{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T22:05:52Z","timestamp":1757455552136},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Diagn Pathol"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>We present a case of a 62-year-old man who underwent total hip arthroplasty for treatment of pathologic femoral neck fracture associated with adefovir dipivoxil-induced osteomalacia. He had a 13-month history of bone pain involving his shoulders, hips, and knee. He received adefovir dipivoxil for treatment of lamivudine-resistant hepatitis B virus infection for 5\u2009years before the occurrence of femoral neck fracture. Orthopedic surgeons should be aware of osteomalacia and pathological hip fracture caused by drug-induced renal dysfunction, which results in Fanconi\u2019s syndrome.<\/jats:p>\n          <jats:p>\n            <jats:bold>Virtual slides<\/jats:bold>\n          <\/jats:p>\n          <jats:p>The virtual slide(s) for this article can be found here: http:\/\/www.diagnosticpathology.diagnomx.eu\/vs\/1600344696739249<\/jats:p>","DOI":"10.1186\/1746-1596-7-108","type":"journal-article","created":{"date-parts":[[2012,8,20]],"date-time":"2012-08-20T10:15:55Z","timestamp":1345457755000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Pathological femoral fractures due to osteomalacia associated with adefovir dipivoxil treatment for hepatitis B: a case report"],"prefix":"10.1186","volume":"7","author":[{"given":"Motoyuki","family":"Tanaka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Setoguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Ishidou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiya","family":"Arishima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masataka","family":"Hirotsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinobu","family":"Saitoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunsuke","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironori","family":"Kakoi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Nagano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Yokouchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junichi","family":"Kamizono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Setsuro","family":"Komiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,8,20]]},"reference":[{"key":"611_CR1","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1111\/j.1365-2265.1995.tb02621.x","volume":"43","author":"BL Clarke","year":"1995","unstructured":"Clarke BL, Wynne AG, Wilson DM, Fitzpatrick LA: Osteomalacia associated with adult Fanconi's syndrome: clinical and diagnostic features. Clin Endocrinol. 1995, 43: 479-490. 10.1111\/j.1365-2265.1995.tb02621.x.","journal-title":"Clin Endocrinol"},{"key":"611_CR2","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1053\/ajkd.2002.36924","volume":"40","author":"D Verhelst","year":"2002","unstructured":"Verhelst D, Monge M, Meynard JL, Fouqueray B, Mougenot B, Girard PM, Ronco P, Rossert J: Fanconi syndrome and renal failure induced by tenofovir: a first case report. Am J Kidney Dis. 2002, 40: 1331-1333. 10.1053\/ajkd.2002.36924.","journal-title":"Am J Kidney Dis"},{"key":"611_CR3","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1359\/jbmr.2004.19.5.714","volume":"19","author":"KE Earle","year":"2004","unstructured":"Earle KE, Seneviratne T, Shaker J, Shoback D: Fanconi's syndrome in HIV\u2009+\u2009adults: report of three cases and literature review. J Bone Miner Res. 2004, 19: 714-721. 