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This was examined in the present study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine foetuses from three sows were inoculated at 55 days of gestation: three with 10<jats:sup>4.3<\/jats:sup>TCID<jats:sub>50<\/jats:sub>of the PCV1 cell culture strain ATCC-CCL33, three with 10<jats:sup>4.3<\/jats:sup>TCID<jats:sub>50<\/jats:sub>of the PCV1 field strain 3384 and three with cell culture medium (mock-inoculated). At 21 days post-inoculation, all 6 PCV1-inoculated and all 3 mock-inoculated foetuses had a normal external appearance. Microscopic lesions characterized by severe haemorrhages were observed in the lungs of two foetuses inoculated with CCL33. High PCV1 titres (up to 10<jats:sup>4.7<\/jats:sup>TCID<jats:sub>50<\/jats:sub>\/g tissue) were found in the lungs of the CCL33-inoculated foetuses. All other organs of the CCL33-inoculated foetuses and all the organs of the 3384-inoculated foetuses were negative (&lt; 10<jats:sup>1.7<\/jats:sup>TCID<jats:sub>50<\/jats:sub>\/g tissue) by virus titration. PCV1-positive cells (up to 121 cells\/10 mm<jats:sup>2<\/jats:sup>in CCL33-inoculated foetuses and up to 13 cells\/10 mm<jats:sup>2<\/jats:sup>in 3384-inoculated foetuses) were found in the heart, lungs, spleen, liver, thymus and tonsils. PCR and DNA sequencing of<jats:italic>Rep<\/jats:italic>recovered CCL33 or 3384 sequences from CCL33- or 3384-inoculated foetuses, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>From this study, it can be concluded that cell culture PCV1 can replicate efficiently and produce pathology in the lungs of porcine foetuses inoculated at 55 days of foetal life.<\/jats:p><\/jats:sec>","DOI":"10.1186\/1746-6148-7-64","type":"journal-article","created":{"date-parts":[[2011,11,16]],"date-time":"2011-11-16T13:52:37Z","timestamp":1321451557000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Outcome of experimental porcine circovirus type 1 infections in mid-gestational porcine foetuses"],"prefix":"10.1186","volume":"7","author":[{"given":"Dipongkor","family":"Saha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J","family":"Lefebvre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Ducatelle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan V","family":"Doorsselaere","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans J","family":"Nauwynck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,10,21]]},"reference":[{"key":"301_CR1","first-page":"153","volume":"226","author":"I Tischer","year":"1974","unstructured":"Tischer I, Rasch R, Tochtermann G: Characterization of papovavirus-and picornavirus-like particles in permanent pig kidney cell lines. 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