{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:58:19Z","timestamp":1790801899486,"version":"4.1.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagn Pathol"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1186\/1746-1596-9-6","type":"journal-article","created":{"date-parts":[[2014,1,20]],"date-time":"2014-01-20T14:07:02Z","timestamp":1390226822000},"source":"Crossref","is-referenced-by-count":7,"title":["Low-grade myxofibrosarcoma following a metal implantation in femur: a case report"],"prefix":"10.1186","volume":"9","author":[{"given":"Weisong","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiansen","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaohui","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlei","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingchun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,1,20]]},"reference":[{"issue":"2","key":"1083_CR1","first-page":"127","volume":"85A","author":"L Angervall","year":"1977","unstructured":"Angervall L, Kindblom LG, Merck C: Myxofibrosarcoma. A study of 30 cases. Acta Pathol Microbiol Scand A. 1977, 85A (2): 127-140.","journal-title":"Acta Pathol Microbiol Scand A"},{"issue":"4","key":"1083_CR2","doi-asserted-by":"publisher","first-page":"1672","DOI":"10.1002\/1097-0142(197704)39:4<1672::AID-CNCR2820390442>3.0.CO;2-C","volume":"39","author":"SW Weiss","year":"1977","unstructured":"Weiss SW, Enzinger FM: Myxoid variant of malignant fibrous histiocytoma. Cancer. 1977, 39 (4): 1672-1685. 10.1002\/1097-0142(197704)39:4<1672::AID-CNCR2820390442>3.0.CO;2-C.","journal-title":"Cancer"},{"issue":"4","key":"1083_CR3","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1097\/00000478-199604000-00001","volume":"20","author":"T Mentzel","year":"1996","unstructured":"Mentzel T, Calonje E, Wadden C, Camplejohn RS, Beham A, Smith MA, Fletcher CD: Myxofibrosarcoma. Clinicopathologic analysis of 75 cases with emphasis on the low-grade variant. Am J Surg Pathol. 1996, 20 (4): 391-405. 10.1097\/00000478-199604000-00001.","journal-title":"Am J Surg Pathol"},{"issue":"6","key":"1083_CR4","doi-asserted-by":"crossref","first-page":"e165","DOI":"10.1177\/030089161209800630","volume":"98","author":"JG Wang","year":"2012","unstructured":"Wang JG, Li YJ, Liu H, Zhao P: Primary cardiac myxofibrosarcoma: a case report and review of the literature. Tumori. 2012, 98 (6): e165-e168.","journal-title":"Tumori"},{"issue":"4","key":"1083_CR5","doi-asserted-by":"crossref","first-page":"e65","DOI":"10.5858\/2004-128-e65-PQCMTL","volume":"128","author":"P Kapur","year":"2004","unstructured":"Kapur P, Sarode V: Pathologic quiz case: myxoid tibial lesion in a 31-year-old man. Low-grade myxofibrosarcoma. Arch Pathol Lab Med. 2004, 128 (4): e65-e66.","journal-title":"Arch Pathol Lab Med"},{"key":"1083_CR6","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/1477-7800-6-16","volume":"6","author":"D Marotta","year":"2009","unstructured":"Marotta D, Angeloni M, Salgarello M, Ricciardella ML, Chalidis B, Maccauro G: Surgical treatment of a giant tibial high-grade mixofibrosarcoma with preservation of limb function: a case report. Int Semin Surg Oncol. 2009, 6: 16-10.1186\/1477-7800-6-16.","journal-title":"Int Semin Surg Oncol"},{"issue":"5","key":"1083_CR7","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1007\/s00428-012-1306-z","volume":"461","author":"S Romeo","year":"2012","unstructured":"Romeo S, Bov\u00e9e JV, Kroon HM, Tirabosco R, Natali C, Zanatta L, Sciot R, Mertens F, Athanasou N, Alberghini M, Szuhai K, Hogendoorn PC, Dei Tos AP: Malignant fibrous histiocytoma and fibrosarcoma of bone: a re-assessment in the light of currently employed morphological, immunohistochemical and molecular approaches. Virchows Arch. 2012, 461 (5): 561-570. 