{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T17:44:10Z","timestamp":1725385450194},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Diagn Pathol"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Ampullary cancer (AC) was classified as pancreatobiliary, intestinal, or other subtype based on the expression of cytokeratin 7 (CK7) and cytokeratin 20 (CK20). We aimed to explore the association of AC subtype with patient prognosis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>The relationship of AC subtype and expression of Osteopontin (OPN) with the prognosis of 120 AC patients after pancreaticoduodenectomy was investigated.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The patients had pancreatobiliary (CK7<jats:sup>+<\/jats:sup>\/CK20<jats:sup>-<\/jats:sup>, n = 24, 20%), intestinal (CK7<jats:sup>-<\/jats:sup>\/CK20<jats:sup>+<\/jats:sup>, n = 29, 24.2%) or other (CK7<jats:sup>+<\/jats:sup>\/CK20<jats:sup>+<\/jats:sup> or CK7<jats:sup>-<\/jats:sup>\/CK20<jats:sup>-<\/jats:sup>, n = 67, 55.8%) subtypes of AC, and their median survival times were 23 \u00b1 4.2, 38 \u00b1 2.8 and 64 \u00b1 16.8 months, respectively. The survival times of 64 OPN<jats:sup>-<\/jats:sup> patients (53.3%) and 56 OPN<jats:sup>+<\/jats:sup> patients (46.7%) were 69 \u00b1 18.4 and 36 \u00b1 1.3 months, respectively. There was no significant effect of AC subtype on survival of OPN<jats:sup>-<\/jats:sup> patients. For OPN<jats:sup>+<\/jats:sup> patients, those with pancreatobiliary AC had a shorter survival time (22 \u00b1 6.6 months) than those with intestinal AC (37 \u00b1 1.4 months, <jats:italic>p<\/jats:italic> = 0.041), and other AC subtype (36 \u00b1 0.9 months, <jats:italic>p<\/jats:italic> = 0.010); intestinal and other AC subtypes had similar survival times.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>The prognosis of AC patients can be estimated based on immunohistochemical classification and OPN status.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1746-1596-6-98","type":"journal-article","created":{"date-parts":[[2011,10,13]],"date-time":"2011-10-13T06:18:47Z","timestamp":1318486727000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Prognosis of ampullary cancer based on immunohistochemical type and expression of osteopontin"],"prefix":"10.1186","volume":"6","author":[{"given":"Xiang-qian","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-hong","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-zhi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,10,13]]},"reference":[{"key":"473_CR1","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1097\/00000658-199807000-00013","volume":"228","author":"JR Howe","year":"1998","unstructured":"Howe JR, Klimstra DS, Moccia RD, Conlon KC, Brennan MF: Factors predictive of survival in ampullary carcinoma. Ann Surg. 1998, 228: 87-94. 10.1097\/00000658-199807000-00013.","journal-title":"Ann Surg"},{"key":"473_CR2","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1111\/j.1349-7006.1994.tb02077.x","volume":"85","author":"W Kimura","year":"1994","unstructured":"Kimura W, Futakawa N, Yamagata S, Wada Y, Kuroda A, Muto T, Esaki Y: Different clinicopathologic findings in two histologic types of carcinoma of papilla of Vater. Jpn J Cancer Res. 1994, 85: 161-166. 10.1111\/j.1349-7006.1994.tb02077.x.","journal-title":"Jpn J Cancer Res"},{"key":"473_CR3","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1097\/00000478-200407000-00005","volume":"28","author":"H Zhou","year":"2004","unstructured":"Zhou H, Schaefer N, Wolff M, Fischer HP: Carcinoma of the Ampulla of Vater: Comparative Histologic\/Immunohistochemical Classification and Follow-up. Am J Surg Pathol. 