{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T21:24:45Z","timestamp":1770153885916,"version":"3.49.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,5,2]],"date-time":"2013-05-02T00:00:00Z","timestamp":1367452800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Diagn Pathol"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Abstract<\/jats:title>\n            <jats:p>Sudden death from an undiagnosed primary intracranial neoplasm is an exceptionally rare event, with reported frequencies in the range of 0.02% to 2.1% in medico-legal autopsy series and only 12% of all cases of sudden, unexpected death due to primary intracranial tumors are due to glioblastomas. We present three cases of sudden, unexpected death due to glioblastoma, with different brain localization and expression. A complete methodological forensic approach by means of autopsy, histological and immunohistochemical examinations let us to conclude for an acute central dysregulation caused by glioblastoma and relative complication with rapid increase of intracranial pressure as cause of death. Although modern diagnostic imaging techniques have revolutionized the diagnosis of brain tumors, the autopsy and the careful gross examination and section of the fixed brain (with coronal section) is still the final word in determining exact location, topography, mass effects and histology and secondary damage of brain tumor and contributed the elucidation of the cause of death. Immunohistochemistry and proteomic analysis are mandatory in such cases.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Virtual slides<\/jats:title>\n            <jats:p>The virtual slide(s) for this article can be found here: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.diagnosticpathology.diagnomx.eu\/vs\/1218574899466985\" ext-link-type=\"uri\">http:\/\/www.diagnosticpathology.diagnomx.eu\/vs\/1218574899466985<\/jats:ext-link>\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1746-1596-8-73","type":"journal-article","created":{"date-parts":[[2013,5,2]],"date-time":"2013-05-02T16:27:36Z","timestamp":1367512056000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Sudden, unexpected death due to glioblastoma: report of three fatal cases and review of the literature"],"prefix":"10.1186","volume":"8","author":[{"given":"Irene","family":"Riezzo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosanna","family":"Zamparese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margherita","family":"Neri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"De Stefano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruggero","family":"Parente","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristoforo","family":"Pomara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuela","family":"Turillazzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Ventura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vittorio","family":"Fineschi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,5,2]]},"reference":[{"key":"755_CR1","first-page":"2463","volume":"26","author":"T Vougiouklakis","year":"2006","unstructured":"Vougiouklakis T, Mitselou A, Agnantis NJ: Sudden death due to primary intracranial neoplasms. A forensic autopsy study. Anticancer Res. 2006, 26: 2463-2466.","journal-title":"Anticancer Res"},{"key":"755_CR2","doi-asserted-by":"publisher","first-page":"751","DOI":"10.3171\/jns.1986.65.6.0751","volume":"65","author":"AL Albright","year":"1986","unstructured":"Albright AL, Guthkelch AN, Packer RJ, Price RA, Rourke LB: Prognostic factors in pediatric brain-stem gliomas. J Neurosurg. 1986, 65: 751-755. 10.3171\/jns.1986.65.6.0751.","journal-title":"J Neurosurg"},{"key":"755_CR3","doi-asserted-by":"publisher","first-page":"2313","DOI":"10.1002\/1097-0142(19831215)52:12<2313::AID-CNCR2820521226>3.0.CO;2-I","volume":"52","author":"AL Albright","year":"1983","unstructured":"Albright AL, Price RA, Guthkelch AN: Brain stem gliomas of children. A clinicopathological study. Cancer. 1983, 52: 2313-2319. 