10.1007\/s00428-012-1306-z.","journal-title":"Virchows Arch"},{"issue":"4","key":"1083_CR8","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1148\/radiographics.14.4.7938770","volume":"14","author":"MD Murphey","year":"1994","unstructured":"Murphey MD, Gross TM, Rosenthal HG: From the archives of the AFIP. Musculoskeletal malignant fibrous histiocytoma: radiologic-pathologic correlation. Radiographics. 1994, 14 (4): 807-826. 10.1148\/radiographics.14.4.7938770.","journal-title":"Radiographics"},{"issue":"2","key":"1083_CR9","first-page":"331","volume":"18","author":"K Nakayama","year":"1997","unstructured":"Nakayama K, Nemoto Y, Inoue Y, Mochizuki T, Soares SB, Ohata K, Katsuyama J, Onoyama Y, Wakasa K: Malignant fibrous histiocytoma of the temporal bone with endocranial extension. AJNR Am J Neuroradiol. 1997, 18 (2): 331-334.","journal-title":"AJNR Am J Neuroradiol"},{"issue":"3","key":"1083_CR10","first-page":"141","volume":"20","author":"R Woodhams","year":"2002","unstructured":"Woodhams R, Kan S, Iwabuchi K, Oka H, Sagiuchi T, Hayakawa K: A case of malignant fibrous histiocytoma (MFH) in the skull bone presenting extensive permeative osteolysis. Radiat Med. 2002, 20 (3): 141-145.","journal-title":"Radiat Med"},{"issue":"1","key":"1083_CR11","doi-asserted-by":"publisher","first-page":"71","DOI":"10.3174\/ajnr.A1317","volume":"30","author":"SW Park","year":"2009","unstructured":"Park SW, Kim HJ, Lee JH, Ko YH: Malignant fibrous histiocytoma of the head and neck: CT and MR imaging findings. AJNR Am J Neuroradiol. 2009, 30 (1): 71-76.","journal-title":"AJNR Am J Neuroradiol"},{"key":"1083_CR12","first-page":"1","volume":"282","author":"C Merck","year":"1983","unstructured":"Merck C, Angervall L, Kindblom LG, Od\u00e9n A: Myxofibrosarcoma. A malignant soft tissue tumor of fibroblastic-histiocytic origin. A clinicopathologic and prognostic study of 110 cases using multivariate analysis. Acta Pathol Microbiol Immunol Scand Suppl. 1983, 282: 1-40.","journal-title":"Acta Pathol Microbiol Immunol Scand Suppl"},{"key":"1083_CR13","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/1746-1596-8-18","volume":"8","author":"XY Lin","year":"2013","unstructured":"Lin XY, Wang Y, Yu JH, Liu Y, Wang L, Li QC, Wang EH: Sclerosing rhabdomyosarcoma presenting in the masseter muscle: a case report. Diagn Pathol. 2013, 8: 18-10.1186\/1746-1596-8-18.","journal-title":"Diagn Pathol"},{"key":"1083_CR14","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1186\/1746-1596-6-127","volume":"6","author":"L Peng","year":"2011","unstructured":"Peng L, Liu Y, Ai Y, Liu Z, He Y, Liu Q: Skull base metastases from a malignant solitary fibrous tumor of the liver. A case report and literature review. Diagn Pathol. 2011, 6: 127-10.1186\/1746-1596-6-127.","journal-title":"Diagn Pathol"},{"issue":"10","key":"1083_CR15","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.1097\/01.pas.0000170343.09562.39","volume":"29","author":"MB Binh","year":"2005","unstructured":"Binh MB, Sastre-Garau X, Guillou L, de Pinieux G, Terrier P, Lagac\u00e9 R, Aurias A, Hostein I, Coindre JM: MDM2 and CDK4 immunostainings are useful adjuncts in diagnosing well-differentiated and dedifferentiated liposarcoma subtypes: a comparative analysis of 559 soft tissue neoplasms with genetic data. Am J Surg Pathol. 2005, 29 (10): 1340-1347. 10.1097\/01.pas.0000170343.09562.39.","journal-title":"Am J Surg Pathol"},{"issue":"10","key":"1083_CR16","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1053\/S0046-8177(03)00404-0","volume":"34","author":"Y Oda","year":"2003","unstructured":"Oda Y, Takahira T, Kawaguchi K, Yamamoto H, Tamiya S, Matsuda S, Tanaka K, Kinukawa N, Iwamoto Y, Tsuneyoshi M: Altered expression of cell cycle regulators in myxofibrosarcoma, with special emphasis on their prognostic implications. Hum Pathol. 2003, 34 (10): 1035-1042. 