{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:17:01Z","timestamp":1770823021949,"version":"3.50.1"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Diagn Pathol"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Angiolymphoid hyperplasia with eosinophilia (ALHE) is a vasocentric process characterized by infiltrates of lymphocytes and eosinophils, usually affecting the muscular arteries of the head and neck. Currently it is unclear whether it is a reactive or neoplastic process.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Report<\/jats:title>\n            <jats:p>We present a 61-year-old African American male with a twenty year history of superficial skin patches involving the head and neck region. An excisional biopsy of a right submental lymph node revealed an atypical T-cell lymphocytic process, diagnosed as peripheral T-cell lymphoma after immunophenotyping and molecular studies. Three months later the patient underwent a biopsy of a left temporal nodule that was diagnosed as ALHE. Subsequently, at two year follow-up, the patient was diagnosed with Mycosis Fungoides. Polymerase chain reaction for T cell receptor gamma showed the same T-cell receptor gene rearrangement in both the temporal mass and the right submental lymph node.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>ALHE with molecular evidence of monoclonality is extremely unusual, as is the association with nodal peripheral T-cell nodal lymphoma. The findings of this case support our hypothesis that ALHE might be an early form of T-cell lymphoma.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1746-1596-3-22","type":"journal-article","created":{"date-parts":[[2008,5,29]],"date-time":"2008-05-29T18:14:26Z","timestamp":1212084866000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Angiolymphoid hyperplasia with eosinophilia developing in a patient with history of peripheral T-cell lymphoma: evidence for multicentric T-cell lymphoproliferative process"],"prefix":"10.1186","volume":"3","author":[{"given":"Luis F","family":"Gonzalez-Cuyar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Tavora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X Frank","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guanghua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron","family":"Auerbach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadine","family":"Aguilera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allen P","family":"Burke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2008,5,29]]},"reference":[{"issue":"12","key":"144_CR1","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1111\/j.1524-4725.1978.tb00586.x","volume":"4","author":"MV Botet","year":"1978","unstructured":"Botet MV, Sanchez JL: Angiolymphoid hyperplasia with eosinophilia: report of a case and a review of the literature. J Dermatol Surg Oncol. 1978, 4 (12): 931-936.","journal-title":"J Dermatol Surg Oncol"},{"issue":"10","key":"144_CR2","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1053\/hupa.2002.128247","volume":"33","author":"W Kempf","year":"2002","unstructured":"Kempf W, Haeffner AC, Zepter K, Sander CA, Flaig MJ, Mueller B, Panizzon RG, Hardmeier T, Adams V, Burg G: Angiolymphoid hyperplasia with eosinophilia: evidence for a T-cell lymphoproliferative origin. Hum Pathol. 2002, 33 (10): 1023-1029. 10.1053\/hupa.2002.128247.","journal-title":"Hum Pathol"},{"issue":"1","key":"144_CR3","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/S0210-4806(05)73210-1","volume":"29","author":"A Villanueva Pena","year":"2005","unstructured":"Villanueva Pena A, de Diego Rodriguez E, Gomez Ortega JM, Hernandez Castrillo A, Lopez Rasines G: [Considerations about angiolymphoid hyperplasia with eosinophilia (ALHE) with regard to a case localized in the penis]. Actas Urol Esp. 2005, 29 (1): 113-117.","journal-title":"Actas Urol Esp"},{"issue":"1","key":"144_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1365-2133.1969.tb15914.x","volume":"81","author":"GC Wells","year":"1969","unstructured":"Wells GC, Whimster IW: Subcutaneous angiolymphoid hyperplasia with eosinophilia. Br J Dermatol. 