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HRCT findings in 15 workers (24.2%) were characterized by ill-defined centrilobular nodular opacities. Workers with ill-defined centrilobular nodular opacities had a lower vital capacity than workers who had no such HRCT-findings (90.9 % pred. vs. 101.8 % pred., p = 0.01). Biological monitoring in plasma and urine revealed higher internal exposure to Al in affected workers (33.5 \u03bcg\/l plasma to 15.4 \u03bcg\/l plasma, p = 0.01) and (340.5 \u03bcg\/g creat. to 135.1 \u03bcg\/g creat., p = 0.007). Years of exposure and concentration of aluminum in urine and plasma appear to be the best predictors for HRCT findings. Age and decreased vital capacity show borderline significance.<\/jats:p>\n          <jats:p>We conclude that aluminosis is still relevant in occupational medicine. With HRCT it is possible to detect early stages of aluminosis and biological monitoring can be used to define workers at high risk.<\/jats:p>","DOI":"10.1186\/1745-6673-1-4","type":"journal-article","created":{"date-parts":[[2006,2,24]],"date-time":"2006-02-24T07:30:30Z","timestamp":1140766230000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Aluminosis \u2013 Detection of an almost forgotten disease with HRCT"],"prefix":"10.1186","volume":"1","author":[{"given":"Thomas","family":"Kraus","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl Heinz","family":"Schaller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Angerer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf-Dieter","family":"Hilgers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Letzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2006,2,17]]},"reference":[{"key":"4_CR1","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1136\/oem.53.1.32","volume":"53","author":"B Sj\u00f6gren","year":"1996","unstructured":"Sj\u00f6gren B, Iregren A, Frech W, et al.: Effects on the nervous system among welders exposed to aluminium and manganese. 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