10.1053\/S0046-8177(03)00404-0.","journal-title":"Hum Pathol"},{"issue":"7","key":"1083_CR17","first-page":"1306","volume":"6","author":"H Kimura","year":"2013","unstructured":"Kimura H, Dobashi Y, Nojima T, Nakamura H, Yamamoto N, Tsuchiya H, Ikeda H, Sawada-Kitamura S, Oyama T, Ooi A: Utility of fluorescence in situ hybridization to detect MDM2 amplification in liposarcomas and their morphological mimics. Int J Clin Exp Pathol. 2013, 6 (7): 1306-1316.","journal-title":"Int J Clin Exp Pathol"},{"issue":"10","key":"1083_CR18","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1016\/j.jocn.2007.07.003","volume":"15","author":"JR Kuo","year":"2008","unstructured":"Kuo JR, Chio CC, Wang CC, Chu YH, Lin KC, Chuang SS: Radiation-induced intra- and extra-cranial high-grade myxofibrosarcoma with tumor bleeding. J Clin Neurosci. 2008, 15 (10): 1151-1154. 10.1016\/j.jocn.2007.07.003.","journal-title":"J Clin Neurosci"},{"key":"1083_CR19","volume-title":"BMJ Case Rep","author":"H Tearada","year":"2012","unstructured":"Tearada H, Nagata M, Mugiya S, Ozono S: High-grade myxofibrosarcoma presenting at the spermatic cord after radiotherapy for prostate cancer. BMJ Case Rep. 2012. doi: 10.1136\/bcr-03-2012-6082"},{"issue":"4","key":"1083_CR20","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1016\/0002-9610(57)90531-7","volume":"93","author":"MR Urist","year":"1957","unstructured":"Urist MR: Trauma and neoplasm; report of a case of desmoid tumor following simple fracture of the radius and ulna. Am J Surg. 1957, 93 (4): 682-688. 10.1016\/0002-9610(57)90531-7.","journal-title":"Am J Surg"},{"key":"1083_CR21","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1097\/00003086-198204000-00043","volume":"164","author":"F Langer","year":"1982","unstructured":"Langer F, Pritzker KP, Gross AE, Shapiro II: Giant cell tumor associated with trauma. Clin Orthop Relat Res. 1982, 164: 245-248.","journal-title":"Clin Orthop Relat Res"},{"issue":"5","key":"1083_CR22","first-page":"439","volume":"16","author":"BS Oppenheimer","year":"1956","unstructured":"Oppenheimer BS, Oppenheimer ET, Danishefsky I, Stout AP: Carcinogenic effect of metals in rodents. Cancer Res. 1956, 16 (5): 439-441.","journal-title":"Cancer Res"},{"issue":"3","key":"1083_CR23","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1302\/0301-620X.38B3.709","volume":"38-B","author":"A McDougall","year":"1956","unstructured":"McDougall A: Malignant tumour at site of bone plating. J Bone Joint Surg Br. 1956, 38-B (3): 709-713.","journal-title":"J Bone Joint Surg Br"},{"key":"1083_CR24","first-page":"315","volume":"12","author":"ER Delgado","year":"1958","unstructured":"Delgado ER: Sarcoma following a surgically treated fractured tibla; a case report. Clin Orthop. 1958, 12: 315-318.","journal-title":"Clin Orthop"},{"issue":"5","key":"1083_CR25","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1002\/1097-0142(197211)30:5<1260::AID-CNCR2820300518>3.0.CO;2-Y","volume":"30","author":"VE Dube","year":"1972","unstructured":"Dube VE, Fisher DE: Hemangioendothelioma of the leg following metallic fixation of the tibia. Cancer. 1972, 30 (5): 1260-1266. 10.1002\/1097-0142(197211)30:5<1260::AID-CNCR2820300518>3.0.CO;2-Y.","journal-title":"Cancer"},{"issue":"2","key":"1083_CR26","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1002\/1097-0142(19800115)45:2<413::AID-CNCR2820450238>3.0.CO;2-#","volume":"45","author":"KJ Tayton","year":"1980","unstructured":"Tayton KJ: Ewing's sarcoma at the site of a metal plate. Cancer. 1980, 45 (2): 413-415. 10.1002\/1097-0142(19800115)45:2<413::AID-CNCR2820450238>3.0.CO;2-#.","journal-title":"Cancer"},{"issue":"4","key":"1083_CR27","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1002\/1097-0142(19810815)48:4<1009::AID-CNCR2820480426>3.0.CO;2-W","volume":"48","author":"I McDonald","year":"1981","unstructured":"McDonald I: Malignant lymphoma associated with internal fixation of a fractured tibia. Cancer. 