{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:20:48Z","timestamp":1791328848565,"version":"4.3.1"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trials"],"published-print":{"date-parts":[[2013]]},"DOI":"10.1186\/1745-6215-14-91","type":"journal-article","created":{"date-parts":[[2013,4,2]],"date-time":"2013-04-02T06:14:27Z","timestamp":1364883267000},"page":"91","source":"Crossref","is-referenced-by-count":33,"title":["A pilot study of the effect of spironolactone therapy on exercise capacity and endothelial dysfunction in pulmonary arterial hypertension: study protocol for a randomized controlled trial"],"prefix":"10.1186","volume":"14","author":[{"given":"Jason M","family":"Elinoff","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Rame","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul R","family":"Forfia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary K","family":"Hall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfeng","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed M","family":"Gharib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled","family":"Abd-Elmoniem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Graninger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonnie","family":"Harper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L","family":"Danner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A","family":"Solomon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"10.1186\/1745-6215-14-91-B2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-1140"},{"key":"10.1186\/1745-6215-14-91-B3","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-115-5-343"},{"key":"10.1186\/1745-6215-14-91-B4","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-121-6-199409150-00003"},{"key":"10.1186\/1745-6215-14-91-B5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199207093270209"},{"key":"10.1186\/1745-6215-14-91-B6","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000102381.57477.50"},{"key":"10.1186\/1745-6215-14-91-B10","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201201-0164OC"},{"key":"10.1186\/1745-6215-14-91-B11","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-1758"},{"key":"10.1186\/1745-6215-14-91-B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.06.068"},{"key":"-","doi-asserted-by":"publisher","DOI":"10.2217\/whe.09.88"},{"key":"10.1186\/1745-6215-14-91-B14","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0b013e3181f9ea8d"},{"key":"10.1186\/1745-6215-14-91-B15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199909023411001"},{"key":"10.1186\/1745-6215-14-91-B16","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa030207"},{"key":"10.1186\/1745-6215-14-91-B17","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2003.02249.x"},{"key":"10.1186\/1745-6215-14-91-B19","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.6.594"},{"key":"10.1186\/1745-6215-14-91-B20","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2003.017368"},{"key":"10.1186\/1745-6215-14-91-B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.03.015"},{"key":"10.1186\/1745-6215-14-91-B22","doi-asserted-by":"publisher","DOI":"10.1080\/03009740802279709"},{"key":"10.1186\/1745-6215-14-91-B23","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-10-0709"},{"key":"10.1186\/1745-6215-14-91-B24","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-006-0286-3"},{"key":"10.1186\/1745-6215-14-91-B26","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.094722"},{"key":"10.1186\/1745-6215-14-91-B27","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.00007109"},{"key":"-","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.284.6329.1607"},{"key":"10.1186\/1745-6215-14-91-B36","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000022687.18568.2A"},{"key":"10.1186\/1745-6215-14-91-B37","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201004-0601OC"},{"key":"10.1186\/1745-6215-14-91-B38","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200604-547OC"},{"key":"10.1186\/1745-6215-14-91-B39","doi-asserted-by":"publisher","DOI":"10.1378\/chest.127.5.1836"},{"key":"10.1186\/1745-6215-14-91-B40","doi-asserted-by":"publisher","DOI":"10.1093\/ejechocard\/jep152"},{"key":"10.1186\/1745-6215-14-91-B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.02.060"},{"key":"10.1186\/1745-6215-14-91-B42","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21267"},{"key":"10.1186\/1745-6215-14-91-B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2008.03.008"},{"key":"10.1186\/1745-6215-14-91-B44","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00327-4"},{"key":"10.1186\/1745-6215-14-91-B45","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)90854-0"},{"key":"10.1186\/1745-6215-14-91-B46","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(98)00702-4"},{"key":"10.1186\/1745-6215-14-91-B47","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000060460.52916.D6"},{"key":"10.1186\/1745-6215-14-91-B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.09.057"},{"key":"10.1186\/1745-6215-14-91-B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.06.036"},{"key":"10.1186\/1745-6215-14-91-B50","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.111.969691"},{"key":"10.1186\/1745-6215-14-91-B51","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00010409"},{"key":"10.1186\/1745-6215-14-91-B52","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200312-1686OC"},{"key":"10.1186\/1745-6215-14-91-B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2007.12.010"},{"key":"10.1186\/1745-6215-14-91-B54","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012106"},{"key":"10.1186\/1745-6215-14-91-B56","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.88.6.555"},{"key":"10.1186\/1745-6215-14-91-B57","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00254.2009"},{"key":"10.1186\/1745-6215-14-91-B58","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200605-128JG"},{"key":"10.1186\/1745-6215-14-91-B59","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.080542"},{"key":"10.1186\/1745-6215-14-91-B60","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.080424"},{"key":"10.1186\/1745-6215-14-91-B61","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-149-8-200810210-00004"},{"key":"10.1186\/1745-6215-14-91-B62","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00107108"},{"key":"10.1186\/1745-6215-14-91-B63","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq152"},{"key":"10.1186\/1745-6215-14-91-B64","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02164-2"},{"key":"10.1186\/1745-6215-14-91-B65","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.026591"},{"key":"10.1186\/1745-6215-14-91-B67","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-85-5-630"},{"key":"10.1186\/1745-6215-14-91-B71","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-69-4-685"},{"key":"10.1186\/1745-6215-14-91-B73","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910220212"},{"key":"10.1186\/1745-6215-14-91-B74","doi-asserted-by":"publisher","DOI":"10.1016\/0720-048X(91)90049-2"},{"key":"10.1186\/1745-6215-14-91-B77","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2431062144"}],"container-title":["Trials"],"original-title":[],"language":"en","deposited":{"date-parts":[[2016,5,16]],"date-time":"2016-05-16T15:34:31Z","timestamp":1463412871000},"score":1,"resource":{"primary":{"URL":"http:\/\/trialsjournal.biomedcentral.com\/articles\/10.1186\/1745-6215-14-91"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":56,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013]]}},"alternative-id":["1745-6215-14-91"],"URL":"https:\/\/doi.org\/10.1186\/1745-6215-14-91","relation":{},"ISSN":["1745-6215"],"issn-type":[{"value":"1745-6215","type":"print"}],"subject":[],"published":{"date-parts":[[2013]]}}}