10.1002\/1097-0142(19831215)52:12<2313::AID-CNCR2820521226>3.0.CO;2-I.","journal-title":"Cancer"},{"key":"755_CR4","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1159\/000121012","volume":"24","author":"PC Burger","year":"1996","unstructured":"Burger PC: Pathology of brain stem astrocytomas. Pediatr Neurosurg. 1996, 24: 35-40. 10.1159\/000121012.","journal-title":"Pediatr Neurosurg"},{"key":"755_CR5","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1002\/1097-0142(20001001)89:7<1569::AID-CNCR22>3.0.CO;2-0","volume":"89","author":"PG Fisher","year":"2000","unstructured":"Fisher PG, Breiter SN, Carson BS, Wharam MD, Williams JA, Weingart JD, Foer DR, Goldthwaite PT, Tihan T, Burger PC: A clinicopathologic reappraisal of brain stem tumor classification. Identification of pilocystic astrocytoma and fibrillary astrocytoma as distinct entities. Cancer. 2000, 89: 1569-1576. 10.1002\/1097-0142(20001001)89:7<1569::AID-CNCR22>3.0.CO;2-0.","journal-title":"Cancer"},{"key":"755_CR6","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/BF02482449","volume":"19","author":"MR Amin","year":"2002","unstructured":"Amin MR, Kamitani H, Watanabe T, Ishibashi M, Ogawa T, Funakoshi T, Miyata H, Ohama E: A topographic analysis of the proliferating tumor cells in an autopsied brain with infiltrative thalamic glioma. Brain Tumor Pathol. 2002, 19: 5-10. 10.1007\/BF02482449.","journal-title":"Brain Tumor Pathol"},{"key":"755_CR7","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1159\/000028937","volume":"32","author":"PC Burger","year":"2000","unstructured":"Burger PC, Cohen KJ, Rosenblum MK, Tihan T: Pathology of diencephalic astrocytomas. Pediatr Neurosurg. 2000, 32: 214-219. 10.1159\/000028937.","journal-title":"Pediatr Neurosurg"},{"key":"755_CR8","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1007\/s00381-002-0609-9","volume":"18","author":"C Di Rocco","year":"2002","unstructured":"Di Rocco C, Iannelli A: Bilateral thalamic tumors in children. Childs Nerv Syst. 2002, 18: 440-444. 10.1007\/s00381-002-0609-9.","journal-title":"Childs Nerv Syst"},{"key":"755_CR9","doi-asserted-by":"publisher","first-page":"548","DOI":"10.3171\/jns.1995.82.4.0548","volume":"82","author":"HG Krouwer","year":"1995","unstructured":"Krouwer HG, Prados MD: Infiltrative astrocytomas of the thalamus. J Neurosurg. 1995, 82: 548-557. 10.3171\/jns.1995.82.4.0548.","journal-title":"J Neurosurg"},{"key":"755_CR10","doi-asserted-by":"publisher","first-page":"355","DOI":"10.3171\/jns.1992.77.3.0355","volume":"77","author":"FJ Epstein","year":"1992","unstructured":"Epstein FJ, Farmer JP, Freed D: Adult intramedullary astrocytomas of the spinal cord. J Neurosurg. 1992, 77: 355-359. 10.3171\/jns.1992.77.3.0355.","journal-title":"J Neurosurg"},{"key":"755_CR11","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1023\/A:1010680924975","volume":"52","author":"MS Kim","year":"2001","unstructured":"Kim MS, Chung CK, Choe G, Kim IH, Kim HJ: Intramedullary spinal cord astrocytoma in adults: postoperative outcome. J Neurooncol. 2001, 52: 85-94. 10.1023\/A:1010680924975.","journal-title":"J Neurooncol"},{"key":"755_CR12","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1002\/cncr.11514","volume":"98","author":"M Santi","year":"2003","unstructured":"Santi M, Mena H, Wong K, Koeller K, Olsen C, Rushing EJ: Spinal cord malignant astrocytomas. Clinicopathologic features in 36 cases. Cancer. 2003, 98: 554-561. 10.1002\/cncr.11514.","journal-title":"Cancer"},{"key":"755_CR13","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1023\/A:1006415703881","volume":"50","author":"HM Strik","year":"2000","unstructured":"Strik HM, Effenberger O, Sch\u00e4fer O, Risch U, Wickboldt J, Meyermann R: A case of spinal glioblastoma multiforme: immunohistochemical study and review of the literature. J Neurooncol. 2000, 50: 239-243. 10.1023\/A:1006415703881.","journal-title":"J Neurooncol"},{"key":"755_CR14","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1007\/s00381-003-0825-y","volume":"19","author":"T Bernhardtsen","year":"2003","unstructured":"Bernhardtsen T, Laursen H, Bojsen-M\u00f8ller M, Gjerris F: Sub-classification of low-grade cerebellar astrocytoma: is it clinically meaningful?. Childs Nerv Syst. 2003, 19: 729-735. 