1981, 48 (4): 1009-1011. 10.1002\/1097-0142(19810815)48:4<1009::AID-CNCR2820480426>3.0.CO;2-W.","journal-title":"Cancer"},{"issue":"5","key":"1083_CR28","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1302\/0301-620X.66B5.6594340","volume":"66","author":"HG Penman","year":"1984","unstructured":"Penman HG, Ring PA: Osteosarcoma in association with total hip replacement. J Bone Joint Surg Br. 1984, 66 (5): 632-634.","journal-title":"J Bone Joint Surg Br"},{"issue":"1","key":"1083_CR29","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1302\/0301-620X.66B1.6319423","volume":"66","author":"J Bag\u00f3-Granell","year":"1984","unstructured":"Bag\u00f3-Granell J, Aguirre-Canyadell M, Nardi J, Tallada N: Malignant fibrous histiocytoma of bone at the site of a total hip arthroplasty. A case report. J Bone Joint Surg Br. 1984, 66 (1): 38-40.","journal-title":"J Bone Joint Surg Br"},{"issue":"5","key":"1083_CR30","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1302\/0301-620X.66B5.6094587","volume":"66","author":"M Swann","year":"1984","unstructured":"Swann M: Malignant soft-tissue tumor at the site of a total hip replacement. J Bone Joint Surg Br. 1984, 66 (5): 629-631.","journal-title":"J Bone Joint Surg Br"},{"issue":"5","key":"1083_CR31","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1302\/0301-620X.68B5.3023388","volume":"68","author":"PC Weber","year":"1986","unstructured":"Weber PC: Epithelioid sarcoma in association with total knee replacement. A case report. J Bone Joint Surg Br. 1986, 68 (5): 824-826.","journal-title":"J Bone Joint Surg Br"},{"issue":"3","key":"1083_CR32","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1302\/0301-620X.69B3.3034914","volume":"69","author":"AW Hughes","year":"1987","unstructured":"Hughes AW, Sherlock DA, Hamblen DL, Reid R: Sarcoma at the site of a single hip screw. A case report. J Bone Joint Surg Br. 1987, 69 (3): 470-472.","journal-title":"J Bone Joint Surg Br"},{"issue":"4","key":"1083_CR33","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1302\/0301-620X.71B4.2549073","volume":"71","author":"M Haag","year":"1989","unstructured":"Haag M, Adler CP: Malignant fibrous histiocytoma in association with hip replacement. J Bone Joint Surg Br. 1989, 71 (4): 701-","journal-title":"J Bone Joint Surg Br"},{"issue":"2","key":"1083_CR34","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/0272-0590(89)90257-1","volume":"13","author":"FW Sunderman Jr","year":"1989","unstructured":"Sunderman FW: Carcinogenicity of metal alloys in orthopedic prostheses: clinical and experimental studies. Fundam Appl Toxicol. 1989, 13 (2): 205-216. 10.1016\/0272-0590(89)90257-1.","journal-title":"Fundam Appl Toxicol"},{"key":"1083_CR35","first-page":"299","volume":"252","author":"JJ Ward","year":"1990","unstructured":"Ward JJ, Thornbury DD, Lemons JE, Dunham WK: Metal-induced sarcoma. A case report and literature review. Clin Orthop Relat Res. 1990, 252: 299-306.","journal-title":"Clin Orthop Relat Res"},{"key":"1083_CR36","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1097\/00003086-199106000-00040","volume":"267","author":"JS Khurana","year":"1991","unstructured":"Khurana JS, Rosenberg AE, Kattapuram SV, Fernandez OS, Ehara S: Malignancy supervening on an intramedullary nail. Clin Orthop Relat Res. 1991, 267: 251-254.","journal-title":"Clin Orthop Relat Res"},{"issue":"2","key":"1083_CR37","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1080\/13577149977794","volume":"3","author":"GM Gatti","year":"1999","unstructured":"Gatti GM, Ivaldi GB, Lartigau E, Marsiglia H, Orecchia R: A Case of RhabdomyoSarcoma Following a Metal Surgical Implant. Sarcoma. 1999, 3 (2): 145-147. 