{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T12:59:50Z","timestamp":1774529990567,"version":"3.50.1"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Diagn Pathol"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1186\/1746-1596-8-169","type":"journal-article","created":{"date-parts":[[2013,10,17]],"date-time":"2013-10-17T17:02:13Z","timestamp":1382029333000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Genetic polymorphisms in plasminogen activator inhibitor-1 predict susceptibility to steroid-induced osteonecrosis of the femoral head in Chinese population"],"prefix":"10.1186","volume":"8","author":[{"given":"Yanqiong","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongtian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shangzhu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangying","family":"Kong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,10,17]]},"reference":[{"key":"1147_CR1","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1155\/2011\/196021","volume":"31","author":"B Balla","year":"2011","unstructured":"Balla B, Pint\u00e9r C, K\u00f3sa JP, Podani J, Tak\u00e1cs I, Nagy Z, Speer G, Horv\u00e1th B, Kor\u00e1nyi L, Lakatos P: Gene expression changes in femoral head necrosis of human bone tissue. Dis Markers. 2011, 31: 25-32. 10.1155\/2011\/196021.","journal-title":"Dis Markers"},{"key":"1147_CR2","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1007\/s11999-008-0147-1","volume":"466","author":"JD Chang","year":"2008","unstructured":"Chang JD, Hur M, Lee SS, Yoo JH, Lee KM: Genetic background of nontraumatic osteonecrosis of the femoral head in the Korean population. Clin Orthop Relat Res. 2008, 466: 1041-1046. 10.1007\/s11999-008-0147-1.","journal-title":"Clin Orthop Relat Res"},{"key":"1147_CR3","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1007\/s10776-003-0646-7","volume":"8","author":"T Asano","year":"2003","unstructured":"Asano T, Takahashi KA, Fujioka M, Inoue S, Satomi Y, Nishino H, Tanaka T, Hirota Y, Takaoka K, Nakajima S, Kubo T: Genetic analysis of steroid-induced osteonecrosis of the femoral head. J Orthop Sci. 2003, 8: 329-333. 10.1007\/s10776-003-0646-7.","journal-title":"J Orthop Sci"},{"key":"1147_CR4","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1186\/1746-1596-7-78","volume":"7","author":"EB Petcu","year":"2012","unstructured":"Petcu EB, Ivanovski S, Wright RG, Slevin M, Miroiu RI, Rinzaniuc K: Bisphosphonate-related osteonecrosis of jaw (BRONJ): an anti-angiogenic side-effect?. Diagn Pathol. 2012, 7: 78-10.1186\/1746-1596-7-78.","journal-title":"Diagn Pathol"},{"key":"1147_CR5","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1186\/1746-1596-5-62","volume":"5","author":"IJ Miller","year":"2010","unstructured":"Miller IJ, Blank A, Yin SM, Mcnickle A, Gray R, Gitelis S: A case of recurrent giant cell tumor of bone with malignant transformation and benign pulmonary metastases. Diagn Pathol. 2010, 5: 62-10.1186\/1746-1596-5-62.","journal-title":"Diagn Pathol"},{"key":"1147_CR6","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1007\/s00776-008-1244-4","volume":"13","author":"M Kuribayashi","year":"2008","unstructured":"Kuribayashi M, Fujioka M, Takahashi KA, Arai Y, Hirata T, Nakajima S, Yoshimura N, Satomi Y, Nishino H, Kondo K, Fukushima W, Hirota Y, Kubo T: Combination analysis of three polymorphisms for predicting the risk for steroid-induced osteonecrosis of the femoral head. J Orthop Sci. 2008, 13: 297-303. 10.1007\/s00776-008-1244-4.","journal-title":"J Orthop Sci"},{"key":"1147_CR7","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1002\/jor.21492","volume":"30","author":"YJ Lee","year":"2012","unstructured":"Lee YJ, Lee JS, Kang EH, Lee YK, Kim SY, Song YW, Koo KH: Vascular endothelial growth factor polymorphisms in patients with steroid-induced femoral head osteonecrosis. J Orthop Res. 2012, 30: 21-27. 