{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T05:12:19Z","timestamp":1777698739896,"version":"3.51.4"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2007,2,8]],"date-time":"2007-02-08T00:00:00Z","timestamp":1170892800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Head Face Med"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Lichen planopilaris (LPP) is an inflammatory disease characterized by a lymphomononuclear infiltrate surrounding the isthmus and infundibulum of the hair follicle of the scalp, that evolves into atrophic\/scarring alopecia. In the active phase of the disease hairs are easily plucked with anagen-like hair-roots. In this study we focused on the expression of integrins and basement membrane components of the hair follicle in active LPP lesions.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Scalp biopsies were taken in 10 patients with LPP and in 5 normal controls. Using monoclonal antibodies against \u03b1<jats:sub>3<\/jats:sub>\u03b2<jats:sub>1<\/jats:sub> and \u03b1<jats:sub>6<\/jats:sub>\u03b2<jats:sub>4<\/jats:sub> integrins we showed the expression of these integrins and of the basement membrane components of the hair follicle in active LPP lesions and in healthy scalp skin.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>In the LPP involved areas, \u03b1<jats:sub>3<\/jats:sub>\u03b2<jats:sub>1<\/jats:sub> was distributed in a pericellular pattern, the \u03b1<jats:sub>6<\/jats:sub> subunit was present with a basolateral distribution while the \u03b2<jats:sub>4<\/jats:sub> subunit showed discontinuous expression at the basal pole and occasionally, basolateral staining of the hair follicle. Conclusion: An altered distribution of the integrins in active LPP lesions can explain the phenomenon of easy pulling-out of the hair with a \"gelatinous\" root-sheath.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1746-160x-3-11","type":"journal-article","created":{"date-parts":[[2007,2,8]],"date-time":"2007-02-08T19:09:10Z","timestamp":1170961750000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Alterated integrin expression in lichen planopilaris"],"prefix":"10.1186","volume":"3","author":[{"given":"Roberto","family":"d'Ovidio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Concetta","family":"Sgarra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Conserva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umberto Filippo","family":"Angelotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Erriquez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caterina","family":"Foti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2007,2,8]]},"reference":[{"key":"73_CR1","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1016\/0190-9622(90)70078-V","volume":"22","author":"M Matta","year":"1990","unstructured":"Matta M, Kibbi AG, Khattar J, Salman SM, Zaynoun ST: Lichen planopilaris: a clinicopathologic study. 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