10.1359\/jbmr.2004.19.5.714.","journal-title":"J Bone Miner Res"},{"key":"611_CR4","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1111\/j.1468-1293.2005.00318.x","volume":"6","author":"MJ Parsonage","year":"2005","unstructured":"Parsonage MJ, Wilkins EG, Snowden N, Issa BG, Savage MW: The development of hypophosphataemic osteomalacia with myopathy in two patients with HIV infection receiving tenofovir therapy. HIV Med. 2005, 6: 341-346. 10.1111\/j.1468-1293.2005.00318.x.","journal-title":"HIV Med"},{"key":"611_CR5","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1086\/499048","volume":"42","author":"AE Zimmermann","year":"2006","unstructured":"Zimmermann AE, Pizzoferrato T, Bedford J, Morris A, Hoffman R, Braden G: Tenofovir-associated acute and chronic kidney disease: a case of multiple drug interactions. Clinical infectious diseases: an official publication of the Infectious Diseases Society of America. 2006, 42: 283-290. 10.1086\/499048.","journal-title":"Clinical infectious diseases: an official publication of the Infectious Diseases Society of America"},{"key":"611_CR6","doi-asserted-by":"publisher","first-page":"E61","DOI":"10.1016\/j.jinf.2004.08.031","volume":"51","author":"A Malik","year":"2005","unstructured":"Malik A, Abraham P, Malik N: Acute renal failure and Fanconi syndrome in an AIDS patient on tenofovir treatment\u2013case report and review of literature. J Infect. 2005, 51: E61-E65. 10.1016\/j.jinf.2004.08.031.","journal-title":"J Infect"},{"key":"611_CR7","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1302\/0301-620X.43B4.647","volume":"43-B","author":"RS Garden","year":"1961","unstructured":"Garden RS: LOW-ANGLE FIXATION IN FRACTURES OF THE FEMORAL NECK. J Bone Joint Surg Br. 1961, 43-B: 647-663.","journal-title":"J Bone Joint Surg Br"},{"key":"611_CR8","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.semnephrol.2009.01.005","volume":"29","author":"SM Ott","year":"2009","unstructured":"Ott SM: Bone histomorphometry in renal osteodystrophy. Semin Nephrol. 2009, 29: 122-132. 10.1016\/j.semnephrol.2009.01.005.","journal-title":"Semin Nephrol"},{"key":"611_CR9","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1210\/jc.2009-2051","volume":"95","author":"T Wong","year":"2010","unstructured":"Wong T, Girgis CM, Ngu MC, Chen RC, Emmett L, Archer KA, Seibel MJ: Hypophosphatemic osteomalacia after low-dose adefovir dipivoxil therapy for hepatitis B. J Clin Endocrinol Metab. 2010, 95: 479-480. 10.1210\/jc.2009-2051.","journal-title":"J Clin Endocrinol Metab"},{"key":"611_CR10","doi-asserted-by":"publisher","first-page":"2305","DOI":"10.1001\/jama.282.24.2305","volume":"282","author":"J Kahn","year":"1999","unstructured":"Kahn J, Lagakos S, Wulfsohn M, Cherng D, Miller M, Cherrington J, Hardy D, Beall G, Cooper R, Murphy R, et al.: Efficacy and safety of adefovir dipivoxil with antiretroviral therapy: a randomized controlled trial. Jama. 1999, 282: 2305-2312. 10.1001\/jama.282.24.2305.","journal-title":"Jama"},{"key":"611_CR11","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1097\/QAD.0b013e32832407f7","volume":"23","author":"H Izzedine","year":"2009","unstructured":"Izzedine H, Kheder-Elfekih R, Housset P, Sarkozy C, Brocheriou I, Deray G: Adefovir dipivoxil-induced acute tubular necrosis and Fanconi syndrome in a renal transplant patient. AIDS (London, England). 2009, 23: 544-545. 10.1097\/QAD.0b013e32832407f7.","journal-title":"AIDS (London, England)"},{"key":"611_CR12","doi-asserted-by":"publisher","first-page":"389","DOI":"10.5009\/gnl.2010.4.3.389","volume":"4","author":"YK Jung","year":"2010","unstructured":"Jung YK, Yeon JE, Choi JH, Kim CH, Jung ES, Kim JH, Park JJ, Kim JS, Bak YT, Byun KS: Fanconi's syndrome associated with prolonged adefovir dipivoxil therapy in a hepatitis B virus patient. Gut and Liver. 2010, 4: 389-393. 