10.1007\/s00381-003-0825-y.","journal-title":"Childs Nerv Syst"},{"key":"755_CR15","first-page":"57","volume":"47","author":"V Gupta","year":"2003","unstructured":"Gupta V, Goyal A, Sinha S, Singh AK, Tatke M, Kumar S, Singh D, Sachdeva PK: Glioblastoma of the cerebellum. A report of 3 cases. J Neurosurg Sci. 2003, 47: 57-164.","journal-title":"J Neurosurg Sci"},{"key":"755_CR16","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1002\/1097-0142(19930801)72:3<856::AID-CNCR2820720335>3.0.CO;2-K","volume":"72","author":"CJ Hayostek","year":"1993","unstructured":"Hayostek CJ, Shaw EG, Scheithauer B, O\u2019Fallon JR, Weiland TL, Schomberg PJ, Kelly PJ, Hu TC: Astrocytomas of the cerebellum. A comparative clinicopathologic study of pilocytic and diffuse astrocytomas. Cancer. 1993, 72: 856-869. 10.1002\/1097-0142(19930801)72:3<856::AID-CNCR2820720335>3.0.CO;2-K.","journal-title":"Cancer"},{"key":"755_CR17","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/s00401-007-0243-4","volume":"114","author":"DN Louis","year":"2007","unstructured":"Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, Scheithauer BW, Kleihues P: The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol. 2007, 114: 97-109. 10.1007\/s00401-007-0243-4.","journal-title":"Acta Neuropathol"},{"key":"755_CR18","first-page":"1832","volume":"74","author":"TM Di Maio","year":"1974","unstructured":"Di Maio TM, Di Maio DJ: Sudden death due to colloid cysts of the third cerebral ventricle. N Y State J Med. 1974, 74: 1832-1834.","journal-title":"N Y State J Med"},{"key":"755_CR19","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1097\/00000433-198003000-00007","volume":"1","author":"SM Di Maio","year":"1980","unstructured":"Di Maio SM, Di Maio VJ, Kirkpatrik JB: Sudden unexpected deaths due to primary intracranial neoplasms. Am J Forensic Med Pathol. 1980, 1: 29-45. 10.1097\/00000433-198003000-00007.","journal-title":"Am J Forensic Med Pathol"},{"key":"755_CR20","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.5858\/2001-125-1024-DIOSDD","volume":"125","author":"G Eberhart Ch","year":"2001","unstructured":"Eberhart Ch G, Morrison A, Gyure KA, Frazier J, Smialek JE, Troncoso JC: Decreasing incidence of sudden death due to undiagnosed primary central nervous system. Arch Pathol Lab Med. 2001, 125: 1024-1030.","journal-title":"Arch Pathol Lab Med"},{"key":"755_CR21","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1002\/1097-0142(196501)18:1<117::AID-CNCR2820180117>3.0.CO;2-4","volume":"18","author":"RW Huntington","year":"1965","unstructured":"Huntington RW, Cummings KL, Moe TI, O\u2019Connell HV, Wybel R: Discovery of fatal primary intracranial neoplasms at medico-legal autopsies. Cancer. 1965, 18: 117-127. 10.1002\/1097-0142(196501)18:1<117::AID-CNCR2820180117>3.0.CO;2-4.","journal-title":"Cancer"},{"key":"755_CR22","first-page":"241","volume":"42","author":"D Schreiber","year":"1981","unstructured":"Schreiber D, Warsok R: Localization of brain tumors in autopsy. Part I: Tumor of the temporal lobe. Zentralbl Neurochir. 1981, 42: 241-250.","journal-title":"Zentralbl Neurochir"},{"key":"755_CR23","first-page":"204","volume":"12","author":"L Tiszlavicz","year":"1993","unstructured":"Tiszlavicz L: Multiple primary intracranial tumors and association of intra and extracranial tumors. An autopsy study. Clin Neuropathol. 1993, 12: 204-210.","journal-title":"Clin Neuropathol"},{"key":"755_CR24","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1186\/1746-1596-7-144","volume":"7","author":"E Turillazzi","year":"2012","unstructured":"Turillazzi E, Bello S, Neri M, Riezzo I, Fineschi V: Colloid cyst of the third ventricle, hypothalamus, and heart: a dangerous link for sudden death. Diagn Pathol. 2012, 7: 144-10.1186\/1746-1596-7-144.","journal-title":"Diagn Pathol"},{"key":"755_CR25","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1007\/s00414-005-0551-y","volume":"119","author":"J Matschke","year":"2005","unstructured":"Matschke J, Tsokos M: Sudden unexpected death due to undiagnosed glioblastoma: report of three cases and review of the literature. Int J Legal Med. 2005, 119: 280-284. 