005322"},{"key":"bibr2-1744-8069-9-51","doi-asserted-by":"publisher","DOI":"10.1592\/phco.2005.25.8.1084"},{"key":"bibr3-1744-8069-9-51","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.1.63"},{"key":"bibr4-1744-8069-9-51","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2005.10.003"},{"key":"bibr5-1744-8069-9-51","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(01)00436-5"},{"key":"bibr6-1744-8069-9-51","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(02)02247-1"},{"key":"bibr7-1744-8069-9-51","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12251"},{"key":"bibr8-1744-8069-9-51","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4637.2009.00741.x"},{"key":"bibr9-1744-8069-9-51","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199010000-00022"},{"key":"bibr10-1744-8069-9-51","doi-asserted-by":"publisher","DOI":"10.1602\/neurorx.2.4.662"},{"key":"bibr11-1744-8069-9-51","doi-asserted-by":"publisher","DOI":"10.2174\/157340606778250216"},{"key":"bibr12-1744-8069-9-51","doi-asserted-by":"publisher","DOI":"10.1124\/mol.109.058834"},{"key":"bibr13-1744-8069-9-51","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2006.05299.x"},{"key":"bibr14-1744-8069-9-51","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2008.06.049"},{"key":"bibr15-1744-8069-9-51","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.t01-1-00035.x"},{"key":"bibr16-1744-8069-9-51","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-01-00171.2000"},{"key":"bibr17-1744-8069-9-51","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M002252200"},{"key":"bibr18-1744-8069-9-51","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2009.08.001"},{"key":"bibr19-1744-8069-9-51","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.9.9.1575"},{"key":"bibr20-1744-8069-9-51","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M310848200"},{"key":"bibr21-1744-8069-9-51","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.228429"},{"key":"bibr22-1744-8069-9-51","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(01)00454-7"}],"container-title":["Molecular Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1186\/1744-8069-9-51","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1186\/1744-8069-9-51","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1186\/1744-8069-9-51","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T00:44:49Z","timestamp":1741653889000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1186\/1744-8069-9-51"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,1]]},"references-count":22,"alternative-id":["10.1186\/1744-8069-9-51"],"URL":"https:\/\/doi.org\/10.1186\/1744-8069-9-51","relation":{},"ISSN":["1744-8069","1744-8069"],"issn-type":[{"type":"print","value":"1744-8069"},{"type":"electronic","value":"1744-8069"}],"subject":[],"published":{"date-parts":[[2013,1,1]]},"article-number":"1744-8069-9-51"}}