1969, 81 (1): 1-14. 10.1111\/j.1365-2133.1969.tb15914.x.","journal-title":"Br J Dermatol"},{"issue":"5 Pt 1","key":"144_CR5","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1016\/S0190-9622(85)70098-9","volume":"12","author":"TG Olsen","year":"1985","unstructured":"Olsen TG, Helwig EB: Angiolymphoid hyperplasia with eosinophilia. A clinicopathologic study of 116 patients. J Am Acad Dermatol. 1985, 12 (5 Pt 1): 781-796.","journal-title":"J Am Acad Dermatol"},{"issue":"5","key":"144_CR6","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1309\/UN1AQ2WJU9HDD72F","volume":"123","author":"CA Moran","year":"2005","unstructured":"Moran CA, Suster S: Angiolymphoid hyperplasia with eosinophilia (epithelioid hemangioma) of the lung: a clinicopathologic and immunohistochemical study of two cases. Am J Clin Pathol. 2005, 123 (5): 762-765. 10.1309\/UN1A-Q2WJ-U9HD-D72F.","journal-title":"Am J Clin Pathol"},{"issue":"1","key":"144_CR7","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.joms.2004.04.029","volume":"63","author":"A Acocella","year":"2005","unstructured":"Acocella A, Catelani C, Nardi P: Angiolymphoid hyperplasia with eosinophilia: a case report of orbital involvement. J Oral Maxillofac Surg. 2005, 63 (1): 140-144. 10.1016\/j.joms.2004.04.029.","journal-title":"J Oral Maxillofac Surg"},{"issue":"3","key":"144_CR8","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1111\/j.1365-4632.2004.02030.x","volume":"44","author":"M Azizzadeh","year":"2005","unstructured":"Azizzadeh M, Namazi MR, Dastghaib L, Sari-Aslani F: Angiolymphoid hyperplasia with eosinophilia and nephrotic syndrome. Int J Dermatol. 2005, 44 (3): 242-244. 10.1111\/j.1365-4632.2004.02030.x.","journal-title":"Int J Dermatol"},{"key":"144_CR9","first-page":"1","volume-title":"Virchows Arch","author":"RK Hejmadi","year":"2005","unstructured":"Hejmadi RK, van Pittius DG, Stephens M, Chasty R, Braithwaite M: Angiolymphoid hyperplasia with eosinophilia (epithelioid haemangioma) occurring within multiple deep lymph nodes and presenting with weight loss and raised CA-125 levels. Virchows Arch. 2005, 1-3."},{"issue":"6","key":"144_CR10","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1016\/j.bjps.2004.11.014","volume":"58","author":"A Satpathy","year":"2005","unstructured":"Satpathy A, Moss C, Raafat F, Slator R: Spontaneous regression of a rare tumour in a child: angiolymphoid hyperplasia with eosinophilia of the hand: case report and review of the literature. Br J Plast Surg. 2005, 58 (6): 865-868. 10.1016\/j.bjps.2004.11.014.","journal-title":"Br J Plast Surg"},{"issue":"12","key":"144_CR11","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1111\/j.1346-8138.2005.tb00888.x","volume":"32","author":"H Suzuki","year":"2005","unstructured":"Suzuki H, Hatamochi A, Horie M, Suzuki T, Yamazaki S: A case of angiolymphoid hyperplasia with eosinophilia (ALHE) of the upper lip. J Dermatol. 2005, 32 (12): 991-995.","journal-title":"J Dermatol"},{"issue":"9","key":"144_CR12","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.5858\/2005-129-1168-AHWEAW","volume":"129","author":"N Zarrin-Khameh","year":"2005","unstructured":"Zarrin-Khameh N, Spoden JE, Tran RM: Angiolymphoid hyperplasia with eosinophilia associated with pregnancy: a case report and review of the literature. Arch Pathol Lab Med. 2005, 129 (9): 1168-1171.","journal-title":"Arch Pathol Lab Med"},{"issue":"4","key":"144_CR13","first-page":"323","volume":"72","author":"GY Zhang","year":"2003","unstructured":"Zhang GY, Jiang J, Lin T, Wang QQ: Disseminated angiolymphoid hyperplasia with eosinophilia: a case report. Cutis. 