{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T20:42:43Z","timestamp":1775508163887,"version":"3.50.1"},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Diagn Pathol"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Talcosis, a granulomatous inflammation of the lungs caused by inhalation of talcum dust, is a rare form of pneumoconiosis. Besides inhalative occupational exposure, intravenous abuse of adulterated drugs is a major cause for this condition. Minerals such as talcum (magnesium silicate) and sand (predominant silicon dioxide) are used to increase both volume and weight of illicit substances. In intravenous heroin-abuse, talcosis is a well-known complication. Here we describe a case of talcosis caused by inhalative abuse of adulterated marijuana.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical history<\/jats:title>\n            <jats:p>A 29-year old man presented with persistent fever, dyspnea and cervical emphysema. He admitted consumption of 'cut' marijuana for several years, preferentially by water pipe smoking.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Morphologic findings<\/jats:title>\n            <jats:p>Lung-biopsies showed chronic interstitial lung disease, anthracotic pigments and birefringent material. Energy dispersive x-ray spectroscopy revealed silicon-containing particles (1-2 \u03bcm) and fine aluminum particles (&lt; 1 \u03bcm), magnesium and several other elements forming a spectrum compatible with the stated water pipe smoking of talcum-adulterated marijuana.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>The exacerbated chronic interstitial lung disease in a 29-year old patient could be attributed to his prolonged abuse of talcum-adulterated marjuana by histopathology and x-ray spectroscopy. Since cannabis consumption is widely spread among young adults, it seems to be justified to raise attention to this form of interstitial pulmonary disease.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Virtual slides<\/jats:title>\n            <jats:p>The virtual slide(s) for this article can be found here: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.diagnomx.eu\/vs\/krause\/html\/start.html\" ext-link-type=\"uri\">http:\/\/www.diagnomx.eu\/vs\/krause\/html\/start.html<\/jats:ext-link>.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1746-1596-7-26","type":"journal-article","created":{"date-parts":[[2012,3,15]],"date-time":"2012-03-15T19:18:14Z","timestamp":1331839094000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Talcum induced pneumoconiosis following inhalation of adulterated marijuana, a case report"],"prefix":"10.1186","volume":"7","author":[{"given":"Andreas Hans","family":"Scheel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Krause","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helmut","family":"Haars","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inge","family":"Schmitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Junker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,3,15]]},"reference":[{"issue":"28","key":"533_CR1","first-page":"627","volume":"53","author":"Centers for Disease Control and Prevention (CDC)","year":"2004","unstructured":"Centers for Disease Control and Prevention (CDC): Changing patterns of pneumoconiosis mortality--United States, 1968-2000. MMWR Morb Mortal Wkly Rep. 2004, 53 (28): 627-32.","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"5","key":"533_CR2","doi-asserted-by":"crossref","first-page":"667","DOI":"10.5858\/134.5.667","volume":"134","author":"S Mukhopadhyay","year":"2010","unstructured":"Mukhopadhyay S, Gal AA: Granulomatous lung disease: an approach to the differential diagnosis. Arch Pathol Lab Med. 2010, 134 (5): 667-90.","journal-title":"Arch Pathol Lab Med"},{"issue":"10","key":"533_CR3","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.7326\/0003-4819-119-10-199311150-00009","volume":"119","author":"CE Cherubin","year":"1993","unstructured":"Cherubin CE, Sapira JD: The medical complications of drug addiction and the medical assessment of the intravenous drug user: 25 years later. 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Rev Mal Respir. 2009, 26 (5): 552-6. 10.1016\/S0761-8425(09)74675-3.","journal-title":"Rev Mal Respir"},{"key":"533_CR6","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1055\/s-0030-1256286","volume":"65","author":"V Neumann","year":"2011","unstructured":"Neumann V, Schulz F, Theile A, L\u00f6seke S, P\u00fcschel K, Tannapfel A: Case Report of a rare Occupational Disease: A During Life Non-Recognized Occupational Disease - Talcosis. Pneumologie. 2011, 65: 471-476. 10.1055\/s-0030-1256286.","journal-title":"Pneumologie"},{"issue":"1","key":"533_CR7","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1378\/chest.98.1.237","volume":"98","author":"M Oubeid","year":"1990","unstructured":"Oubeid M, Bickel JT, Ingram EA, Scott GC: Pulmonary talc granulomatosis in a cocaine sniffer. Chest. 1990, 98 (1): 237-239. 10.1378\/chest.98.1.237.","journal-title":"Chest"},{"issue":"12","key":"533_CR8","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1016\/0046-8177(92)90053-6","volume":"23","author":"AE Gibbs","year":"1992","unstructured":"Gibbs AE, Pooley FD, Griffiths DM, Mitha R, Craighead JE, Ruttner JR: Talc pneumoconiosis: a pathologic and mineralogic study. Hum Pathol. 1992, 23 (12): 1344-54. 10.1016\/0046-8177(92)90053-6.","journal-title":"Hum Pathol"},{"key":"533_CR9","unstructured":"Bundeszentrale f\u00fcr Gesundheitliche Aufkl\u00e4rung 2011: Der Cannabiskonsum Jugendlicher und junger Erwachsener in Deutschland 2010. Ergebnisse einer aktuellen Repr\u00e4sentativbefragung und Trends. K\u00f6ln: Bundeszentrale f\u00fcr Gesundheitliche Aufkl\u00e4rung, [http:\/\/www.bzga.de\/forschung\/studien-untersuchungen\/studien\/suchtpraevention\/?sub=63]"}],"container-title":["Diagnostic Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1746-1596-7-26.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T18:58:12Z","timestamp":1630522692000},"score":1,"resource":{"primary":{"URL":"https:\/\/diagnosticpathology.biomedcentral.com\/articles\/10.1186\/1746-1596-7-26"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,15]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["533"],"URL":"https:\/\/doi.org\/10.1186\/1746-1596-7-26","relation":{},"ISSN":["1746-1596"],"issn-type":[{"value":"1746-1596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,15]]},"assertion":[{"value":"8 January 2012","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 March 2012","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 March 2012","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"26"}}