{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T01:56:09Z","timestamp":1773280569722,"version":"3.50.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2012,2,23]],"date-time":"2012-02-23T00:00:00Z","timestamp":1329955200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Head Face Med"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Introduction<\/jats:title>\n            <jats:p>It has been shown that Low Level Laser (LLL) has a positive effect on bone formation. The aim of this study was to evaluate the effect of low level laser on condylar growth during mandibular advancement in rabbits.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Materials and methods<\/jats:title>\n            <jats:p>Continuous forward mandibular advancement was performed in fourteen male Albino rabbits with the mean age of 8 weeks and the mean weight of 1.5 \u00b1 0.5 kg, with acrylic inclined planes. The rabbits were randomly assigned into two groups after 4 weeks. LLL (KLO3: wave length 630 nm) was irradiated at 3 points around the TMJ, through the skin in the first group. The exposure was performed for 3 minutes at each point (a total of 9 minutes) once a day for 3 weeks. The control group was not exposed to any irradiation. The rabbits in both groups were sacrificed after two months and the histological evaluation of TMJ was performed to compare fibrous tissue, cartilage, and new bone formation in condylar region in both groups. Disc displacement was also detected in both groups. Student's t-test, Exact Fisher and Chi square tests were used for the statistical analysis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The formation of fibrous tissue was significantly lower, while bone formation was significantly greater in lased group as compared with control group. The thickness of cartilage did not differ significantly between two groups.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Irradiation of LLL (KLO3) during mandibular advancement in rabbits, increases bone formation in condylar region, while neither increase in the cartilage thickness nor fibrous tissues was observed.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1746-160x-8-4","type":"journal-article","created":{"date-parts":[[2012,2,23]],"date-time":"2012-02-23T13:14:12Z","timestamp":1330002852000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The effect of low level laser on condylar growth during mandibular advancement in rabbits"],"prefix":"10.1186","volume":"8","author":[{"given":"Mostafa","family":"Abtahi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Poosti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nasrollah","family":"Saghravanian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamran","family":"Sadeghi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hooman","family":"Shafaee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,2,23]]},"reference":[{"issue":"4","key":"221_CR1","first-page":"311","volume":"10","author":"JN Sharma","year":"2009","unstructured":"Sharma JN: Epidemiology of malocclusions and assessment of orthodontic treatment need for the population of eastern Nepal. World J Orthod. 2009, 10 (4): 311-6.","journal-title":"World J Orthod"},{"issue":"5","key":"221_CR2","doi-asserted-by":"publisher","first-page":"e791","DOI":"10.4317\/medoral.15.e791","volume":"15","author":"M Celikoglu","year":"2010","unstructured":"Celikoglu M, Akpinar S, Yavuz I: The pattern of malocclusion in a sample of orthodontic patients from Turkey. Med Oral Patol Oral Cir Bucal. 2010, 15 (5): e791-6.","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"221_CR3","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/0002-9416(85)90063-6","volume":"88","author":"KR Remmer","year":"1985","unstructured":"Remmer KR, Mamandras AH, Hunter WS, Way DC: Cephalometric changes associated with treatment using the activator, the Frankel appliance, and the fixed appliance. Am J Orthod. 1985, 88: 363-372. 10.1016\/0002-9416(85)90063-6.","journal-title":"Am J Orthod"},{"key":"221_CR4","first-page":"177","volume":"51","author":"JA McNamara Jr","year":"1981","unstructured":"McNamara JA: Components of class II malocclusion in children 8-10 years of age. Angle Orthod. 1981, 51: 177-202.","journal-title":"Angle Orthod"},{"key":"221_CR5","first-page":"83","volume-title":"Textbook of Orthodontics","author":"R Staley","year":"2001","unstructured":"Staley R: Etiology and prevalence of malocclusion. Textbook of Orthodontics. Edited by: Bishara S. 2001, Philadelphia: WB Saunders, 83-96."},{"issue":"4","key":"221_CR6","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1067\/mod.2001.113265","volume":"119","author":"GD Singh","year":"2001","unstructured":"Singh GD, Clark WJ: Localization of mandibular changes in patients with class II division 1 malocclusions treated with twin-block appliances: finite element scaling analysis. Am J Orthod Dentofacial Orthop. 2001, 119 (4): 419-25. 10.1067\/mod.2001.113265.","journal-title":"Am J Orthod Dentofacial Orthop"},{"issue":"3","key":"221_CR7","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1179\/14653121043110","volume":"37","author":"W Clark","year":"2010","unstructured":"Clark W: Design and management of Twin Blocks: reflections after 30 years of clinical use. J Orthod. 