{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T05:22:09Z","timestamp":1773292929993,"version":"3.50.1"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2012,5,23]],"date-time":"2012-05-23T00:00:00Z","timestamp":1337731200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Trials"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Resuscitation at birth with 100% oxygen is known to increase the oxidative burden with concomitant deleterious effects. Although fractions of inspired oxygen (FiO<jats:sub>2<\/jats:sub>)\u2009&lt;\u2009100% are widely used in preterm infants, starting resuscitation at a (too) low FiO<jats:sub>2<\/jats:sub> may result in hypoxia. The objective of this study is to compare the safety and efficacy of resuscitating very preterm infants with an initial FiO<jats:sub>2<\/jats:sub> of 30% versus 65%.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\/design<\/jats:title>\n            <jats:p>In this double-blind, randomized controlled trial, 200 very preterm infants with a gestational age\u2009&lt;\u200932 weeks will be randomized to start resuscitation after birth with either 30% or 65% oxygen. The FiO<jats:sub>2<\/jats:sub> will be adjusted based on oxygen saturation measured by pulse oximetry (SpO<jats:sub>2<\/jats:sub>) and pulse rate (which should be over 100 beats per minute) in order to achieve a target SpO<jats:sub>2<\/jats:sub> of 88\u201394% at 10 min of life. The FiO<jats:sub>2<\/jats:sub> and pulse oximetry data will be continuously recorded.<\/jats:p>\n            <jats:p>The primary outcome is survival without bronchopulmonary dysplasia, as assessed by a physiological test at 36 weeks postmenstrual age. The secondary outcomes include the time to achieve SpO<jats:sub>2<\/jats:sub>\u2009&gt;\u200988%, Apgar score at 5 min, cumulative O<jats:sub>2<\/jats:sub> exposure, oxidative stress (as determined by glutathione synthesis and oxidative stress markers), retinopathy of prematurity, brain injury and neurodevelopmental outcome at 2 years of age.<\/jats:p>\n            <jats:p>This study will provide insight into determining the appropriate initial FiO<jats:sub>2<\/jats:sub> to start resuscitation of very preterm infants.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Trial registration<\/jats:title>\n            <jats:p>\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.trialregister.nl\" ext-link-type=\"uri\">http:\/\/www.trialregister.nl<\/jats:ext-link>, NTR243.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1745-6215-13-65","type":"journal-article","created":{"date-parts":[[2012,5,31]],"date-time":"2012-05-31T17:15:24Z","timestamp":1338484524000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Resuscitation of very preterm infants with 30% vs. 65% oxygen at birth: study protocol for a randomized controlled trial"],"prefix":"10.1186","volume":"13","author":[{"given":"Denise","family":"Rook","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henk","family":"Schierbeek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne C","family":"van der Eijk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariangela","family":"Longini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Buonocore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maximo","family":"Vento","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes B","family":"van Goudoever","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marijn J","family":"Vermeulen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,5,23]]},"reference":[{"key":"1014_CR1","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1159\/000143397","volume":"94","author":"OD Saugstad","year":"2008","unstructured":"Saugstad OD, Ramji S, Soll RF, Vento M: Resuscitation of Newborn Infants with 21 % or 100 % Oxygen: An Updated Systematic Review and Meta-Analysis. 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