10.1007\/s00414-005-0551-y.","journal-title":"Int J Legal Med"},{"key":"755_CR26","first-page":"55","volume":"7","author":"PC Burger","year":"2007","unstructured":"Burger PC, Scheithauer BW: Tumors of the Central Nervous System. AFIP Atlas of Tumor pathology. Fourth Series. 2007, 7: 55-","journal-title":"Fourth Series"},{"key":"755_CR27","first-page":"336","volume":"47","author":"H Matsumoto","year":"1993","unstructured":"Matsumoto H, Yamamoto K: A case of sudden death by undiagnosed glioblastoma multiforme. Nihon Hoigaku Zasshi. 1993, 47: 336-369.","journal-title":"Nihon Hoigaku Zasshi"},{"key":"755_CR28","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.forsciint.2005.08.006","volume":"158","author":"K Shiferaw","year":"2006","unstructured":"Shiferaw K, Pizzolato GP, Perret G, Harpe RL: Sudden, unexpected death due to undiagnosed frontal glioblastoma in a schizophrenic patient. Forensic Sci Int. 2006, 158: 200-203. 10.1016\/j.forsciint.2005.08.006.","journal-title":"Forensic Sci Int"},{"key":"755_CR29","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1007\/s00381-005-1215-4","volume":"22","author":"EA Elgamal","year":"2006","unstructured":"Elgamal EA, Richards PG: Sudden death in children due to intracranial mass lesion. Childs Nerv Syst. 2006, 22: 305-309. 10.1007\/s00381-005-1215-4.","journal-title":"Childs Nerv Syst"},{"key":"755_CR30","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1097\/PAF.0b013e3181e8d0ef","volume":"31","author":"JT Sutton","year":"2010","unstructured":"Sutton JT, Cummings PM, Ross GW, Lopes MB: Sudden death of a 7-year-old boy due to undiagnosed glioblastoma. Am J Forensic Med Pathol. 2010, 31: 278-280. 10.1097\/PAF.0b013e3181e8d0ef.","journal-title":"Am J Forensic Med Pathol"},{"key":"755_CR31","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1093\/neuonc\/1.1.44","volume":"1","author":"P Kleihues","year":"1999","unstructured":"Kleihues P, Ohgaki H: Primary and secondary glioblastomas: from concept to clinical diagnosis. Neuro Oncol. 1999, 1: 44-51.","journal-title":"Neuro Oncol"},{"key":"755_CR32","doi-asserted-by":"publisher","first-page":"6892","DOI":"10.1158\/0008-5472.CAN-04-1337","volume":"64","author":"H Ohgaki","year":"2004","unstructured":"Ohgaki H, Dessen P, Jourde B, Horstmann S, Nishikawa T, Di Patre PL, Burkhard C, Sch\u00fcler D, Probst-Hensch NM, Maiorka PC, Baeza N, Pisani P, Yonekawa Y, Yasargil MG, L\u00fctolf UM, Kleihues P: Genetic pathways to glioblastoma: a population-based study. Cancer Res. 2004, 64: 6892-6899. 10.1158\/0008-5472.CAN-04-1337.","journal-title":"Cancer Res"},{"key":"755_CR33","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1093\/jnen\/64.6.479","volume":"64","author":"H Ohgaki","year":"2005","unstructured":"Ohgaki H, Kleihues P: Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and ologodendroglial gliomas. J Neuropathol Exp Neurol. 2005, 64: 479-489.","journal-title":"J Neuropathol Exp Neurol"},{"key":"755_CR34","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1097\/00005072-199807000-00005","volume":"57","author":"Y Tohma","year":"1998","unstructured":"Tohma Y, Gratas C, Biernat W, Peraud A, Fukuda M, Yonekawa Y, Kleihues P, Ohgaki H: PTEN (MMAC1) mutations are frequent in primary glioblastomas (de novo) but not in secondary glioblastomas. J Neuropathol Exp Neurol. 1998, 57: 684-689. 10.1097\/00005072-199807000-00005.","journal-title":"J Neuropathol Exp Neurol"},{"key":"755_CR35","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1111\/j.1750-3639.1996.tb00848.x","volume":"6","author":"K Watanabe","year":"1996","unstructured":"Watanabe K, Tachibana O, Sata K, Yonekawa Y, Kleihuses P, Ohgaki H: Overexpression of the EGF receptor and p53 mutations are mutually exclusive in the evolution of primary and secondary glioblastomas. Brain Pathol. 1996, 6: 217-223. 