10.1002\/jor.21492.","journal-title":"J Orthop Res"},{"key":"1147_CR8","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1007\/s00774-007-0770-z","volume":"25","author":"K Tamura","year":"2007","unstructured":"Tamura K, Nakajima S, Hirota Y, Takahashi KA, Fujioka M, Kubo T, Iwatani Y, Ozono K: Genetic association of a polymorphism of the cAMP-responsive element binding protein-binding protein with steroid-induced osteonecrosis after kidney transplantation. J Bone Miner Metab. 2007, 25: 320-325. 10.1007\/s00774-007-0770-z.","journal-title":"J Bone Miner Metab"},{"key":"1147_CR9","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1007\/s00776-010-1452-6","volume":"15","author":"XY Guan","year":"2010","unstructured":"Guan XY, Han D: Role of hypercoagulability in steroid-induced femoral head necrosis in rabbits. J Orthop Sci. 2010, 15: 365-370. 10.1007\/s00776-010-1452-6.","journal-title":"J Orthop Sci"},{"key":"1147_CR10","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1177\/147323001003800333","volume":"38","author":"G Wang","year":"2010","unstructured":"Wang G, Zhang CQ, Sun Y, Feng Y, Chen SB, Cheng XG, Zeng BF: Changes in femoral head blood supply and vascular endothelial growth factor in rabbits with steroid-induced osteonecrosis. J Int Med Res. 2010, 38: 1060-1069. 10.1177\/147323001003800333.","journal-title":"J Int Med Res"},{"key":"1147_CR11","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1517\/13543776.2013.782393","volume":"23","author":"YM Fortenberry","year":"2013","unstructured":"Fortenberry YM: Plasminogen activator inhibitor-1 inhibitors: a patent review (2006 - present). Expert Opin Ther Pat. 2013, 23: 801-815. 10.1517\/13543776.2013.782393.","journal-title":"Expert Opin Ther Pat"},{"key":"1147_CR12","doi-asserted-by":"publisher","first-page":"2331","DOI":"10.1007\/s00296-013-2717-0","volume":"33","author":"NK Singh","year":"2013","unstructured":"Singh NK, Gupta A, Behera DR, Dash D: Elevated plasminogen activator inhibitor type-1 (PAI-1) as contributing factor in pathogenesis of hypercoagulable state in antiphospholipid syndrome. Rheumatol Int. 2013, 33: 2331-2336. 10.1007\/s00296-013-2717-0.","journal-title":"Rheumatol Int"},{"key":"1147_CR13","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1055\/s-0033-1334487","volume":"39","author":"PJ Declerck","year":"2013","unstructured":"Declerck PJ, Gils A: Three decades of research on plasminogen activator inhibitor-1: a multifaceted serpin. Semin Thromb Hemost. 2013, 39: 356-364. 10.1055\/s-0033-1334487.","journal-title":"Semin Thromb Hemost"},{"key":"1147_CR14","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.trsl.2006.05.001","volume":"148","author":"X Tan","year":"2006","unstructured":"Tan X, Cai D, Wu Y, Liu B, Rong L, Chen Z, Zhao Q: Comparative analysis of serum proteomes: discovery of proteins associated with osteonecrosis of the femoral head. Transl Res. 2006, 148: 114-119. 10.1016\/j.trsl.2006.05.001.","journal-title":"Transl Res"},{"key":"1147_CR15","doi-asserted-by":"publisher","first-page":"281","DOI":"10.2220\/biomedres.31.281","volume":"31","author":"A Hozumi","year":"2010","unstructured":"Hozumi A, Osaki M, Sakamoto K, Goto H, Fukushima T, Baba H, Shindo H: Dexamethasone-induced plasminogen activator inhibitor-1 expression in human primary bone marrow adipocytes. Biomed Res. 2010, 31: 281-286. 10.2220\/biomedres.31.281.","journal-title":"Biomed Res"},{"key":"1147_CR16","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1186\/1471-2474-12-82","volume":"12","author":"K Sakamoto","year":"2011","unstructured":"Sakamoto K, Osaki M, Hozumi A, Goto H, Fukushima T, Baba H, Shindo H: Simvastatin suppresses dexamethasone-induced secretion of plasminogen activator inhibitor-1 in human bone marrow adipocytes. BMC Musculoskelet Disord. 