2010, 37 (3): 209-16. 10.1179\/14653121043110.","journal-title":"J Orthod"},{"key":"221_CR8","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/0002-9416(72)90023-1","volume":"62","author":"JC Elgoyhen","year":"1972","unstructured":"Elgoyhen JC, Moyers RE, McNamara JA, Riolo ML: Craniofacial adaptation of protrusive function in young rhesus monkeys. Am J Orthod. 1972, 62: 469-480. 10.1016\/0002-9416(72)90023-1.","journal-title":"Am J Orthod"},{"key":"221_CR9","first-page":"25","volume":"10","author":"AG Petrovic","year":"1972","unstructured":"Petrovic AG: Mechanisms and regulation of mandibular condylar growth. Acta Morphol Neerl Scand. 1972, 10: 25-34.","journal-title":"Acta Morphol Neerl Scand"},{"key":"221_CR10","first-page":"4","volume":"71","author":"S Ruf","year":"2001","unstructured":"Ruf S, Baltromejus S, Pancherz H: Effective condylar growth and chin position changes in activator treatment: a cephalometric roentgenographic study. Angle Orthod. 2001, 71: 4-11.","journal-title":"Angle Orthod"},{"key":"221_CR11","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/0002-9416(82)90463-8","volume":"82","author":"JA McNamara Jr","year":"1982","unstructured":"McNamara JA, Hinton RJ, Hoffman DL: Histologic analysis of temporomandibular joint adaptation to protrusive function in young adult rhesus monkeys (Macaca mulatta). Am J Orthod. 1982, 82: 288-298. 10.1016\/0002-9416(82)90463-8.","journal-title":"Am J Orthod"},{"key":"221_CR12","first-page":"418","volume":"72","author":"M Rodrigues de Almeida","year":"2002","unstructured":"Rodrigues de Almeida M, Castanha Henriques JF, Rodrigues de Almeida R, Ursi W: Treatment effects produced by Frankel appliance in patients with class II, division 1 malocclusion. Angle Orthod. 2002, 72: 418-425.","journal-title":"Angle Orthod"},{"key":"221_CR13","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1093\/ejo\/7.4.273","volume":"7","author":"S Kiliaridis","year":"1985","unstructured":"Kiliaridis S, Engstrom C, Thilander B: The relationship between masticatory function and craniofacial morphology. I. A cephalometric longitudinal analysis in the growing rat fed a soft diet. Eur J Orthod. 1985, 7: 273-283.","journal-title":"Eur J Orthod"},{"key":"221_CR14","first-page":"631","volume":"73","author":"T El-Bialy","year":"2003","unstructured":"El-Bialy T, El-Shamy I, Graber TM: Growth modification of the rabbit mandible using therapeutic ultrasound: is it possible to enhance functional appliance results?. Angle Orthod. 2003, 73: 631-639.","journal-title":"Angle Orthod"},{"key":"221_CR15","doi-asserted-by":"publisher","first-page":"964","DOI":"10.2319\/080708-414.1","volume":"79","author":"R Oyonarte","year":"2009","unstructured":"Oyonarte R, Zarate M, Rodriguez F: Low-intensity pulsed ultrasound stimulation of condylar growth in rats. Angle Orthod. 2009, 79: 964-970. 10.2319\/080708-414.1.","journal-title":"Angle Orthod"},{"key":"221_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1749-799X-5-1","volume":"5","author":"S Bashardoust Tajali","year":"2010","unstructured":"Bashardoust Tajali S, Macdermid JC, Houghton P, Grewal R: Effects of low power laser irradiation on bone healing in animals: a meta-analysis. J Orthop Surg Res. 2010, 5: 1-10.1186\/1749-799X-5-1.","journal-title":"J Orthop Surg Res"},{"key":"221_CR17","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1007\/s10103-009-0670-7","volume":"25","author":"S Kazem Shakouri","year":"2010","unstructured":"Kazem Shakouri S, Soleimanpour J, Salekzamani Y, Oskuie MR: Effect of low-level laser therapy on the fracture healing process. Lasers Med Sci. 2010, 25: 73-77. 10.1007\/s10103-009-0670-7.","journal-title":"Lasers Med Sci"},{"key":"221_CR18","doi-asserted-by":"publisher","first-page":"e616","DOI":"10.4317\/medoral.15.e616","volume":"15","author":"PE Kreisner","year":"2010","unstructured":"Kreisner PE, Blaya DS, Gaiao L, Maciel-Santos ME, Etges A, Santana-Filho M, de Oliveira MG: Histological evaluation of the effect of low-level laser on distraction osteogenesis in rabbit mandibles. Med Oral Patol Oral Cir Bucal. 2010, 15: e616-618.","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"221_CR19","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.joms.2006.10.002","volume":"65","author":"M Miloro","year":"2007","unstructured":"Miloro M, Miller JJ, Stoner JA: Low-level laser effect on mandibular distraction osteogenesis. J Oral Maxillofac Surg. 2007, 65: 168-176. 10.1016\/j.joms.2006.10.002.","journal-title":"J Oral Maxillofac Surg"},{"key":"221_CR20","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/s10103-009-0651-x","volume":"25","author":"M Seifi","year":"2010","unstructured":"Seifi M, Maghzi A, Gutknecht N, Mir M, Asna-Ashari M: The effect of 904 nm low level laser on condylar growth in rats. Lasers Med Sci. 2010, 25: 61-65.","journal-title":"Lasers Med Sci"},{"key":"221_CR21","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1067\/mod.2001.112875","volume":"119","author":"AB Rabie","year":"2001","unstructured":"Rabie AB, Zhao Z, Shen G, Hagg EU, Dr O, Robinson W: Osteogenesis in the glenoid fossa in response to mandibular advancement. Am J Orthod Dentofacial Orthop. 