10.5009\/gnl.2010.4.3.389.","journal-title":"Gut and Liver"},{"key":"611_CR13","doi-asserted-by":"publisher","first-page":"442","DOI":"10.4254\/wjh.v2.i12.442","volume":"2","author":"M Minemura","year":"2010","unstructured":"Minemura M, Tokimitsu Y, Tajiri K, Nakayama Y, Kawai K, Kudo H, Hirano K, Atarashi Y, Yata Y, Yasumura S, et al.: Development of osteomalacia in a post-liver transplant patient receiving adefovir dipivoxil. World J Hepatol. 2010, 2: 442-446. 10.4254\/wjh.v2.i12.442.","journal-title":"World J Hepatol"},{"key":"611_CR14","doi-asserted-by":"publisher","first-page":"381","DOI":"10.3350\/kjhep.2008.14.3.381","volume":"14","author":"HJ Lee","year":"2008","unstructured":"Lee HJ, Choi JW, Kim TN, Eun JR: A case of severe hypophosphatemia related to adefovir dipivoxil treatment in a patient with liver cirrhosis related to hepatitis B virus. The Korean Journal of Hepatology. 2008, 14: 381-386. 10.3350\/kjhep.2008.14.3.381.","journal-title":"The Korean Journal of Hepatology"},{"key":"611_CR15","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1053\/hupa.2001.25586","volume":"32","author":"N Tanji","year":"2001","unstructured":"Tanji N, Tanji K, Kambham N, Markowitz GS, Bell A, D\u2019Agati VD: Adefovir nephrotoxicity: possible role of mitochondrial DNA depletion. Hum Pathol. 2001, 32: 734-740. 10.1053\/hupa.2001.25586.","journal-title":"Hum Pathol"},{"key":"611_CR16","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1124\/mol.56.3.570","volume":"56","author":"T Cihlar","year":"1999","unstructured":"Cihlar T, Lin DC, Pritchard JB, Fuller MD, Mendel DB, Sweet DH: The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1. Mol Pharmacol. 1999, 56: 570-580.","journal-title":"Mol Pharmacol"},{"key":"611_CR17","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1053\/ajkd.2003.50037","volume":"41","author":"H Izzedine","year":"2003","unstructured":"Izzedine H, Launay-Vacher V, Isnard-Bagnis C, Deray G: Drug-induced Fanconi's syndrome. Am J Kidney Dis. 2003, 41: 292-309. 10.1053\/ajkd.2003.50037.","journal-title":"Am J Kidney Dis"},{"key":"611_CR18","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1016\/j.gcb.2008.07.001","volume":"32","author":"T Asselah","year":"2008","unstructured":"Asselah T, Lada O, Boyer N, Martinot M, Marcellin P: Treatment of chronic hepatitis B. Gastroenterol Clin Biol. 2008, 32: 749-768. 10.1016\/j.gcb.2008.07.001.","journal-title":"Gastroenterol Clin Biol"},{"key":"611_CR19","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.1053\/gast.2002.37058","volume":"123","author":"CL Lai","year":"2002","unstructured":"Lai CL, Rosmawati M, Lao J, Van Vlierberghe H, Anderson FH, Thomas N, Dehertogh D: Entecavir is superior to lamivudine in reducing hepatitis B virus DNA in patients with chronic hepatitis B infection. Gastroenterology. 2002, 123: 1831-1838. 10.1053\/gast.2002.37058.","journal-title":"Gastroenterology"},{"key":"611_CR20","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1053\/j.gastro.2005.06.055","volume":"129","author":"TT Chang","year":"2005","unstructured":"Chang TT, Gish RG, Hadziyannis SJ, Cianciara J, Rizzetto M, Schiff ER, Pastore G, Bacon BR, Poynard T, Joshi S, et al.: A dose-ranging study of the efficacy and tolerability of entecavir in Lamivudine-refractory chronic hepatitis B patients. Gastroenterology. 2005, 129: 1198-1209. 