10.1111\/j.1750-3639.1996.tb00848.x.","journal-title":"Brain Pathol"},{"key":"755_CR36","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1038\/labinvest.3780009","volume":"80","author":"H Fujisawa","year":"2000","unstructured":"Fujisawa H, Reis RM, Nakamura M, Colella S, Yonekawa Y, Kleihues P, Ohgaki H: Loss of heterozygosity on chromosome 10 is more extensive in primary (de novo) than in secondary glioblastomas. Lab Invest. 2000, 80: 65-72. 10.1038\/labinvest.3780009.","journal-title":"Lab Invest"},{"key":"755_CR37","first-page":"1327","volume":"10","author":"CS Jung","year":"2011","unstructured":"Jung CS, Unterberg AW, Hartmann C: Diagnostic markers for glioblastoma. Histol Histopathol. 2011, 10: 1327-1341.","journal-title":"Histol Histopathol"},{"key":"755_CR38","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.2353\/ajpath.2007.070011","volume":"5","author":"H Ohgaki","year":"2007","unstructured":"Ohgaki H, Kleihues P: Genetic pathways to primary and secondary glioblastoma. Am J Pathol. 2007, 5: 1445-1453.","journal-title":"Am J Pathol"},{"key":"755_CR39","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1007\/s00401-010-0736-4","volume":"120","author":"MJ Riemenschneider","year":"2010","unstructured":"Riemenschneider MJ, Jeuken JWM, Wesseling P, Reifenberger G: Molecular diagnostics of gliomas: state of the art. Acta Neuropathol. 2010, 120: 567-584. 10.1007\/s00401-010-0736-4.","journal-title":"Acta Neuropathol"},{"key":"755_CR40","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/BF00146880","volume":"10","author":"DL Silbergeld","year":"1991","unstructured":"Silbergeld DL, Rostomily RC, Alvord ECJ: The cause of death in patients with glioblastoma is multifactorial: clinical factors and autopsy findings in 117 cases of supratentorial glioblastoma in adults. J Neuro-Oncol. 1991, 10: 179-185. 10.1007\/BF00146880.","journal-title":"J Neuro-Oncol"},{"key":"755_CR41","doi-asserted-by":"publisher","first-page":"204","DOI":"10.3171\/2012.4.JNS101702","volume":"117","author":"M Salvati","year":"2012","unstructured":"Salvati M, Pichierri A, Piccirilli M, Floriana Brunetto GM, D\u2019Elia A, Artizzu S, Santoro F, Arcella A, Giangaspero F, Frati A, Simione L, Santoro A: Extent of tumor removal and molecular markers in cerebral glioblastoma: a combined prognostic factors study in a surgical series of 105 patients. J Neurosurg. 2012, 117: 204-211. 10.3171\/2012.4.JNS101702.","journal-title":"J Neurosurg"},{"key":"755_CR42","doi-asserted-by":"publisher","first-page":"5011","DOI":"10.1021\/pr3005698","volume":"11","author":"A Turtoi","year":"2012","unstructured":"Turtoi A, Musmeci D, Naccarato AG, Scatena C, Ortenzi V, Kiss R, Murtas D, Patsos G, Mazzucchelli G, De Pauw E, Bevilacqua G, Castronovo V: Sparc-like protein 1 is a new marker of human glioma progression. J Proteome Res. 2012, 11: 5011-5021. 10.1021\/pr3005698.","journal-title":"J Proteome Res"},{"key":"755_CR43","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1186\/1746-1596-7-69","volume":"7","author":"Q Wang","year":"2012","unstructured":"Wang Q, Deng J, Yuan J, Wang L, Zhao Z, He S, Zhang Y, Tu Y: Oncogenic reg IV is a novel prognostic marker for glioma patient survival. Diagn Pathol. 2012, 7: 69-10.1186\/1746-1596-7-69.","journal-title":"Diagn Pathol"}],"container-title":["Diagnostic Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1746-1596-8-73.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1746-1596-8-73\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1746-1596-8-73.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T23:53:49Z","timestamp":1630540429000},"score":1,"resource":{"primary":{"URL":"https:\/\/diagnosticpathology.biomedcentral.com\/articles\/10.1186\/1746-1596-8-73"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,2]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["755"],"URL":"https:\/\/doi.org\/10.1186\/1746-1596-8-73","relation":{},"ISSN":["1746-1596"],"issn-type":[{"value":"1746-1596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,2]]},"assertion":[{"value":"17 March 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 April 2013","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 May 2013","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"73"}}