2001, 119: 390-400. 10.1067\/mod.2001.112875.","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"221_CR22","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1093\/ejo\/cjp078","volume":"32","author":"M Yamaguchi","year":"2010","unstructured":"Yamaguchi M, Hayashi M, Fujita S, Yoshida T, Utsunomiya T, Yamamoto H, Kasai K: Low-energy laser irradiation facilitates the velocity of tooth movement and the expressions of matrix metalloproteinase-9, cathepsin K, and alpha(v) beta(3) integrin in rats. Eur J Orthod. 2010, 32: 131-139. 10.1093\/ejo\/cjp078.","journal-title":"Eur J Orthod"},{"key":"221_CR23","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1093\/ejo\/26.4.353","volume":"26","author":"AB Rabie","year":"2004","unstructured":"Rabie AB, Xiong H, Hagg U: Forward mandibular positioning enhances condylar adaptation in adult rats. Eur J Orthod. 2004, 26: 353-358. 10.1093\/ejo\/26.4.353.","journal-title":"Eur J Orthod"},{"key":"221_CR24","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1046\/j.1365-3164.1999.00148.x","volume":"10","author":"M Scardino","year":"1999","unstructured":"Scardino M, Swaim S, Sartin E, Hoffman C, Oglivie G, Hanson R, Coolman SL, Davenport E: The effects of omega-3 fatty acid diet enrichment on wound healing. Veterinary Dermatology. 1999, 10: 283-90. 10.1046\/j.1365-3164.1999.00148.x.","journal-title":"Veterinary Dermatology"},{"key":"221_CR25","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1002\/jbmr.5650110613","volume":"11","author":"M Bliziotes","year":"1996","unstructured":"Bliziotes M, Murtagh J, Wiren K: Beta-adrenergic receptor kinase-like activity and beta-arrestin are expressed in osteoblastic cells. J Bone Miner Res. 1996, 11: 820-826.","journal-title":"J Bone Miner Res"},{"key":"221_CR26","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1007\/s00508-008-0932-6","volume":"120","author":"E Stein","year":"2008","unstructured":"Stein E, Koehn J, Sutter W, Wendtlandt G, Wanschitz F, Thurnher D, Baghestanian M, Turhani D: Initial effects of low-level laser therapy on growth and differentiation of human osteoblast-like cells. Wien Klin Wochenschr. 2008, 120: 112-117. 10.1007\/s00508-008-0932-6.","journal-title":"Wien Klin Wochenschr"},{"key":"221_CR27","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1089\/pho.2005.23.161","volume":"23","author":"A Stein","year":"2005","unstructured":"Stein A, Benayahu D, Maltz L, Oron U: Low-level laser irradiation promotes proliferation and differentiation of human osteoblasts in vitro. Photomed Laser Surg. 2005, 23: 161-166. 10.1089\/pho.2005.23.161.","journal-title":"Photomed Laser Surg"},{"key":"221_CR28","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1034\/j.1600-0501.2000.011006540.x","volume":"11","author":"O Dortbudak","year":"2000","unstructured":"Dortbudak O, Haas R, Mallath-Pokorny G: Biostimulation of bone marrow cells with a diode soft laser. Clin Oral Implants Res. 2000, 11: 540-545. 10.1034\/j.1600-0501.2000.011006540.x.","journal-title":"Clin Oral Implants Res"},{"key":"221_CR29","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1089\/pho.2006.2075","volume":"25","author":"X Liu","year":"2007","unstructured":"Liu X, Lyon R, Meier HT, Thometz J, Haworth ST: Effect of lower-level laser therapy on rabbit tibial fracture. Photomed Laser Surg. 2007, 25: 487-494. 10.1089\/pho.2006.2075.","journal-title":"Photomed Laser Surg"},{"key":"221_CR30","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1016\/j.tripleo.2003.11.008","volume":"97","author":"M Khadra","year":"2004","unstructured":"Khadra M, Kasem N, Haanaes HR, Ellingsen JE, Lyngstadaas SP: Enhancement of bone formation in rat calvarial bone defects using low-level laser therapy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004, 97: 693-700. 10.1016\/j.tripleo.2003.11.008.","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"}],"container-title":["Head &amp; Face Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1746-160X-8-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1746-160X-8-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1746-160X-8-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1746-160X-8-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T18:25:52Z","timestamp":1630520752000},"score":1,"resource":{"primary":{"URL":"https:\/\/head-face-med.biomedcentral.com\/articles\/10.1186\/1746-160X-8-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,23]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["221"],"URL":"https:\/\/doi.org\/10.1186\/1746-160x-8-4","relation":{},"ISSN":["1746-160X"],"issn-type":[{"value":"1746-160X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,23]]},"assertion":[{"value":"28 September 2011","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 February 2012","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 February 2012","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"4"}}