2011, 12: 82-10.1186\/1471-2474-12-82.","journal-title":"BMC Musculoskelet Disord"},{"key":"1147_CR17","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1111\/aji.12116","volume":"70","author":"K Magdoud","year":"2013","unstructured":"Magdoud K, Herbepin VG, Touraine R, Almawi WY, Mahjoub T: Plasminogen Activator Inhibitor 1 4G\/5G and -844G\/A Variants in Idiopathic Recurrent Pregnancy Loss. Am J Reprod Immunol. 2013, 70: 246-252. 10.1111\/aji.12116.","journal-title":"Am J Reprod Immunol"},{"key":"1147_CR18","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1097\/00003086-200105000-00004","volume":"386","author":"CJ Glueck","year":"2001","unstructured":"Glueck CJ, Freiberg RA, Fontaine RN, Tracy T, Wang P: Hypofibrinolysis, thrombophilia, osteonecrosis. Clin Orthop Relat Res. 2001, 386: 19-33.","journal-title":"Clin Orthop Relat Res"},{"key":"1147_CR19","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1097\/00007890-200210270-00016","volume":"74","author":"P Ferrari","year":"2002","unstructured":"Ferrari P, Schroeder V, Anderson S, Kocovic L, Vogt B, Schiesser D, Marti HP, Ganz R, Frey FJ, Kohler HP: Association of plasminogen activator inhibitor-1 genotype with avascular osteonecrosis in steroid-treated renal allograft recipients. Transpl. 2002, 74: 1147-1152. 10.1097\/00007890-200210270-00016.","journal-title":"Transpl"},{"key":"1147_CR20","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1186\/1471-2474-12-160","volume":"12","author":"H Kim","year":"2011","unstructured":"Kim H, Cho C, Cho Y, Cho S, Yoon K, Kim K: Significant associations of PAI-1 genetic polymorphisms with osteonecrosis of the femoral head. BMC Musculoskelet Disord. 2011, 12: 160-10.1186\/1471-2474-12-160.","journal-title":"BMC Musculoskelet Disord"},{"key":"1147_CR21","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1097\/01.TP.0000101433.99651.96","volume":"77","author":"T Asano","year":"2004","unstructured":"Asano T, Takahashi KA, Fujioka M, Inoue S, Ueshima K, Hirata T, Okamoto M, Satomi Y, Nishino H, Tanaka T, Hirota Y, Kubo T: Relationship between postrenal transplant osteonecrosis of the femoral head and gene polymorphisms related to the coagulation and fibrinolytic systems in Japanese subjects. Transpl. 2004, 77: 220-225. 10.1097\/01.TP.0000101433.99651.96.","journal-title":"Transpl"},{"key":"1147_CR22","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/s100670200078","volume":"21","author":"KH Koo","year":"2002","unstructured":"Koo KH, Kim R, Kim YS, Ahn IO, Cho SH, Song HR, Park YS, Kim H, Wang GJ: Risk period for developing osteonecrosis of the femoral head in patients on steroid treatment. Clin Rheumatol. 2002, 21: 299-303. 10.1007\/s100670200078.","journal-title":"Clin Rheumatol"},{"key":"1147_CR23","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.2106\/JBJS.E.01041","volume":"88","author":"MA Mont","year":"2006","unstructured":"Mont MA, Jones LC, Hungerford DS: Nontraumatic osteonecrosis of the femoral head: ten years later. J Bone Join t Surg(Am). 2006, 88: 1117-1132.","journal-title":"J Bone Join t Surg(Am)"},{"key":"1147_CR24","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1136\/ard.60.12.1145","volume":"60","author":"K Oinuma","year":"2001","unstructured":"Oinuma K, Harada Y, Nawata Y, Takabayashi K, Abe I, Kamikawa K, Moriya H: Osteonecrosis in patients with systemic lupus erythematosus develops very early after starting high dose corticosteroid treatment. Ann Rheum Dis. 2001, 60: 1145-1148. 10.1136\/ard.60.12.1145.","journal-title":"Ann Rheum Dis"},{"key":"1147_CR25","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/j.jbspin.2009.04.002","volume":"76","author":"Y Sun","year":"2009","unstructured":"Sun Y, Feng Y, Zhang C: The effect of bone marrow mononuclear cells on vascularization and bone regeneration in steroid-induced osteonecrosis of the femoral head. Joint Bone Spine. 2009, 76: 685-690. 10.1016\/j.jbspin.2009.04.002.","journal-title":"Joint Bone Spine"},{"key":"1147_CR26","first-page":"930","volume":"62","author":"XY Yang","year":"2007","unstructured":"Yang XY, Xu DH: MDR1(ABCB1) gene polymorphisms associated with steroid-induced osteonecrosis of femoral head in systemic lupus erythematosus. Pharm. 