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On occasion GCTs of bone undergo frank malignant transformation to undifferentiated sarcomas. Here we report a case of GCT of bone that at the time of recurrence was found to have undergone malignant transformation. Concurrent metastases were found in the lung, but these were non-transformed GCT.<\/jats:p>","DOI":"10.1186\/1746-1596-5-62","type":"journal-article","created":{"date-parts":[[2010,10,6]],"date-time":"2010-10-06T18:15:13Z","timestamp":1286388913000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["A case of recurrent giant cell tumor of bone with malignant transformation and benign pulmonary metastases"],"prefix":"10.1186","volume":"5","author":[{"given":"Ira J","family":"Miller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Blank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suellen M","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Mcnickle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Gray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Gitelis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,9,22]]},"reference":[{"issue":"9","key":"307_CR1","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1007\/s00432-008-0370-x","volume":"134","author":"M Balke","year":"2008","unstructured":"Balke M, Schremper L, Gebert C, Ahrens H, Streitbuerger A, Koehler G, Hardes J, Gosheger G: Giant cell tumor of bone: treatment and outcome of 214 cases. 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