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Repeated intradermal injections of<jats:italic>Ascaris suum<\/jats:italic>extract were performed in both lateral thoracic areas of six conscious hypersensitive Beagle dogs, topically treated during 8 consecutive days. Adelmidrol (2%) was applied to one side and vehicle to the other. 24 hours after the last antigen challenge, two biopsies (adelmidrol- and vehicle-treated side) were obtained for each dog at the antigen injection site.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A significant reduction in the antigen-induced wheal areas was observed on the 4<jats:sup>th<\/jats:sup>and 7<jats:sup>th<\/jats:sup>day of adelmidrol treatment. Moreover, cutaneous mast cell numbers were significantly decreased in biopsies obtained after 8 consecutive days of topical adelmidrol treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results obtained in the present study show that topical treatment with adelmidrol might represent a new therapeutic tool in controlling the early and late allergic inflammatory skin responses in companion animals.<\/jats:p><\/jats:sec>","DOI":"10.1186\/1746-6148-8-230","type":"journal-article","created":{"date-parts":[[2012,11,26]],"date-time":"2012-11-26T15:23:01Z","timestamp":1353943381000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Inhibitory effect of topical Adelmidrol on antigen-induced skin wheal and mast cell behavior in a canine model of allergic dermatitis"],"prefix":"10.1186","volume":"8","author":[{"given":"Santiago","family":"Cerrato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Brazis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Federica","family":"della Valle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alda","family":"Miolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Puigdemont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,11,26]]},"reference":[{"key":"545_CR1","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1016\/S0190-9622(87)70294-1","volume":"17","author":"M Nazzaro-Porro","year":"1987","unstructured":"Nazzaro-Porro M: Azelaic acid. 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