2004, 28: 875-882. 10.1097\/00000478-200407000-00005.","journal-title":"Am J Surg Pathol"},{"key":"473_CR4","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1007\/s11605-010-1156-4","volume":"14","author":"LB de Paiva Haddad","year":"2010","unstructured":"de Paiva Haddad LB, Patzina RA, Penteado S, Montagnini AL, da Cunha JE, Machado MC, Jukemura J: Lymph node involvement and not the histophatologic subtype is correlated with outcome after resection of adenocarcinoma of the ampulla of vater. J Gastrointest Surg. 2010, 14: 719-728. 10.1007\/s11605-010-1156-4.","journal-title":"J Gastrointest Surg"},{"key":"473_CR5","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/S0242-6498(04)93977-6","volume":"24","author":"F Le Pessot","year":"2004","unstructured":"Le Pessot F, Ranty ML, Hellot MF, Lemoine F, Teniere P, Testart J, Metayer J: Cytokeratins 7 and 20 immunohistochemistry in ampullary carcinomas. Ann Pathol. 2004, 24: 312-318. 10.1016\/S0242-6498(04)93977-6.","journal-title":"Ann Pathol"},{"key":"473_CR6","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1111\/j.1365-2559.2009.03227.x","volume":"54","author":"A Westgaard","year":"2009","unstructured":"Westgaard A, Schjolberg AR, Cvancarova M, Eide TJ, Clausen OP, Gladhaug IP: Differentiation markers in pancreatic head adenocarcinomas: MUC1 and MUC4 expression indicates poor prognosis in pancreatobiliary differentiated tumours. Histopathology. 2009, 54: 337-347. 10.1111\/j.1365-2559.2009.03227.x.","journal-title":"Histopathology"},{"key":"473_CR7","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1136\/jcp.2005.035832","volume":"60","author":"D Santini","year":"2007","unstructured":"Santini D, Baldi A, Vincenzi B, Mellone P, Campioni M, Antinori A, Borzomati D, Coppola R, Magistrelli P, Tonini G: Mucin 2 (MUC2) and mucin 5 (MUC5) expression is not associated with prognosis in patients with radically resected ampullary carcinoma. J Clin Pathol. 2007, 60: 1069-1070.","journal-title":"J Clin Pathol"},{"key":"473_CR8","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1177\/1066896911405654","volume":"19","author":"T Moriya","year":"2011","unstructured":"Moriya T, Kimura W, Hirai I, Takasu N, Mizutani M: Expression of MUC1 and MUC2 in Ampullary Cancer. Int J Surg Pathol. 2011, 19: 441-447. 10.1177\/1066896911405654.","journal-title":"Int J Surg Pathol"},{"key":"473_CR9","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1097\/SLA.0b013e31821994a8","volume":"254","author":"F Ehehalt","year":"2011","unstructured":"Ehehalt F, Rummele P, Kersting S, Lang-Schwarz C, Ruckert F, Hartmann A, Dietmaier W, Terracciano L, Aust DE, Jahnke B, Saeger HD, Pilarsky C, Grutzmann R: Hepatocyte Nuclear Factor (HNF) 4alpha Expression Distinguishes Ampullary Cancer Subtypes and Prognosis After Resection. Ann Surg. 2011, 254: 302-310. 10.1097\/SLA.0b013e31821994a8.","journal-title":"Ann Surg"},{"key":"473_CR10","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1007\/s00534-004-0898-3","volume":"11","author":"HP Fischer","year":"2004","unstructured":"Fischer HP, Zhou H: Pathogenesis of carcinoma of the papilla of Vater. J Hepatobiliary Pancreat Surg. 2004, 11: 301-309. 