2007, 62: 930-932.","journal-title":"Pharm"},{"key":"1147_CR27","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1186\/1471-2474-8-78","volume":"8","author":"K Kawate","year":"2007","unstructured":"Kawate K, Yajima H, Sugimoto K, Ono H, Ohmura T, Kobata Y, Murata K, Shigematsu K, Kawamura K, Kawahara I, Maegawa N, Tamai K, Takakura Y, Tamai S: Indications for free vascularized fibular grafting for the treatment of osteonecrosis of the femoral head. BMC Musculoskelet Disord. 2007, 8: 78-10.1186\/1471-2474-8-78.","journal-title":"BMC Musculoskelet Disord"},{"key":"1147_CR28","doi-asserted-by":"publisher","first-page":"G814","DOI":"10.1152\/ajpgi.00017.2013","volume":"304","author":"S Kenny","year":"2013","unstructured":"Kenny S, Steele I, Lyons S, Moore AR, Murugesan SV, Tiszlavicz L, Dimaline R, Pritchard DM, Varro A, Dockray GJ: The role of plasminogen activator inhibitor (PAI)-1 in gastric mucosal protection. Am J Physiol Gastrointest Liver Physiol. 2013, 304: G814-G822. 10.1152\/ajpgi.00017.2013.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"1147_CR29","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1161\/ATVBAHA.113.301224","volume":"33","author":"A Ichimura","year":"2013","unstructured":"Ichimura A, Matsumoto S, Suzuki S, Dan T, Yamaki S, Sato Y, Kiyomoto H, Ishii N, Okada K, Matsuo O, Hou FF: Vaughan DE, van Ypersele de Strihou C, Miyata T: A Small Molecule Inhibitor to Plasminogen Activator Inhibitor 1 Inhibits Macrophage Migration. Arterioscler Thromb Vasc Biol. 2013, 33: 935-942. 10.1161\/ATVBAHA.113.301224.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"1147_CR30","doi-asserted-by":"publisher","first-page":"e54883","DOI":"10.1371\/journal.pone.0054883","volume":"8","author":"L Li","year":"2013","unstructured":"Li L, Nie W, Zhou H, Yuan W, Li W, Huang W: Association between plasminogen activator inhibitor-1\u2013675 4G\/5G polymorphism and sepsis: a meta-analysis. PLoS One. 2013, 8: e54883-10.1371\/journal.pone.0054883.","journal-title":"PLoS One"},{"key":"1147_CR31","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.neulet.2012.03.090","volume":"516","author":"Y Fang","year":"2012","unstructured":"Fang Y, Zhang L, Zeng Z, Lian Y, Jia Y, Zhu H, Xu Y: Promoter polymorphisms of SERPINE1 are associated with the antidepressant response to depression in Alzheimer's disease. Neurosci Lett. 2012, 516: 217-220. 10.1016\/j.neulet.2012.03.090.","journal-title":"Neurosci Lett"},{"key":"1147_CR32","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1161\/01.ATV.0000204731.17646.f2","volume":"26","author":"S Su","year":"2006","unstructured":"Su S, Chen S, Zhao J, Huang J, Wang X, Chen R, Gu D: Plasminogen activator inhibitor-1 gene: selection of tagging single nucleotide polymorphisms and association with coronary heart disease. Arterioscler Thromb Vasc Biol. 2006, 26: 948-954. 10.1161\/01.ATV.0000204731.17646.f2.","journal-title":"Arterioscler Thromb Vasc Biol"}],"container-title":["Diagnostic Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1746-1596-8-169.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T19:36:09Z","timestamp":1630611369000},"score":1,"resource":{"primary":{"URL":"https:\/\/diagnosticpathology.biomedcentral.com\/articles\/10.1186\/1746-1596-8-169"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,17]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["1147"],"URL":"https:\/\/doi.org\/10.1186\/1746-1596-8-169","relation":{},"ISSN":["1746-1596"],"issn-type":[{"value":"1746-1596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,17]]},"assertion":[{"value":"3 October 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 October 2013","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2013","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"169"}}