10.1080\/13577149977794.","journal-title":"Sarcoma"},{"issue":"3","key":"1083_CR38","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1080\/000164700317412004","volume":"71","author":"P Hinarejos","year":"2000","unstructured":"Hinarejos P, Escuder MC, Monllau JC, Alvarez P, Lloreta J, Ballester J: Fibrosarcoma at the site of a metallic fixation of the tibia\u2013a case report and literature review. Acta Orthop Scand. 2000, 71 (3): 329-332. 10.1080\/000164700317412004.","journal-title":"Acta Orthop Scand"},{"issue":"1","key":"1083_CR39","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1053\/adpa.2003.50006","volume":"7","author":"JE Adams","year":"2003","unstructured":"Adams JE, Jaffe KA, Lemons JE, Siegal GP: Prosthetic implant associated sarcomas: a case report emphasizing surface evaluation and spectroscopic trace metal analysis. Ann Diagn Pathol. 2003, 7 (1): 35-46. 10.1053\/adpa.2003.50006.","journal-title":"Ann Diagn Pathol"},{"issue":"4","key":"1083_CR40","first-page":"549","volume":"75","author":"A Albert","year":"2009","unstructured":"Albert A, Lootvoet L, Lejeune E, Beugnies A, Himmer O: Angiosarcoma around a knee arthroplasty. Report of a case and literature review. Acta Orthop Belg. 2009, 75 (4): 549-553.","journal-title":"Acta Orthop Belg"},{"issue":"6","key":"1083_CR41","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1053\/j.jfas.2010.08.009","volume":"49","author":"B Palraj","year":"2010","unstructured":"Palraj B, Paturi A, Stone RG, Alvarez H, Sebenik M, Perez MT, Bush LM: Soft tissue anaplastic large T-cell lymphoma associated with a metallic orthopedic implant: case report and review of the current literature. J Foot Ankle Surg. 2010, 49 (6): 561-564. 10.1053\/j.jfas.2010.08.009.","journal-title":"J Foot Ankle Surg"},{"key":"1083_CR42","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1186\/1752-1947-5-198","volume":"5","author":"O Dorrestijn","year":"2011","unstructured":"Dorrestijn O, Jutte PC: Osteosarcoma in the distal femur two years after an ipsilateral femoral shaft fracture: a case report. J Med Case Rep. 2011, 5: 198-10.1186\/1752-1947-5-198.","journal-title":"J Med Case Rep"},{"issue":"9","key":"1083_CR43","doi-asserted-by":"publisher","first-page":"2747","DOI":"10.1007\/s00216-011-5232-8","volume":"401","author":"Y Nuevo-Ord\u00f3\u00f1ez","year":"2011","unstructured":"Nuevo-Ord\u00f3\u00f1ez Y, Montes-Bay\u00f3n M, Blanco-Gonz\u00e1lez E, Paz-Aparicio J, Raimundez JD, Tejerina JM, Pe\u00f1a MA, Sanz-Medel A: Titanium release in serum of patients with different bone fixation implants and its interaction with serum biomolecules at physiological levels. Anal Bioanal Chem. 2011, 401 (9): 2747-2754. 10.1007\/s00216-011-5232-8.","journal-title":"Anal Bioanal Chem"},{"issue":"4","key":"1083_CR44","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1038\/sj.bjc.6600758","volume":"88","author":"N Coen","year":"2003","unstructured":"Coen N, Kadhim MA, Wright EG, Case CP, Mothersill CE: Particulate debris from a titanium metal prosthesis induces genomic instability in primary human fibroblast cells. Br J Cancer. 2003, 88 (4): 548-552. 10.1038\/sj.bjc.6600758.","journal-title":"Br J Cancer"}],"container-title":["Diagnostic Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1746-1596-9-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,24]],"date-time":"2022-03-24T05:27:45Z","timestamp":1648099665000},"score":1,"resource":{"primary":{"URL":"https:\/\/diagnosticpathology.biomedcentral.com\/articles\/10.1186\/1746-1596-9-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,20]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["1083"],"URL":"https:\/\/doi.org\/10.1186\/1746-1596-9-6","relation":{},"ISSN":["1746-1596"],"issn-type":[{"value":"1746-1596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,20]]},"article-number":"6"}}