10.1053\/j.gastro.2005.06.055.","journal-title":"Gastroenterology"},{"key":"611_CR21","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/S0272-6386(12)80820-1","volume":"23","author":"JZ Melnick","year":"1994","unstructured":"Melnick JZ, Baum M, Thompson JR: Aminoglycoside-induced Fanconi's syndrome. Am J Kidney Dis. 1994, 23: 118-122.","journal-title":"Am J Kidney Dis"},{"key":"611_CR22","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1053\/ejpn.2002.0585","volume":"6","author":"H Yoshikawa","year":"2002","unstructured":"Yoshikawa H, Watanabe T, Abe T: Fanconi syndrome caused by sodium valproate: report of three severely disabled children. Eur J Paediatr Neurol. 2002, 6: 165-167. 10.1053\/ejpn.2002.0585.","journal-title":"Eur J Paediatr Neurol"},{"key":"611_CR23","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1016\/S0022-3476(68)80124-6","volume":"73","author":"J Otten","year":"1968","unstructured":"Otten J, Vis HL: Acute reversible renal tubular dysfunction following intoxication with methyl-3-chromone. J Pediatr. 1968, 73: 422-425. 10.1016\/S0022-3476(68)80124-6.","journal-title":"J Pediatr"},{"key":"611_CR24","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1001\/archinte.1979.03630390032014","volume":"139","author":"ND Vaziri","year":"1979","unstructured":"Vaziri ND, Ness RL, Fairshter RD, Smith WR, Rosen SM: Nephrotoxicity of paraquat in man. Arch Intern Med. 1979, 139: 172-174. 10.1001\/archinte.1979.03630390032014.","journal-title":"Arch Intern Med"},{"key":"611_CR25","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1016\/S0272-6386(96)90476-X","volume":"28","author":"JC Lo","year":"1996","unstructured":"Lo JC, Chertow GM, Rennke H, Seifter JL: Fanconi's syndrome and tubulointerstitial nephritis in association with L-lysine ingestion. Am J Kidney Dis. 1996, 28: 614-617. 10.1016\/S0272-6386(96)90476-X.","journal-title":"Am J Kidney Dis"},{"key":"611_CR26","first-page":"62","volume":"54","author":"W Varavithya","year":"1971","unstructured":"Varavithya W, Chulajata R, Ayudthya PS, Preeyasombat C: Fanconi syndrome caused by degraded tetracycline. J Med Assoc Thail= Chotmaihet thangphaet. 1971, 54: 62-67.","journal-title":"J Med Assoc Thail= Chotmaihet thangphaet"},{"key":"611_CR27","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1093\/ndt\/13.6.1547","volume":"13","author":"A Negro","year":"1998","unstructured":"Negro A, Regolisti G, Perazzoli F, Davoli S, Sani C, Rossi E: Ifosfamide-induced renal Fanconi syndrome with associated nephrogenic diabetes insipidus in an adult patient. Nephrol Dial Transplant. 1998, 13: 1547-1549. 10.1093\/ndt\/13.6.1547.","journal-title":"Nephrol Dial Transplant"},{"key":"611_CR28","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1111\/j.1399-0012.2005.00447.x","volume":"20","author":"I Morard","year":"2006","unstructured":"Morard I, Mentha G, Spahr L, Majno P, Hadengue A, Huber O, Morel P, Giostra E: Long-term renal function after liver transplantation is related to calcineurin inhibitors blood levels. Clin Transplant. 2006, 20: 96-101. 10.1111\/j.1399-0012.2005.00447.x.","journal-title":"Clin Transplant"}],"container-title":["Diagnostic Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1746-1596-7-108.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T20:07:49Z","timestamp":1630526869000},"score":1,"resource":{"primary":{"URL":"https:\/\/diagnosticpathology.biomedcentral.com\/articles\/10.1186\/1746-1596-7-108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,20]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["611"],"URL":"https:\/\/doi.org\/10.1186\/1746-1596-7-108","relation":{},"ISSN":["1746-1596"],"issn-type":[{"value":"1746-1596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,20]]},"assertion":[{"value":"30 May 2012","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 June 2012","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 August 2012","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"108"}}