2003, 72 (4): 323-326.","journal-title":"Cutis"},{"issue":"2","key":"144_CR14","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1097\/00000372-199804000-00001","volume":"20","author":"G Vadlamudi","year":"1998","unstructured":"Vadlamudi G, Schinella R: Traumatic pseudoaneurysm: a possible early lesion in the spectrum of epithelioid hemangioma\/angiolymphoid hyperplasia with eosinophilia. Am J Dermatopathol. 1998, 20 (2): 113-117. 10.1097\/00000372-199804000-00001.","journal-title":"Am J Dermatopathol"},{"issue":"7","key":"144_CR15","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1034\/j.1600-0560.2001.280705.x","volume":"28","author":"KA Jang","year":"2001","unstructured":"Jang KA, Ahn SJ, Choi JH, Sung KJ, Moon KC, Koh JK, Shim YH: Polymerase chain reaction (PCR) for human herpesvirus 8 and heteroduplex PCR for clonality assessment in angiolymphoid hyperplasia with eosinophilia and Kimura's disease. J Cutan Pathol. 2001, 28 (7): 363-367. 10.1034\/j.1600-0560.2001.280705.x.","journal-title":"J Cutan Pathol"},{"issue":"5","key":"144_CR16","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1111\/j.1365-2133.2005.06421.x","volume":"152","author":"J Andreae","year":"2005","unstructured":"Andreae J, Galle C, Magdorf K, Staab D, Meyer L, Goldman M, Querfeld U: Severe atherosclerosis of the aorta and development of peripheral T-cell lymphoma in an adolescent with angiolymphoid hyperplasia with eosinophilia. Br J Dermatol. 2005, 152 (5): 1033-1038. 10.1111\/j.1365-2133.2005.06421.x.","journal-title":"Br J Dermatol"},{"issue":"2","key":"144_CR17","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1111\/j.1365-4632.2004.02361.x","volume":"45","author":"WS Chong","year":"2006","unstructured":"Chong WS, Thomas A, Goh CL: Kimura's disease and angiolymphoid hyperplasia with eosinophilia: two disease entities in the same patient. Case report and review of the literature. Int J Dermatol. 2006, 45 (2): 139-145. 10.1111\/j.1365-4632.2004.02361.x.","journal-title":"Int J Dermatol"},{"issue":"3","key":"144_CR18","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.bjoms.2004.11.023","volume":"43","author":"PL Ramchandani","year":"2005","unstructured":"Ramchandani PL, Sabesan T, Hussein K: Angiolymphoid hyperplasia with eosinophilia masquerading as Kimura disease. Br J Oral Maxillofac Surg. 2005, 43 (3): 249-252. 10.1016\/j.bjoms.2004.11.023.","journal-title":"Br J Oral Maxillofac Surg"},{"issue":"4","key":"144_CR19","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1038\/modpathol.3800060","volume":"17","author":"AP Burke","year":"2004","unstructured":"Burke AP, Jarvelainen H, Kolodgie FD, Goel A, Wight TN, Virmani R: Superficial pseudoaneurysms: clinicopathologic aspects and involvement of extracellular matrix proteoglycans. Mod Pathol. 2004, 17 (4): 482-488. 10.1038\/modpathol.3800060.","journal-title":"Mod Pathol"}],"container-title":["Diagnostic Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1746-1596-3-22.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T12:34:16Z","timestamp":1630499656000},"score":1,"resource":{"primary":{"URL":"https:\/\/diagnosticpathology.biomedcentral.com\/articles\/10.1186\/1746-1596-3-22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5,29]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["144"],"URL":"https:\/\/doi.org\/10.1186\/1746-1596-3-22","relation":{},"ISSN":["1746-1596"],"issn-type":[{"value":"1746-1596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,5,29]]},"assertion":[{"value":"18 February 2008","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 May 2008","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 May 2008","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"22"}}