10.1007\/s00534-004-0898-3.","journal-title":"J Hepatobiliary Pancreat Surg"},{"key":"473_CR11","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/1746-1596-5-75","volume":"5","author":"Y Kawabata","year":"2010","unstructured":"Kawabata Y, Tanaka T, Nishisaka T, Inao T, Nishi T, Yano S: Cytokeratin 20 (CK20) and apomucin 1 (MUC1) expression in ampullary carcinoma: Correlation with tumor progression and prognosis. Diagn Pathol. 2010, 5: 75-","journal-title":"Diagn Pathol"},{"key":"473_CR12","doi-asserted-by":"publisher","first-page":"1516","DOI":"10.1097\/JTO.0b013e3181eba6bd","volume":"5","author":"CM Goparaju","year":"2010","unstructured":"Goparaju CM, Pass HI, Blasberg JD, Hirsch N, Donington JS: Functional heterogeneity of osteopontin isoforms in non-small cell lung cancer. J Thorac Oncol. 2010, 5: 1516-1523. 10.1097\/JTO.0b013e3181eba6bd.","journal-title":"J Thorac Oncol"},{"key":"473_CR13","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1158\/1078-0432.CCR-1405-2","volume":"10","author":"D Coppola","year":"2004","unstructured":"Coppola D, Szabo M, Boulware D, Muraca P, Alsarraj M, Chambers AF, Yeatman TJ: Correlation of osteopontin protein expression and pathological stage across a wide variety of tumor histologies. Clin Cancer Res. 2004, 10: 184-190. 10.1158\/1078-0432.CCR-1405-2.","journal-title":"Clin Cancer Res"},{"key":"473_CR14","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1378\/chest.10-1146","volume":"139","author":"JM Lorenzen","year":"2011","unstructured":"Lorenzen JM, Nickel N, Kramer R, Golpon H, Westerkamp V, Olsson KM, Haller H, Hoeper MM: Osteopontin in patients with idiopathic pulmonary hypertension. Chest. 2011, 139: 1010-1017. 10.1378\/chest.10-1146.","journal-title":"Chest"},{"key":"473_CR15","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1097\/JTO.0b013e3181ae2844","volume":"4","author":"S Isa","year":"2009","unstructured":"Isa S, Kawaguchi T, Teramukai S, Minato K, Ohsaki Y, Shibata K, Yonei T, Hayashibara K, Fukushima M, Kawahara M, Furuse K, Mack PC: Serum osteopontin levels are highly prognostic for survival in advanced non-small cell lung cancer: results from JMTO LC 0004. J Thorac Oncol. 2009, 4: 1104-1110. 10.1097\/JTO.0b013e3181ae2844.","journal-title":"J Thorac Oncol"},{"key":"473_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2011\/963614","volume":"28","author":"Y Li","year":"2011","unstructured":"Li Y, Li L, Wang JT, Kan X, Lu JG: Elevated content of osteopontin in plasma and tumor tissues of patients with laryngeal and hypopharyngeal carcinoma associated with metastasis and prognosis. Med Oncol. 2011, 28: 1-6. 10.1007\/s12032-009-9402-x.","journal-title":"Med Oncol"},{"key":"473_CR17","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.jhep.2010.06.030","volume":"54","author":"W Sieghart","year":"2011","unstructured":"Sieghart W, Wang X, Schmid K, Pinter M, Konig F, Bodingbauer M, Wrba F, Rasoul-Rockenschaub S, Peck-Radosavljevic M: Osteopontin expression predicts overall survival after liver transplantation for hepatocellular carcinoma in patients beyond the Milan criteria. J Hepatol. 2011, 54: 89-97. 10.1016\/j.jhep.2010.06.030.","journal-title":"J Hepatol"},{"key":"473_CR18","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1007\/s11605-009-1035-z","volume":"14","author":"W Likui","year":"2010","unstructured":"Likui W, Hong W, Shuwen Z: Clinical significance of the upregulated osteopontin mRNA expression in human colorectal cancer. J Gastrointest Surg. 2010, 14: 74-81. 10.1007\/s11605-009-1035-z.","journal-title":"J Gastrointest Surg"},{"key":"473_CR19","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1038\/sj.bjc.6605834","volume":"103","author":"GF Weber","year":"2010","unstructured":"Weber GF, Lett GS, Haubein NC: Osteopontin is a marker for cancer aggressiveness and patient survival. Br J Cancer. 