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In a previous study, a Finnish group demonstrated that\n                      <jats:italic>DISC1<\/jats:italic>\n                      polymorphisms were associated with autism and Asperger syndrome. However, the results were not replicated in Korean population. To determine whether\n                      <jats:italic>DISC1<\/jats:italic>\n                      is associated with autism in Chinese Han population, we performed a family-based association study between\n                      <jats:italic>DISC1<\/jats:italic>\n                      polymorphisms and autism.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We genotyped seven tag single nucleotide polymorphisms (SNPs) in\n                      <jats:italic>DISC1<\/jats:italic>\n                      , spanning 338 kb, in 367 autism trios (singleton and their biological parents) including 1,101 individuals. Single SNP association and haplotype association analysis were performed using the family-based association test (FBAT) and Haploview software.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We found three SNPs showed significant associations with autism (rs4366301: G &gt; C, Z = 2.872,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.004; rs11585959: T &gt; C, Z = 2.199,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.028; rs6668845: A &gt; G, Z = 2.326,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.02). After the Bonferroni correction, SNP rs4366301, which located in the first intron of\n                      <jats:italic>DISC1<\/jats:italic>\n                      , remained significant. When haplotype were constructed with two-markers, three haplotypes displayed significant association with autism. These results were still significant after using the permutation method to obtain empirical\n                      <jats:italic>p<\/jats:italic>\n                      values.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Our study provided evidence that the\n                      <jats:italic>DISC1<\/jats:italic>\n                      may be the susceptibility gene of autism. It suggested\n                      <jats:italic>DISC1<\/jats:italic>\n                      might play a role in the pathogenesis of autism.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/1744-9081-7-14","type":"journal-article","created":{"date-parts":[[2011,5,17]],"date-time":"2011-05-17T14:14:45Z","timestamp":1305641685000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Evidence for association between Disrupted-in-schizophrenia 1 (DISC1) gene polymorphisms and autism in Chinese Han population: a family-based association study"],"prefix":"10.1186","volume":"7","author":[{"given":"Fanfan","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meixiang","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihua","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianlan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,5,15]]},"reference":[{"key":"331_CR1","volume-title":"The Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV)","author":"American Psychiatric Association","year":"1994","unstructured":"American Psychiatric Association: The Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV). 1994, Washington, DC: American Psychiatric Publishing Inc"},{"key":"331_CR2","first-page":"217","volume":"2","author":"L Kanner","year":"1943","unstructured":"Kanner L: autistic disturbances of affective contact. 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