{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T14:45:33Z","timestamp":1772721933670,"version":"3.50.1"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Diagn Pathol"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Abstract<\/jats:title>\n            <jats:p>Madelung\u2019s disease or multiple symmetric lipomatosis (MSL) is a rare disorder of unknown etiology which typically presents symmetrically subcutaneous accumulation of non-encapsulated adipose tissue which slowly grows around the neck, upper part of the arms, pelvis, back and thigh. This disease is also frequently associated with hepatopathy, glucose intolerance, hyperuricemia, and malignant tumors of the upper airways. Nevertheless, only one description of malignant transformation of Madelung\u2019s disease has been presented in literature. Here, we report a case of liposarcomatous transformation of Madelung\u2019s disease in a 59-year-old Italian woman with a coincidental diagnosis of breast cancer.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Virtual slide<\/jats:title>\n            <jats:p>The virtual slide for this article can be found here: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.diagnosticpathology.diagnomx.eu\/vs\/3480884087499351\" ext-link-type=\"uri\">http:\/\/www.diagnosticpathology.diagnomx.eu\/vs\/3480884087499351<\/jats:ext-link>\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1746-1596-7-116","type":"journal-article","created":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T20:53:54Z","timestamp":1346532834000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Malignant transformation of Madelung\u2019s disease in a patient with a coincidental diagnosis of breast cancer: a case report"],"prefix":"10.1186","volume":"7","author":[{"given":"Maddalena","family":"Borriello","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Lucidi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnaldo","family":"Carbone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vito","family":"Iannone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella","family":"Ferrandina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,9,1]]},"reference":[{"key":"570_CR1","first-page":"106","volume":"37","author":"OW Madelung","year":"1888","unstructured":"Madelung OW: Uber den Fetthals (diffuses Lipom des Halses). 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Aesthetic Plast Surg. 2010, 34 (2): 153-156. 10.1007\/s00266-009-9374-4.","journal-title":"Aesthetic Plast Surg"},{"key":"570_CR11","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1002\/path.1212","volume":"198","author":"E Nisoli","year":"2002","unstructured":"Nisoli E, Regianini L, Briscini L, Bulbarelli A, Busetto L, Coin A, Enzi G, Carruba MO: Multiple symmetric lipomatosis may be the consequence of defective noradrenergic modulation ofproliferation and differentiation of brown fat cells. J Pathol. 2002, 198: 378-387. 10.1002\/path.1212.","journal-title":"J Pathol"},{"issue":"3","key":"570_CR12","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/0278-2391(92)90332-T","volume":"50","author":"J Fern\u00e1ndez Sanrom\u00e1n","year":"1992","unstructured":"Fern\u00e1ndez Sanrom\u00e1n J, D\u00edaz Gonzalez F, Rodriguez Campo FJ: Benign symmetrical lipomatosis with mediastinal involvement and growth retardation. 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