2010, 103: 861-869. 10.1038\/sj.bjc.6605834.","journal-title":"Br J Cancer"},{"key":"473_CR20","volume-title":"Urol Oncol","author":"HL Ke","year":"2009","unstructured":"Ke HL, Chang LL, Yang SF, Lin HH, Li CC, Wu DC, Wu WJ: Osteopontin overexpression predicts poor prognosis of upper urinary tract urothelial carcinoma. Urol Oncol. 2009"},{"key":"473_CR21","doi-asserted-by":"publisher","first-page":"4859","DOI":"10.1182\/blood-2009-02-204818","volume":"114","author":"JA Powell","year":"2009","unstructured":"Powell JA, Thomas D, Barry EF, Kok CH, McClure BJ, Tsykin A, To LB, Brown A, Lewis ID, Herbert K, Goodall GJ, Speed TP, Asou N, Jacob B, Osato M, Haylock DN, Nilsson SK, D'Andrea RJ, Lopez AF, Guthridge MA: Expression profiling of a hemopoietic cell survival transcriptome implicates osteopontin as a functional prognostic factor in AML. Blood. 2009, 114: 4859-4870. 10.1182\/blood-2009-02-204818.","journal-title":"Blood"},{"key":"473_CR22","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1016\/j.oraloncology.2008.12.006","volume":"45","author":"CY Chien","year":"2009","unstructured":"Chien CY, Su CY, Chuang HC, Fang FM, Huang HY, Chen CH, Chen CM, Huang CC: Comprehensive study on the prognostic role of osteopontin expression in oral squamous cell carcinoma. Oral Oncol. 2009, 45: 798-802. 10.1016\/j.oraloncology.2008.12.006.","journal-title":"Oral Oncol"},{"key":"473_CR23","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1080\/07357900802375738","volume":"27","author":"H Cho","year":"2009","unstructured":"Cho H, Kang ES, Kim YT, Kim JH: Diagnostic and prognostic impact of osteopontin expression in endometrial cancer. Cancer Invest. 2009, 27: 313-323. 10.1080\/07357900802375738.","journal-title":"Cancer Invest"},{"key":"473_CR24","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1093\/ndt\/gfq498","volume":"26","author":"JM Lorenzen","year":"2011","unstructured":"Lorenzen JM, Hafer C, Faulhaber-Walter R, Kumpers P, Kielstein JT, Haller H, Fliser D: Osteopontin predicts survival in critically ill patients with acute kidney injury. Nephrol Dial Transplant. 2011, 26: 531-537. 10.1093\/ndt\/gfq498.","journal-title":"Nephrol Dial Transplant"},{"key":"473_CR25","doi-asserted-by":"publisher","first-page":"651","DOI":"10.4161\/cbt.3.7.919","volume":"3","author":"NT Van Heek","year":"2004","unstructured":"Van Heek NT, Maitra A, Koopmann J, Fedarko N, Jain A, Rahman A, Iacobuzio-Donahue CA, Adsay V, Ashfaq R, Yeo CJ, Cameron JL, Offerhaus JA, Hruban RH, Berg KD, Goggins M: Gene expression profiling identifies markers of ampullary adenocarcinoma. Cancer Biol Ther. 2004, 3: 651-656. 10.4161\/cbt.3.7.919.","journal-title":"Cancer Biol Ther"},{"key":"473_CR26","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1245\/s10434-006-9128-3","volume":"14","author":"M Bloomston","year":"2007","unstructured":"Bloomston M, Ellison EC, Muscarella P, Al-Saif O, Martin EW, Melvin WS, Frankel WL: Stromal osteonectin overexpression is associated with poor outcome in patients with ampullary cancer. Ann Surg Oncol. 2007, 14: 211-217.","journal-title":"Ann Surg Oncol"},{"key":"473_CR27","doi-asserted-by":"publisher","first-page":"144","DOI":"10.4161\/cbt.10.2.12160","volume":"10","author":"HP Hsu","year":"2010","unstructured":"Hsu HP, Shan YS, Lai MD, Lin PW: Osteopontin-positive infiltrating tumor-associated macrophages in bulky ampullary cancer predict survival. Cancer Biol Ther. 2010, 10: 144-154. 10.4161\/cbt.10.2.12160.","journal-title":"Cancer Biol Ther"},{"key":"473_CR28","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-3656-4","volume-title":"AJCC Cancer Staging Manual (6th Edition)","author":"FL Greene","year":"2002","unstructured":"Greene FL, Page DL, Fleming ID, Fritz A, Balch CM, Haller DG, Morrow M: AJCC Cancer Staging Manual (6th Edition). 2002, New York, NY: Springer, 6","edition":"6"},{"key":"473_CR29","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1309\/1NCM-46QX-3B5T-7XHR","volume":"115","author":"NS Goldstein","year":"2001","unstructured":"Goldstein NS, Bassi D: Cytokeratins 7, 17, and 20 reactivity in pancreatic and ampulla of vater adenocarcinomas. Percentage of positivity and distribution is affected by the cut-point threshold. Am J Clin Pathol. 2001, 115: 695-702. 10.1309\/1NCM-46QX-3B5T-7XHR.","journal-title":"Am J Clin Pathol"},{"key":"473_CR30","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1111\/j.1600-0714.2006.00493.x","volume":"36","author":"H Matsuzaki","year":"2007","unstructured":"Matsuzaki H, Shima K, Muramatsu T, Ro Y, Hashimoto S, Shibahara T, Shimono M: Osteopontin as biomarker in early invasion by squamous cell carcinoma in tongue. J Oral Pathol Med. 2007, 36: 30-34.","journal-title":"J Oral Pathol Med"},{"key":"473_CR31","doi-asserted-by":"publisher","first-page":"3043","DOI":"10.1245\/s10434-010-1143-8","volume":"17","author":"KH Hsu","year":"2010","unstructured":"Hsu KH, Tsai HW, Lin PW, Hsu YS, Shan YS, Lu PJ: Osteopontin expression is an independent adverse prognostic factor in resectable gastrointestinal stromal tumor and its interaction with CD44 promotes tumor proliferation. Ann Surg Oncol. 2010, 17: 3043-3052. 10.1245\/s10434-010-1143-8.","journal-title":"Ann Surg Oncol"},{"key":"473_CR32","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1634\/theoncologist.2008-0081","volume":"13","author":"GH Yang","year":"2008","unstructured":"Yang GH, Fan J, Xu Y, Qiu SJ, Yang XR, Shi GM, Wu B, Dai Z, Liu YK, Tang ZY, Zhou J: Osteopontin combined with CD44, a novel prognostic biomarker for patients with hepatocellular carcinoma undergoing curative resection. Oncologist. 2008, 13: 1155-1165. 10.1634\/theoncologist.2008-0081.","journal-title":"Oncologist"},{"key":"473_CR33","first-page":"609","volume":"21","author":"X Zhang","year":"2009","unstructured":"Zhang X, Tsukamoto T, Mizoshita T, Ban H, Suzuki H, Toyoda T, Tatematsu M: Expression of osteopontin and CDX2: indications of phenotypes and prognosis in advanced gastric cancer. Oncol Rep. 2009, 21: 609-613.","journal-title":"Oncol Rep"}],"container-title":["Diagnostic Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1746-1596-6-98.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T17:05:49Z","timestamp":1630515949000},"score":1,"resource":{"primary":{"URL":"https:\/\/diagnosticpathology.biomedcentral.com\/articles\/10.1186\/1746-1596-6-98"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,13]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["473"],"URL":"https:\/\/doi.org\/10.1186\/1746-1596-6-98","relation":{},"ISSN":["1746-1596"],"issn-type":[{"value":"1746-1596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10,13]]},"assertion":[{"value":"30 August 2011","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 October 2011","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 October 2011","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"98"}}